Telangana, a rapidly developing state in India, is committed to transforming its higher education landscape to meet the demands of the 21st century. This abstract outlines the key strategies and initiatives being implemented to elevate educational standards and ensure that students receive a world-class learning experience. This paper explores the efforts and strategies implemented to elevate the standards of higher education in Telangana, focusing on the challenges and opportunities encountered in delivering quality education. Over the past decade, Telangana has taken significant steps to enhance its higher education system by improving infrastructure, curriculum, teaching methodologies, and fostering collaborations with national and international institutions. The introduction of state-specific initiatives, such as the Telangana Academy for Skill and Knowledge (TASK), along with reforms in university governance, accreditation processes, and the promotion of research and innovation, has played a crucial role in improving educational outcomes. The paper also delves into the socio-economic impact of these improvements, particularly the increased employability of graduates, their contributions to the local economy, and the role of emerging institutions like Young India Skill University. By addressing both the successes and ongoing challenges, this study aims to provide insights into how quality higher education can be a catalyst for regional development and social mobility in Telangana.

Dr gedam kamalakar

Innovations to enrich mathematics learning resources can be expressed in the form of culture-based or ethnomatematic learning. The purpose of this study was to analyze the ethnomatematic content of Selogending Temple in Kandangan as mathematics teaching material for grade 4 elementary school students. This type of research uses qualitative research. Sources of research data are Selogending Temple and resource persons related to the Selogending Temple site. This study uses data collection methods in the form of observation, interviews, and documentation. Qualitative data analysis techniques used are reduction and data exposure, and drawing conclusions. Based on the results of the study, it can be concluded that there are mathematical elements in Selogending Temple including plane geometry, spatial geometry and reflection. The Selogending Temple building which has ethnomatic content is the Entrance Gate, Mbah Tejo Kusumo Petilasan, Mbah Pukulun Petilasan, Patrapan Hall, shrine, Padma, Wadung Prabu, Linggasiwa, and Mbah Raden Selogending Petilasan. Inovasi untuk memperkaya sumber belajar matematika dapat dituangkan dalam bentuk pembelajaran berbasis kebudayaan atau etnomatematika. Tujuan penelitian ini adalah menganalisis muatan etnomatematika pada Candi Selogending di Kandangan, Kabupaten Lumajang, Provinsi Jawa Timur sebagai bahan ajar matematika kelas 4 SD. Jenis penelitian ini menggunakan penelitian kualitatif. Sumber data penelitian adalah Candi Selogending dan narasumber terkait situs Candi Selogending. Penelitian ini menggunakan metode pengumpulan data berupa observasi, wawancara, dan dokumentasi. Teknik analisis data kualitatif yang digunakan yaitu reduksi dan pemaparan data, serta penarikan kesimpulan. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat unsur matematika pada Candi Selogending meliputi bangun geometri bidang, geometri ruang dan pencerminan. Bangunan Candi Selogending memiliki yang memiliki muatan etnomatematika adalah Gapura Pintu Masuk, Petilasan Mbah Tejo Kusumo, Petilasan Mbah Pukulun, Balai Patrapan, tempat pemujaan, Padma, Wadung Prabu, Linggasiwa, dan Petilasan Mbah Raden Selogending.

Educare: journal of primary education

La socialisation en Afrique de l’Ouest se fait par des canaux normatifs dont le mariage. Ce lien sacré, scellé par les Hommes et béni par Dieu, est une nécessité humaine et reste un goulot social pour plusieurs femmes. Sur cette entité géographique patriarcale, la condition féminine relève très souvent d’’un chemin de croix’ pour un épanouissement multiforme. Issoufi DICKO et Safiatou BA se saisissent de cette facette de la thématique du genre pour questionner les vies et les règles traditionnelles en contexte de modernité. Les deux jeunes écrivains maliens portent, entre condition féminine et inversion sexuelle, un regard sans complaisance sur leur société en profonde mutation. Trame nourricière de leurs ouvrages respectifs, ces thèmes leur permettent de mettre en scène des personnages hauts en couleur et en courage. Contrariées en partie par leurs quotidiens et la vie, le système patriarcal et l’embrigadement socioreligieux, leurs héroïnes s’indignent et se révoltent contre les sorts qui leur sont imposés. Défiant les règles de la vie en couple et celles socio-culturelles, elles s’érigent en rempart des dérives sociales perpétrées contre les femmes. Parallèlement à la condition féminine et les conflictualités de la vie en couple, le lesbianisme balbutiant au Mali est convoqué. Issoufi DICKO et Safiatou BA décrivent méticuleusement les arcanes de son enracinement progressif. Cette contribution aborde, avec la méthode qualitative, la condition féminine et l’homosexualité au Mali, entre fiction et réalité sociale. L’objectif de cette contribution est d’analyser la condition féminine et l’homosexualité à travers les deux romans.

