Streptococcus bovis/gallolyticus was considered as lower grade pathogen involved in endocarditis. Recent accumulating evidence has suggested that Streptococcus bovis/gallolyticus plays an important role in the initiation and development of colorectal cancer. This study was aimed to address the association between Streptococcus bovis/gallolyticus and colorectal cancer among Libyan patients, to determine the dominant biotype of Streptococcus bovis/gallolyticus associated with colorectal cancer patients and to evaluate the antibiotic susceptibly patterns of isolated strains. The study involved 20 colorectal cancer patients, 20 patients with large adenomas polyp and 20 people with healthy colonic mucosa as a control group. All the candidates were subjected to colonoscopy and histopathological examinations and conformation. The suspected and normal cases were then diagnosed according to the protocol used by the medicine specialist and grouped in accord with the study aim. All biopsies were handled and treated to isolate the suspected positive colonies of Streptococcus bovis/gallolyticus. Of the 20 colorectal cancer patients, seven patients (35%) were found to be Streptococcus bovis/gallolyticus carriers, (95% CI 1.22 - 1.72, p < 0.05). Nine patients (45%) were diagnosed colorectal cancer positive at age above 60 years old, eight patients (40%) at age 40 - 60 years old and three patients (15%) at age bellow 40 years old. Also, nine out of 20 patients (45%) with large adenomas polyp were found to be Streptococcus bovis/gallolyticus carriers, (95% CI 2.16 - 2.71, p < 0.05). Of the 20 healthy people with colonic mucosa, Streptococcus bovis/gallolyticus never been isolated. Streptococcus. bovis biotype II/I and Streptococcus. equinis were both susceptible to the above mentioned antibiotic classes, although Streptococcus bovis biotype I was highly resistance to most clinically used antibiotics. However, there was strong relationship between Streptococcus bovis/gallolyticus and colorectal cancer or large polyp formation. However, it is not well understood whether the bacterium has a pathogenic role in the initiation and progression of neoplasia or just an epiphenomenon of colorectal neoplasms.

Mediterranean journal of pharmacy and pharmaceutical sciences

The current study used the chick emesis model to explore the anti-emetic effect of the methanolic extract of Acalypha ornata Hochst—roots. Emesis was induced by the oral administration of copper sulfate to male chicks. Acalypha ornata root extract (150 mg/kg orally) showed an anti-emetic effect and was compared with the reference drug chlorpromazine

Dr. salman ahmed

Penelitian ini adalah jenis penelitian deskriptif-kualitatif. Penelitian ini secara umum bertujuan untuk mendeskripsikan muatan nilai-nilai karakter yang terdapat pada buku siswa kelas IV Tema Indahnya Kebersamaan. Sumber data penelitian adalah buku siswa kelas IV Tema Indahnya Kebersamaan. Data penelitian berupa nilai-nilai karakter yang terdapat pada buku siswa yaitu nilai sopan, nilai santun, nilai religius, nilai nasionalisme, nilai mandiri, nilai gotong royong, dan nilai integritas. Berdasarkan analisis yang telah dilakukan, jumlah nilai karakter yang ditemukan sebanyak 84. Jumlah tersebut merupakan akumulasi dari semua tema yang terdiri dari tiga subtema yaitu keberagaman budaya bangsaku, kebersamaan dalam keberagaman dan bersyukur atas keberagaman. Adapun rincian jumlah setiap karakter yaitu: (1) sopan 2; (2) santun 4; (3) religius 22; (4) nasionalisme 26; (5) mandiri 10; (6) gotong royong 19; dan (7) integritas 1. Berdasarkan hasil analisis muatan nilai-nilai karakter pada buku siswa kelas IV tema Indahnya Kebersamaan dapat disimpulkan bahwa buku siswa tema Indahnya Kebersamaan kelas IV SD/MI memuat 7 nilai karakter.

