An attempt was made for screening of salt tolerant against sodium chloride (NaCl) salt and growth promotion efficacy of eight different phosphate solubilizing bacterial (PSB) isolates under in vitro conditions. An efficient isolate which exhibited maximum phosphate solubilization, salt tolerant, Indole-3-Acetic Acid (IAA) production and root colonization potential in maximum concentration of NaCl (7%) was identified as Bacillus cereus based on 16S rRNA sequencing. It was recorded that highest phosphate solubilization in 7% NaCl concentration (70% and 374 μg/mL) in agar plate and broth assay respectively. IAA production was observed to be decreased when salt concentration increases, the isolate showed significant amount of IAA in normal culture media without amendment of NaCl (74.94 μg/mL) and at 7% gradual decrease of IAA production was observed (30 μg/mL). Maximum colonization of isolate in the roots of Zea mays was also observed in the study.
Provision of clean water is one of the United Nations Sustainable Development Goals. Water quality assessment as an ongoing exercise, in view of the threat of contamination from natural sources and human activities, plays a pivotal role in the sustainable management of water resources. Potable water samples were collected from Enugu Metropolis for water quality assessment. The physicochemical parameters were determined using APHA (1995 - 1998) protocols, and the presence of 7 heavy metals (Chromium, Zinc, Manganese, Silver, Cadmium, Iron and Lead) in the waters were determined using Atomic Absorption Spectrophotometer (AAS). The results of the physicochemical analysis of the four samples show a pH range of 8.60 - 8.95mg/l; this result showed that pH of the water samples were slightly alkaline and above the WHO stipulated range of 6.50 - 8.50. Acidity ranged from 5.00 - 6.88mg/l, while alkalinity values were between 7.52 - 13.00mg/l. The total dissolved solid (TDS) and total solids (TS) was present in very minute quantities and below their permissible limit of 0.45mg/l; while total suspended solid (TSS) was not present at all. The heavy metal analysis showed that all but 2 heavy metals (Cadmium and Lead) were below the permissible standard set by the WHO in all four samples. Cadmium was present in samples A and C with values 0.021mg/l and 0.006mg/l respectively, which is above its WHO limit of 0.005mg/l; while Lead was present in samples A, B and C with values of 0.021mg/l, 0.011mg/l and 0.015 mg/l respectively, which were above the WHO limit of 0.010mg/l. Given the well-documented toxicity of certain metals, there is a need for safety checks to be carried out in potable water companies to address the source of this contamination and ensure production of safer drinking water.
Fueled by the recent advancements in pervasive environment, affluent context aware systems is among the rousing in computing today, including embedded environment, different wireless network technology, electronic communication and so on. Context-Aware Collaborative Filtering using Genetic Algorithm approach resulted in an improved mobile business model by determining optimal similarities between contexts. In this work, we plan to devise a hybrid framework called Multi-distribution Perceptron and Hidden Markov Model to smoothen the mobile networks with different degrees of context- confidence. Initially, Multi-distribution Layer Perceptron Model is designed aiming at improving the precision rate with the aid of Multi-distribution Bayesian Posterior measure. Experimental analysis shows that the M-PHMM framework is able to reduce the computational complexity for obtaining user patterns by 26.05% and improve the precision rate by 18.90% compared to the state-of-the- art works.
