Yield Analysis of Maize Hybrids Lenient to Turcicum Leaf Blight Disease in Southern Districts of Karnataka

Veerabhadraswamy al

Jobelyn® is a multi-functional natural dietary supplement made from Sorghum bicolour with very high anti-oxidant and anti-inflammatory capacities. The study investigated the role of Jobelyn® in the attenuation of oxido-inflammatory markers induced by tramadol use, abuse and discontinuation over 17 days in rats. The experimental observational study was carried out using male adult albino rats weighing between 100 and 170 g. The experimental design involved five groups. Rats were randomly divided into groups of five, consisting of group 1 (normal control rats), and group 2 (rats treated with tramadol at 40 mg/kg/day) were administered for 10 days and discontinued for seven days. Group 3 administered incremental doses of tramadol from 40 mg/kg/day to 100 mg/kg/day over 10 days and discontinued for seven days. A similar treatment protocol was administered for group 4 and group 5 but were treated with Jobelyn® at a dose of 200 mg/kg/day at the discontinuation phases for seven days. Behavioral assessments (elevated plus maze model of anxiety and open field model of locomotor activity) and biomarkers of oxido-inflammatory stress were assessed. Tramadol-treated groups had significant anxiety responses and locomotory deficits in comparison to the control group. Tramadol-treated groups had significant elevations of nitrites and malondehyde and reduced enzymatic markers such as catalase, glutathione, reduced glutathione, superoxide dismutase, G-s-transferase, glutamic acid decarboxylase and increased activity of acetylcholinesterase when compared to control group. Administration of Jobelyn® attenuated the responses and ameliorated the oxido-inflammatory biomarkers similar to levels in control group. Tramadol induces oxido-inflammatory stress markers in the prefrontal, striatum and hippocampus in rats. Anxiety and locomotory behavioral actions on tramadol treatment were elevated despite discontinuation for seven days. Thus, Jobelyn® at 200 mg/kg/day ameliorated oxido-inflammatory markers induced by tramadol and decreased anxiety responses in albino rats.

Mediterranean journal of pharmacy and pharmaceutical sciences

Effect of germination and fermentation on the nutrient contents, functional and antioxidant activities of pigeon pea (Cajanus cajan) flour were investigated. The pigeon pea seeds were sorted, cleaned and processed into germinated, fermented and raw flours. The flour samples obtained were analyzed for proximate composition, mineral contents, antinutrient contents, functional properties and antioxidant/free radical scavenging properties using standard methods. The results of the proximate composition showed that the moisture content within the range of 9.62±0.02-9.96±0.01, crude protein content 16.63±0.01-24.17±0.01, crude fibre content 1.41±0.01-2.59±0.01, lipid 4.33±0.01-5.61±0.01, ash content 1.62±0.01-2.17±0.01, carbohydrate 56.80±0.02 - 62.47±0.01 and energy values 366.91 - 374.40kcal/100g. The result of elemental mineral analysis showed magnesium as the major mineral element in the sample (91.32±0.02 to 123.75±0.04mg/g), calcium (96.02 ± 0.02 - 110.14 ± 0.003mg/g), phosphorus (39.11 ± 0.02 - 46.12 ± 0.03mg/g), sodium (8.63 ± 0.02 - 12.61 ± 0.001mg/g), Iron (3.08 ± 0.02 - 4.11 ± 0.001mg/g) and zinc (2.04 ± 0.01 - 3.17mg/g) respectively. The result of the functional properties showed optimal gelatinization temperature ranged from 73.610C - 89.410C, emulsion capacity, 11.88 - 43.42%, foam stability,28.22 to 65.81%, foaming capacity,15.83 to 21.11%, bulk density,0.53 - 0.71g/ml, water absorption capacity, 1.11 and 1.51ml/g while oil absorption capacity,0.84 - 1.14ml/g. The sensory properties of the moi-moi from the processed flours showed that the colour test, (6.33 -7.53), flavour (7.63 to 7.75), taste (5.13 to 5.53), mouth-feel (7.25 to 7.36), overall acceptability (6.93±0.04 - 8.83±0.04). The results of the phenolic content ranged from 20.13mg\GAE, 53.43mg\GAE and 42.64mg\GAE for raw processed, malted and fermented samples respectively. The results of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) antioxidant activity of ethanolic extracts showed IC50values of 0.810, 1.177 and 1.014mg\ml for the raw, malted and fermented seed extracts respectively. The moisture, crude protein and fibre contents was significantly increased (p>0.05) during germination and fermentation whereas lipid, carbohydrate, ash and energy values were significantly (p<0>0.05) increased the % scavenging properties of pigeon pea extract though that of germination was higher. Malting and fermentation significantly (p<0.05) decreased the sensory properties of moi-moi produced. Based on the result obtained, regular consumption of pigeon pea will be a proactive measure against heart diseases and other related disorders in the human body.