Educare: journal of primary education

COVID-19 pandemic has spread all over the world and has caused psychological impacts. Medical students are known to be vulnerable population, experiencing higher levels of anxiety, depression and other psychological disorders compared to non-medical students. The nature of life changes like what happened and still happening during the pandemic have its impact on mental health of the students. The aim of this study was to identify the psychological impacts of COVID-19 on medical students among different universities to develop profiles to characterize students' anticipated levels of psychological impacts during the pandemic. Also, to search for potential risk factors that could make students more likely to experience these impacts. An online survey was filled by medical students (n = 100) at faculties of medicine, dentistry, pharmacy and medical sciences of different universities: University of Benghazi, Libyan International Medical University, Omar Almokhtar University, Cairo University and Alexandria University. The students were taken to the further analysis. Thus, 55% of the participants had psychological impacts due to the pandemic and 17% had severe effect. Some of these impacts were actually positive as a large number (58%) of the participants felt relaxed during the pandemic. Multiple stressors were identified that contributed to the increased levels of stress, anxiety and depression. These included concern about academic performance (80%), concern about self/dear-one’s health (90%), difficulty with concentration (46%), disruption to sleeping patterns (78%), increased social isolation (26%), disruption to eating patterns (48%), changing in the living environment (26%), financial difficulties (34%) increased class workload (20%) depressive thoughts (37%) and suicidal thoughts (07%). In conclusion, the study indicates that COVID-19 pandemic have positive and negative impacts on medical students. Thus, it is suggested that measures need to alleviate students’ stress, which might have harmful effects in different aspects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Algae are used by human beings for food from ancient times, as they contain a wide range of elements. Using inexpensive, in-house bioassays for screening and monitoring of extracts where the aim of these bioassays is to provide a front-line screen that can be followed up by more specific and expensive bioassays. The phytochemical screening, assessment of toxicity and effects on growth parameters of Traticum sativum of ethanol and dichloromethane extracts of five macro-algal species (two green, two brown and one red) collected from Libyan coast were studied. The Brine shrimp lethality assay was conducted to determine the toxic effects of seaweed extracts on Artemia Salina nauplii larvae and this was to provide a front-line screen that can be backed up by specific and expensive bioassays once the active compounds have been isolated. The effect of seaweeds liquid fertilizer on growth parameters of Traticum sativum were examined using in vitro seed germination in petri dishes bioassay. Seed germination percentage, fresh and dry weight, shoots length and roots length were the parameters recorded in young seedlings post germination. Ethanolic and dichloromethane extracts of the five algae samples represented the presence of several chemical constituents. All extracts exhibited LC50 > 1000 μg per ml. In this study, all algal extracts are non-toxic according to Brine shrimp lethality assay so they may be considered as edible seaweeds. Different effects on growth parameters of Traticum sativum suggested the presence of micro-elements, macro-elements and different concentrations of plant growth hormones.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Malaria is a systemic disease caused by various species of Plasmodium, transmitted through the bite of a female Anopheles mosquito. According to the World Health Organisation, there were 214 million cases of malaria worldwide in 2015. Nigeria’s burden of malaria is about 51million cases and 207,000 deaths annually, accounting for 60% of outpatient visits to hospitals, 11% of maternal mortality, and 30% of child mortality. The study aimed to compare RDT and microscopy in malaria diagnosis in a District Hospital in Enugu state, Southeast Nigeria. Methods: Blood samples of 300 suspected cases of acute malaria were tested for malaria parasite using RDT and microscopy simultaneously. Results: In 2017, the study found a malaria prevalence of 25% (46.2% in children, and 18.1% in adults) in Awgu. RDT was positive in 38% and microscopy in 70.3% of cases. Both RDT and microscopy were positive in 36.3%, negative in 28.3%, and discordant in 35.4%. Sensitivity of RDT was 50.7% (89.4% in children, and 25.6% in adults). RDT had a specificity of 100% (both children and adults), positive predictive value of 1 (both children and adults), and negative predictive value of 0.6 (0.5 in children, 0.6 in adults). Conclusions: RDT (SD Malaria Ag P. f) had more sensitivity in children (89.4%) than adults (25.6%), and the occurrence of false negative results was more in adults (46.8%) than children (9.5%). All negative RDT results need to be examined microscopically, to rule out false negative cases.