The Construction Industry is one of the industries contributing highest GDP in Indian economy. The material that is most chosen in construction Industry is concrete. Concrete is a material made with Cement, Fine aggregate in the form of sand, Coarse aggregate in the form of gravel and water. With increasing scarcity of sand, construction works are coming to jolt and thereby increasing the need for choosing an alternative material. Vermiculite is a material which after exfoliation can be used as a filler material replacing sand partially without affecting strength much. One more material Granite (by product which is a waste is causing lot of environmental Issues), produced from granite industry, is available in India in several million tons. Coarse aggregate generally used is a crushed aggregate obtained from rocks like granite, basalt and soon. Recycled aggregate is an aggregate which is obtained after demolishing of an existing building, which is a waste causing economical in balance and which if put into use can not only decrease the construction cost but also make this waste into a better use. In the present study, for a M35 grade of concrete, Vermiculite (0, 5%, 10% and 15% of weight of sand) and granite powder (fixed at 10% of weight of sand used) is used to replace sand partially and in the place of normal coarse aggregate, recycled aggregate is used which is 20 mm passing and 12 mm retained After preparation of Mix-Design(1:1.83:2.69 with w/c ratio of 0.38) the concrete cubes are casted to test for compressive strength after curing for 28 days, 56 days and 90 days. Forsec brand super plasticizer is used to take care of workability requirements. Durability test in the form of resistance to attack of sulphuric acid was conducted along with compressive strength. The test results were promising at 10% replacement levels of Vermiculite.
Background: Dilation of pupil in Ophthalmic OPD is a routine procedure. Whether a sympathomimetic agent like phenylephrine should be used in hypertensive patients is still a question to be answered. This study tries to resolve the issue. Objective: To evaluate cardiovascular effects of combination of topical 5% phenylephrine and 0.8% Tropicamide. Method: Total 150 patients were subjected for this study (male and female) between 30-80 years of age. Combination of 5% phenylephrine and 0.8% tropicamide eye drops was instilled at an interval of 15 minutes thrice in the eyes of each patient. Any change in BP or HR was recorded Result: The data was collected and subjected to appropriate statistical method using R software version 4.2.1. This study has shown no significant increase in Blood Pressure and Heart Rate after instillation of 5% Phenylephrine and 0.8% Tropicamide eye drops except in one case. Conclusion: We conclude that combination of 5% Phenylephrine and 0.8% Tropicamide can be safely used in all patients who come for ocular examination but precautionary measures should be taken in hypertensive patients.
: About 12% of the world population is affected by different forms of urolithiasis, the recurrence rate of which is 47-60% in females and 70-80% in males. According to WHO, 75% of people rely on traditional medicines to prevent and cure different ailments. Similarly, the majority of the world population uses several plants to treat problems related to the urinary tract system, of which urolithiasis is the primary cause. The review aims to collect data on the plants used in different parts of the world and cultures against urolithiasis, including their parts, mode of preparation, dosage, and administration. A literature review was conducted for traditionally used antiurolithiatic plants. The articles mentioning plant, parts, mode of preparation, dose and route of administration were selected. This information was extracted to compose Mono and Polyherbal antiurolithiatic formulations used in Appalachia (a region in the Eastern United States), Canada, India, Iran, Israel, Italy, Jordan, Latin America, Pakistan, Turkey and Yemen. The review provides essential data about plants used as antiurolithiatic in different parts of the world. The information is not only useful for ordinary people but also for the scientific community to carry out further phytochemical, pharmacological and toxicological studies for discovering new, effective, safer molecules against urolithiasis.