Okechukwu obed chukwuemeka

WSN is a low-power system and are often used in numerous monitoring uses, such as healthcare, environmental, and systemic health surveillance, in addition to military surveillance. It is important to reduce network resource usage since many of these applications need to be installed in locations that are virtually inaccessible to humans. Many protocols for WSN to extend the presence of the network have been established to solve this problem. In the energy efficiency of WSN networks, routing protocols play an important role since they help minimize power usage and response time and provide sensor networks with high data density and service quality. This study also employed a Hopfield neural network and the findings from this study are presented next to each other to enable comparison. This paper also discusses how to easily and accurately capture and handle WSN collisions. Future experiments that require the usage of neural networks and so many fuzzy structures will be able to prevent a crash in these respects.

Mohd haroon

This article explores the intersection of Artificial Intelligence (AI) and personalized healthcare, focusing on how AI-driven technologies are revolutionizing the delivery of individualized medical care. Through an in-depth examination of recent advancements, practical implementations, and ethical considerations, this paper elucidates the transformative role of AI in tailoring treatments, improving diagnostic precision, and enhancing overall patient outcomes.

Dhruvitkumar talati

Due to the rapid growth in the field of science and technology, IoT (Internet of Things) has become emerging technique for connecting heterogeneous technologies related to our daily needs that can affect our lives tremendously. It allows the devices to be connected to each other and controlled or monitored through handheld devices. The IoT network is a heterogeneous network that links several small hardware restriction devices, and where conventional security architectures and techniques cannot be used. So, providing protection to the IoT network involves a diverse range of specialized techniques and architectures. This paper focuses on the requirements of defense, current state of the art and future directions in the field of IoT.

Dr. chandrashekhar uppin

Improper use of medicines may carry possible health dangers and more evidence continues to stand that adverse drug reactions to medicines are common but often preventable. Self-medication phenomena with over the counter medicines is common among people. It is regarded as essential issue of self-care. Over the counter medicines use such as analgesics among children and adolescents is continuously increasing in Libya. This constitutes an important public health concern. The aim of this study is to focus on adolescent's self-medication phenomena about the over the counter medicines that teens frequently used to treat minor and serious diseases. This work collected information throughout survey-comprised number of questions for the teenagers bought medicines from private pharmacies at two different secondary schools in Benghazi city, Libya, without prescription. The sample size was 120 students, 58 males and 62 females in age range of 15-18 years. Data collected from questionnaire were analyzed for pattern of medicine use. Male adolescents bought toothache and muscle-spasm medicines more frequently than female adolescents. On the other hand, female adolescents administered more over the counter medications monthly than males. The use of over the counter medicines has been found highly rated and exaggerated among secondary school teenagers. In conclusion, adolescents have to be educated regarding over the counter medicine use in Libya. The need for promoting the appropriate use of medicines healthcare system is an important issue. This can be achieved through an educational strategy involved different public sectors such as health and education authorities.