Emmanuel umegbolu

Over the past 20 years, universities have been faced with sustained change, driven by external factors. This has led to the evolution of the teaching and research mission and the creation and rise of the third mission. Such mission extension has led to the emergence of entrepreneurial universities which has seen a move from traditional research and teaching business models, to business models which incorporate a much wider range of activities, to meet stakeholder demands as well as sustaining and growing universities in the era of intense national and international competition. This special issue extends knowledge by providing novel insights into the multidimensional antecedent contextual influences, consequences and implications of university mission expansion. We also provide a foundational research agenda which will help guide future research exploring the changing and expanding university missions and business models. Higher education system plays an important role for the country’s overall development which includes industrial, social, economic etc. Indian higher education system is third largest in the world. The role of Indian higher educational institutes such as colleges and universities in the present time is to provide quality based education in the field of education, research etc to empower youth for self sustainability. This paper includes the key challenges that India is currently facing in higher education and also includes some initiatives taken by the government to meet those challenges.

Dr gedam kamalakar

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

Mamta gaur

: Analgesic, anti-inflammatory and diuretic activities of the methanol extract of two varieties of Cicer arietinum viz black or Desi and white or Kabuli were tested in 200 and 400 mg/kg doses. For the analgesic effect of the extracts, acetic acid-induced writhing, tail immersion and hot plate tests were employed in mice. The anti-inflammatory activity was carried out by carrageenan-induced inflammation in rats, whereas the diuretic action was determined using metabolic cages for rats. Animals were divided into six groups (n=7): (1) Control (2) Standard (3) MECAB 200 (4) MECAB 400 (5) MECAW 200 (6) MECAW 400. All extracts and standard drugs were administered orally. Acute oral toxicity of the extracts was also checked in mice up to 2000mg/kg dose, which showed a favorable safety. Significant analgesic and anti-inflammatory effects were observed. The results of diuretic activity were significant at the 12th and 24th hrs. Therefore, it is concluded that the methanol extracts of the seeds of Cicer arietinum have analgesic, anti-inflammatory and diuretic potential.

Dr. salman ahmed

Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

The main focus of this study is the coverage of New Straits Times (NST) of the first Palestinian General Elections for two presidential candidates namely, Yasser Arafat and Samiha Khalil. This study aimed to explore if any of Entman’s 1993 framing functions was used in the coverage of this issue and to explore whether the tone of NST coverage was negative, positive, balanced or neutral. To achieve the aims of this study, qualitative content analysis of elections stories from NST has been adopted. The number of news stories was eight, and the time frame started from 19th January to 13th February 1996, where three of these stories were published on the same day of 22nd January, two days after holding the elections on 20th January. Defining problems and diagnosing causes were the most prominent of Entman’s four framing functions presented in all the articles. The moral judgment function was included in four news stories, and suggesting remedies was included in two news stories out of eight. The findings revealed that Yasser Arafat received 50% balanced coverage, followed by 37.5% positive coverage, and only 12.5% negative coverage, while Samiha Khalil received 67% balanced coverage, compared to 33% positive coverage.

Mohammed fadel arandas

Object: The main purpose of the research is to develop modern tools for insurance management in the global economic crisis, to make an objective assessment based on a critical analysis of existing ones, to identify situations that could lead to international economic, social, and natural threats. It is made some recommendations for the development of insurance calculations for the republic of Uzbekistan. Methods: Methods for reforming modern calculation of insurance tariffication are recommended by means of theories of probabilities, statistical and mathematical analysis, and foreign advanced countries practical types of summarizing. Findings: While making an analysis, it has found that modern tools for the insurance management of Uzbekistan are needed. We proved this by the results of the modern calculation of insurance. For the development of the insurance market of Uzbekistan, it should be analyzed by means of penetration and density of insurance premiums, making the deepest calculation of risks of the economy of Uzbekistan, and using the main principles and formulas of the theory of probability. Conclusions: In the end, we can take some results, and give some recommendations such as using the tools of theories of probabilities can help us find the main risks of economy, it’s powers of influences of the market economy, statistical and mathematical analysis also add some practical, objective results for making under control of any types of insurance risks

