Air pollution is a major health problem in developing countries and has adverse effects on human health and the environment. Non-thermal plasma is an effective air pollution treatment technology. In this research, the performance of a dielectric barrier discharge (DBD) plasma reactor packed with glass and ceramic pellets was evaluated in the removal of SO2 as a major air pollutant from air in ambient temperature. The response surface methodology was used to evaluate the effect of three key parameters (concentration of gas, gas flow rate, and voltage) as well as their simultaneous effects and interactions on the SO2 removal process. Reduced cubic models were derived to predict the SO2 removal efficiency (RE) and energy yield (EY). Analysis of variance results showed that the packed-bed reactors (PBRs) studied were more energy efficient and had a high SO2 RE which was at least four times more than that of the non-packed reactor. Moreover, the results showed that the performance of ceramic pellets was better than that of glass pellets in PBRs. This may be due to the porous surface of ceramic pellets which allows the formation of microdischarges in the fine cavities of a porous surface when placed in a plasma discharge zone. The maximum SO2 RE and EY were obtained at 94% and 0.81 g kWh−1, respectively under the optimal conditions of a concentration of gas of 750 ppm, a gas flow rate of 2 l min−1, and a voltage of 18 kV, which were achieved by the DBD plasma packed with ceramic pellets. Finally, the results of the model's predictions and the experiments showed good agreement.
Indian Economy is the world's 06 th largest economy (2021 Nominal GDP) and 03 rd largest by purchasing power parity (2021 PPP). Salaried workers are a consistent group of tax paying citizens that give roughly 12% of overall revenue to a government through income tax. Due to which tax planning has assumed special importance for salaried individuals. All taxpayers in India have a variety of tax saving choices. These choices provide a variety of exclusions and deductions that help to reduce the total tax burden. Deductions are provided from Sections 80C through 80U, and qualifying taxpayers can claim them. Hence it is essential for the individual tax payer to know all their possible tax regulations and for tax compliance. It is totally legal and, in fact, a wise option when tax planning is done within the boundaries set by the relevant authorities. However the salaried individuals are not able to plan their taxes which results in opting for the wrong investment options. The objective of the study is to determine the level of awareness among the salaried individual on several tax planning methods offered on professional tax under the income tax act and to identify the factors influencing the tax planning behaviour of the salaried individuals..
La problématique de l’accès à l’eau potable soulève de nombreux enjeux de développement au regard des impacts qu’elle génère en milieu rural. C’est pourquoi plusieurs organisations internationales œuvrent aux côtés de l’Etat ivoirien afin de garantir un accès durable et sécurisé à cette ressource pour les populations. Cependant, il existe encore des zones en Côte d’Ivoire où les populations continuent de vivre au quotidien des pénuries d’eau potable. C’est le cas de la Sous-Préfecture de Gboguhé où cette problématique entrave considérablement le développement socioéconomique des villages. Partant de ce contexte, cette contribution tente d’analyser les impacts de la pénurie d’eau potable dans cette zone en s’inscrivant dans une perspective socioanthropologique. Pour ce faire, elle se base sur une approche essentiellement qualitative, mobilisant les techniques de revue de littérature, d’entretiens semi-directifs et d’observations directes pour la production de données. L’étude révèle que la pénurie d’eau potable dans la sous-préfecture de Gboguhé est un facteur de vulnérabilité chez les populations locales au regard des impacts sociaux, économiques, sanitaires et territoriaux qu’elle entraîne.