Mediterranean journal of pharmacy and pharmaceutical sciences

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders worldwide. It is mainly associated with a loss of dopaminergic neurons in the substantia nigra pars compacta

Nagarjuna narayanasetti

Vitamin D deficiency is a public health concern affecting many individuals as it is highly prevalent in all parts of the world. Recent studies have reported an association of vitamin D deficiency with cardiometabolic alterations such as dyslipidemia. The study aimed to evaluate vitamin D and lipid profile levels among the Libyan adult population and investigate the correlation of vitamin D deficiency with the alteration of lipid profile levels. A cross-sectional study was conducted at Janzour Hospital among 193 subjects (107 males and 86 females) whose ages ranged between 20 and 50 years over three months from Sept to Dec 2023. Vitamin D, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein levels were estimated. The total mean vitamin D levels were 8.31±4.74, 23.83±2.78, and 42.67±7.95 ng/dl for deficiency, insufficiency, and sufficiency, respectively. The findings revealed significant alterations in cholesterol (increase), triglyceride (increase), LDL-cholesterol (increase), and HDL-cholesterol (decrease) among subjects who had vitamin D deficiency or insufficiency as compared to subjects having vitamin D sufficiency. Vitamin D levels were negatively correlated with cholesterol, triglyceride, and LDL cholesterol, and they were positively associated with HDL cholesterol. The incidence of dyslipidemia is higher in the vitamin D deficiency group than in the insufficiency and sufficiency groups. It is essential to frequently monitor lipid profiles among vitamin D-deficient individuals to avoid subsequent disorders or damages associated with the alterations of lipid profile patterns.

Mediterranean journal of pharmacy and pharmaceutical sciences

Experimental trials were conducted on the compatibility of urea 2% with insecticides of different groups viz., monocrotophos 36SL @ 500 ml/ha, cypermethrin 25EC @ 125 ml/ha, quinalphos 25EC @ 1000 ml/ha and novaluron 10EC @ 375 ml/ha against larval population of Helicoverpa armigera in the field conditions on chickpea cultivar “HC-1” during Rabi season 2011-12 and 2012-13 at CCS Haryana Agricultural University, Hisar (Haryana). These insecticides were found compatible with urea. Minimum larval population of H. armigera was recorded in novaluron 10EC @ 375 ml/ha at 3, 7 and 10 days after spraying. Monocrotophos 36SL @ 500 ml/ha, quinalphos 25EC @ 1000 ml/ha and cypermethrin 25EC @ 125 ml/ha could not provide consistent results against H. armigera. The larval population, pod damage and incidence were statistically at par with insecticides and their combination. No phytotoxicity effect was observed on the leaves with urea application in combination with insecticides. Minimum per cent pod damage (7.3%), maximum grain yield (14.6 q/ha) and monetary returns (` 6265/ha) was realized from novaluron 10EC @ 375 ml/ha plus 2% urea as compared to other treatments.

Dr. babu lal jat

Multiple choice questions (MCQs) and short essay questions (SEQs) are common methods of the assessment of medical students in courses of pharmacology. Poorly constructed test items (questions) are a widespread problem resulting in failure to assess learning objectives. It has been reported that there are 36.0% to 65.0% flawed test items in medical education assessment tools. Thus, the objective of this study was to evaluate MCQs by determining the item writing flaws (IWFs) and to evaluate the SEQs by determining the cognitive level of each item. Four pharmacology tests were administered to third-year pharmacy students at Department of Pharmacology, Faculty of Pharmacy, Omar Al-Mukhtar University, Bayda, Libya. These were evaluated by determining the IWFs and the level of the cognitive domains. Based on Buckwalter’s modification of Bloom’s taxonomy cognitive level, for the SEQs, 30.0% of the questions were attempted to check recall of information, 26.0% were attempted to evaluate understanding and interpretation of data and 43.0% of the questions were attempted to check the application of knowledge for solving a particular problem. For the MCQs, 94.6% of the questions were attempted to evaluate the understanding and interpretation of data. For the IWFs, there were more than 40.0% of flawed questions. The most common writing flaws were the negative stem (47.4%), unfocused item (16.0%), non-homogenous in grammar and contents (10.0%), all the above (10.0%) and clang association (05.0%). In a short essay, the SEQs were of excellent quality because they were equally distributed among the three levels of cognitive (level I, II and III). On the other hand, the most common mistakes IWFs of the MCQs were the negative stem (47.0%) and the idea was not clearly and concisely stated in the stem (16.0%). This study concludes that questions in SEQs are valid to measure the learning objective but MCQs were not in pharmacology courses in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