Ikboljon odashev mashrabjonovich

The study was conducted on glass slides to observe the growth patterns of urinary calcium oxalate monohydrate crystals and their inhibition using 5, 10, 15 and 20 % Phaseolus lunatus seed infusion. For this purpose, a drop of gel medium (sodium metasilicate of 1.06 specific gravity and 3M acetic acid solution) at pH 5.02-5.17 was placed in the middle of a glass slide and converted into a gel. A 1 M oxalic acid drop was dropped to the left, and 1 M calcium chloride and magnesium acetate (1:1) solution was dropped to the right side of the properly formed gel. The glass slide was observed under a microscope till it was completely dried. In the case of the crystal inhibition study, a drop of Phaseolus lunatus infusion was also added to the right side after adding calcium chloride and magnesium acetate solution. The results without infusion showed detailed morphology and aggregation patterns of observed crystals such as donuts, dumbbells, needles, platy, prismatic, rosette, round edges, X-shape crystals, and loose and compact aggregates. All infusions of Phaseolus lunatus showed defective crystals. 5% infusion inhibited crystals of all morphologies with their loose and compact aggregates except X-shaped crystals and rosettes. Meanwhile, 10% and 15 % infusions decreased X-shaped and rosette crystals. 20 % infusion showed defective rosettes. The microscopic study of calcium oxalate crystal growth and its inhibition is simple and provides rapid qualitative analysis of antiurolithiatic activity.

Dr. salman ahmed

Ecbalium elaterium has a very violent effect on the body and has little use in modern herbalism. Little is known about the acute and chronic toxicities of ecbalium elaterium in human. This study aims to determine the acute toxicity (LD50) of fruit extract and another aerial part extract of the ecballium elaterium in experimental animals. Thus, male albino mice were divided into different groups each group consists of six mice receiving 40, 46, 52, 61, and 69 mg/kg of fruit extract of ecballium elaterium, respectively. Other groups were given 1000, 1412, 1995, 2818, and 3981 mg/kg of the areal part of ecballium elaterium extract, respectively. The LD50 in both treatments was determined by using the Spearman-Karber method. The LD50 of the fruit and aerial parts of ecballium were 55 mg/kg and 2112.5 mg/kg, respectively. The present findings showed significant weight loss after one month of treatment with 1400 mg/kg and 40 mg/Kg of fruit and aerial part extracts, respectively. The results indicated that the fruit extract is highly toxic as compared to the extract of the aerial parts.

Mediterranean journal of pharmacy and pharmaceutical sciences

The purpose of the study was to find out the effect of pranayama on type-2 diabetes on metropolitan people. In the present study researcher wants to observe the effect of pranayama on type 2 diabetes on metropolitan people and to develop a specific package for type 2 diabetes. For this purpose researcher collect 60 sample from nearest diabetic Clinic and Hospital in the city and it is randomly divided into two groups one is experimental and another is control group. In the study researcher used bio-chemistry lab tools. In the study research design used Pre-test, post-test control-experimental group and researcher used two variable type 2 diabetes as dependent and pranayama used as independent variable and in the study there was significant effect of yogic practices on type 2 diabetes.