In the name of Allah, Most Gracious, Most Merciful. Blessed be He in Whose hands is Dominion; and He over all things hath Power;- He Who created Death and Life, that He may try which of you is best in deed: and He is the Exalted in Might, Oft-Forgiving;- He Who created the seven heavens one above another: No want of proportion wilt thou see in the Creation of (Allah) Most Gracious. So turn thy vision again: seest thou any flaw? Again turn thy vision a second time: (thy) vision will come back to thee dull and discomfited, in a state worn out. And we have, (from of old), adorned the lowest heaven with Lamps, and We have made such (Lamps) (as) missiles to drive away the Evil Ones, and have prepared for them the Penalty of the Blazing Fire. For those who reject their Lord (and Cherisher) is the Penalty of Hell: and evil is (such), Destination. When they are cast therein, they will hear the (terrible) drawing in of its breath even as it blazes forth, Almost bursting with fury: Every time a Group is cast therein, its Keepers will ask, “Did no Warner come to you?” They will say: “Yes indeed; a Warner did come to us, but we rejected him and said, ´Allah never sent down any (Message): ye are nothing but an egregious delusion!´” They will further say: “Had we but listened or used our intelligence, we should not (now) be among the Companions of the Blazing Fire!” They will then confess their sins: but far will be (Forgiveness) from the Companions of the Blazing Fire! As for those who fear their Lord unseen, for them is Forgiveness and a great Reward. And whether ye hide your word or publish it, He certainly has (full) knowledge, of the secrets of (all) hearts. Should He not know,- He that created? and He is the One that understands the finest mysteries (and) is well-acquainted (with them). It is He Who has made the earth manageable for you, so traverse ye through its tracts and enjoy of the Sustenance which He furnishes: but unto Him is the Resurrection. Do ye feel secure that He Who is in heaven will not cause you to be swallowed up by the earth when it shakes (as in an earthquake)? Or do ye feel secure that He Who is in Heaven will not send against you a violent tornado (with showers of stones), so that ye shall know how (terrible) was My warning? But indeed men before them rejected (My warning): then how (terrible) was My rejection (of them)? Do they not observe the birds above them, spreading their wings and folding them in? None can uphold them except (Allah) Most Gracious: Truly (Allah) Most Gracious: Truly it is He that watches over all things. Nay, who is there that can help you, (even as) an army, besides (Allah) Most Merciful? In nothing but delusion are the Unbelievers. Or who is there that can provide you with Sustenance if He were to withhold His provision? Nay, they obstinately persist in insolent impiety and flight (from the Truth). Is then one who walks headlong, with his face grovelling, better guided,- or one who walks evenly on a Straight Way? Say: “It is He Who has created you (and made you grow), and made for you the faculties of hearing, seeing, feeling and understanding: little thanks it is ye give. Say: “It is He Who has multiplied you through the earth, and to Him shall ye be gathered together.” They ask: When will this promise be (fulfilled)? – If ye are telling the truth. Say: “As to the knowledge of the time, it is with Allah alone: I am (sent) only to warn plainly in public.” At length, when they see it close at hand, grieved will be the faces of the Unbelievers, and it will be said (to them): “This is (the promise fulfilled), which ye were calling for!” Say: “See ye?- If Allah were to destroy me, and those with me, or if He bestows His Mercy on us,- yet who can deliver the Unbelievers from a grievous Penalty?” Say: “He is (Allah) Most Gracious: We have believed in Him, and on Him have we put our trust: So, soon will ye know which (of us) it is that is in manifest error.” Say: See ye?- If your stream be some morning lost (in the underground earth), who then can supply you with clear-flowing water?
Background In 2016, the Tanzanian government shifted the vaccine supply chain responsibilities from the Medical Store Department (MSD) to the Expanded Program on Immunization (EPI) to reduce costs. However, cost estimates that informed the decision were based on invoice value of vaccines and related supplies, rather than a proper economic evaluation study. Therefore, this study aims to compare the actual storage and distribution costs of vaccines and related supplies between MSD to EPI. Method Micro-costing approach was used to estimate resource use at MSD and EPI for the year 2018. Data were collected through a review of documents, warehouse databases, and interviews with key staff at MSD and EPI. We included both capital and recurrent costs. Microsoft Excel® was used for analysis with input data from the UNICEF forecasting tool, WHOs vaccine volume and capacity estimation tool, diesel generator calculator, and supply chain service fee estimator version 1.02. Results The total vaccine storage and distribution costs were estimated to be USD 1,996,286 at MSD and USD 543,648 at EPI. Distribution and program management costs represented 41% (USD 819,288) and 38% (USD 762,968) of the total costs at MSD, while storage and distribution costs represented 43% (USD 234,423) and 34% (USD 184,620) of the total costs at EPI, respectively. The cost drivers at MSD were fuel and transport (21%), receiving and dispatch (19%) and, program management personnel cost (14%), while at EPI were storage space (20%), program management personnel cost (18%) and fuel and transport (15%). Conclusion The storage and distribution of vaccines in Tanzania via the EPI reduced the vaccine supply chain cost to about 27% of the program costs at MSD.
