Cardiovascular disorders are known as one of the leading health problems which are associated with mortality worldwide. Myocardial ischemia (MI) is the improper blood supply to the myocardium, which leads to severe complications to life-threatening problems like AMI, atherosclerosis, hypertension, cardiac hypertrophy, as well as diabetic-associated complications such as diabetic atherosclerosis/cardiomyopathy/hypertension. Despite several efforts, the current therapeutic platforms are unrelated to significant results. Hence, it seems that developing novel therapies is required. Increasing evidence indicates that curcumin (CRC) acts as a cardioprotective agent. Given that CRC and its analogues exert their cardioprotective effects via affecting various cardiovascular disease-related mechanisms (i.e., Inflammation and oxidative stress). Herein, we have highlighted the protective impacts of CRC against MI for the first time. This review might be a stepping stone for further investigation into the clinical implications of the CRC against MI. Furthermore, it highlights a legitimate concern for the scientific community, seeking novel techniques and characteristic dynamic biopharmaceuticals against myocardial ischemia.

Dr. salman ahmed

The use of performance feedback in the workplace has gained popularity over the years, yet school heads have been challenged in providing it to teachers. In the initial interview, they shared that evaluation results can impact teachers’ motivation, and that feedback should be done carefully. However, they failed to clearly articulate a specific mechanism that had been applied in this vital role. Also, no studies have provided clear detail on the feedback mechanism used by school heads in the past. For this reason, a study explored the feedback mechanisms employed by school heads in conveying the performance evaluation results to teachers. This study employed a narrative inquiry, and interviews were conducted with five school heads and five teachers who were chosen purposively for this research. Responses were recorded using a voice recorder. These responses were transcribed and analyzed using thematic narrative analysis. Based on transcripts, the study identified six emergent themes, such as conversational (one-on-one), relational, reflective, technical, reinforcing, and properly situated mechanisms in conveying performance evaluation results to teachers. Thus, a new feedback mechanism framework was developed.

Manuel caingcoy

To the editor, On April 24, 2025, the World Health Organization (WHO) issued an urgent call to reinvigorate global action to end malaria, releasing updated guidelines that reflect both progress and persisting challenges in combating this deadly disease. [1] This renewed guidance arrives at a critical juncture: global malaria cases have plateaued, progress is faltering, and health systems in endemic regions face increasing strain from drug resistance, climate change, and funding shortfalls.

Karishma

Background: Prescribing patterns in systemic hypertension vary from place to place. Studies have shown that cost could be one of the factors responsible for non-adherence to treatment among hypertensive patients. Nigerian pharmacoeconomics studies have not provided a general guide on cost-effective prescribing for hypertensive patients in the country. The aim of the study was to examine the prescribing patterns, do cost effectiveness and cost minimisation analyses of the commonly prescribed antihypertensives, and determine if cost is a major reason many of the hypertensive patients of the District Hospital are usually lost to follow up. Methods: 5267 adult (≥18 years) non-antenatal patients’ cards of 2016 were reviewed for hypertension. Examination of the prescriptions, cost-effectiveness and cost-minimisation analyses of the commonly prescribed antihypertensives were done. Results: 12.6% of the patients were hypertensive. 73% of these hypertensive patients were treated pharmacologically. 40.8% adhered to treatment. 73% of the adherent ones responded to treatment. Amlodipine was the most expensive prescribed antihypertensive (N22). Amiloride-hydrochlorothiazide with the largest cost effectiveness ratio (CER) (9) was the most cost effective of all the combinations. Lisinopril- hydrochlorothiazide (N17) was preferable to the triple combination of lisinopril-amlodipine-hydrochlorothiazide (N39), and amlodipine-hydrochlorothiazide (N32) in cost minimisation. Conclusions: Cost of drugs probably had played a significant role in non-adherence to treatment among hypertensive patients in the District Hospital in 2016, since moduretic with the largest CER (9) and nifedipine with the greatest BP reduction when combined with hydrochlorothiazide (56/22 mm Hg) were rarely prescribed.