Shekhar boro

Worldwide, the threat created by antibiotic resistance to public health calls for immediate action. Antibiotic resistance is one of the main causes of the emergence and spread of dispensing of antibiotics without a prescription. This study aims to investigate the dispensing of antibiotics without a prescription and the reason behind that in the community pharmacy in Libya. The study was randomized analytical conducted between March and April 2023 among pharmacists and assistant pharmacists employed by community pharmacies in various Libyan areas Tripoli, Zawia, and Sabratha. The data were analyzed by Fisher's exact and Chi-square tests to predict the determinations of dispensing antibiotics without prescriptions. In this study, a total of 293 participants were included, 63 had been excluded because they did not meet the inclusion of the study. The remaining 230 were enrolled for final analysis, most of them were female subjects (70.7%). Findings showed that 78.7% of the participants consulted with patients about the reason for requesting a specific type of antibiotic, while 68.7% dispensed antibiotics with probiotics. Study participants with 2 - 4 years' work experience were 76.6% higher toward dispensing of antibiotics without a prescription (P=0.683). The major reason for dispensing antibiotics without prescriptions were pharmacists knowledgeable enough to give a patient antibiotics without a prescription (68.3%). In Libya, misuse of antibiotics by the public is widespread. People can purchase antibiotics without prescription. Thus, dispensing of antibiotics without a prescription in community pharmacies is an alarming issue in Libya which can increase antibiotics resistance. Pharmacists' knowledgeable is high in dispensing patients antibiotics without a prescription, but patient pressure and financial issues are the major reasons behind dispensing antibiotics without a prescription. It can be recommended that the importance of antimicrobial stewardship and the need for ongoing education support for community pharmacy professionals is of importance.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction: The prevalence of oral hygiene behaviors (OHB) is very low among school children in Ethiopia. However, the determinants of student's readiness/intention to perform those behaviors have been remained unstudied. Objective: This study aimed to identify the determinants of oral hygiene behavioral intention (OHBI) among preparatory school students based on the theory of planned behavior (TPB). Methods and materials: An institution-based cross-sectional study was conducted among 393 students. A 98-item self-administered questionnaire was used to evaluate oral hygiene knowledge (OHK), oral hygiene behavior (OHB), and OHBI based on TPB variables [attitude (ATT), subjective norms (SN) and perceived behavioral control (PBC)]. Descriptive statistics and structural equation modeling analysis (SEM) were employed to confirm relationships and associations among study variables. A p-value of less than 0.05 and a 95% confidence interval were used to declare statistical significance. Results: A total of 393 students were participated with a response rate of 97.5%. The mean age of the participants (54% females) was 18 (± 1.3) with an age range of 16 to 24. The TPB model was well fitted to the data and explained 66% of the variance in intention. ATT (β = 0.38; 95% CI, (0.21, 0.64)), SN (β = 0.33; 95% CI, (0.05, 0.83)) and PBC (β = 0.29; 95% CI, (0.13, 0.64)) were significant predictors of OHBI, where ATT was the strongest predictor of OHBI. Conclusion: The TPB model explained a large variance in the intention of students to improve their OHB. All TPB variables were significantly and positively linked to stronger intent, as the theory suggests. Furthermore, these results suggest that the model could provide a framework for oral hygiene promotion interventions in the study area. Indeed, these interventions should focus on changing the attitudes of students towards OHB, creation of positive social pressure, and enabling students to control OHB barriers.

Kegnie shitu

For the following report, the company identified is Maxcart. Maxcart is a new retail company operating in the retail industry in the United States (US). The company will have its chain of supermarket stores in different cities in the US. The company plans to deal in electronic goods, groceries, clothing, toys, non-prescription medicines, furniture, etc. The following report will provide an overview of the HRM system of Maxcart and the various HR policies and programs that will be effective at Maxcart.

Zamzam abdelazim

This article explores how telemedicine, especially with the help of artificial intelligence (AI), is transforming healthcare. It covers its applications in monitoring patients, managing chronic diseases like diabetes, and improving cardiovascular care. The importance of wearable devices and non-invasive blood glucose monitoring is highlighted. The article emphasizes how AI-driven remote patient monitoring can enhance healthcare by providing early intervention, reducing hospitalizations, and offering personalized care.

Dhruvitkumar talati

Hydatid disease or hydatidosis is a worldwide zoonosis disease caused by the tapeworm of Echinococcus granulosus and still widely endemic in Tunisia especially in rural areas where the sheep-dog cycle is dominant. It is an important public health problem in the pediatric age group causing significant morbidity and mortality. We report a case of primary hydatid cyst of the small intestine in a child and we want to highlight the difficulty that we meet in the diagnosis despite the contribution of imaging.

Sameh