The present study focused on analysing the impact of ‘Make in India’ campaign on FDI inflows in country. The research period is divided in two parts one is pre ‘MII’ & another is post ‘MII’ period. The analysis of ‘Make in India’ campaign is done to identify the scope of the campaign & methodology of working of various allied departments monitoring campaign. The present research work also attempted to take overview of various policy reforms initiated by Government of India to promote the FDI as well domestic investment in 25 sectors shortlisted under MII. The FDI inflows statistics reveals that, the post MII period is showing the highest growth in FDI equity inflows as compare to same period i.e. 2009- 2014. The MII initiative is one of the reason for the jump in FDI inflows. The overview of policy reforms shows that GOI through DIPP attempted to open almost all sectors for 100% FDI through automatic route. Government has provided multiple incentives for Foreign Investors to establish their manufacturing facilities in country but very negligible response has been seen in the nature of FDI equity inflows in the same period. Further results of study reveals that multiple ‘MOU’s have been signed by States & Central Governments, but they yet not converted in actual investments. The major reasons behind the same is lack of SWOT analysis through Governments before inviting the foreign investors. As well lack of basic infrastructure, land, lack of skilled manpower, cheap & un interrupted power supply to MIDC’s & SEZ’s is yet not successfully provided, lower rankings in Ease Of Doing Business (EODB), Global Manufacturing Competitiveness Index (GMCI) is also cause of concern & tumbling block in the success of MII mission..

Anshuman vijay magar

Cloud computing is a technology of delivering resources such as hardware, software (virtual too) and bandwidth over the network to the consumers worldwide. All the services are requested and accessed through a web browser or web service. The main advantage that cloud is provided to the nation worldwide is that it is not so easily affordable to one and all. Multi-conglomerate companies invest a lot of money on the cloud and let people access it for a smaller cost and even free at the lowest level of the consumer chain. In this paper we address to the problems that the cloud technology faces and how it can be overcome.

Pavan m

The coexistence of Moyamoya syndrome (MMS) and Graves’ disease (GD) is uncommon. Here, we report a case of a 41-year-old Filipino female, who presented with thyrotoxicosis and acute ischemic stroke. Based on her clinical presentation, cerebral computed tomography angiography, and thyroid function tests, she was diagnosed with MMS and GD. Her Burch-Wartofsky point scale score was 30, suggesting an impending thyroid storm. Antithyroid therapy was started with her neurological status deterioration initially, but after controlling the thyroid storm, the patient’s neurological status stabilized. She remained stable till she travelled to her country. We hypothesized that MMS in a patient with GD is mediated through anti-dsDNA antibodies, by altering key biological mechanisms, that is, inflammation, neutrophil extracellular traps, and apoptosis that drive a distinctive and coordinated immune and vascular activation. To the best of our knowledge, this is the first case of MMS associated with GD reported in Qatar.

