For a long time, cardiovascular diseases have been the leading cause of death worldwide. Machine learning has found significant usage in the medical field as it can find patterns in data. Classification models can help cardiologists to diagnose heart diseases and minimize misdiagnosis accurately. In this paper, we explored a dataset related to heart disease and compared the accuracy of 43 machine learning classification models. The dataset for this research was downloaded from Kaggle; it contained 1190 observations, 11 features (age, sex, chest pain type, resting blood pressure, serum cholesterol, fasting blood sugar, resting electrocardiogram results, maximum heart rate achieved, exercise induced angina, oldpeak, the slope of the peak exercise ST segment) and a binary target variable (no heart disease or observed cardiovascular disease). For data exploration, preprocessing, training, testing, and predictor importance analysis, we used MATLAB R2004a software and the Classification Learner app included in this software. Before training machine learning classification models, we divided the dataset into a training set (90% of observations) and a test set (10% of observations). To prevent overfitting during the training of classification models, 10-fold cross-validation was used. The result showed that the best accuracy was reached with an optimized ensemble classification model (validation accuracy: 0.9262 and test accuracy: 0.9580). After calculating the permutation importance of each feature, we observed that the most important feature among all 11 features was the slope of the peak exercise ST segment.

Ladislav végh

To improve education quality and governance, the Higher Education Commission of India (HECI) has proposed four regulatory entities, including the National Accreditation Council (NAC). To build up India as a universal knowledge giant over the next ten years, the policy promotes equitable educational opportunities and transformative initiatives. To significantly improve the standards for higher education in India, quality control, accreditation, & ranking systems become crucial. With an emphasis on quality, employability, and lifelong learning, the National Education Policy-2020 (NEP-2020) seeks to create a flexible, value-based educational system that integrates 21st-century capabilities. India's higher education is currently at a critical juncture, requiring transformation to enhance its overall contribution to society and address social injustices. This involves examining how information is produced and how students are taught to promote sustainability and social responsibility. Higher education institutions must comprehend and address student expectations regarding quality because the service sector is expanding quickly due to liberalization, privatization, and globalization. As a result, evaluating service quality becomes crucial for future enhancements and feedback. The Higher Education Commission of India (HECI) legislation, 2018, was introduced by the Ministry of Human Resource Development toward the end of June with the goal of repealing the University Grants Commission (UGC) Act, 1956, which has been in place for seven decades. The HECI will interchange with the University Grants Commission (UGC), which has been the foundation of India's college and university structure. This transition analyzes the proposed bill and examines its shortcomings. This advocates that the current bill be unsuccessful in reporting the flaws of the previous official; instead, it merely reflects those issues and will not resolve the long-standing problems of low autonomy and subpar instruction in the higher education system. As the new regulator, HECI's strategy isn't very revolutionary. Regulators who encourage centralization of duties to reduce autonomy must be disregarded at moments when Indian institutions are striving to rank highly in the world.

Dr. awadhesh singh gautam

Background:- Tribals are weaker section which holds in outstanding number of tribal population in our country. They are not having proper knowledge on osteoporosis. Osteoporosis is a significant problem in aging population especially in females, it impacts structural and social burden on health care services in tribals. Objective:- Aim of this study is to determine the knowledge regarding osteoporosis among tribal premenopausal women in tribal area of Guntur Dist. Andhra Pradesh Methods:- This study is descriptive quantitative study conducted among 177 Sugali women & 23 Chenchu women of tribal area in Guntur Dist. Andhra Pradesh from 2015 November to December 2015. A self-administered questionnaire was used to assess the knowledge on osteoporosis by conducting Pre-Tests on this group of people. After Educational Intervention was given with the help of self-instructional module and also conducted a Post Test on these same Group of people Results:- The mean age was 40 to 50 years. Majority of the participants are 177 (100%) Sugali women and 23 Chenchu women in these 177 in which n.150 (84%) women are having poor knowledge and remaining 27 (16%) women have average knowledge. In Chenchu women 20 (86%) women were having poor knowledge and remaining 3 (14%) women have average knowledge on all five aspects of questions regarding Osteoporosis, Menopause, Diet, Exercises and Preventive Methods. After Educational Intervention was given their knowledge was improved by a fraction on Osteoporosis. In the Post-Test 101 (57%) women gained average knowledge but remaining 76 (43%) women remained with poor knowledge among Sugali Women. Out of 23 (100%) women of Chenchu tribe 7 (30%) women got average knowledge and the remaining 16 (70%) women remained with poor Knowledge on Osteoporosis Conclusion:- Although majority of participants had low level of knowledge on Osteoporosis in all aspects regarding Menopause, Diet, Exercises and Preventive methods of Osteoporosis. They perceived a little knowledge on Osteoporosis in all aspects towards preventing Osteoporosis. Comparitively Sugali women are having better knowledge than Chenchu women in all aspects of Osteoporosis. Key words:- Osteoporosis, Knowledge, Effect, Pre-Menopausal, Tribal Women.