Production process in the manufacturing industries has proven wasteful of the resources in the production process over time. integrating of lean principles in the manufacturing activities has brought notable success in a complex and slow production process in an industry. This study aims at integrating of lean principles to a product development process to eliminate break down cases as it makes the process easy as well as speeding up the product development in an automotive industry. Three major phases are applied in product development namely; the early concept phase, middle core design and the launch phase. An exceptional definition of products development of lean principles are applied to come up with an analysis framework. Through interviews, observations, documentation and experience barriers that causes large number of wastes can be established. Lean principles will then be applied to eliminate such causes in the product development and then derive conclusion that shows the industry the process of lean in product development in the entire process
To the editor, On April 24, 2025, the World Health Organization (WHO) issued an urgent call to reinvigorate global action to end malaria, releasing updated guidelines that reflect both progress and persisting challenges in combating this deadly disease. [1] This renewed guidance arrives at a critical juncture: global malaria cases have plateaued, progress is faltering, and health systems in endemic regions face increasing strain from drug resistance, climate change, and funding shortfalls.
L’émergence des territoires et l’épuisement des saltus stimulent des questions foncières longtemps restées en veilleuse. Au T ogo en général et spécifiquement dans l’Ouest de la Région des Savanes, la terre est une propriété privée des lignages. Le droit foncier y repose sur la prééminence du droit du premier occupant et matérialisé par une divinité appelée Tingban. L’insuffisance des preuves de prééminence et l’authenticité des fétiches, source de droit, opposent souvent les collectivités. La présente étude décrit l’épuisement des ressources foncières et analyse les conflits fonciers qui opposent les collectivités dans l’Ouest de la Région des Savanes. La méthodologie adoptée repose sur l’observation participante, la recherche documentaire et les entretiens. Les résultats révèlent de nombreuses disputes socio-foncières qui opposent les lignages, les villages et les cantons. Les collectivités contestent entre elles, les droits de paternité sur les terres dans 74% des cas alors que 26% des querelles foncières sont dus aux remises en cause des limites des propriétés collectives. Ces contestations plongent leurs racines dans la complexité du droit foncier coutumier fondé sur la prééminence du droit du premier occupant. Elles sont aussi liées à la non maîtrise des limites des domaines fonciers lignagers et des territoires cantonaux respectivement par les descendants, les chefs de villages et les chefs de cantons.
Urolithiasis is a common worldwide problem with high recurrence. This review covers Euphorbiaceae twenty (20), Cucurbitaceae eighteen (18), Acanthaceae and Amaranthaceae fifteen (15), Cupressaceae twelve (12), Caryophyllaceae eleven (11), Anacardiaceae ten (10), Amaryllidaceae, Apocynaceae and Asparagaceae nine (09), Ericaceae and Equisetaceae eight (08), Arecaceae and Caesalpiniaceae seven (07), Chenopodiaceae six (06), Aspleniaceae, Capparidaceae and Crassulaceae five (05) plants used globally in different countries. Hopefully, this review will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery.
A simple, precise, accurate, sensitive, specific and reliable stability indicating RP-HPLC method was developed for the simultaneous estimation of Miconazole (MIC) and Ornidazole (ORN) in pharmaceutical dosage form. The method was developed with mobile phase containing buffer (0.05M potassium dihydrogen ortho phosphate, ph3.5): Methanol in the ratio of 25:75, C18 (250 x 4.6mm, 5µm) as a stationary phase and flow rate was 1 ml/min. Detection was carried out at 236nm in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Miconazole and Ornidazole at 6.58 and 3.26 min respectively. The proposed method has been validated for precision, accuracy, robustness. Thus, the statistical analysis confirms that developed methods were successfully used for analysis of formulation and thereby can be used for routine analysis of drugs in Quality Control laboratories.
The subjective experience of consciousness, a cornerstone of human existence, is profoundly disrupted in disorders of consciousness (DOC) arising from severe brain injuries, spanning-states from coma to the minimally conscious state. A significant challenge in clinical practice is the phenomenon of covert consciousness, in which individuals may retain awareness despite the absence of overt behavioral responsiveness. Diagnosis based solely on observable behavior is inherently limited by factors such as co-occurring motor impairments, the fluctuating nature of consciousness, and subjective interpretation, potentially leading to misclassification. To overcome these limitations, neuroscientific methodologies have advanced significantly. To address these limitations, neuroscientific methods have advanced considerably. Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) provide objective evidence of preserved brain activity and cognitive processing, enabling detection of willful modulation and offering prognostic insight. Electrophysiological techniques—including electroencephalography (EEG), event-related potentials (ERPs), transcranial magnetic stimulation combined with EEG (TMS-EEG), and advanced downstate analysis—further reveal dynamic neural patterns indicative of residual awareness. The detection of covert consciousness has profound ethical, clinical, and societal implications. It necessitates a re-examination of patient rights, end-of-life decision-making, the use of brain-computer interfaces, and societal conceptions of personhood. This evolving understanding mandates a shift towards integrating objective neuroscientific assessments with compassionate, person-centered care, aiming to preserve dignity and navigate the complex ethical landscape of severe brain injury.