Emmanuel umegbolu

Purpose: Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder mostly characterized by gonadotropins release and/or action deficiencies. Both isolated (idiopathic hypogonadotropic hypogonadism) and syndromic (Kallmann) forms are identified depending on the olfactory ability. Clinical and genetic heterogeneities of CHH have been widely explored, thus improving our understanding of the disease's pathophysiology. This work aims to (1) provide a detailed clinical and hormonal description of normosmic CHH patients and (2) identify the mutation linked to the studied phenotype. Participants and methods: We investigated three affected patients with normosmic CHH, belonging to a consanguineous Tunisian family. Patients underwent an insulin-induced hypoglycemia test. We performed whole exome sequencing to identify the causal mutation. Results: At first diagnosis, a total gonadotropic deficiency was identified in all patients. The insulin-induced hypoglycemia test has also revealed a reduced cortisol secretion and complete growth hormone deficiency. At 20.8 years, one female exhibited a spontaneous recovery of the hypothalamic-pituitary-adrenal axis function, unlike her affected siblings who still depend on corticosteroid replacement therapy. Herein, we identified a novel homozygous nonstop mutation (c.1195T>C) in KISS1R gene in all affected subjects. This mutation led to the substitution of the physiologic stop codon by an arginine (p.X399R). Conclusions: Our study highlights the importance of the KISS1R signaling, in gonadotropin-releasing hormone neurons, in the control of reproductive function. Additionally, our data suggests a complex central and peripheral metabolic control of puberty, through the hypothalamic KISS1R signaling. We suggest a mutual link between the hypothalamic-pituitary-gonadal, -adrenal, and -somatotropic axes.

Mariam moalla

The purpose of this study is to explore the belief of teacher educators about the relationship between teaching and research. Keeping in view the role of the teacher educators, a survey was done. The beliefs of teacher educators were explored with the help of an opinionaire. The collected data were analyzed through qualitative method of analysis. It was found that the secondary teacher educators were positive about the need of research with a little dilemma between teaching and research.

Rupal mankad

Argostemma quarantena, a new rubiaceous species from Vagamon Hills of southern Western Ghats, India is described and illustrated here. The species shows similarities with two south Indian endemics, A. anupama and A. courtallense, but differs in many qualitative attributes. The present status of genus Argostemma in India is briefly discussed. An artificial key for the identification of Argostemma in Western Ghats is also provided.

Dr. anoop balan

The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked to anticancer, antihyperlipidemic, hypoglycemic, and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan-induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetylsalicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg doses demonstrated analgesic and anti-inflammatory activities, but in hot plate, results were unreliable as significant activity started after 90 minutes. A 5ml/kg dose was administered orally in mice for a toxicity test, and no toxicity symptoms were observed. Therefore, PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.

Dr. salman ahmed

This study aims to examine and compare the levels and patterns of aggressive behavior among higher secondary students in rural, semi-urban, and urban areas. Aggression among adolescents is a significant concern, and understanding its variations across different settings can provide valuable insights for intervention and prevention strategies. The study employs a review-based research design, using articles published between 1993 and 2023 to collect data on aggressive behavior of higher secondary students. For this purpose, a review of the literature was performed by using the search words “aggressive behavior”, “higher secondary students”, “rural”, “semi-urban”, “urban” in the databases like Google Scholar, ResearchGate, Academia, Shodhganga, PubMed, JSTOR and Elsevier for articles. The results will shed light on the prevalence, types, and potential factors influencing aggression in these areas, informing the development of targeted interventions and policy recommendations and statistical analyses will be employed to examine the relationships between variables. Importance and Scope of the Topic: Aggressive behavior is a topic that affects us all. From playground bullies to road rage enthusiasts, aggressive behavior has a significant impact on our daily lives. Understanding the causes and consequences of aggression is crucial in finding ways to prevent and manage such behavior. After all, the world would be a much better place if we all knew how to calm down and express our frustrations in healthy ways.