Karishma

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused more than five million deaths throughout the world and more than five thousand deaths in Libya, a little is known about the mortality rate and the risk factors for death from this serious infectious disease in Libya. Thus, it is aimed in this study to identify the potential risk factors for mortality from SARS-CoV-2 infections among 176 Libyan COVID-19 patients in Zawia city. This research is a retrospective cohort study that was conducted on 176 randomly selected volunteers who had been infected with SARS-CoV-2 during a period of December 2020 to February 2021 in Zawia city, Libya. Following filling the prepared validated questionnaire by COVID-19 patients, the data was analyzed to determine the previously mentioned risk factors. The mean age (SD) of the total 176 participated COVID-19 patients was 45.06 (± 17.7) and the mortality rate among these total involved cases (mild to severe cases) was 10.8%. It is found that the mortality among the severe COVID-19 cases was 41.3% and the mean age (SD) of COVID-19 deaths was 69.1 years (13.8) and 73.7% of them were 60 years old or older. In addition, it is found that 63.2% of the SARS-CoV-2 deaths were females and 78.9% of them had a positive history of chronic diseases. Moreover, it was found that the most common chronic diseases among COVID-19 deaths are diabetes mellitus and hypertension (73.3% and 53.3%, respectively). Collectively, it is concluded that COVID-19 elderly female patients aging 60 years or older with a positive history of chronic disease are more likely at high risk for death from SARS-CoV-2 infection among the participated COVID cases.

Mediterranean journal of pharmacy and pharmaceutical sciences

In this report, Tesco PLC's operation and project management have been fully elaborated on. Tesco PLC is a retail organization that deals with retailing and other related activities in insurance service and retail banking (REUTERS, 2020). Tesco is multinational general merchandise and groceries with headquarters at Welwyn Garden City in England. Based on gross revenue rating, Tesco is the third-largest retailer in the world. Tesco was created by Jack Cohen in 1919 in Hackney, London as a set of markets stalls. Tesco developed and expanded very fast in the whole world and above 100 Tesco shops in the entire Facebook. Tesco has segments in ROI and the UK that is; central Europe (Hungary, Slovakia, and the Czech Republic), the Republic of Ireland, and the United Kingdom which do similar activities to those done in Tesco bank in the United Kingdom (Bedford, 2022). Tesco avails different personal banking packages (services and products) that include personal loans, personal current accounts, and credit card receivables. Tesco's businesses are therefore Tesco Hungary, Tesco UK, Tesco Czech Republic, Tesco Slovakia, Tesco Ireland, Dunnhumby, and Tesco Bank.

Zamzam abdelazim

Corona virus pandemic has swept a major section of the world population. In terms of infectivity it�s higher than any pandemic in the recent past. Corona virus, a member of the family Coronaviridae, spread from bat to human through an intermediate host pangolin. It has lower mortality rate than the previous pandemics in last 100 years such as Spanish Flu(1918-20),Asian Flu (1957-58), SARS Corona virus (SARS-Cov) (2003), H1N1 Swine Flu Pandemic(2009-10), Middle East Respiratory Syndrome (MERS) (2012), West African Ebola (2014-16) etc. Research shows Covid spike attaches ACE2 receptor; it leads to a release of cytokine into the blood capillaries near the alveoli and may ultimately turn into pneumonia. The alveoli get collapsed leading ARDF. The pulmonary inflammation proceeds to systemic inflammation that causes multiple organ failure. Drug like Chloroquine, Lopinavir/ritonavir, and Remdesivir may halt the spread of the virus in the body. Antipyretic is prescribed to reduce the temperature. This article comprises of detail mechanism of the dreadful disease along with its diagnosis and proposed treatment. This exploratory study mainly designed to generate awareness and provide information to the individuals who want to know the A to Z of Covid in nutshell. This article may create a pathway to number of upcoming scientific researches and may attract them to work on this field to enhance the probability of inventing appropriate vaccine and medicine to fight against this contagious disease and to win the battle against this Global Pandemic.