Mangeswari k

The leaves of khat (Catha edulis) are chewed as a social habit for the central stimulant action of their cathinone content. There is growing concern about the health hazards of chronic khat chewing. Many authors have addressed the adverse effects of khat chewing on the cardiovascular and other systems. Based on a limited number of case reports and few prospective controlled studies, associations between khat chewing and the occurrence of myocardial infarction, dilated cardiomyopathy, and vascular diseases such as hypertension and cerebrovascular ischemia have been proposed. This review outlines the current knowledge on the adverse health effects of khat chewing on the cardiovascular system, assesses the strength and the limitations of the studies, and identifies the questions that the future studies should address.

Karishma

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel, efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medicines. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signalling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemopreventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed

Ethanol extract of Luffa cylindrica (L.) Roem. Fruit peel was evaluated for antiemetic and anti-inflammatory effects using the chick emesis model and carrageenan-induced rat paw edema. The antiemetic effect was observed at 150 mg /kg body weight whereas the anti-inflammatory effect was observed at doses of 500, 750 and 1000 mg /kg body weight orally. Chlorpromazine 150mg/kg and indomethacin 10mg/kg orally were used as standard anti-emetic and anti-inflammatory drugs. The anti-emetic effect was determined by calculating the mean decrease in the number of retchings compared to those of the control group after 10 minutes of copper sulfate (50mg/kg orally) administration. The degree of paw oedema of all the groups was measured using a plethysmometer at the 5th hour of carrageenan (1% w/v) administration. The extract exhibited statistically significant anti-emetic (P< 0.001) and anti-inflammatory (P< 0.05) effects.

Dr. salman ahmed

Acenocoumarol is the only oral antivitamin K anticoagulant prescribed and marketed in Algeria for the prevention and treatment of thromboembolic diseases. Nevertheless, the difficulty of handling this drug linked to a narrow therapeutic index and to great inter- and intra- individual variabilities of the response to the treatment poses a major public health issue because of its iatrogenic risk. To improve the management of patients on acenocoumarol and optimize its dosage adjustment and reduce iatrogenic secondary to vitamin K antagonists, our main objective work is to assess the knowledge, attitude and practice of health care professionals regarding this anticoagulant agent. We conducted a multicenter descriptive cross-sectional study from April to May 2021. We interrogated 152 health professionals of all ages, all sexes and all grades from different health departments in Oran City (Algeria) prescribing anticoagulants, through a validated questionnaire made up of 26 questions. Statistical analysis was achieved by SPSS version 20 software. Thus, 59.9% were women with a sex ratio of 0.67, 92.8% knew that acenocoumarol belongs to the antivitamin K class, 45.0% chose INR and PT as follow-up parameters, 36.0% chose INR alone and 78.9% were unaware of acenocoumarol dose adjustment algorithms as well as 82.0% were unaware of the existence of pharmacogenetics testing. 54.0% use the recommendations of the HAS for dosage adjustment of patients on acenocoumarol. 07.9% suggested using pharmacogenetic tests to improve the dosage adjustment of acenocoumarol, 06.6% suggested patient follow-up and 05.9% suggested therapeutic patient education as well as 74.3%, wanted to do training on. Therefore, this study highlighted gaps in the medical practice of physicians in terms of dosage adjustment, pharmacogenetics and its impact on dosage optimization. However, the evaluation of their knowledge was considered unsatisfactory. To overcome this lack of knowledge, it seems necessary to make physicians aware of the contribution of pharmacogenetics of acenocoumarol in Algeria.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction: Augmented Reality (AR) technology is increasingly recognized for its potential to enhance various aspects of dental practice, including treatment planning, patient education, and training. Despite this potential, the understanding of dental professionals' knowledge, attitudes, and practices regarding AR technology remains underexplored. The objective of this research is to examine the experience, perceived advantages, and real application of augmented reality (AR) Technologies of dental faculty and students. Methodology: A sample of 132 dental students, some integrated into the workforce as part-time private dentists, and faculty members of a single dental school, completed a self-administered online survey. Knowledge and application of AR technology in dentistry, and Experience with AR practice, were the constructs of the study. An administered questionnaire, partially digital and partially paper and pencil, was divided into two parts: Knowledge Assessment and Practice Assessment. The survey results were analyzed using reference statistics. Results: Knowledge Assessment respondents confirmed understanding Augmented Reality (AR) technology (69.7), and AR technology in dental training/education was recognized (65.9). 57.6% of the participants in the Practice Assessment declared absence of AR in their educational and/or professional practice, but an AR technology practice was wanted (67.4). The self-rated proficiencies that 44.47% of the respondents professed were in the range of self-score 3 in the application of AR (moderate). A small fraction (16.7) declared their AR application self-score was above the higher order. Conclusion: It can be concluded from this work that AR technology in academic and practical dentistry is vastly underutilized, notwithstanding the high realization and appreciation for its application.