Abdul jaleel kuzhiyengal mambra

This present study evaluated the quality attributes of functional bread developed from the blends of wheat and soy-okara (SOF) flour. A completely randomized design which generated six (6) experimental runs based on different combinations of wheat (60–90%) and soy-okara (10–40%) flours was adopted for the production of functional bread. The flour blends were processed into bread and analyzed for sensory properties. The optimum flour combination in obtaining higher sensory acceptability was 85.34% WHF and 14.66% SOF with desirability function of 85% using numerical optimization techniques. The control (100% whole-wheat bread) and optimized bread produced were assessed for physicochemical, antioxidant properties and sensory qualities. The carbohydrate, calcium, phosphorus, and sodium of the optimized bread were significantly higher (p<0.05) than in the control sample having 58.14 and 75.14%, 128.80, and 75.60 mg/100 g, 68.18 and 63.77 and 13.83 ppm and 12.62 ppm respectively. The total flavonoid and phenolic contents of the control and optimized bread were significantly (p<0.05) different with values ranging from 92.77 to 114.86 mg/100 g and 66.43 to 57.51 mg/100 g respectively. A significant variation was observed in the sensory qualities between the control and optimized bread. The study revealed that the nutritional and antioxidant properties of the developed functional bread validate its potential health-promoting effects.

Okechukwu obed chukwuemeka

The Atlas of Shear Zone Structures in Meso-Scale illustrates the morphological characteristics of shear zones within the Himalayas that have been gathered by the author’s intensive field observations over the last decade. The book deals with various shear zone-related structures, produced in brittle and/or ductile regimes. The shear sense indicators and associated microstructures are also described.

Rajkumar ghosh

Cloud computing is used to achieve sustainability in terms of computing. It reduces energy and resource consumption. Most of the companies have been moving their applications to the cloud to reduce power, energy re-source, and carbon emission. Today's computing landscape is rapidly shifting toward creating applications to leverage Cloud platforms to have necessary features such as elasticity, virtualization, low cost, and pay-per-use. Cloud computing's rising demand and versatility are achieving acceptance in the research community as a means of implementing large-scale electronic systems in the format of workflows (set of tasks). One of the most important objectives of this effort is to trim down makespan which is the total period taken by the resources to complete all workflow activities. Another foremost objective of this work is to satiate all the user-delineated time constraints while scheduling workflow activities.

Mohd haroon

This is a non-inclusive collection of my published articles.

Mostafa eissa

Avec une très grande intelligence narrative, Leila SLIMANI (2016) déforme les codes du polar et commence par la fin. « Le bébé est mort » la première ligne avec laquelle s’ouvre la scène du meurtre des enfants par la nourrice au visage d’ange. La finesse du détail pertinent et la construction par petites touches des personnages terriblement crédibles caractérisent la plume de Leila SLIMANI. Débarrasser de l’horreur, le lecteur se met à la recherche des failles de cette étrangère de la famille. Rien n’est en trop : dialogues, descriptions, narration haletante et histoire émouvante, ce sont les atouts de la récompense de cette œuvre par le prestigieux prix Goncourt. Inspirer par un fait divers affreux, la romancière livre une photographie d’un ordre social illégal et les forces invisibles qui couvent les relations dans notre société. Leila SLIMANI met en relief une intrigue aux conséquences dramatiques, les contraintes d’une modernité qui s’imposent, infectant la maternité des femmes assoiffées de liberté.

Assanvo

Ethanol extract of Luffa cylindrica (L.) Roem. Fruit peel was evaluated for antiemetic and anti-inflammatory effects using the chick emesis model and carrageenan-induced rat paw edema. The antiemetic effect was observed at 150 mg /kg body weight whereas the anti-inflammatory effect was observed at doses of 500, 750 and 1000 mg /kg body weight orally. Chlorpromazine 150mg/kg and indomethacin 10mg/kg orally were used as standard anti-emetic and anti-inflammatory drugs. The anti-emetic effect was determined by calculating the mean decrease in the number of retchings compared to those of the control group after 10 minutes of copper sulfate (50mg/kg orally) administration. The degree of paw oedema of all the groups was measured using a plethysmometer at the 5th hour of carrageenan (1% w/v) administration. The extract exhibited statistically significant anti-emetic (P< 0.001) and anti-inflammatory (P< 0.05) effects.

