Objective: This study fills an important research gap by focusing on the effectiveness of low-impact exercise in Parkinson's disease (PD), taking into account the different challenges faced by people with varying degrees of disease severity. Motivation: Unlike generic investigations into exercise and PD, our research prioritizes low-impact activities, considering safety concerns related to balance deficits and coordination challenges in the PD population. The study aligns with a patient-centred approach, aiming to provide a safer alternative to traditional exercise modalities. Approach: Conducting a comprehensive literature review, we conducted an online literature search on various databases, specifically investigating about low-impact exercises on both motor and non motor symptoms in PD individuals. Review process involved capturing diverse intervention types, durations, frequencies, and intensities. Findings: The amalgamation of diverse outcome measures, including UPDRS, Berg Balance Scale, TUG, 6MWT, and PDQ-39, showcased the multifaceted impact of low-impact exercises on both movement related and non-movement related symptoms. Notably, aerobic exercises being treadmill walking, cycling, and group sessions, emerged as pivotal interventions, demonstrating improvements in gait, balance, flexibility, and overall quality of life for PD individuals. Conclusion: While acknowledging limitations, such as potential publication bias and a focus on aerobic exercises, this study provides meaningful decision making information for clinicians and researchers. Future research should diversify interventions and methodologies to enhance the evidence base and address nuanced aspects of low-impact exercises in PD management. The results of this review contribute to the existing body of knowledge regarding the nuanced benefits of personalized low-impact exercise for Parkinson's disease.

Nagarjuna narayanasetti

HIV/AIDS cases in Indonesia continue to increase and have spread to all provinces in Indonesia. Bandung is one of the cities with a high number of people living with HIV/AIDS in Indonesia. As one of the areas with the highest number of reported HIV cases, the Bandung city government seeks prevention and treatment through the role of existing stakeholders. However, stigma and discrimination against people living with HIV & AIDS, now referred to as PLHIV, are still found and are difficult to eliminate. People diagnosed as contaminated with the HIV & AIDS virus often get a negative stigma. This study aims to analyze how to remove the stigma and discrimination of people with HIV/AIDS through the role of civil society. The research results show that stigma against HIV is often directed at certain minority groups and is often associated with morals and religion. Meanwhile, discrimination against people with HIV is manifested in violations of individual rights in the economic, social, and cultural spheres. The issue of stigma and discrimination against PLWHA has not received serious attention. Therefore, the role of civil society is very important because it can open a dialogue with the community regarding HIV/AIDS to dispel myths that tend to discriminate against PLHIV.

Syahrul tuba

Emesis is defined as a forceful expulsion of stomach contents via the mouth. The adverse effects of available anti-emetic drugs potentiate us to evaluate natural products to explore effective natural anti-emetics with fewer side effects. The fruits of Illicium verum Hook. f. were selected for anti-emetic activity based on their folkloric use against gastrointestinal complaints. Crude methanolic extract and its aqueous, dichloromethane, ethylacetate and hexane fractions were evaluated using the copper sulphate-induced chick emesis model. Emesis was induced by the oral administration of copper sulfate 10 ml/kg body weight and metoclopramide (150 mg/kg p.o.) as a standard anti-emetic drug. The anti-emetic effect was observed by calculating the mean decrease in the number of retches compared to that of the control. Methanolic extract and its fractions were tested at 25, 50 and 75 mg/kg oral doses. Among all tested fractions, ethyl acetate showed the highest (94.46%), and hexane showed the lowest (56.30%) anti-emetic activity at 50 mg/kg. Further, isolation and purification from the same fractions are in process to discover effective natural anti-emetic compound(s) with less unwanted effects.

Dr. salman ahmed

The present study focused on analysing the impact of ‘Make in India’ campaign on FDI inflows in country. The research period is divided in two parts one is pre ‘MII’ & another is post ‘MII’ period. The analysis of ‘Make in India’ campaign is done to identify the scope of the campaign & methodology of working of various allied departments monitoring campaign. The present research work also attempted to take overview of various policy reforms initiated by Government of India to promote the FDI as well domestic investment in 25 sectors shortlisted under MII. The FDI inflows statistics reveals that, the post MII period is showing the highest growth in FDI equity inflows as compare to same period i.e. 2009- 2014. The MII initiative is one of the reason for the jump in FDI inflows. The overview of policy reforms shows that GOI through DIPP attempted to open almost all sectors for 100% FDI through automatic route. Government has provided multiple incentives for Foreign Investors to establish their manufacturing facilities in country but very negligible response has been seen in the nature of FDI equity inflows in the same period. Further results of study reveals that multiple ‘MOU’s have been signed by States & Central Governments, but they yet not converted in actual investments. The major reasons behind the same is lack of SWOT analysis through Governments before inviting the foreign investors. As well lack of basic infrastructure, land, lack of skilled manpower, cheap & un interrupted power supply to MIDC’s & SEZ’s is yet not successfully provided, lower rankings in Ease Of Doing Business (EODB), Global Manufacturing Competitiveness Index (GMCI) is also cause of concern & tumbling block in the success of MII mission..

Anshuman vijay magar

The wind tunnel experimental study has been carried out on a double delta wing of different geometrical configurations such as 80°/45°, 75°/45° and 70°/45° sweep angles given as Model I, Model II and Model III with various freestream velocities from 10 to 40 m/s with a step of 10 m/s in Hindustan Institute of Technology and Science, Chennai, Low Speed Wind tunnel (HITSLSWT). The experiment is conducted for the measurement of lift and drag forces using single component force balance. The investigation was done to look into the effects of changing the double delta wing's leading edge sweep angles. Three differentmodels have been tested at various angles of attack ranging from0° to +16° and 0° to −16° with 4° and four different freestream velocities based on the delta wing’s chord. It is observed that the influence of variation of leading edge sweep angles affects the performance of aerodynamic characteristics of themodel. The increase in angle in attack with increased velocity gives better aerodynamic performance. This paper provides good insight into the aerodynamic force measurement of double delta wing and the low-speed performance of the models.

Boopathy govindarajan

Aminopyrine (AM) has been used as a model substrate for investigation of drug metabolism. The major metabolic route is N-demethylation that was confirmed in liver microsomes. The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating the N-demethylation of 4-di-methylaminoantipyrine (4-DMAA) to 4-methylaminoantipyrine (4-MAA). The contribution of human CYP to the metabolism of (4-DMAA) to (4-MAA) in human was investigated using virus expressed human CYP, human liver microsomes with chemical inhibition studies. The substrate of 4-dimethylaminantipyrine was employed at different concentrations (11.5, 23, 46, 115 and 230 µmol per l) with varying concentrations of selective inhibitors of CYP (CYP1A2), (CYP3A4), (CYP2C8),(CYP2A6), (CYP2D6), (CYP2C19) and (CYP1A1). 4-DMAA and 4-MAA were analysed by HPLC and enzyme kinetic parameters (Km and Vmax) were calculated from the concentration data. The transformation of 4-dimethylaminoantipyrine to 4-methyaminoantipyrine by microsomes prepared from baculovirus-expressed human CYP was pronounced with CYP2D6. The metabolism of 4-dimethylaminoantipyrine was inhibited by 60.0% and 55.17% by a concentration of 100 µmo per l of the known CYP2D6 inhibitors quinidine and moclobemide. The corresponding Ki values were 0.050 and 0.11 mM, respectively. The corresponding IC50 values were 0.06 and 0.13 mM, respectively. The enzyme CYP2D6 apparently has an important role in N-demethyl-ation of 4-dimethylaminoantipyrine.

Mediterranean journal of pharmacy and pharmaceutical sciences

India is in the midst of a severe second wave of Covid-19. As per the Global Commission for Post-Pandemic Policy by mid-April of 2021, India had manufactured nearly 17 percent of all Covid-19 vaccine doses globally. It was the world’s fourth-largest producer, after China (about 36 percent), the United States (about 22 percent) and the European Union (more than 17 percent). Even so, following a shortage of vaccines and with insufficient local production, Government of India decided to import more foreign vaccines with quicker approval process for vaccines accepted in US/EU markets. India is currently using made-in-India vaccines, namely, Covishield manufactured by Serum Institute India and Covaxin of Bharat Biotech in its COVID-19 immunisation programme. The shortcoming in the production of vaccines and its dissemination within the country urges one to understand who the local producers are and how the market is playing out. This paper looks at the evolving market structure of vaccine production in India in the textbook framework of an oligopoly market. We use secondary data sources and daily newspaper briefs.

Nandini

Use of chemical fungicide to control plant diseases causes several adverse effects such as, development of resistance in the pathogen, residual toxicity, pollution to the environment etc. So an alternative way to overcome the usage of dreadful chemicals is very important. The use of plant extracts as biofungicide is one of the popular and effective method. Araucaria columnaris is a commonly seen ornamental plant known as Christmas tree. It’s a South African species, under the family Araucariaceae. Hence, in the present study, the plant resin extract was tested in-vitro against major plant pathogensby preliminary bioassay. It was found that up to 95% reduction of mycelium growth was observed against major phytopathogens such as Fusarium oxysporyum, Rhizoctoniasp, Cylindrocladiumsp, Alternariasp, and Colletrotricum sp., causing tomato wilt, damping off, foliage blight, and leaf blight diseases in economically important plants. Up to our knowledge it is the first report showing the antifungal activity of Araucaria columnaris resin as antifungal agent. By using this valuable tree, further work will be done to formulate commercial biofungicide.

Dr. saranya devi k

During the 16th century, firearms played a transformative role in Indian warfare, considerably enhancing the effectiveness of the Mughal army. The introduction of muskets and artillery by Babur in 1526 revolutionized military strategies, giving the Mughals a decisive advantage in battles and sieges. The Mughal army’s structure, particularly under Akbar’s Mansabdari system, centralized control and ensured a loyal, efficient military force. This technological and organizational superiority enabled the Mughals to consolidate power over diverse regions through a combination of military might and diplomacy. By the 17th century, there was a significant change in rebellions as firearms started being used by peasants. This shift in weaponry fundamentally altered the nature of these uprisings, empowering the peasantry in new ways to resist authority. Multiethnic regional powers also recognized the importance of firearms, acquiring them from the Mughals or Europeans, and employing them effectively in battles. In the mid-18th century, the Marathas and later the Mysore Sultanate took a notable step by establishing arms factories and engaging European experts to produce advanced firearms. This marked a departure from the past, where regional powers typically relied on the Mughals or European companies for firearm procurement. This shift toward domestic arms production signaled a move toward greater self-sufficiency and the development of advanced firepower. By the 18th century, the Mughal Empire was in decline, and multiethnic regional powers and European colonial forces, equipped with advanced firearms, challenged and eventually overshadowed Mughal dominance.

Bidyut patar

India is not known as a country to be in for a bisexual person. Homosexual acts even within wedlock are a punishable offence in India. Legal battles over provisions in the Indian Penal Code which criminalizes any sexual act “against the order of nature” are rife. Even though Kerala has been hailed as a paradox inside India (mainly due to its human development parameters), the social, cultural and legal environment in the state is hostile to individuals who question hetero-normativity. Non-judgemental and unbiased scientific therapy or counselling are seldom available to sexual minorities. This paper is an attempt to map the experiences of a female who is openly bisexual, and is living in Kerala. An ethnographic interview was conducted where the experiences of the participant are explored, from the relationship dynamics as seen by her, to sexual experiences and difficulties in relationships. A reference is also made to the personal and social support systems that are in place for the Lesbian, Gay, Bisexual, Transgender (LGBT) community in Kerala and their role in initiating discourses regarding the topic. A few pointers for future studies in the topic, especially within the context of Kerala are also put forward.

Dr. chinchu c

Micro-level assessment of vulnerability to climate change creates basis for policy formulation. The study specifically ascertained the levels and determinants of vulnerability to climate change among selected food crop farmers. Data collected were analysed using descriptive statistics and ordinary least square regression analysis. The result revealed that 15.95%, 68.97% and 15.08% of the households were highly vulnerable, moderately vulnerable and less vulnerable to climate change respectively. This implies a varied effect on crop farmers. The result also showed that amount saved, extension contacts, household expenditure and value of crop were significant at 1% level. The study recommended the provision of basic amenities and soft loans to farmers as well as an improvement in extension services. It also advocated the introduction of effective climate change mitigation and adaptive measures to boost agricultural output in their area.

Comfort chikezie

Brucellosis is a zoonotic infection often linked to direct or indirect exposure to animals or unpasteurized dairy products. Atypical presentations in patients without classical risk factors pose significant diagnostic and management challenges. A 68-year-old woman presented with a 2-month history of burning pain involving cervical and lumbar regions, associated with weight loss, decreased appetite, and subjective fever. Examination revealed paravertebral tenderness and left knee swelling with effusion. Previous MRI showed multifocal marrow edema and soft tissue thickening in the lumbar spine, suggesting infection or inflammation. The patient denies exposure to unpasteurized dairy products, raw meat, or animals. Brucella serology revealed positive IgG with Brucella melitensis titer 1:160, later confirmed by blood cultures. PET imaging demonstrated multifocal metabolically active arthritic changes involving the spine, shoulders, and knees. Arthrocentesis confirmed inflammatory arthritis due to brucellosis. The patient was started on doxycycline, rifampin, and a 14-day course of intravenous gentamicin. During hospitalization, management was complicated by persistent knee pain and swelling requiring multimodal analgesia. Spinal brucellosis in the absence of classical risk factors is an odd presentation, emphasizing the importance of maintaining a high index of suspicion in endemic regions. Advanced imaging and microbiological confirmation are pivotal procedures in diagnosis. Early recognition of atypical brucellosis is critical to prevent complications and improve outcomes.

Karishma

Effective project management requires an understanding of how stakeholders are impacted by project failure. It draws attention to the effects on those involve finances, reputations, and emotions, assisting organizations in risk avoidance and fostering stakeholder satisfaction, trust, and long-term success. The purpose of this study is to provide proactive risk management, stakeholder involvement, and project result strategies. In order to compile this study, we have used a number literature reviews ranging from 2004 to 2023. The study's findings show that project failure results in significant financial losses, harms reputation, has legal ramifications, affects employee wellbeing, stifles relationships with stakeholders, stifles innovation, and endangers communities and the environment. By Adopting proactive risk management, strong governance, open communication, employee support, stakeholder involvement, strategic resource allocation, and social and environmental responsibility to reduce these negative effects and achieve sustainable project outcomes. The policymakers, practitioners and academia should focus risk factors those are associated with the project failure and hance manage a good harmony among the stakeholders.

Nazim ullah

A 28-year-old female presented with recurrent chronic abdominal pain. An abdominal ultrasound revealed cholelithiasis, characterized by two large stones and several smaller ones. Laboratory tests including liver function tests were within normal limits. A laparoscopic cholecystectomy revealed an enlarged dark black liver, with round margins suggestive of Dubin Johnson syndrome (Figure 1) , while the Gallbladder was distended with multiple calculi inside. Successful laparoscopic cholecystectomy was done with a liver biopsy. Histopathology of the gallbladder revealed chronic cholecystitis. A liver biopsy confirmed the diagnosis of Dubin Johnson Syndrome. The follow-up was uneventful.

Karishma

Assessing students' progress in introductory programming courses is crucial for identifying learning gaps and improving teaching methods. This study evaluates the effectiveness of Moodle-based tests with randomized questions in monitoring student progress in C programming courses at J. Selye University during the 2023/24 academic year. A series of ten tests were administered across two courses, covering essential programming topics such as data types, variables, conditional statements, loops, two-and three-dimensional arrays, recursion, and sorting algorithms. The results revealed significant variations in student performance, with recursion and the pretest/posttest loops presenting the greatest challenges. The correlation analysis of test scores showed strong relationships among related topics, confirming the structured progression of the curriculum. These findings suggest that Moodle-based assessments offer valuable insights into students' learning trajectories, enabling educators to adapt their instructional strategies accordingly. Such insights can help optimize introductory programming curricula, enhancing student engagement and understanding.

Ladislav végh

Wireless Sensor Networks (WSNs) received enormous attention in recent years due to its phenomenal ability of implementation in various fields. WSNs consist of a large number of small sensor nodes. These nodes are very cheap in terms of cost. In military operations, there is always a threat of being attacked by enemies. So, the use of these cheap sensor nodes will help to reduce the loss. In this project, the security of data transmission in WSNs for military applications is analyzed. It discusses the available scenarios of using sensor nodes in the military uses. The aim is to present a better deployment of sensor nodes for military purposes with the help of cryptographic techniques. This project will try to identify different areas in which we can reduce the damage in case of militant’s attack or enemy’s outbreak using an intelligent deployment of nodes. It is proposed to use the WSNs in battlefield surveillance to closely monitor the critical areas and borders to obtain information about enemy activity in that area. Hence, militant’s will gather information quickly which will result in quick response. Border monitoring is an essential component of military surveillance to prevent enemy’s intrusion. Here the proposed work provides security using several techniques to encrypt and decrypt the data in WSNs. Elliptic Curve cryptography involves Attribute based encryption which is more complicate to hack. As well as skipjack is used to create digital signature to avoid unauthorized users.

Dr h shaheen

Here is presented a short review on the medical potency of the most toxic plant of Europe. In many countries it isn't concerned any more as therapeutic agent in medicine due to frequent intoxications. However, in the homeopathy, preparations and patent medicines still contain aconitine and other alkaloids (abundant levels). There exists even a US Patent "ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF" (No. US 9,085,536 B2 by du Bois et al. 2015).

Stefan dahl

The soil samples were collected from Melia dubia plantations in two different locations in Tamil Nadu. A total of twenty five actinomycetes isolates were isolated and they were screened for melanin pigment production using different culture media. Only two isolates were able to produce melanin pigment under in vitro study and one isolate showed positive reaction to L-tyrosine substrate. Based on morphological and bio-chemical characters the isolate was identified as Streptomyces sp. The DNA of the isolate was isolated and its 16S rDNA gene was amplified and sequenced. The phylogenetic analysis of Streptomyces puniciscabiei was carried out.

Dr. saranya devi k

This paper throws light on the role played by culture and traditions specifically of Hindu religion in legitimising the subordinate position of women in Indian society. Along with presenting a brief account on the status of women from ancient times to contemporary situation, the sex-gender binary has also been explored. How a child after his birth socialised to behave in a certain way on the basis of his/her sex has been noted. This process of socialisation is based on the age old customs and traditions which are discriminatory in nature. The male child is taught to be strong, dominating and aggressive in nature and henceforth assigned laborious work to do for managing the finances of house. On the other hand, female child is taught to be sensitive, loving and caring and therefore assigned to manage household work, child nurturing and motherhood related responsibilities.

Swati sharma

Micro Gas Turbines (MGTs) are compact power generation systems that offer several advantages such as highpower density, low emissions, and fuel flexibility. They are commonly used in remote areas where grid connectivity is limited or unreliable. However, MGTs suffer from inherent instability issues due to their small size and high rotational speeds. These instabilities can lead to irregular speed responses, affecting the overall performance and reliability of the system. To address these concerns, the researchers utilized a genetic algorithm (GA)-based approach and conducted sensitivity studies to analyze the iteration parameter of the GA and its impact on the speed response of the MGTs. To evaluate the performance of the developed solution, they employed the Mean Step of Absolute Speed Error (MSASE) evaluation metric and compared the outcomes of the proposed strategy with a baseline Proportional Integral (PI)-only solution. The results demonstrated that the proposed solution surpassed the baseline approach by delivering a superior error response. Similarly, the findings suggested that the optimal iteration parameter setting for the GA was a maximum of 30 compared to 20 and 10 consequently lessening the settling time from 140s to 60s. Accordingly, the researchers concluded that optimizing the GA's iteration parameter could lead to enhanced stability in the speed response of the MGT units. Subsequently, this can bolster the power generation capacities of the units, highlighting the potential for enhanced efficiency and stability in MGT operations. As a final recommendation, the study advised practitioners working with MGTs to adopt the proposed GA-based speed control strategy to optimize the overall performance and reliability of these units.

Fxintegrity publishing