Oral sphere journal of dental and health sciences

Arenaria serpyllifolia L. is a medicinally important plant found in subtropical and temperate regions of the Himalayas from Nepal to Kashmir. The plant is used traditionally to treat kidney and bladder-related problems. Flavonoids and xanthone-containing compounds, such as epicatechin, japonicumone, quercetin, etc, are reported in the plants. Plants have shown Inhibitory effects on Carboxyl esterase

Dr. salman ahmed

n India, the education sector has been always attentive to adopt innovations and techniques in the teaching-learning process due to various challenges. But nowadays, academic institutions are becoming flexible in accepting the new teaching and learning techniques to satisfy the student sector which as cited as the most vital entity in the educational sector. New technologies, tools, and techniques are proving as a boom for innovative teaching and learning practices. One of the emerging teaching technique is Blended learning which is a process refers to “mixing of the different learning environment for educational transfer”. It combines the traditional face to face classroom method with online learning method supported by advanced technology and tools. Blended learning should be viewed not only as a temporal construct but also as a fundamental redesign model. Through this content, delivery becomes digital and online. Truly blended learning requires teachers should adopt the approach as guides and mentors and learning should go beyond the classroom walls. Blended learning is also known as Hybrid learning. Although, Indian Government is taking initiatives to implement a blending learning approach yet there is a need to access the behavioral aspect of the students to use this blending learning approach. Adopting a blended learning approach must start with a re-examination of the intended learning outcomes.The deployment of cloud in the blended learning process makes its existence more strong. This study is the review of literature selected to identify the need for blended learning deploy with cloud in the teaching-learning process in the Higher Education Sector.

Inderbir kaur

Metformin is considered the first-line treatment as a monotherapy for patients with type 2 diabetes mellitus. Emerging evidence suggests that metformin may have a renoprotective role; therefore, understanding the impact of metformin dose and therapy duration on renal function may significantly improve renal outcomes in type 2 diabetes patients. This study aims to investigate the renoprotective effects of metformin by analyzing its dose-dependent impacts on the estimated glomerular filtration rate in patients with type 2 diabetes mellitus. A retrospective cross-sectional study design was used from September 2022 to October 2023. Data from 302 type 2 diabetes patients were collected from patient files at the Benghazi Diabetic Center and the Aljabal Al-Alkdar Diabetic Center, including all with type 2 diabetes mellitus patients on varying doses of metformin. The collected data included age, gender, metformin dose, duration of metformin therapy, urea, and creatinine. Exclusion criteria included patients with significant comorbidities such as chronic kidney disease (other than diabetic nephropathy), liver disease, heart failure, or malignancy; those taking nephrotoxic medications; individuals with recent acute illnesses or surgical procedures; pregnant or lactating women; participants with inadequate medical records; and patients who were non-adherent to metformin therapy. Survival analysis was conducted to evaluate the effect of different metformin doses on the estimated glomerular filtration rate. The study analyzed 302 diabetic patients, of whom 46.0% were male and 54.0% were female. The age was 58.3±11.9 years. The HbA1c was 7.7%±1.3%. The duration of diabetes was 11.4±8.1 years. The creatinine was 1.0±0.9 mg/dL, and the urea was 36.7±23.8 mg/dL. Data analysis revealed a statistically significant difference in survival distribution across the dose groups. Different metformin doses significantly impact the estimated glomerular filtration rate, suggesting that dosage plays a crucial role in maintaining renal function.

