The Construction Industry is one of the industries contributing highest GDP in Indian economy. The material that is most chosen in construction Industry is concrete. Concrete is a material made with Cement, Fine aggregate in the form of sand, Coarse aggregate in the form of gravel and water. With increasing scarcity of sand, construction works are coming to jolt and thereby increasing the need for choosing an alternative material. Vermiculite is a material which after exfoliation can be used as a filler material replacing sand partially without affecting strength much. One more material Granite (by product which is a waste is causing lot of environmental Issues), produced from granite industry, is available in India in several million tons. Coarse aggregate generally used is a crushed aggregate obtained from rocks like granite, basalt and soon. Recycled aggregate is an aggregate which is obtained after demolishing of an existing building, which is a waste causing economical in balance and which if put into use can not only decrease the construction cost but also make this waste into a better use. In the present study, for a M35 grade of concrete, Vermiculite (0, 5%, 10% and 15% of weight of sand) and granite powder (fixed at 10% of weight of sand used) is used to replace sand partially and in the place of normal coarse aggregate, recycled aggregate is used which is 20 mm passing and 12 mm retained After preparation of Mix-Design(1:1.83:2.69 with w/c ratio of 0.38) the concrete cubes are casted to test for compressive strength after curing for 28 days, 56 days and 90 days. Forsec brand super plasticizer is used to take care of workability requirements. Durability test in the form of resistance to attack of sulphuric acid was conducted along with compressive strength. The test results were promising at 10% replacement levels of Vermiculite.

Kiran kumar narasimhan

Assessment of convergent validity of latent variables is one of the steps in conducting structural equation modeling via partial least squares (PLS-SEM). In this paper, we illustrate such an assessment using a loadings-driven approach. The analysis employs WarpPLS, a leading PLSSEM software tool.

Johnny amora

Plant secondary metabolites refer to various chemical compounds that plants produce. Still, they are not directly involved in essential growth processes like primary metabolites (such as sugars, amino acids, and lipids). The term "secondary metabolite" has generated controversy, as it implies these compounds are of minor importance to plants. "Special metabolites" may be a more suitable term. These metabolites protect plants from both abiotic and biotic stress. The vast diversity of plant secondary metabolites showcases plants' incredible adaptability and versatility, providing an arsenal of chemical tools to defend against herbivores, protect from pathogens, attract pollinators and seed dispersers, adaptability and thrive in environmental interactions. Plants can, therefore, survive under less-than-ideal conditions. The profound impact of plant secondary metabolites highlights the intricate relationship between plants and humanity, opening doors to innovative applications with far-reaching implications.

Dr. salman ahmed

In 2016, the World Health Organization (WHO) estimated that approximately 4.2 million premature deaths world wide were attributable to exposure to particulate matter 2.5 μm (PM2.5). This study assessed the environmental burden of disease attributable to PM2.5 at the national level in Malaysia. We estimated the population-weighted exposure level (PWEL) of PM10 concentrations in Malaysia for 2000, 2008, and 2013 using aerosol optical density (AOD) data from publicly available remote sensing satellite data (MODIS Terra). The PWEL was then converted to PM2.5 using Malaysia's WHO ambient air conversion factor. We used AirQ+ 2.0 software to calculate all-cause (natural), ischemic heart disease (IHD), stroke, chronic obstructive pulmonary disease (COPD), lung cancer (LC), and acute lower respiratory infection (ALRI) excess deaths from the National Burden of Disease data for 2000, 2008 and 2013. The averagePWELs for annual PM2.5 for 2000, 2008, and 2013 were 22 μg m-3, 18 μg m-3 and 24 μg m-3, respectively. Using the WHO 2005 Air Quality Guideline cut-off point of PM2.5 of 10 μg m-3, the estimated excess deaths for 2000, 2008, and 2013 from all-cause (natural) mortality were between 5893 and 9781 (95 % CI: 3347–12,791), COPD was between 164 and 957 (95 % CI: 95–1411), lung cancer was between 109 and 307 (95 % CI: 63–437), IHD was between 3 and 163 deaths, according to age groups (95 % CI: 2–394) and stroke was between 6 and 155 deaths, ac-cording to age groups (95 % CI: 3–261). An increase in estimated health endpoints was associated with increased estimated PWEL PM2.5 for 2013 compared to 2000 and 2008. Adhering the ambient PM2.5 level to the Malaysian AirQuality Standard IT-2 would reduce the national health endpoints mortality

Mohamad iqbal mazeli

The seed flours of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn. were investigated for their total, soluble and insoluble oxalate contents by HPLC. The total oxalate content of Macrotyloma uniflorum, Phaseolus lunatus and Phaseolus vulgaris were 1.24, 1.77 and 1.71 mg/ g, respectively. The % age of soluble oxalate was Macrotyloma uniflorum (19.50), Phaseolus lunatus (15.08) and Phaseolus vulgaris (15.88). The calculated soluble oxalate: calcium ratio of all tested legume flours is lesser than one and hence will not create any resistance in calcium bioavailability.

Dr. salman ahmed

Investigating school performance and competencies, especially on leadership, received a considerable attention in the past. In fact, there have been multitudes of evidence that leadership can impact school performance, student achievement, or outcome. Also, there was no single measurement of school performance. This study examined the influence of leadership and core behavioral competencies on the school performance of school heads. This was to build a new model of school performance. Using an explanatory research design, it administered a survey questionnaire to 192 randomly chosen school heads from the 37 districts of Department of Education Division of Surigao del Sur. Also, it used data mining for the performance ratings of school heads from the division office. Regression analysis tested three hypothesized models of school performance where leadership and core behavior competencies serve as independent variables. Results showed that leading people was a significant predictor of school performance. Thus, leading people can best explain the school improvement as a proposed model. The results have implications for future research, leadership practice, and theoretical development of school performance model among school heads.