Food nutrients are essential for the growth and development of human. In several parts of the world, Cocoyam (Colocasia esculenta), is a tropical root crop cultivated for food formulations and consumption by humans. This study was conducted to assess the nutritional evaluation (weight gain, protein efficiency ratio, net protein retention, and biological value) of the processed cocoyam, soya bean (Glycine max) flours and their blends by feeding trials using Albino rabbits. The sun-dried samples were milled to size (sieve with 25 µm aperture size) to obtain homogenous flours. Blends were obtained with various ratios according to the percentage of soya bean/cocoyam flours. The biological value, protein efficiency ratio, and net protein retention were analysed using standard methods for the calculations. Net protein retention of soya bean flour was higher than that for cocoyam flour. The highest biological value was given by the 50% blend, while the lowest was given by the control diet. The higher the protein efficiency ratio values, the higher the protein quality. The highest protein efficiency ratio value was given by soya bean flour, while the lowest value was from Cocoyam flour. The best blend of Cocoyam and soya bean flours obtained based on chemical and nutritional evaluations was the 50% blend of soya bean and Cocoyam flours.
Mediterranean journal of pharmacy and pharmaceutical sciences
Background: Irritable bowel syndrome (IBS) is a very common gastrointestinal dis-order worldwide, but research regarding this disease is rare in Bangladesh. This studyaimed to assess the prevalence of IBS and its associated risk factors among universitystudents in Bangladesh.Methods: This is a cross-sectional study. A total of 300 randomly selected partici-pants were included in this study. By using a structured questionnaire and anthropo-metric methods, we collected all the required data for our study. The diagnosis of IBSwas based on Rome III criteria.Results: The overall prevalence of IBS was 39.3%, but the majority (77.3%) had nobasic awareness of IBS. In our study, anxiety and depression (χ2 = 6.817; odds ratio[OR] = 1.910; 95% confidence interval [CI] = 1.172, 3.113; P = 0.011) had a signif-icant relationship with IBS and IBS had a significant (P < 0.001) relationship withfood intolerance (χ2 = 8.737; OR = 2.130; 95% CI = 1.284, 3.531), chest pain(χ2 = 7.482; OR = 2.035; 95% CI = 1.218, 3.401), and insomnia (χ2 = 19.320;OR = 2.907; 95% CI = 1.794, 4.709). In our dietary data, the intake patterns of vege-tables (P = 0.000), fast food (P = 0.000), and tea–coffee (P = 0.003) showed astrong significant association with IBS. On the other hand, monthly household income(P = 0.154) and body mass index (BMI) (P = 0.138) showed no significant associa-tion with IBS. Among our study subjects, IBS-constipation (54.2%) was more com-mon than IBS-diarrhea (27.1%) and IBS-mixed (18.6%). Moreover, among the 118IBS respondents, 67.8% had a headache with increased flatulence (95.8%) as the mostcommon IBS-related complication.Conclusion: IBS is common in university students of Bangladesh and is associatedwith anxiety, depression, and particular dietary patterns.