Mediterranean journal of pharmacy and pharmaceutical sciences

Tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis. The disease mainly affects lungs and causes pulmonary tuberculosis. It can also affect intestine, meninges, skin, bones and other tissues of the body. Although the drugs alone can cure TB, it still remains a major public health problem worldwide. The aim of the study was to assess the quality of life and medication adherence in TB patients. The Quality of life was assessed using SF-36 in patients receiving DOTS treatment in initial or continuous phase while the medication adherence was analyzed using Morisky Green Levine Scale. Subjects were also counselled about their disease during their first visit and a follow up was done after a month. A total of 152 subjects were enrolled in the study of which majority of the subjects had Pulmonary TB (55.26%). Diabetes was found to be the most common comorbidity followed by HTN. The average Physical Component Summary (PCS) and Mental component summary (MCS) were found to be 44.34 and 39.60 respectively. Females had a better quality of life scores compared to males. High adherence was seen in 32.24% of patients while 28.29% had low adherence. Follow up was done for 135 subjects. 15 subjects defaulted and 2 of them died. There was a significant increase in the QoL scores and medication adherence after one month. A significant association was found between the Physical functioning (p=0.001) and emotional wellbeing (p=0.01) with Duration of treatment indicating that subjects who had completed more than one month of their treatment had marked improvement in Physical functioning and emotional well-being scores

Dr mahendrakumar r

Three species of arbuscular mycorrhizal fungi (Glomus fasiculatum, Glomus mossae and Acaulispora laevis) were used as bio-agents to manage black bundle disease of maize caused by C.acremonium. The results revealed that colonization of arbuscular mycorrhizal fungi in root system of the host reduce the percentage of disease incidenceconsiderably.In the pots inoculated with G. fasiculatum no disease incidence (0.0%) was recorded whereas, in the pots inoculated with A. leavis and G. mossae 16.66 % of disease incidence was recorded and the pots treated with pathogen shows 66.66% of disease incidence compare to control. Among the three bio-agents, Glomus fasiculatumproved to be more effective in managing the disease followed by G.mossae and A. laevis. In addition, all the three AM fungi enhanced the plant growth when they are used alone as inoculum as compared to dual inoculation with the C. acremonium and overall control. This clearly suggests that, AM fungi if used, can serve dual purpose. It can be used as bio-control agent as it shows negative antagonistic interaction soil borne plant pathogens and used as growth promoter because of the ability to supply macro and micro nutrients to the host plants.

Veerabhadraswamy al

Regularly used toothbrushes can be heavily contaminated with microorganisms, while inappropriate storage may increase the microbial load on these toothbrushes. Toothbrushes Microbial contamination can help to transmit many diseases, especially for people with mouth and/or Gum problems. This study aims to find the easiest and most available way to sterile toothbrushes at home. 24 adult volunteers were divided into four groups, the first three groups were asked to sterilize their toothbrushes with Dettol, water salt and hot water, while the fourth group toothbrushes were a positive control. Results showed that toothbrushes sterilized with Dettol gave the least contamination rate of 12.5%, toothbrushes sterilized with salt came next with 37.5%, while toothbrushes sterilized with hot tap water were the next with 50%. The toothbrushes of the fourth group which was used as the positive control were totally contaminated with different types of bacteria. Six bacterial agents were isolated; they are Staphylococcus Sp., Streptococcus sp., Bacillus Sp., E.coli, Pseudomonas Sp., and Salmonella sp. It was concluded that the use of Dettol was very effective in reducing the number of contamination of toothbrushes but its unacceptable flavour limiting its use. Other volunteers were comfortable with the use of salt and hot water as it was almost effective. The research suggests a group of recommendations to avoid the transmission of pathogens through toothbrushes and ensure healthy usage.

Kamal singh

In present study various fungicides were screened against blast (leaf and neck) and sheath blight disease of rice. Among them, Conika 50% WP (Kasugamycin 5% + Copper Oxychloride 45% WP), Dhanucop Team (Tricyclazole 75% WP) and RIL-068/F1 48 WG (Kresoxim methyl 40% + Hexaconazole 8% WG) were found effective against blast diseases. While, the seed treatment fungicide Isotianil SC 200 and its combination with Trifloxystrobin 500 SC were found least effective against leaf and neck blast diseases. However, in case of sheath blight, Thifluzamide 24% SC, RIL-068/F1 48 WG (Kresoxim methyl 40% + Hexaconazole 8% WG), Propiconazole 25% EC (Tilt), Tricyclazole 75% WP (Beam) and a new combination fungicide, Fluxapyroxad 62.5 g/l + Epoxiconazlle 62.5 g/l EC (Adexar w/v EC) were found effective.

