Plants produce a diverse range of bioactive compounds making them rich source of different types of medicines. The plants are mostly cultivated for decoration and to enhance the appearance of houses, gardens, road sides, and also for commercial purposes such as floral decorations in form of bouquet. They are also source of fragrant oils for perfume making and cosmetic. However only very few of these plant species have found to be used in medicine and little or no literature exit on their chemical and biological activities. Araucaria columnaris is an ornamental plant, commonly known as Christmas tree, belonging to the family Araucariaceae. Plant resin was used for the present study, antibacterial activity and GC-MS analysis of Araucaria columnaris resin was carried out. The resin was subjected to solvent extraction using decreasing polarity solvents (aqueous, methanol, ethyl acetate and benzene). TLC profiling of all the extracts gives an idea about the presence of various phytochemicals and its fractions were checked for antibacterial activity against major clinical pathogens. It was found that fraction 4 (F4) of methanolic extact showed maximum zone of inhibition against Gram positive organisms. This fraction was subjected to GC-MS analysis; the result revealed the presence of a board range of many medicinal compounds and antioxidant activity of resin of Araucaria columnaris were identified.

Dr. saranya devi k

The kidney contains mineral deposits in various phases of calcium salts, such as calcium oxalate and calcium phosphate. Calcium hydrogen phosphate dihydrate (CaHPO4.2H2O) / brushite is a stable form of calcium phosphate, which exists in the form of kidney and bladder stones. The study aimed to explore the possible morphological features of brushite crystals. The study was carried out on a glass slide under a microscope to observe the growth patterns of these crystals. For this purpose, a drop of gel medium (sodium meta silicate solution + 1M orthophosphoric acid solution) at pH 4.99-5.09 was placed in the middle of a glass slide and converted into a gel. A 1M calcium chloride drop was added to form the gel adequately. The glass slide was observed under a microscope till it was completely dried. Calcium hydrogen phosphate dihydrate was formed as elementary needles, needle clusters, an assemblage of needles with platy crystals, plates with spatial branches, radiating assemblage of platy crystals, star shape crystals and tetragonal bipyramidal. The Current study provides brushite crystallisation phases on glass slides for the first time. It may also be used as a model to evaluate prophylactic management against renal stones through in vitro assessment of crystal growth and aggregation inhibition and modulation of developing or developed crystals by using different natural products. However, it was a preliminary study with no quantitative or statistical analysis.

Dr. salman ahmed

Higher Education has an important role in the task of rebuilding a nation and it pavCes the way for overall development of a nation. The twentieth century has witnessed several revolutions like Green revolution, White revolution, I.T revolution, so on and so forth, taking human civilization to new heights. At the start of 21st century, we gave a lot of importance given to higher education. Every country realized the value of higher education and the benefits that accrue from it. “The social demands for higher education continue to increase. The inabilities of the state to support this growing demand result in new financing arrangements for higher education. The recent reforms in this area could be broadly divided into two categories: the privatization of public institutions and the establishment of private institutions of higher education. Privatization implies the application of market principles in the operation of public institutions, while ownership rests within the public domain. Promotion of the private sector implies the growth and expansion of the non-state sector in higher education, and very often this sector does not rely on state funding for its growth and expansion. Both of these measures have paved the way for market operations in higher education

Dr gedam kamalakar

Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative medicine for treating neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin, and naringin (NRG), have been shown to possess promising potential in treating neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.