Dr. salman ahmed

Humans have used natural products to treat different pathological conditions since immemorial. Numerous plants have been reported to have antitussive activity. Our present study aimed to evaluate the ethanolic extract of Arenaria serpyllifolia (Carophyllaceae, Whole plant), Caesalpinia pulcherrima (Caesalpiniaceae, Aerial parts) and Fragaria nubicola (Rosaceae, Whole plant) for antitussive activity at the doses of 200, 400 mg/kg in healthy albino rats. Cough is a symptom and defensive reflex of removing the toxic, irritating substances and pathogens from the larynx, trachea and bronchi. Cough is usually considered a disease related to the lungs. Several substances are responsible for the stimulation of cough reflexes. Among the most common are dust, histamine and bronchoconstriction. Arenaria serpyllifolia is a small annual herb commonly called Thyme-leaved sandwort, found in uncultivated land, arid meadows and cliffs. Caesalpinia pulcherrima is an ornamental plant, usually 2 m tall, known as a Peacock flower. Fragaria nubicola grows in wooded valleys, forest margins and meadows. It is commonly known as wild strawberry. These plants have been used traditionally for cough suppression by different societies. In this study, cough was induced by using the sulphur dioxide induction method. Animals were divided into eight groups of ten animals each, and all the drugs were administered orally. Group I was the control group, while Group II was the standard. A dose-dependent inhibition of cough was observed for all extracts. At 200 and 400 mg/kg doses, all three extracts proved highly significant compared to standard. So, it proves and supports the traditional use of plants for relieving cough.

Dr. salman ahmed

There is a close relationship between a marketing strategy and its ability to realise its mission, vision, and business strategy. A case in point is the Nike brand that focuses on creating meaningful stories for its loyal fan base. It achieves this by inducing emotions into the customer base through "emotional branding" to realise its vision of expanding human potential by creating groundbreaking sports innovations. Nike's marketing campaign strategy involves building meaningful stories and tag lines using a traditional narrative of a hero who overcomes every challenge brought forth through its slogan of "Just Do It." The brand also has a distribution strategy of using subsidiaries like Converse, Jordan, and Hurley and channels like retailers, e-commerce, and supermarkets to reach out to millions of its customers (Mahdi, Abbas, Mazar, & George, 2015). To achieve its mission of bringing innovation and inspiration to every athlete globally, the brand has invested in top-notch technologies like hyper-adapt as part of a marketing strategy.

Zamzam abdelazim

Management accounting refers to the process of collecting, organising, and recording financial transactions with the aim of providing information for the management to make informed decisions about the operation of an organisation (Ameen, Ahmed, and Abd Hafez, 2018). Management accounting allows organisations to conform to the expectations of various financial agencies, such as tax agencies, by ensuring that all transactions that take place within an organisation are done correctly (Järvinen, 2016), thus enabling the organisation to meet its goals and objectives.

Zamzam abdelazim

Study objectives: The study aimed to evaluate the antitussive effect of aerial parts of ethanolic extract of Caesalpinia pulcherrima (Caesalpiniaceae). Methods: In this study, cough was induced by the sulfur dioxide induction method. Four groups of animals were made, with six animals in each group, and all drugs were administered orally. Group I was used as a control, group II as a standard, and groups III and IV received 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract. Results: Caesalpinia pulcherrima aerial parts (CPAP) extract suppressed cough. Doses of 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract showed highly significant results compared to the standard at 60 and 90 min of drug administration. Conclusion: From the above results, it can be concluded that plants have significant activity in cough suppression.

Dr. salman ahmed

Improper use of medicines may carry possible health dangers and more evidence continues to stand that adverse drug reactions to medicines are common but often preventable. Self-medication phenomena with over the counter medicines is common among people. It is regarded as essential issue of self-care. Over the counter medicines use such as analgesics among children and adolescents is continuously increasing in Libya. This constitutes an important public health concern. The aim of this study is to focus on adolescent's self-medication phenomena about the over the counter medicines that teens frequently used to treat minor and serious diseases. This work collected information throughout survey-comprised number of questions for the teenagers bought medicines from private pharmacies at two different secondary schools in Benghazi city, Libya, without prescription. The sample size was 120 students, 58 males and 62 females in age range of 15-18 years. Data collected from questionnaire were analyzed for pattern of medicine use. Male adolescents bought toothache and muscle-spasm medicines more frequently than female adolescents. On the other hand, female adolescents administered more over the counter medications monthly than males. The use of over the counter medicines has been found highly rated and exaggerated among secondary school teenagers. In conclusion, adolescents have to be educated regarding over the counter medicine use in Libya. The need for promoting the appropriate use of medicines healthcare system is an important issue. This can be achieved through an educational strategy involved different public sectors such as health and education authorities.

Mediterranean journal of pharmacy and pharmaceutical sciences