Field studies were carried out in wet seasons of 2014 and 2015 in rice fields of College Farm, Rajendranagar, Hyderabad to understand the abundance and biodiversity of spiders in varied rice cultivation systems. Design of the experiment was split plot with three main modules, viz., transplanted, broadcasted and drum sown rice and subtreatments under each main module included three plant protection methods viz., organic protection, farmers’ practices and ‘no protection’ practices. Results showed that predator numbers in ‘no protection’ and organic protection plots of all main treatments were more than in farmers’ practices indicating the impact of the chemical pesticides. A total of 22 genera of spiders belonging to 12 families were recorded which comprised of seven guilds based on their hunting strategies and microhabitats. Shannon diversity index ranged between 1.83 and 2.26 and Pielou’s evenness index was 0.59-0.72 in two years of study indicating a stable ecosystem and even species distribution in rice crop at Rajendranagar. Study of the guild assemblage indicated that orb-weavers constituted 28.1% of the population, ground runners 23.51%, space web builders 18.38%, sheet-web builders 13.12%, stalkers 8.04% and ambushers made upto 0.38% of the spider population. Understanding the vertical stratification of various spider genera on the plant gave further insight into the prey preferences of these predators.
Indoor thermal comfort and air quality are essential for occupant well-being, while simultaneously optimizing energy consumption in buildings. Achieving a balance between these factors presents a significant challenge, as indoor environments are dynamic and energy demands fluctuate. By modifying ventilation rates in response to real-time data, demand-controlled ventilation systems can reduce energy consumption and enhance indoor comfort and air quality. However, optimizing these systems with advanced predictive models remains a complex task. To address this challenge, this publication proposes a Dual-Stream Multi-Dependency Graph Neural Network (DMGNN)-based energy-efficient ventilation management technique that maximizes indoor air quality and thermal comfort. The suggested method seeks to enhance thermal comfort and air quality by maximizing heating, ventilation, and air conditioning (HVAC) operations while reducing energy consumption. Initially data are collected from an Indoor Air Quality Monitoring Dataset. The DMGNN is employed to capture the complex dependencies between environmental factors such as temperature, humidity, and CO2 concentrations, considering both temporal and spatial relationships. Implementing the proposed system and evaluating it through simulations in various building environments demonstrates notable improvements in thermal comfort, indoor air quality, and energy economy. The suggested system’s performance is contrasted with that of other current methods, showing superior energy efficiency and optimization of both indoor air quality and occupant comfort. This study presents an innovative, scalable framework for smart building management, promoting sustainable energy solutions.
Research on treatment for diabetes and co-occurring eating disorders is sparse. We examined outcomes from multidisciplinary residential treatment for women with type 1 diabetes and eating disorders and the impact of treatment duration on outcomes. Participants were 29 women with type 1 diabetes and eating disorders receiving residential treatment. Repeated measures analyses of variance examined changes in blood glucose and psychological symptoms over treatment. Analyses were repeated to include treatment by duration interactions. Treatment produced significant reductions in blood glucose, eating disorder symptoms, and psychological concerns. Longer treatment duration was associated with greater improvements in psychological symptoms. Disordered eating is alarmingly common among individuals with type 1 diabetes mellitus, with rates of co-occurring diabetes and eating disorders estimated as high as 40% (Young etal., 2012; Young-Hyman & Davis, 2012). The most commonly noted link between type 1 diabetes and eating disorders is in the form of purging through insulin omission for weight loss purposes (Darbar & Mokha, 2008), which has been noted for individuals with diabetes co- occurring with anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS; Nielsen, 2002; Peveler & Fairburn, 1989). However, even among individuals with diabetes who do not omit insulin, eating disorder symptoms are elevated (Jones, Lawson, Daneman, Olmsted, & Rodin, 2000).