Veerabhadraswamy al

The main objective of this study is to examine the relationship between globalization, resource conflicts and peace –building in Africa, with particular emphasis on Nigerian’s north-central geo-political zone. The wave of globalization that has swept across the world with its attendant socio-economic and political consequences lies at the heart of this study. The debate that is raging currently amongst intelligentsias, public analysts, and the international community point to the fact that the global system has suffered increasing setbacks occasioned by the impacts of globalization and contestation for scarce natural resource endowments. The changes that have emerged for several decades in both developed and developing nations, with the latter having a greater share of repercussions, have remained largely daunting. The multiplier effects of these changes have resulted in worsening crisis situations, with a fast growth rate of intra-state and/or trans-regionalized networked conflicts, which is why Africa and indeed Nigeria, has become a hotbed for contestations recently. This work adopts a qualitative approach as a method of investigation. This work relies on classic works of experts in the broader discipline of globalization and conflict resolutions, the essence of which is to clearly define ways of ensuring absolute peace in Nigeria’s north-central zone. The paper observes that guaranteeing peace-building requires the adoption of both vertical and horizontal approaches as templates for the realization of peace objectives.

Canice erunke

Currently, the use of internet-connected applications for storage by different organizations have rapidly increased with the vast need to store data, cybercrimes are also increasing and have affected large organizations and countries as a whole with highly sensitive information, countries like the United States of America, United Kingdom and Nigeria. Organizations generate a lot of information with the help of digitalization, these highly classified information are now stored in databases via the use of computer networks. Thus, allowing for attacks by cybercriminals and state-sponsored agents. Therefore, these organizations and countries spend more resources analyzing cybercrimes instead of preventing and detecting cybercrimes. The use of network forensics plays an important role in investigating cybercrimes; this is because most cybercrimes are committed via computer networks. This paper proposes a new approach to analyzing digital evidence in Nigeria using a proactive method of forensics with the help of deep learning algorithms - Convolutional Neural Networks (CNN) to proactively classify malicious packets from genuine packets and log them as they occur.

Dr. chandrashekhar uppin

In this paper, we propose a deep learning approach for visual recognition of bird species in noisy environments. Bird species recognition has been a challenging task due to the high variation in bird appearances and the presence of noise and clutter in natural environments. Our approach utilizes a deep convolutional neural network (CNN) to learn discriminative features from bird images and classify them into different species. We also incorporate data augmentation techniques to increase the diversity of the training data and improve the robustness of the model. To address the issue of noisy environments, we introduce a novel noise-robust loss function that penalizes the model for incorrect predictions caused by noise. We evaluate our approach on a dataset of bird images collected from diverse environments and compare it with state-of-the-art methods. Our results demonstrate that our approach achieves superior performance in both clean and noisy environments, highlighting the effectiveness of our noise-robust loss function. Our approach has the potential to be applied in real world scenarios for bird species recognition and conservation.

Pk dutta

The experiments were conducted at CCS HAU, Hisar (Haryana) to study the morpho physico-chemical components of resistance to pod borer, Helicoverpa armigera in pigeonpea with different sowing dates. In different four sowing dates, the minimum pod infestation (1.70%) was recorded in (D4) 3rd week of July sown crop, whereas, it was observed maximum (4.54%) in (D2) 1st week of July sown crop. In different pigeonpea varieties, the minimum mean pod infestation (2.45%) was recorded in AL-201, whereas, the maximum mean pod infestation (3.72%) was recorded in Pusa-992. The glandular (type A) and non-glandular (type B) trichomes on pods of top and middle canopy of the plant and pod wall thickness were associated with resistance to H. armigera, whereas, the non-glandular lengthy (type C) trichomes and pod length were associated with susceptibility to this insect. The expression of resistance to H. armigera was also associated with the high amount of fat, phenol and tannin content. Crude protein and total soluble sugar content were responsible for higher pod infestation.

Dr. babu lal jat

In the construction industry lot of natural sand is being used in the preparation of concrete. Levels of natural sand are depleting day by day. The cost of natural sand is also increasing every day. Therefore, there is a need for alternative materials to natural sand. In this study, exfoliated vermiculite is replacing natural sand partially. Vermiculite at 5%, 10%, and 15% is used for replacement. The concrete cubes are cast for M 30 grade to determine the optimal percentage of replacement of natural sand by vermiculite. In this study, coarse aggregate used includes both normal aggregate and recycled aggregate. The water-cement ratio of 0.45 is adopted. The durability tests conducted include the sulfate resistance Test and the chloride resistance test. The cost analysis was also done and results are presented. The test results are promising when vermiculite was used to replace natural sand at 10%.

Kiran kumar narasimhan