Background Type 2 diabetes and obesity are serious public health concerns globally and a growing burden in Africa. Both conditions have serious repercussions on health when they co-occur, yet the extent of their co-occurrence in Africa remains unknown. Therefore, this review aimed to identify the prevalence and associated factors of overweight and obesity among persons with type 2 diabetes in Africa. Method A systematic search was conducted on PubMed, MEDLINE, Embase, African Index Medicus (AIM), and African Journals Online (AJOL) for observational studies that reported the prevalence of overweight and/or obesity among type 2 diabetes patients in Africa. The prevalence data from individual studies were aggregated through a random-effects meta-analysis. The I2 statistic was used to evaluate between-studies heterogeneity, while subgroup analysis and mixed-effects meta-regression were performed to identify sources of heterogeneity. We assessed publication bias using funnel plots and Egger’s test. This review adhered to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Results Of 1753 records retrieved, 80 articles were eligible for this review, with 74 cross-sectional studies included in the meta-analysis. The pooled prevalence of overweight and obesity was 35.6% and 25.6% respectively, while the overall prevalence of both overweight and obesity was 61.4%. Also, the pooled prevalence of both overweight and obesity across the five geographical areas in Africa ranged from 56.9% in East Africa to 88.5% in Southern Africa. Nineteen factors were significantly associated with overweight and obesity among patients with type 2 diabetes. Conclusion The high prevalence of overweight and obesity among patients with type 2 diabetes is a significant public health concern that transcends geographical boundaries within Africa. The findings from this review highlight the need for innovative weight management interventions that are tailored to the cultural context of the African setting
The current study was designed to explore the anti-inflammatory effects of the crude hexane and ethanol extracts of the leaves and male flowers of Luffa cylindrica (L.) Roem., (sponge gourds) to validate its folk use. These extracts produced significant anti-inflammatory effects (p.o.) at doses of 500, 750 and 1000 mg/kg b.w. in carrageenin-induced paw oedema in rats compared to those obtained with indomethacin. The results of the present study provide evidence for the anti-inflammatory properties of the leaves and male flowers of Luffa cylindrica, which have potential therapeutic applications for inflammatory diseases.
Medicinal plants have been known for thousands of years and are highly esteemed worldwide as a rich source of therapeutic agents for preventing and curing diseases. Nowadays, a large number of the population suffers from gallstones. The gall stones problem is increasing significantly due to changes in living styles and conditions, i.e. industrialization and malnutrition. Medicinal plants have been used for centuries due to their cultural acceptability, efficacy, safety and lesser side effects than synthetic drugs. The review aims to gather information on the plants utilized in various parts of society against gallstones. The information is useful for ordinary people and the scientific community to carry out further phytochemical, pharmacological and toxicological studies to discover new, effective and safer molecules against gallstones.
Autophagy is a self-digesting mechanism responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy. In microautophagy cytoplasm material is sequestered through direct invagination to the lysosomal membrane. Whereas in CMA proteins flagged with pentapeptide motif (KFERQ) were selectively degraded through direct translocation into lysosome. Macroautophagy involves the formation of subcellular double-membrane-bound structures called autophagosomes that contain degradable contents of cytoplasm materials and deliver them into lysosomes for breakdown by lysosomal enzymes. The molecular mechanism of autophagy involves several conserved Atg (autophagy-related) proteins. Systems produce modified complexes Atg8-PE and Atg5-Atg12-Atg16 as autophagy regulators. Autophagy is activated in response to diverse stress and physiological conditions. For example, food deprivation, hyperthermia, and hypoxia are mediated by factors like insulin/IGF-1, m-TOR signaling, FOXO transcription factors, and chaperones. The perturbance in autophagy may lead to several types of cancers, myopathies, and neuromuscular disorders. Several autophagy inducers and inhibitors like 3-methyladenine (3-MA), bafilomycin A1, LY294002 (LY), and Velcade have been used to treat disease is an intense field of study.
A Man-Machine System means an activity occurring/occurred with the involvement of a human being with the help of some tools used to interact with the material. In small foundries, the moulding process is manual & labours have to work in different psychological moods, stress, and strain, without training on ergonomic posture, in different environmental factors such as temperature, vibrations, noise dust which affects productivity and also the amount of human energy input to produce the component. This paper makes an attempt to develop a mathematical model to relate productivity with various parameters and identify the most sensitive parameter to control productivity.
In this article, we establish the exact wave solutions of the Boussinesq equation and the (2 + 1)-dimensional extended shallow water wave equation by applying the new generalized (G'/G)-expansion method. When the condition of the fluid is such that the horizontal length scale is much greater than the vertical length scale, the shallow water equations are mostly suitable. In Ocean engineering, Boussinesq-type equations are commonly used in computer simulations for the model of water waves in shallow seas and harbors. We explained the new generalized (G'/G)-expansion method to seek further general traveling wave solutions of the above mentioned equations. The traveling wave solutions attained by this method are exposed in terms of hyperbolic, trigonometric and rational functions. The shape of the obtained solutions are bell shaped soliton, kink soliton, singular kink soliton, singular soliton, singular periodic solution and compaction. This method is very influential mathematical tool for extracting exact solutions of NLEEs which frequently arise in mathematical physics, engineering sciences and many scientific real world application fields.