Assanvo

Currently, vehicle to vehicle communication is an important application and thrust area of research. In this paper the author highlighted the workings, executions, implementations and the application of the Internet of Things (IoT) in transport management and vehicle to vehicle communication systems. The main advantage of this Industry 4.0 based IoT technology is that it helps us to reduce road traffic and accidents. The limitations of GPS like accuracy, precision, effective analysis, etc. has led to the evolution of Mobile based V2V communication which is more effective, error proof, result oriented and smart. For proper analysis of traffic vehicle to vehicle communication is established. Random Data from vehicles taken by numerous sensors. Any car coming in its variety could effortlessly share the data by either of two cars nearby. With the help of vehicle to vehicle communication we can provide a path of emergency vehicles to reach the destination quickly. Based on the V2V application, Red and Green signals can be marked on the path as per traffic density and the emergency vehicle can take the shortest, fastest and low density route. Similar such examples are elaborated in the current research manuscript that will help the researcher in effectively finding the research gap for further advancement, analysis, innovation and optimization.

Vartika agarwal

Cloud computing is used to achieve sustainability in terms of computing. It reduces energy and resource consumption. Most of the companies have been moving their applications to the cloud to reduce power, energy re-source, and carbon emission. Today's computing landscape is rapidly shifting toward creating applications to leverage Cloud platforms to have necessary features such as elasticity, virtualization, low cost, and pay-per-use. Cloud computing's rising demand and versatility are achieving acceptance in the research community as a means of implementing large-scale electronic systems in the format of workflows (set of tasks). One of the most important objectives of this effort is to trim down makespan which is the total period taken by the resources to complete all workflow activities. Another foremost objective of this work is to satiate all the user-delineated time constraints while scheduling workflow activities.

Mohd haroon

Hypertension is a public health issue that significantly increases the risk of health problems and decreases health quality of life of the patients. Angiotensin converting enzyme inhibitors are used to control hypertension by preventing production of angiotensin II in turn decrease blood pressure, thus it may enhance the quality of life. This study aims to assess the effect of angiotensin converting enzyme inhibitors on the quality of life of patients with hypertensive aging 40 years or older in Benghazi city in comparison with other classes of hypertension medications. A case control observational study was conducted, adopting the structured face-to-face interviewing survey technique. Over 150 patients who visited Benghazi medical center during the study period (November, 2019 to March, 2020), to follow up their chronic disease. The investigators used a pre-validated, pre-piloted questionnaire that has been adopted from SF 36 and modified according to the updated literature review; responses to each question were coded and analyzed. The results display that antihypertensive medications were found to be significantly related to the limitation on the physical activity domain and found that medications decrease the limitation on the activity with about 20% of the patients who taking angiotensin receptor blockers (20%) and 30% of the patients taking angiotensin converting enzyme inhibitors, 40% of the patients had no limitations on bending kneeling and stooping. Moreover, on the limitations on walking more than one kilometre, the results were about 15% of the patients taking angiotensin receptor blockers and 30% of the patients taking angiotensin converting enzyme inhibitors had a slightly or no limitation on walking more than a kilometre. Thus, the findings indicate that antihypertensive medications have a positive effect on quality of life of the patient in limitation on activity domain but no conclusive difference was found between angiotensin converting enzyme inhibitors and angiotensin receptor blockers medications.