Background: Information on Bleomycin pulmonary toxicity (BPT) in Qatar is scarce. The aim of this study was to estimate the prevalence of BPT and to describe its clinical significance and outcome in germ cell tumor (GCT) patients who received bleomycin-containing regimens.Methods: This retrospective cross-sectional study was conducted at the National Center for Cancer Care and Research. It included all patients diagnosed with GCT and treated with a bleomycin-containing regimen between January 2002 and December 2008 Results: We identified fourteen patients with GCT who received bleomycin containing regimen. Four of them (28.5%) had developed BPT, and they were males with mean age of 39.3±8.3 years (range: 25-46 years). The calculated creatinine clearance before treatment was normal in the 4 cases. Evaluation of the chest computed tomography scan before starting bleomycin containing regimens revealed that none of our patients had pre-existing parenchymal lung disease. The mean cumulative bleomycin dose was 187.5± 153.7 U, while the mean time to onset of BPT was 3.5±2.1 months. Once the diagnosis of BPT was established, bleomycin was discontinued in the four patients and short courses of dexamethasone were administered. Two patients (50%) died, while one patient survived with a fibrosis sequel, and the fourth patient recovered without a fibrosis sequel. Conclusion: BPT is one of the life-threatening side effects of this drug that every doctor should be aware of when treating GCT, therefore, a high index of suspicious is needed for early recognition of BPTs.
Ayurvedic formulations are of three types, Herbal, Mineral and Herbo-Mineral. Of which, Herbomineral is prepared either by Khalweeya or by Bhasmeekarana procedures. The quality of Bhasma depends on the number of putas given. Rasa Bhasma is one such kind of a Herbo-mineral preparation which can be obtained by Puta procedure as described in texts of Rasa Shastra. Though there are different procedures mentioned for preparation of Rasa Bhasma, maarana done with Gorvara puta seems to be an apt way to obtain the final product. Puta is the generalised way of heat application used during the pharmaceutical procedures of Rasa dravyas, where the purified organic Metal/Mineral is converted completely into powder form which can be absorbed easily into the body without causing any ill effects. Different types of Puta have been explained for bhasmeekarana of different metals and minerals. Among them, certain putas have been mentioned where Mandaagni plays a crucial role in Maarana (Incineration). These Mandaagniputas are in use of preparing certain Bhasmas like ShilajitBhasma, HaratalaBhasma, GouripashanaBhasma, and PaaradaBhasma. As these drugs are having relatively low boiling and melting points when compared to other dravyas, and are easy to evaporate when exposed to high temperatures, they need a standardized quantum of heat by which they can be transformed into Bhasma. Gorvara puta is one such kind where agni plays a major role in the preparation of Bhasma. So, the present study A Comprehensive Study of Gorvara Puta in Preparation of Rasa Bhasmahas has been under taken.
Lytic lesions in adult spine are a common manifestation of aggressive disease such as primary bone tumor, metastasis, myeloma, or infectious pathology. Xanthoma arising in the spine with purely intraosseous component is an extremely rare occurrence with only six cases reported in the adult population, none in the cervical region. We report the first case of primary xanthoma of the cervical spine in a 50‑year‑old male solely confined to osseous compartment. The imaging mimics of lytic lesion with expansile mass in adult spine are reiterated.