Penelitian ini bertujuan untuk melihat seberapa besar dampak kualitas produk, persepsi konsumen dan brand image terhadap keputusan pembelian produk endorsement pada masyarakat di Medan dengan menggunakan word of mouth sebagai variabel moderasi. Sampel penelitian ini adalah sebesar 100 orang responden dengan teknik analisis data menggunakan analisis jalur (path analysis). Hasil dari penelitian ini menunjukkan kualitas produk, persepsi konsumen dan brand image berpengaruh terhadap keputusan pembelian produk endorsement pada masyarakat di Medan. Lebih lanjut, word of mouth tidak memoderasi kualitas produk terhadap keputusan pembelian dan juga tidak memoderasi persepsi konsumen terhadap keputusan pembelian namun word of mouth memoderasi brand image terhadap keputusan pembelian produk endorsement bagi masyarakat di Medan.
Community acquired pneumonia is a prevalent disease in the Emergency Department (ED). The literature reveals that clinical practice could not be related with guidelines recommendations. The aim of this study is to determine the impact of the implementation of the recommendations of the Spanish society of Emergency Medicine in the Hospital Clínico Universitario Lozano Blesa (Zaragoza) ED in the management of community acquired pneumonia. Use of Pneumonia Severity Index (PSI) estimation was used to assess the adherence. This study was carried out from December, 2014 to February, 2015. Data was compared with the previous two months. The indicators management (discharge or admission decision, adequacy and anti-biotherapy) as well as the incidence of PSI estimation before and after the intervention in these parameters were evaluated. 209 patients were included, 97 before the intervention and 112 after the intervention. No significant differences were observed in the calculation of PSI. A significant decrease of admissions was observed after the intervention in the patients in whom the PSI was calculated (68.8% vs. 45.0%, p < 0.05). A greater use of the Observation Room was aimed at those patients in whom the PSI was calculated (06.3% vs. 17.5%, p < 0.05). PSI calculation significantly increased antibiotic prescription adherence (88.9% vs. 75.2%, p < 0.05). There were no modifications in the prescription after the intervention. In conclusion, PSI is a useful and effective measure to achieve a greater adherence to the recommendations. However, despite the positive trend in the use of the PSI and its interpretation, a low-intensity intervention is not sufficient to generalize its use.
Mediterranean journal of pharmacy and pharmaceutical sciences
Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.
Trans fatty acids (TFA) are the geometrical isomers of monounsaturated and polyunsaturated fatty acids that affect the functional and physicochemical properties of these fatty acids, which in turn affect their metabolism in humans. Since the database available for trans fatty acids in food from India is scarce, the research report generates data about trans fatty acid content in selected foods popular in north India. In this report, various food samples like cookies, chocolates, biscuits, pizza, fries, indigenous snacks like samosa, pakora and indigenous sweets like jalebi, gulab jamun, and laddoo were analyzed for the Trans Fatty Acid (TFA) content by gas chromatography. A large variation was found in trans fatty acid content among these food samples. The results also showed that only 4.5% of the samples were found to contain TFA less than 0.5% while approximately 8% of samples having more than 5% TFA (1 branded and 6 non-branded samples). Also, a large variation was found in the trans fatty acid content of branded and non-branded food samples with the mean value of TFA in branded and non-branded food groups as 1.781 and 6.125 respectively and the t-value of 0.852 between the two groups. When regulations are emphasizing on labelling the TFA content on the product, there are arrays of unlabelled products which are not governed under any regulations. Hence there is a need for strong food regulations to bring levels of trans fats in processed foods to negligible levels.
Université Nazi Boni
Central Council For Research In Unani Medicine, Ministry Of Ayush, Government Of India, New Delhi