Mediterranean journal of pharmacy and pharmaceutical sciences

The growing study of foreign policy change offers various explanations of change and continuity in foreign policy. By focusing on the actors of foreign policy decision-making, past scholarship has mainly concentrated on the role of institutional and noninstitutional factors in foreign policy change. However, decentralized decision-making is more relevant to democratic regimes than authoritarian regimes. Despite the abundance of case studies on foreign policy making in nondemocracies, advancements in the conceptual understanding of foreign policy change in authoritarian regimes are still needed. Addressing Uzbekistan’s foreign policy, this article proposes an advanced framework to explain why and how foreign policy change takes place under authoritarian leaders. A leader’s perception of the external environment is argued to be a decisive factor inducing authoritarian leaders to (re)consider their regime survival strategy. Concern with regime survival, in turn, shapes foreign policy goals which are manifested in distinctive foreign policy behavior of a leader. Ultimately, the behavior of a leader translates into certain foreign policy outcomes.

Feruza madaminova

This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

Environmental factors are known to influence carcinogenesis. Pollutants, such as heterocyclic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs) are examples of environmental borne procarcinogens. Procarcinogens are not active carcinogens although, they require bio-activation, via enzymes such as cytochrome P450 (CYP) to transform to active product. CYP1A1 isoform, regulated by aryl hydrocarbon receptor (AhR) plays a significant role in the bio-activation of PAHs and HAs. AhR has multiple co-activators and co-repressors for AhR that have been identified S remarkably. Silencing mediator for retinoid and thyroid hormone receptors (SMRT) was designated as a major co-repressor for AhR. In the present study, it is examined the effect of SMRT over expression on the cyp1a1 mRNA levels in murine hepatoma Hepa 1c1c7 cell line. Hepa 1c1c7 cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM) and competent cells have successfully been produced using calcium chloride method. Cells were transformed using plasmid DNA and Lipofectamine. TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) was employed as an inducing agent for CYP1A1. The total cellular RNA was isolated and real-time PCR of Cyp1a1 was conducted. A statistical analysis was conducted by using one-way analysis of variance followed by Student-Newman-Keuls test. The results showed that cells transfected with the co-repressor SMRT has lower TCDD-mediated induction of cyp1a1 mRNA without affecting constitutive Cyp1a1 mRNA levels, i.e., SMRT was able to significantly decrease inducible Cyp1a1 mRNA levels in Hepa 1c1c7 cells. The present findings also demonstrated that calcium chloride is a convenient method for routine transformation. Thus, this study opens a new avenue for the management of carcinogenesis involving CYP1A1 inducing carcinogens.

Mediterranean journal of pharmacy and pharmaceutical sciences

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

Assessment of convergent validity of latent variables is one of the steps in conducting structural equation modeling via partial least squares (PLS-SEM). In this paper, we illustrate such an assessment using a loadings-driven approach. The analysis employs WarpPLS, a leading PLSSEM software tool.

Johnny amora

Impurity is something that is impure or makes something else impure. An impure substance may be defined as follows: a substance of interest mixed or impregnated with an extraneous or usually inferior substance, from the standpoint of its usage, the drug substance is compromised in terms of purity even if it contains another material with superior pharmacological or toxicological properties. The impurity may be developed either during formulation, or upon aging of both API’s and formulated API’s in medicines. The presence of these unwanted chemicals, even in small amount, may influence the efficacy and safety of the pharmaceutical products. The impurities are not necessarily always inferior. Highly sophisticated instrumentation, such as mass spectra meters attached to a Gas Chromatography or HPLC, are inevitable tools in the identification of minor components (drugs, impurities, degradation products, metabolites) in various matrices. Present article reveals different impurities found in the API’s, methods for identifying them and the possible measures to deal with the interferences caused by them in pharmaceutical analysis.

Prasanna pradhan

Assessing students' progress in introductory programming courses is crucial for identifying learning gaps and improving teaching methods. This study evaluates the effectiveness of Moodle-based tests with randomized questions in monitoring student progress in C programming courses at J. Selye University during the 2023/24 academic year. A series of ten tests were administered across two courses, covering essential programming topics such as data types, variables, conditional statements, loops, two-and three-dimensional arrays, recursion, and sorting algorithms. The results revealed significant variations in student performance, with recursion and the pretest/posttest loops presenting the greatest challenges. The correlation analysis of test scores showed strong relationships among related topics, confirming the structured progression of the curriculum. These findings suggest that Moodle-based assessments offer valuable insights into students' learning trajectories, enabling educators to adapt their instructional strategies accordingly. Such insights can help optimize introductory programming curricula, enhancing student engagement and understanding.

Ladislav végh

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Penelitian ini adalah jenis penelitian deskriptif-kualitatif. Penelitian ini secara umum bertujuan untuk mendeskripsikan muatan nilai-nilai karakter yang terdapat pada buku siswa kelas IV Tema Indahnya Kebersamaan. Sumber data penelitian adalah buku siswa kelas IV Tema Indahnya Kebersamaan. Data penelitian berupa nilai-nilai karakter yang terdapat pada buku siswa yaitu nilai sopan, nilai santun, nilai religius, nilai nasionalisme, nilai mandiri, nilai gotong royong, dan nilai integritas. Berdasarkan analisis yang telah dilakukan, jumlah nilai karakter yang ditemukan sebanyak 84. Jumlah tersebut merupakan akumulasi dari semua tema yang terdiri dari tiga subtema yaitu keberagaman budaya bangsaku, kebersamaan dalam keberagaman dan bersyukur atas keberagaman. Adapun rincian jumlah setiap karakter yaitu: (1) sopan 2; (2) santun 4; (3) religius 22; (4) nasionalisme 26; (5) mandiri 10; (6) gotong royong 19; dan (7) integritas 1. Berdasarkan hasil analisis muatan nilai-nilai karakter pada buku siswa kelas IV tema Indahnya Kebersamaan dapat disimpulkan bahwa buku siswa tema Indahnya Kebersamaan kelas IV SD/MI memuat 7 nilai karakter.

Educare: journal of primary education

Cryopreservation is a process that preserves intact living cells, tissues or any other biological constructs by cooling and storing the samples to very low temperatures in order to maintain their viability and to save them for future use. At very low temperatures, enzymatic and chemical activities that may cause harm to the biological material are effectively stopped. Cryopreservation methods look to reach very low temperatures without causing further harm caused by the creation of ice crystals during freezing. Cryopreservation human samples for storage including variety of diseases such as cancer, genetic and degenerative disorders and bio-banking. This review aims to describe and highlight dimethyl sulfoxide in cryopreservation. Dimethyl sulfoxide is a non-toxic solvent and is one of the most commonly used pharmaceutical agent with a varied range of pharmacological actions including membrane penetration, anti-inflammatory effects and local analgesia as well as weak bacteriostatic. The main use of dimethyl sulfoxide is a vehicle for some drugs to enhancing the action of the drug and helping penetration of other drugs into the skin. However, dimethyl sulfoxide has been the cryopreservative agent of choice in situation to its exceptional performance in mitigating freezing-related damages. It is frequently used in cell banking applications as a cryoprotectant. When added to media, it prevents intracellular and extracellular crystals from forming in cells during the freezing process. There has been a concern over the toxicity of dimethyl sulfoxide and its potential side effects in different highly concentration after administration to patients. Therefore, there has been growing demand for robust dimethyl sulfoxide for cryopreservation method that can improve safety and maintain potency and efficacy

Mediterranean journal of pharmacy and pharmaceutical sciences

Vitamin C is associated with history of the cause of the ancient hemorrhagic disease scurvy. Vitamin C is an essential nutrient with important antioxidant properties. It is required by the body for normal physiological function. The body cannot synthesize vitamin C, it is present in nature through foods and other natural sources and it exists as a nutritional food supplement. The antioxidant activity of vitamin C protects the body from free radical damage. Vitamin C is essential for the development and maintenance of connective tissues. It is used as therapeutic agent in many diseases and disorders. Vitamin C plays an important role in several metabolic functions, as the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin, and the conversion of cholesterol to bile acids. Vitamin C supplementation resulted in a significant increase in vitamin C levels in populations; its high intake is associated with positive effects on cardiovascular risk factors. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight infections. It has an important role in bone formation, wound healing and the maintenance of healthy gums. There is profound beneficial effect of vitamin C in respect to human diseases as cancer, atherosclerosis, diabetes, neurodegenerative disease and many metal toxicities. Several vitamin C analogs have been produced as anticancer and antioxidant activity. Vitamin C is useful if it is used as adjuvant therapy for several chronic diseases. Thus, this review summarizes the importance of vitamin C in the body’s physiology and biochemistry, in addition, the different mechanisms that vitamin C is implicated to treat different acute and chronic diseases. Future exploration should pay attention to chronic disease management by vitamin C.

Mediterranean journal of pharmacy and pharmaceutical sciences

Field experiments were conducted at CCS Haryana Agricultural University, Hisar during kharif season of 2013 and 2014 to determine the effect of weather parameters on the incidence of pod borer complex on early maturing pigeonpea varieties. The study revealed that the infestation of Helicoverpa armigera and Maruca vitrata started with the onset of bud initiation and reached its peak at flowering stage. The maximum H. armigera larval population (1.83 larvae plant-1) was recorded in 1st week of July sown crop, whereas, the maximum incidence of M. vitrata (21.17 webs plant-1) was recorded in 2nd week of July sown crop. The larval population of H. armigera was significantly and positively correlated with the maximum temperature, followed by minimum temperature.Incidence of M. vitrata was negatively correlated with evening relative humidity and wind speed which was significant at p  0.05 level of significance.

Dr. babu lal jat

Introduction Ataque de nervios (ADN) is a cultural syndrome prevalent in Puerto Ricans characterized as an episode of intense emotional upset due to overwhelming stress. Methods The Ataque de Nervios Questionnaire , developed at the Center for the Study and Treatment for Fear and Anxiety (CETMA), served as the diagnostic tool for this retrospective secondary data analysis. We evaluated three models regarding ADN’s function as a marker of (1) sociodemographic vulnerability, (2) health history risk, and (3) psychological vulnerability. This last model was subdivided to assess the scores of screening tests regarding anxiety (Anxiety Sensitivity Inventory, Beck Anxiety Inventory, and State-Trait Anxiety Inventory), affect (Beck Depression Inventory, Emotional Dysregulation Scale, Positive and Negative Affective Schedule), personality (NEO Five-Factor Inventory), and trauma (considering the responses to the Childhood Trauma Questionnaire and the Life Event Checklist). Results Our study sample had a total of 121 Puerto Rican adult patients from CETMA out of which 75% had ADN. We differentiated subjects according to their ADN status with t-tests and Mann-Whitney U tests and evaluated our models using logistic regressions. People with ADN showed more anxiety, depressive symptoms, emotional dysregulation, and negative affect than those without ADN. They also revealed lower positive affect and agreeableness. Highly extraverted but minimally agreeable personalities related to ADN. Living with a partner and being employed were risk factors for ADN. Having higher educational levels showed the strongest effect size: it greatly reduced the odds of an ataque . Discussion These characteristics suggest a distinct profile of ADN seen in employed, educated, adult Puerto Ricans living on the Island experiencing anxiety. Our study provides clinical tools to comprehend our patients’ ADN experience, enriching our practice as culturally competent health providers.

Alisha m subervi vázquez

Background:Calcium, the very important mineralhelps in growth and development ofinfants.Calcium helps in building strong bones, teeth,proper functioning of nerves and muscle, blood clot and in activating the enzymes that convert food into energy. Infants and Children are growing new bone all the time, they need continuous supply of calcium to support the healthy growth.Milk is the only food for infants which is richest source of calcium. Some infants are sensitive to lactose in milk because they have Lactose Intolerance. The present study aimsto develop an alternate milk forlactose intolerance infants with finger millet and pearl millet.Method:Traditional methods were used to process the milletswhich help in retaining and increasing the nutritional content in millets.The millet milk was analyzed for calcium content using the ICPMS.The millet milk was supplemented for 6 weeks to albino rats in comparison with cow milk. The tibia weight and length were measured and calcium content in tibia was analyzed. Result:The calcium content of the millet milk was 80mg/100mlwhere as in cow milk it was 120mg/100ml.The mean calcium content of the tibia inalbino rats was15.35±3.50mg/dl fed with millet milkand20.40±3.74mg/dl in rats fed with cow milk.Conclusion: The developed millet milk contain good amount of calcium on par with cow’s milk, it can be used as substitute milk for lactose intolerant infants.

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