Dipa mitra

Menstruation is a normal physiological impact on each girl’s life. Menstruation is monthly uterine bleeding for 3-5 days after every 28 days from puberty till menopause. A change in mood, behaviour, appearance of some abnormal vague symptoms is often noticed in the second half of the cycle. Symptoms are severe enough to disturb the life cycle of a woman called premenstrual syndrome (PMS). The study aimed to assess the premenstrual symptoms and coping strategies among adolescent girls. The majority of the students suffered from premenstrual syndrome. Objective: to assess the premenstrual symptoms and coping strategies among adolescent girls. Methodology: A nonexperimental descriptive research design was adopted in this study. Non probability convenient sampling technique was used to select the sample size of 30 adolescent girls. The assessment of premenstrual symptoms and coping strategies was carried out using a self-reported Likert’s rating scale. Data was analyzed by using descriptive and inferential statistics. Result: Majority (93.3%) of the samples sometimes had physiological and psychological problems, 90% of them had behavioural symptoms. Majority (43.3%) of the samples always followed coping strategies and 16.7% of the samples sometimes followed coping strategies and 40% never followed any coping strategies. Conclusion: PMS was common among students at 18-24 years. The most common physical symptoms experienced by adolescent girls were headache, backache and lower abdominal pain. Adolescent girls used coping strategies as taking hot / cold drinks, do not express anger to others, and turn to study and forget things, hearing music and taking medications. Keywords: Premenstrual Symptoms, physiological, psychological & behavioural symptoms, Coping Strategies, Adolescent Girls.

Elsi queen

Diabetes is a global issue, the diabetes epidemic is expected to continue, and the burden of diabetes causes catastrophic expenditure for healthcare system. The current study aimed to determine the presentation, the clinical feature and cardio-vascular risk factors in patients with diabetes. A retrospective observational study had been conducted in out-patients department at Almustaqpal Almosherq Centre during September, 2013 till September, 2020, the total number of attended out-patients department were 1 024, 820 patients who were selected for this study. A special perform was completed for every patient, which included details about patient’s demographics, points in clinical history, relevant investigations and clinical examinations were recorded. The study reported that out of 820 patients, 66% (n = 538) was female and their age range was between 14 - 87 years with a mean age of 56.53 ± 13.49 years, 96% (n = 791) were clinically diagnosed as type II diabetes, 07% of the patients were diagnosed as pre-diabetes, the duration of diabetes ranged from newly diagnosed to more than 10 years, with 46% (n = 379) of the studied population were more than 10 years diabetes duration, 70% (581) were presented with classical symptoms of diabetes. Initial treatment for diabetes also different in the studied sample, were absent of anti-diabetic medications in 30% (n = 248) of the patients, they refused to start glucose lowering drugs, 34.6% (n = 284) of them have morbid obesity (body mass index is more than 40), 80% (n = 662) have high HBA1c (more than 8 g%), 40.3% (n = 240/596) were uncontrolled hypertension on anti-hypertension drugs, 95.6% (n = 682/713) were controlled on treatment of lipid lowering drugs. This study showing the presentation of diabetes were the common, type II diabetes, at age group between 41 - 66 years about 65%, female sex, with high body mass index, high glycated hemglobulin and uncontrolled hypertension. There is concern that diabetic patients were occurring at a high frequency in younger adults, where longer duration of illness could increase the risk of developing more complications in later life. The rate of coexist cardiovascular risk factors (hypertension, dyslipidaemia and obesity) in Libyan patients with diabetes is highlighted.

Mediterranean journal of pharmacy and pharmaceutical sciences

Currently, vehicle to vehicle communication is an important application and thrust area of research. In this paper the author highlighted the workings, executions, implementations and the application of the Internet of Things (IoT) in transport management and vehicle to vehicle communication systems. The main advantage of this Industry 4.0 based IoT technology is that it helps us to reduce road traffic and accidents. The limitations of GPS like accuracy, precision, effective analysis, etc. has led to the evolution of Mobile based V2V communication which is more effective, error proof, result oriented and smart. For proper analysis of traffic vehicle to vehicle communication is established. Random Data from vehicles taken by numerous sensors. Any car coming in its variety could effortlessly share the data by either of two cars nearby. With the help of vehicle to vehicle communication we can provide a path of emergency vehicles to reach the destination quickly. Based on the V2V application, Red and Green signals can be marked on the path as per traffic density and the emergency vehicle can take the shortest, fastest and low density route. Similar such examples are elaborated in the current research manuscript that will help the researcher in effectively finding the research gap for further advancement, analysis, innovation and optimization.

Vartika agarwal