: Analgesic, anti-inflammatory and diuretic activities of the methanol extract of two varieties of Cicer arietinum viz black or Desi and white or Kabuli were tested in 200 and 400 mg/kg doses. For the analgesic effect of the extracts, acetic acid-induced writhing, tail immersion and hot plate tests were employed in mice. The anti-inflammatory activity was carried out by carrageenan-induced inflammation in rats, whereas the diuretic action was determined using metabolic cages for rats. Animals were divided into six groups (n=7): (1) Control (2) Standard (3) MECAB 200 (4) MECAB 400 (5) MECAW 200 (6) MECAW 400. All extracts and standard drugs were administered orally. Acute oral toxicity of the extracts was also checked in mice up to 2000mg/kg dose, which showed a favorable safety. Significant analgesic and anti-inflammatory effects were observed. The results of diuretic activity were significant at the 12th and 24th hrs. Therefore, it is concluded that the methanol extracts of the seeds of Cicer arietinum have analgesic, anti-inflammatory and diuretic potential.
Market trends indicate that natural health products are being used to maintain health as well as prevent and treat many medical conditions. A recent Canadian survey showed that 71% of the Canadian population have used a natural health product. Among these, many reports that they take natural health products on a daily basis. This review emphasizes on Canadian post-market surveillance system that apply to natural health products for human use. The public's perception is that the natural health products are all-natural, safe and effective, but there is still a wide variety of harms linked with these products. The post-market surveillance system is the monitoring window to observe and control the adverse effects of using natural health products. There are many activities involved in the post-surveillance to ensure the quality of the approved natural health products. Despite the fact that post-market surveillance plays a very important role in eliminating and/or reduce the risk of using natural health products, there are still some challenges and more work to be done to improve the outcome of the post-market surveillance of the natural health products.
Mediterranean journal of pharmacy and pharmaceutical sciences
During the last two decades, the concept of Fibre Metal Laminates (FMLs) has been evolved to find solution to the requirement of improving mechanical properties and reducing structural weight of elemental components of aircraft structures. In this work FML is prepared using Al 2024 by placing alternately with glass/carbon/aramid Fibres. From experimental results of FML shows greater advantage in mechanical properties then aluminium monolithic layer and this composite fibre laminates individual. The FMLs tested in this work were made of 3 layers of 2024 T3 aluminium alloy 0.28 mm thickness and fibre mats. The 5-3/2 laminates of size 300x300 mm with 3 mm thick were prepared using Vacuum Assisted Resin Transfer Moulding (VARTM) in cold compaction and test specimen were cut by using abrasive water jet machining as per ASTM Standards. The adhesion between fibre and metal layer will play a major role in strength of FML. By keeping this in consideration FMLs were prepared without blow holes and capable of withstanding delamination while preparing specimens through water jet and during various tests employed. The fracture surfaces of destructed specimens are studied with help Scanning Electron Microscope (SEM) image. Similarly, the numerical simulation of all the tests were done using Ansys APDL 10.0 Software. It is observed that aramid FML have substantially stronger in longitudinal directions. Hence, more priority given in this paper to investigate tensile strength and fatigue life of aramid FML.
Oxalate is widely distributed in plant foods as potassium, sodium and ammonium oxalates (water-soluble form) and as insoluble calcium oxalates. Oxalate forms strong chelates with dietary calcium, thus rendering the complex unavailable for absorption and assimilation. It precipitates as insoluble salts accumulating in the renal glomeruli and contributes to the development of renal disorders. The seed flours of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn. were investigated for their total, soluble and insoluble oxalate contents by HPLC. The total oxalate content of M. uniflorum, P. lunatus and P. vulgaris was 1.24, 1.77 and 1.71 mg/ g, respectively. The %age of soluble oxalate were M. uniflorum (19.50), P. lunatus (15.08) and P. vulgaris (15.88). Only soluble oxalate is responsible for oxalate absorption (bioavailability) and its excretion. Overall, the total oxalate content is high in legume flour of M. uniflorum, P. lunatus, and P. vulgaris, but the soluble oxalates are very low. Therefore, all these three legumes don't have the adverse effects of oxalate on minerals bioavailability and risk of urolithiasis.
Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .