In this article, we form the exact wave solutions of the Jimbo-Miwa equation and the Calogero-Bogoyavlenskii-Schiff equation by applying the new generalized (G'/G)-expansion method. We explained the new generalized (G'/G)-expansion method to look for more general traveling wave solutions of the above mentioned equations. The traveling wave solutions attained by this method are in terms of hyperbolic, trigonometric and rational functions. The graphical representation of the obtained solutions is kink soliton, singular kink soliton, singular soliton and singular periodic solution. This method is very significant for extracting exact solutions of NLEEs which habitually occur in mathematical physics, engineering sciences and applied mathematics.
Abstract: Recent studies on hydrogels have shown them as promising biomaterials for numerous applications involving tissue engineering, drug-screening, drug-delivery, and 3-D bioprinting because they show unique physicochemical properties. The ability of these structures to hold large amounts of water is because of their hydrophilic nature that provides a soft and hydrated environment like natural tissues. This makes them ideal for mimicking the extracellular matrix and supporting cell growth and proliferation. In tissue engineering, hydrogels might be used to create scaffolds that promote cell growth and facilitate tissue regeneration. Hydrogels can also be engineered in such a way that they intimate the mechanical and biochemical in vivo characteristics making them a versatile tool for applications in tissue engineering. Hydrogels are being used in drug screening, as they can be functionalized with different biochemicals in order to match the microenvironment of specific tissues. This allows researchers to study how drugs interact with cells and tissues in-vitro conditions, which can lead to more efficient strategies for drug development. For applications in drug delivery hydrogels are designed to release drugs in a sustainable and controlled way, improving the drug efficacy and reducing the toxicity of drugs. Designing can also be done in a way that they can target specific tissues and cells making them a promising tool for personalized medicine. Hydrogels are being used in 3-D bioprinting, where they serve as bio-inks that can be fabricated into complex structures with high precision. In comparison to conventional technologies, this is a promising technique that allows the construction of complex three-dimensional structures in a sequential manner by a computeraided system. One major challenge in bioprinting is finding such material that is suitable for printing and also satisfies the mechanical strength requisite for tissue engineering applications. That is where hydrogels serve as the most appropriate model and have encouraging or favorable operation potential as cell-affable materials. This technique has revolutionized tissue engineering by allowing researchers to create functional tissues and organoids and spheroids. Overall, hydrogel-based tissue engineering, drug screening, drug delivery, and 3D bioprinting are exciting areas of research with great potential to significantly impact different areas of medicine and biology.
Monosodium urate monohydrate crystals are deposited in peripheral joints, causing gout and eliciting an intense localized inflammatory attack. In contrast, collecting ducts and medullary interstitium is a urinary calculus, which causes dysuria, nausea and hematuria. The purpose of the present study is to observe possible growth patterns of monosodium urate monohydrate crystals. The crystals were grown in test tubes using a single diffusion gel technique and were observed on the 7th,14th, 21st, 28th, and 40th days. Needle and spherulite-type crystals were observed on the 14th day, while arboresque, crystal sheaves, densely branched, dumbbell, mushroom-type spherulites, plumose and hexagonal prismatic crystals were observed for the first time. After the 40th day, complete spherulites were observed with their aggregates. The crystals were characterized by Scanning Electron Microscopy, Energy-Dispersive X-ray and Fourier Transform infrared spectroscopies. The pattern of MSUM will help determine the role of different natural products in the modulation, inhibition or promotion of these crystals by affecting the shape, size, transparency, approximate number and total mass of growing crystals. In case of inhibition or modulation, it will help evaluate prophylactic management. In contrast, the promotion of the crystal will give an idea about the risk factors of gout and kidney stones.
The presented mathematical model is used to form machine cells, optimize costs of exceptional elements and design the shop floor layout for various demands of components. The complete similarity measure algorithm forms machine cells and part families in a refined form. Later, exceptional elements are eliminated in linear programming optimization model by using machine duplication and part subcontract. Then the shop floor layout is designed to have optimized material movements between cells and within a cell. The performance evaluation of cell formation algorithm is done on case studies of various batch sizes to give the process capability compared with other similar methods. The result from a linear programming optimization model is cost savings, machines duplicated, parts subcontracted, inter intra cellular movements. Finally, the output of inbound facility design is the floor layout which has machine cell clusters with optimized floor area.
COVID-19 pandemic has spread all over the world and has caused psychological impacts. Medical students are known to be vulnerable population, experiencing higher levels of anxiety, depression and other psychological disorders compared to non-medical students. The nature of life changes like what happened and still happening during the pandemic have its impact on mental health of the students. The aim of this study was to identify the psychological impacts of COVID-19 on medical students among different universities to develop profiles to characterize students' anticipated levels of psychological impacts during the pandemic. Also, to search for potential risk factors that could make students more likely to experience these impacts. An online survey was filled by medical students (n = 100) at faculties of medicine, dentistry, pharmacy and medical sciences of different universities: University of Benghazi, Libyan International Medical University, Omar Almokhtar University, Cairo University and Alexandria University. The students were taken to the further analysis. Thus, 55% of the participants had psychological impacts due to the pandemic and 17% had severe effect. Some of these impacts were actually positive as a large number (58%) of the participants felt relaxed during the pandemic. Multiple stressors were identified that contributed to the increased levels of stress, anxiety and depression. These included concern about academic performance (80%), concern about self/dear-one’s health (90%), difficulty with concentration (46%), disruption to sleeping patterns (78%), increased social isolation (26%), disruption to eating patterns (48%), changing in the living environment (26%), financial difficulties (34%) increased class workload (20%) depressive thoughts (37%) and suicidal thoughts (07%). In conclusion, the study indicates that COVID-19 pandemic have positive and negative impacts on medical students. Thus, it is suggested that measures need to alleviate students’ stress, which might have harmful effects in different aspects.
Mediterranean journal of pharmacy and pharmaceutical sciences
Background: The goal of nursing profession is to prepare the nurses to meet diverse needs of the patients, delivering holistic care to the patients. It is the need of the hour for the Nursing students to utilize their knowledge, skills, and technologies to practice independently and collaboratively with all health professionals. Any type of negligence in their work may result in dire consequences. Method: Descriptive Survey Research design was adopted for a study to assess the Academic Procrastination factors for General Nursing students at selected Schools of Nursing, Bhopal, with Sample size of 50 General Nursing students. Result: Result revealed that majority, 35 nursing students were male whereas 15 were females, majority of students (18) were in age group of 22-23 years, 32 students were in GNM 3rd year, mostly (43) resided in Urban area, majority (44) belongs to nuclear family, and 28 mothers as compared to 41 fathers of students were educated. Out of 50 respondents who were the subjects of research on the causes of academic procrastination, namely: 12 respondents (24%) said that it was caused by habit, 15 respondents (30%) answered Poor time management, 23 respondents (46%) said it was due to Tiredness, 28 respondents (56%) said it was due to peer pressure, 22 respondents (44%) due to Low motivation, 14 respondents (28%) answered unclear tasks, and 36 (72 %) said it was due to Deadlines for submission. Majority of nursing students 38 (76%) were moderately affected by Personal factors, and by Environmental factors only 26 (52%) students were moderately affected as compared to academic factors at 12 (24%) students who were moderately affected. Conclusion: The study concluded that personal and environmental factors have more effects on academic procrastination as compared to academic factors
Plant secondary metabolites refer to various chemical compounds that plants produce. Still, they are not directly involved in essential growth processes like primary metabolites (such as sugars, amino acids, and lipids). The term "secondary metabolite" has generated controversy, as it implies these compounds are of minor importance to plants. "Special metabolites" may be a more suitable term. These metabolites protect plants from both abiotic and biotic stress. The vast diversity of plant secondary metabolites showcases plants' incredible adaptability and versatility, providing an arsenal of chemical tools to defend against herbivores, protect from pathogens, attract pollinators and seed dispersers, adaptability and thrive in environmental interactions. Plants can, therefore, survive under less-than-ideal conditions. The profound impact of plant secondary metabolites highlights the intricate relationship between plants and humanity, opening doors to innovative applications with far-reaching implications.
Lightweight materials are increasingly being used in engineering applications today. Composites are replacing traditional metallic materials in a variety of sectors, including aerospace, defence, and aircraft production, where there is a demand for structural materials with high strength-to-weight and stiffness-to-weight ratios. Natural fibre composites are also increasingly used in place of synthetic fibre composites in a variety of technical fields due to their affordability and environmental friendliness. In this particular study, Kevlar (Aramid fibres) is combined with other materials to improve the mechanical characteristics and impact resistance of composites. The only material that costs more than Kevlar is carbon fibres. The goal is to maximize mechanical qualities while utilizing the fewest amounts of pricey Kevlar fibres possible. The hand layup technique was used to create the hybrid composites, which included both natural and Aramid fibres. The performance of various mechanical properties was then assessed. In addition, a morphological examination was done to look at the interior structure of the composite materials that were examined. The results show that the hybrid composite, with or without the addition of nanoparticles, demonstrates great strength with little reliance on Kevlar fibres.
This paper proposes EPyNet, a deep learning architecture designed for energy reduced audio emotion recognition.In the domain of audio based emotion recognition, where discerning emotional cues from audio input is crucial, the integration of artificial intelligence techniques has sparked a transformative shift in accuracy and performance.Deep learning , renowned for its ability to decipher intricate patterns, spearheads this evolution. However, the energy efficiency of deep learning models, particularly in resource-constrained environments, remains a pressing concern. Convolutional operations serve as the cornerstone of deep learning systems. However, their extensive computational demands leading to energy-inefficient computations render them as not ideal for deployment in scenarios with limited resources. Addressing these challenges, researchers came up with one-dimensional convolutional neural network (1D CNN) array convolutions, offering an alternative to traditional two-dimensional CNNs, with reduced resource requirements. However , this array-based operation reduced the resource requirement, but the energy-consumption impact was not studied. To bridge this gap, we introduce EPyNet, a deep learning architecture crafted for energy efficiency with a particular emphasis on neuron reduction. Focusing on the task of audio emotion recognition, We evaluate EPyNet on five public audio corpora-RAVDESS, TESS, EMO DB, CREMA D, and SAVEE.We propose three versions of EPyNet, a lightweight neural network designed for efficient emotion recognition, each optimized for different trade-offs between accuracy and energy efficiency. Experimental results demonstrated that the 0.06M EPyNet reduced energy consumed by 76.5% while improving accuracy by 5% on RAVDESS, 25% on TESS, and 9.75% on SAVEE. The 0.2M and 0.9M models reduced energy consumed by 64.9% and 70.3%, respectively. Additionally, we compared our Proposed 0.06M system with the MobileNet models on the CIFAR-10 dataset and achieved significant improvements. The 1035 proposed system reduces energy by 86.2% and memory by 95.7% compared to MobileNet, with a slightly lower accuracy of 0.8%. Compared to MobileNetV2, it improves accuracy by 99.2% and reduces memory by 93.8%. When compared to MobileNetV3, it achieves 57.2% energy reduction, 85.1% memory reduction, and a 24.9% accuracy improvement. We further test the scalability and robustness of the proposed solution on different data dimensions and frameworks.
The purpose of the presenting review was to share the medicinal and surgical contribution of Greco-Arabic Muslim scientists in diagnosis, surgery and natural medicines for managing and treating urolithiasis. The contribution of Al-Antaki, Al-Baghdadi, Al-Baitar, Al-Bokhari, Al-Razi, Al-Zahrawi, Ibn Sina, and Ibn Zuhr was highlighted. The data compilation was preliminary, and much more efforts are still needed to restore the missing continuity in the history of medicine.
Cystic fibrosis is a challenging disease which creates many complications. The impact caused from cystic fibrosis on an adolescent is a challenging phase for their lives. Negative impacts like the society’s pressure, anxiety and depression are few common reasons that are being unspoken and ignored due to complexity of the disease. This study is aimed to identify the necessary gaps and educate the necessary policy makers and CF center health care team to have a better understanding about the context of the aftermath of cystic fibrosis and enhance better patient care. More over this systematic review also points out the main trends in this field of study. Qualitative study and quantitative are prominently used research methods to gain an understanding the about the gaps in the research. However, there is still a scarcity of quantitative and mixed research methods. Furthermore, limitations such as language, cultural influences were identified whilst going through the analysis. Overall through the information given in the following in this study more information regarding that warrants answers can be identified which will lead to proper care towards the teenagers who suffers from cystic fibrosis.
Sheath blight and Sheath rot of rice caused by Rhizoctonia solani and Sarocladium oryzae is an economically important disease causing rigorous yield losses. Biological control of the disease using plant growth promoting rhizobacteria (PGPR) is a potential substitute to the presently available chemical control methods. The present investigation was aimed to study the plant growth promoting (PGP) activity and antagonistic activity of two rhizobacteria Pseudomonas fluorescence and Rhizobium sp., isolated from rhizosphere area of rice, against two major rice pathogens. In the present work IAA (Indole acetic acid production) was found maximum amount in Pseudomonas fluorescence (30 mg / ml) and trace amount in Rhizobium sp. Maximum amount of Siderophore production was noticed in both isolates. Pseudomonas fluorescence showed positive result for the HCN production but Rhizobium sp., was found to be negative and both bacterial isolates solubilized phosphate in very effective manner. Both rhizobacteria were found to produce ammonia and catalase. The cross streak studies revealed that the complete inhibition of mycelia growth of Rhizotonia solani (85%) and partial inhibition of Sarocladium oryzae (45%) against two rhizobacteria. Antifungal compound extracted from both rhizobacteria were found to exhibit maximum antagonism against rice pathogens. This result concluded that both PGPR’s can be used as best bio-control agent against rice pathogens instead of hazards chemicals.
Personnel Department is the predominant component of HRD unit of North Eastern Karnataka Road Transport Corporation (NEKRTC), though HRD has been identified and designated as a separate Department. Basically the existing Personnel Department is qualified to be called HR Department OR even a better name would be Human Resources Management Department, since it would correctly reflect the comprehensive and all inclusive nature of the functions of the existing Personnel Department, which covers all features of Human Resources Management, namely Forecast of requirement of Human Resources, Planning for Recruitment, In-service care Co-ordination, Control and Regulation as also Retirement and all matters related to Personnel Administration. It should be its function to plan for training appropriately along with recruitment of personnel from all the Departments. The present Human Resource Development. Is ill-equipped and does not have the comprehension of concept and perception of HRD.
Resveratrol, a polyphenol predominantly present in red grapes, has attracted interest due to its possible health advantages. The anti-inflammatory, antioxidant, and vasodilatory properties of this substance indicate that it may have a beneficial effect on wound healing in individuals with diabetes mellitus. This study aims to determine the role of resveratrol on type 2 diabetic wound healing on total protein and albumin levels in rats. 20 male adult Albino Wistar rats were rendered diabetic using a high-fat diet and an alloxan injection (120 mg/kg). The rats were grouped into four: non-diabetic control group (negative control), diabetic control group (positive control), diabetic treatment group 1 (resveratrol: 10 mg/kg) and diabetic treatment group 2 (resveratrol: 20 mg/kg). Excisional wounds were created and monitored for wound closure over a defined treatment period of 14 days. Studies were conducted and expressed using physical and biochemical indices. The data demonstrated wound healing activities via biochemical indices, and histological and macroscopic methods. There was a difference in fasting blood glucose between the diabetic control group with the treatment groups. There was a difference between the diabetic control group compared to the group treated with resveratrol 10 mg/kg and 20 mg/kg in the weight of the rats. There was no significant acceleration in total albumin and globulin levels in the diabetic wounded group treated with resveratrol (10 mg and 20 mg). The results suggest that resveratrol treatment does not affect on total albumin and globulin levels in diabetic rats.
Mediterranean journal of pharmacy and pharmaceutical sciences
Bone resorption is created by different etiological factors, such as tumors, infections, and trauma. When defects are too large and healing is not possible in a spontaneous way, the defect is called a critical size defect, which is defined as the smallest size of an intra-osseous wound that will not heal spontaneously during the lifetime of the individual. This study was conducted to evaluate the use of a mineralized plasmatic matrix versus bone graft alone or in the augmentation of bony cavities in animals. Ten adult male dogs ranging in age from 12 months to 18 months with a mean weight of ten kilograms were used in this study. Bone cavities were made in the tibia of each animal. The upper holes were implanted with a bovine bone material substitute the medial holes were implanted with a mineralized plasmatic matrix and the lower holes were left free from any implant material acting as control. The dogs were euthanized at 2, 4, and 6 weeks and prepared for H and E stain and trichrome stain. The healing process of bone cavities implanted with mineralized plasmatic matrix was better compared to cavities filled with bone grafts and those left to heal spontaneously. Mineralized plasmatic matrix facilitates graft application, in its stabilization, and improves cell penetration into the graft.
Mediterranean journal of pharmacy and pharmaceutical sciences
Network on a chip is a concept in which a single silicon chip is used to implement the com-munication features of large-scale to very large-scale integration systems. For high-end System on Chip de-signs, Network on Chip is considered the best integrated solution. NoC has several advantages over dedicat-ed wiring and buses i.e. increased bandwidth, low latency, less power consumption and scalability. Reduc-tion in the latency (end-to-end latency and network latency), loss probability, energy consumption and re-sponse time are the basic parameters which are considered by the researchers for the optimization of the networks-on-chip topologies. In this paper we review the most popular technologies and also some recent topologies for interconnection networks. We study their performance and summarize their strengths & weakness.
Background: Sickle cell disease (SCD) is one of the most common genetic diseases worldwide, with very high prevalence rates in sub-Saharan Africa, especially Nigeria. Given the importanceand benefits of newborn screening (NBS), it is essential to assess awareness and acceptance of NBS for SCD and the factors influencing its acceptance in this region. Methods: This was a hospital-based, cross-sectional study that examined pregnant women attending the antenatal clinic for their first visit between August 1 and October 31, 2023. This antenatal clinic has an average annual attendance of 1,521 pregnant women who come for their first visit. The data obtained were analyzed using IBM SPSS Statistics (version 20), and the results were presented in prose, tables, and figures as appropriate. A level of statistical significance was set at p < 0.05. Results: Three hundred and two (302) pregnant women were recruited for the study. Though there was low awareness (13.2%), there was a high acceptance rate (96.7%) of NBS for SCD amongst the women studied. However, the type of marriage (monogamous marriage, p = 0.029) was the only factor found to have a significant relationship with the respondents’ willingness to accept NBS for SCD. Conclusions: Community education, with an emphasis on married couples, women of reproductive age, and religious leaders, should be intensified. The monogamous marriage setting may reflect marital stability, social support, or correlated socioeconomic factors on health decision-making. However, this may have different implications in different societies.
The purpose of this study is to look at development trends and patterns of structural change in India's rural and labour markets. The rural labour strength have been moving from agricultural sector to non-agricultural sector for a living, after a long period of change (due to pain and growth-induced motives). Although the manufacturing sector lags, the building industry is a significant growing sector that employs rural people. Some improvements in rural areas have been made since the implementation of the MGNREGA rural employment development programme, but it has its own set of problems that experts are discussing. Furthermore, the rural labour market is plagued by high unemployment as a result of both the agricultural and non-farm sectors' failure to absorb rural employees. Nonetheless, the continuing COVID-19 epidemic has worsened its situation by causing a job-loss catastrophe. The rural labour market's future will become more unclear as a consequence of Covid pandemic-induced opposite migration of city workers to their villages, which has worsened food security and poverty issues in rural regions.
Olfactory Reference Disorder (ORD) is defined by a continuous fixation on the belief that one is exuding an unpleasant or offensive body odor or breath, which is either imperceptible or only marginally detectable by others. This report describes a 26-year-old male who sought assistance due to his conviction of emitting a foul odor from his mouth and nose, prompting him to visit multiple dentists and otolaryngologists. His condition led to social withdrawal, resulting in feelings of despair and powerlessness. The Mental Status Examination (MSE) revealed a depressed mood, suicidal thoughts, and an obsession with the perceived smell. Both MRI and EEG findings were normal. The patient was diagnosed with ORD and depression based on the Yale-Brown Obsessive-Compulsive Scale – Olfactory Reference Syndrome (YBOCS-ORS) and the Hamilton Depression Rating Scale (HAM-D). He was prescribed fluoxetine at a dosage of 40 mg, along with a low dose of olanzapine. Furthermore, Cognitive Behavioral Therapy (CBT) was initiated to support his recovery. Ultimately, the patient secured employment. Although he continued to have lingering thoughts of an unpleasant odor at a low intensity, he managed to function adequately and engage in social interactions more effectively.
The control of highly pathogenic avian influenza (HPAI) in Nigeria from inception is predicated on effective biosecurity by stamping out policy but outbreaks of the disease continued to re-occur with altered clinico-pathologic manifestations. This study undertook the qualitative assessment of the clinico- pathological features of HPAI H5N1 during the 2021/2022 outbreaks in commercial poultry and peri-domestic birds in northern Nigeria. A total of 22 commercial poultry farms with 53,932 laying chickens and 3 households with 120 backyard broiler chickens, 18 indigenous chickens, 10 peafowls and 9 geese were investigated for HPAI. The clinico-pathologic manifestations observed in commercial poultry were subtle compared to previous presentations of the disease except in the peafowls, geese, broilers and indigenous chickens. The interspecies mortality rates significantly varied from 1.6% to 19.6% for laying chickens and 33.3% to 100% for broilers, indigenous chickens, geese and peafowls. Based on the history of sudden and high mortality, clinical signs and post mortem lesions observed, three diseases; HPAI, very virulent Newcastle disease and fowl cholera were drawn out as differential diagnoses. However, a tentative diagnosis of HPAI was made and samples were sent to the National Veterinary Research Institute, Vom, Plateau State, Nigeria for confirmatory diagnosis. Results of the laboratory tests conducted on the samples using one step flu A screening and duplex real time RT-PCR and virus isolation in embryonated chicken eggs confirmed HPAI H5N1 in twenty-five farms. It is concluded that the continuous though, irregular outbreaks of HPAI and emerging clinico-pathologic manifestations are pointers to failure of control and that the disease may become endemic. It is recommended that government should review its policy on the control of HPAI to include the adoption of zoned vaccination with close monitoring.