Dr. salman ahmed

Parkinson’s disease is a common movement disorder associated primarily with oxidative stress-mediated degeneration of dopaminergic neurons. Earlier studies showed that Sorghum bicolor-based supplement (SbS) exhibited antioxidant and neuroprotective activities and might likely rescue the death of dopaminergic neurons in Parkinson’s disease. This study examined the effect of SbS on rotenone-induced Parkinsonian-like motor deficits in rats and the involvement of oxidative stress and pro-inflammatory cytokines. Rats were divided into six groups and treated orally with sunflower oil (vehicle-control), rotenone (2.5 mg/kg) alone or in combination with each dose of SbS (50, 100, and 200 mg/kg) and levodopa-carbidopa (10 mg/kg) on an alternate day for 28 days. The changes in motor functions were evaluated on day 28 and the brain concentrations of oxidative stress biomarkers and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) were determined. Rotenone caused motor deficits by impaired locomotor activity in the open field test and induced catalepsy in the bar test, which were attenuated by SbS. Rats pretreated with SbS had reduced brain levels of malondialdehyde, nitrite, and pro-inflammatory cytokines compared to rotenone controls. SbS mitigated rotenone-induced depletion of reduced glutathione and antioxidant enzymes in the rat brain. The results suggest that SbS ameliorated rotenone-induced Parkinsonian-like motor dysfunctions by reducing neuronal oxidative stress and pro-inflammatory cytokines in rats.

Mediterranean journal of pharmacy and pharmaceutical sciences

In this work a set of some cyclic peroxy ketals were tested for their antimalarial activities. Quantitative structure activity relationship (QSAR) analysis was applied to 20 organic compounds of the above mentioned derivatives using Physicochemical, informational and 2D-autocorelation parameters and modeled their antimalarial activity (logIC 50) values. The multiple regression analysis clearly indicates that 5 BIC, 1 IC, MATS4v and ST parameters yielded the best model having R 2 value of 0.9515. The predictive powers of the models were explained using LOO (Leave-One-Out) Cross validation procedure. The results are also discussed on the basis of ridge regression.

Dr. shweta sharma

The study was conducted by researcher on Coping strategies adopted among adolescents in selected Schools, Distt. Mohali, Punjab. The main aim of this study was to assess on Coping strategies adopted among adolescents, to find out the association between coping strategies adopted among adolescents with their selected socio demographic variables.Descriptive Research design has been used to assess the Coping strategies among 400 adolescents studying in Golden Bell’s school,Sector-77 and Shemrock School, sector 69, in Distt Mohali,Punjab. The sample was selected by Systematic random sampling technique. Pilot study was conducted on 10% of population and sample consists of 40 adolescents. Data on Coping Strategies adopted among adolescents were collected under two sections, Section A- Socio demographic variables and Section B- Coping Strategies Scale of Prof. A.K. Srivastava to assess coping strategies adopted among adolescents. Data was analyzed through Descriptive and inferential statistical methods. The results showed that majority of adolescents were adopting moderate Coping Strategies.There was significant association between Coping Strategies adopted by adolescents with their selected demographic variable such as Class of study, Occupational Status of Mother and Monthly Family Income.Based on the findings of the study, recommendations were drawn on nursing service, nursing education, nursing administration and nursing research.

Anu sharma

Introduction: Use of endotracheal tube (ETT) has many limitations. There is a need for an airway device with similar safety and good side effect profile. In this prospective observational study, the oxygenation and ventilation parameters between patients who were inserted Proseal laryngeal mask airway (PLMA) or ETT for laparoscopic surgeries were compared. Materials and Methods: After ethical committee approval, informed consent was obtained from sixty patients (thirty in each group) posted for elective laparoscopic surgery. Following induction of general anaesthesia and paralysis, PLMA or ETT was inserted and pressure control mode was used for ventilation. The following parameters were measured: a. Oxygen saturation and changes in FiO2 needed to ensure a target SpO2> 95%, EtCO2 and changes in respiratory rate and inspiratory pressure needed to ensure a target EtCO2 between 35-45 mmHg. b. Insertion characteristics of airway device and gastric tube, hemodynamic responses, incidence of complications. Statistical Analysis: Chi-square test was used to analyze qualitative data. Independent t test was used to assess quantitative variables. Repeated measures ANOVA was used to compare the outcome measures over time adjusted for duration of surgery and anaesthesia. P values<0> Results: Both groups were comparable with respect to age, gender and weight. Oxygenation and ventilation parameters achieved with both ETT and PLMA were comparable and satisfactory. Haemodynamic parameters increased significantly in ETT group compared to PLMA group during airway insertion and removal. Also, postoperative sore throat was comparatively less in the PLMA group. Conclusion: Hence we conclude that PLMA may be considered as an alternative to ETT in airway management of patients undergoing laparoscopic surgeries with comparable oxygenation and ventilation parameters and improved side effect profile.

Kamal singh

Here is presented a short review on the medical potency of the most toxic plant of Europe. In many countries it isn't concerned any more as therapeutic agent in medicine due to frequent intoxications. However, in the homeopathy, preparations and patent medicines still contain aconitine and other alkaloids (abundant levels). There exists even a US Patent "ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF" (No. US 9,085,536 B2 by du Bois et al. 2015).

Stefan dahl

Social media use is inherently linked to everyday life in the digital world, from professional contexts to leisure time. Prior research focused on antecedents of social media use such as personality traits, age, gender, social skills, and also on broad range of its various effects. Positive effects include extension of friendship network, diminishing anxiety in social interaction, and improving exercise motivation. Problematic social media use and addiction are related to stress, depression, suicidal thoughts, loneliness, and scarce school engagement. Less attention has been paid to the relationship between social media use and well-being. Inconsistent results were obtained; being emphasized either small relationship between time spent using social media and psychological well-being, or absence of significant correlation. Aims: Therefore, we analyzed in this research what degree and how active social media use and self-esteem would lead to subjective well-being. Starting from the necessary distinction between the passive and active social media use, the aim of this study was to analyze the direct and indirect effects of active use and self-esteem on subjective well-being. Method: Based on a cross-sectional design, the survey data was collected from a sample consisted of 653 participants (male = 274; M age = 21.52; SD = 4.33). To verify the hypothesized direct and indirect effects included in the multiple mediation model, a path analysis was performed. Results: The findings showed positive association between active social media use, self-esteem, affective engagement in social media use, sense to belong to online community, number of friends/followers, and subjective well-being, The path analysis revealed excellent fit between proposed mediation model and sample data. Active social media use has directly effect on subjective well-being, and indirectly via sense to belong to online community. Interaction between active social media use and self-esteem significantly predicts subjective well-being. The relationship between affective engagement in social media use and sense to belong to online community is mediated by number of friends or followers on social media platforms. Conclusion: The findings of this study extend the previous research, providing support for the relationship between active social media use and subjective well-being. Keywords: active social media use; number of friends/followers; affective engagement in social media use; sense to belong to online community; subjective well-being; mediation analysis.

Elena stănculescu

Background: Pulses are well known richest source of vegetable protein and is known as poor man’s food because of its essential component in diet. The frontline demonstrations of pulses were carried out on 311.8 ha area with 694 demonstrations in different clusters of Nagaur district of Rajasthan. Methods: Front line demonstrations on chickpea, mung bean and moth bean crop were conducted by Krishi Vigyan Kendra, Nagaur-I, Agriculture University, Jodhpur during rabi and Kharif season of 2011-12 to 2019-20. Result: In demonstrations up to 29.43%, 30.29% and 35.22% yield increase of chickpea, mungbean and moth bean crop was observed over the farmer’s practices in the year 2011-12, 2017 and 2016. The yield gap between improved technology and conventional farmer’s practices was ranging from 1.98 to 4.54 q/ha, 0.61 to 2.55 q/ha and 0.6 to 1.68 q/ha, respectively. Whereas, the highest net returns of ` 71,881 ha-1 , ` 45,884 ha-1 and ` 14,315 ha-1 was observed in the year 2019-20, 2014 and 2016, respectively with the highest incremental cost benefit ratio of 1:3.71, 1:3.95 and 1:1.97 under demonstrations practices.

Dr. babu lal jat

Background: Many individuals today use herbs as a drug alongside medicine and non-physician-recommended medications, as herbs are thought to be natural and safe. However, many herbs can potentially interact with other drugs, causing hazardous effects and diminished therapeutic effects of different prescriptions. Objective: It ought to be comprehended that herbal drugs contain multiple active compounds in different percentages, which can change the enzymatic frameworks, transporters, and physiological processes. Methods: Data on pharmacokinetic drug interactions with herbal products were searched using different search engines, such as Google Scholar, Scopus, and ScienceDirect. Results: This worldwide increment in herbal drug popularity has risen concerning HDIs. These PD or PK interactions are particularly significant for medications. Assessment of herbal drug interactions is complex because of inconsistency in herbal drug composition and frequently meagre information on active constituent pharmacokinetics. These restrictions are further bewildered by the differing points of view concerning herbal product regulation. Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices regarding patient safety. The expanding comprehension of HDPKI will direct more attention to potential interactions.

Dr. salman ahmed

Brucellosis is a zoonotic infection often linked to direct or indirect exposure to animals or unpasteurized dairy products. Atypical presentations in patients without classical risk factors pose significant diagnostic and management challenges. A 68-year-old woman presented with a 2-month history of burning pain involving cervical and lumbar regions, associated with weight loss, decreased appetite, and subjective fever. Examination revealed paravertebral tenderness and left knee swelling with effusion. Previous MRI showed multifocal marrow edema and soft tissue thickening in the lumbar spine, suggesting infection or inflammation. The patient denies exposure to unpasteurized dairy products, raw meat, or animals. Brucella serology revealed positive IgG with Brucella melitensis titer 1:160, later confirmed by blood cultures. PET imaging demonstrated multifocal metabolically active arthritic changes involving the spine, shoulders, and knees. Arthrocentesis confirmed inflammatory arthritis due to brucellosis. The patient was started on doxycycline, rifampin, and a 14-day course of intravenous gentamicin. During hospitalization, management was complicated by persistent knee pain and swelling requiring multimodal analgesia. Spinal brucellosis in the absence of classical risk factors is an odd presentation, emphasizing the importance of maintaining a high index of suspicion in endemic regions. Advanced imaging and microbiological confirmation are pivotal procedures in diagnosis. Early recognition of atypical brucellosis is critical to prevent complications and improve outcomes.

Karishma

Recent reports showed an association between bariatric surgery and the development of acute pancreatitis. This report presents a case of acute pancreatitis following a laparoscopic sleeve gastrectomy (LSG) in a 24-year-old Indian female patient, who presented to the Emergency Department at Hamad General Hospital, Qatar, with severe epigastric pain and persistent vomiting 13 days after LSG. She was diagnosed with acute pancreatitis based on a high level of lipase greater than three times the upper limit of normal, and a computed tomography scan of the abdomen, which was consistent with acute pancreatitis. The patient was treated conservatively with a significant improvement in her symptoms and laboratory tests throughout her admission and consequently was discharged.

Karishma

Hemolytic uremic syndrome (HUS) is a microangiopathic thrombotic disease, which is classified into atypical, typical, and secondary types. Thrombocytopenia, acute kidney failure, and hemolysis are the main features of HUS regardless of its type. Infection with Shiga toxin-producing Escherichia coli causes typical HUS, and gene mutations trigger atypical HUS, while secondary HUS is associated with bone marrow transplantation, autoimmunity, cancer, and other diseases. New insights into the pathogenesis of HUS have emerged over the past decades, suggesting an important role of the complement system in disease pathogenesis, which has been reinforced by the efficacy of plasma exchange and monoclonal antibodies in its treatment. In this review, we performed an updated review of HUS with a focus on understanding its pathogenesis.

Karishma

The purpose of this research was to investigate the relationship between affective tendencies in embarrassing situations and cheating behavior in a sample of adolescents. Two objectives were addressed: first, exploring the relationship between cheating behavior and shame-proneness, guilt-proneness, externalization, and detachment; second, analyzing the mediating role of detachment in the relationship between externalization and cheating behavior. The results showed positive correlations between the cheating behavior and externalization and detachment, a negative correlation with guilt, and no relation with shame. It was confirmed the mediating role of detachment. Implications for educators were discussed, emphasizing the importance of stimulation of students’ moral rules understanding.

Elena stănculescu

Gastrointestinal parasites constitute a serious problem to poultry production in Africa. But often times they are usually ignored by the majority of farmers. Whereas, it is one of the major leading causes of ill-health and high mortality rates in the poultry industry. This study was conducted to determine the prevalence of gastrointestinal parasites of chicken slaughtered at the Jalingo market. A total of 500 gastrointestinal tracts of local chicken comprising of 250 from males and 250 from females were collected from the poultry slaughtering and dressing section of the Jalingo market, and screened for gastrointestinal helminths using the saturated sodium chloride floatation techniques. An overall prevalence of 28.6% (143/500) was recorded with a prevalence of 16.8% (84/500) in males and 11.8% (59/500) females. Nine different species parasites comprising five nematodes and four cestodes, were recorded. Nematodes were the most predominant intestinal parasite with a prevalence rate of 89 (62.2%). And Ascaridia galli 45 (50.5%) was found to be the most prevalent nematode. Other nematodes observed were Capillaria annulata 13.4% (12/89), Heterakis gallinarum 2.2% (2/89), Strongyloides avium 32.5% (29/89), and Syngamus trachea 1.1% (1/89) having the lowest prevalence. Railliatina tetragona 57.4% (31/143) was the most prevalent cestode recorded. Other Cestodes were Hymenolepis carioca 27.7% (15/54), Raillietina cesticellus 12.9% (7/54), and Davainea proglottina 1.8% (1/54). No trematode was recorded in this study. This study showed that nematodes and cestodes were the common helminth parasites in local chicken. There is therefore the need for educating the farmers on the impact of gastrointestinal parasite infection in chicken and the need to institute good management practices so as to reduce their effects on productivity. Sex of the chicken had no statistically significant difference (X2 = 6.12, df = 1; P > 0.05) on the prevalence of helminths.

Bitrus inuwa

Yield Analysis of Maize Hybrids Lenient to Turcicum Leaf Blight Disease in Southern Districts of Karnataka

Veerabhadraswamy al

In this paper, we propose a deep learning approach for visual recognition of bird species in noisy environments. Bird species recognition has been a challenging task due to the high variation in bird appearances and the presence of noise and clutter in natural environments. Our approach utilizes a deep convolutional neural network (CNN) to learn discriminative features from bird images and classify them into different species. We also incorporate data augmentation techniques to increase the diversity of the training data and improve the robustness of the model. To address the issue of noisy environments, we introduce a novel noise-robust loss function that penalizes the model for incorrect predictions caused by noise. We evaluate our approach on a dataset of bird images collected from diverse environments and compare it with state-of-the-art methods. Our results demonstrate that our approach achieves superior performance in both clean and noisy environments, highlighting the effectiveness of our noise-robust loss function. Our approach has the potential to be applied in real world scenarios for bird species recognition and conservation.

Pk dutta

Fungal infection of the nails (onychomycosis) is a common condition that is hard to cure. The fungus hidden in the nail is difficult to treat with antifungal medications, and infected nails take months to heal. Antifungal nail polish can occasionally be used to treat mild cases, but blood-stream-permeable medications are required to treat more serious infections. We need something better because even these are not always successful and can have negative side effects like skin rash or liver issues. Additionally, onycholysis (the separation of the nail plate) creates a moist environment that can encourage the growth of fungi. Moreover, immunosuppressive medication use may worsen onychomycosis. In this example, the diseased entity's clinical presentation in an adult patient was described.

Mediterranean journal of pharmacy and pharmaceutical sciences