Manuel caingcoy

Urolithiasis has been a common problem for centuries and has a high recurrence. This review covers the forty-two (42) antiurolithiatic plants of the family Apiaceae used in 18 different countries. Hopefully, this review will not only be helpful for the general public but also attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Analysis of Edaphic Factors in Few Villages of Mysuru District

Veerabhadraswamy al

In olden days in most of the family male members were meant for earning income to the family where as the female members looked after the house works. In most of the family it was followed. After some time it was felt that if the female members are involved in some works other than the family affairs it would be the support extended by them to their spouse and family members. Therefore, in some family the female members were allowed to work in some industries and agriculture. Most of the women members supported to the family members the work or job involved by the male members of the family. Being India a country having more than 65 percent of its population are residing in rural areas. They depend only on agriculture and allied industries of agriculture. Due to the failure of rainfall and problems of insects and the monsoon nowadays the farmer could not earn even the amount incurred by them to cultivate the produces. But the necessity of the family is going on increasing day by day. Further, the prices of the domestic utilities are also increasing like anything. It is very difficult to run the family with single earning. Therefore, it is necessary for both the male and female members in the family to bring income to meet their requirements. In urban areas, there is more number of industries, which provide employment opportunities to both of the gender. However, if consider the position of the village women, they do not have much awareness on industrial work. Further, they have only limited literacy knowledge, which paved them to engage only in agriculture labour, which further made them weak in their financial position, as there is only limited scope for income in the agriculture work. Hence, most of the family in the rural parts of the country led a very poor life, which worsens the younger generation particularly in education. To minimize the unemployment problems in the rural areas and to generate the income to the family in the rural parts, the central government introduced Micro Finance to encourage the rural public to generate income to their family by way of doing small business or involved in some self-employment activities. As a part of the development of women in the rural areas, Self-help groups were established in the year 1993-94 in Uthrapradesh. But the evolution of SHGs commenced in 1990s. Micro finance plays vital role in the empowerment of women particularly in the village areas by providing financial assistance through self-help groups in the local areas since 1990. Andhra Pradesh government emphasizes more on the development of women through Self-help groups. The banks are given direction to provide more volume loan to the self-help groups. More number of self help groups was established in all villages. NGOs and government create awareness among all women in the rural areas to form self-group even for each line and street in all villages of Andhra Pradesh. We happened to see number of SHGs is being established and functioning well. The self-help group members are involved in various activities like running a canteen, manufacturing pickles and handy crafts and cloth items, etc. The local banks are adopting the particular villages for providing loan to self-help groups. Though the Micro finance extends maximum support to the development of women and the self help groups, the members in self-help groups have different views about micro finance and face many issues in getting the loan and the repayment of the loan. In many occasions, the members in self-help groups are compelled by family members not to involve in SHGs activities because of various reasons. In some of the SHGs the income level of the members is very low when compared with the income from other SHGs. What are the actual causes? What is the role of micro finance in empowerment of women? To know all these reasons a thorough study is to be undertaken.

Dr tatayya bommali

We exist in a conscious experience of life that is transitive and moment-by-moment, yet significant enough non-zero-time latencies exist across the visual, auditory, and somatosensory systems that transduction and processing do not take place instantly. This paper attempts to examine these non-zero-time latencies to resolve the conflict, ultimately suggesting that instead of consciousness accessing an external world, it accesses a high-fidelity bioelectric representation of the external world generated during this pre-conscious time interval. This external representation is the byproduct of Default Space Theory (DST), which indicates that oscillatory movements of the brain and body form a continuous three-dimensional "default space" over time. The default space exists as we exist, separately. Our external inputs from the retina, cochlea, and dermis "clothing" the default internal configuration occur via phase-locked neural oscillations over time, which occur at significant non-zero latencies. For example, the earliest cortical stages for auditory and tactile processing occurs at ~10–20ms, while the olfactory and visual features of stimuli occur at ~50–70ms. This doesn't mean we're perceiving them in time; it's quite the opposite. We're not perceiving in time because the default space is so well-templated all at once that somehow, the brain must erase this time interval and use the integrated multisensory processing to update continuously. Thus, we need to redefine consciousness as this continuously updated internal projection of externalized realities instead of an experience of what's outside.

Genesis scientific publications

To satisfy user expectations and resource needs, academic libraries are realizing more and more how important it is to integrate innovative technologies. Effective use of technology is essential to educational libraries' success. A thorough analysis finds new trends that university libraries are using to satisfy present demands. In the twenty-first century, libraries are becoming dynamic establishments that meet the changing demands of society. These consist of data literacy, digitization, and the incorporation of augmented and virtual reality technologies. Additionally, libraries are becoming community hubs for educational programs like seminars and lectures. Libraries are helping people navigate the immense ocean of information, and data literacy along with knowledge skills is essential. Services driven by AI are improving client experiences and expediting procedures. With libraries implementing eco-friendly architectural designs & community engagement tactics, sustainability projects are becoming more and more well-known. Libraries are responding to these shifts by creating creative solutions, including collaborations, environmental initiatives, and AI integration, all while overcoming financial limitations. To remain relevant, they are adopting cutting-edge strategies like AI-powered services, collaborations, sustainability, virtual and alternative reality technologies, open data initiatives, maker spaces, & creative labs. Libraries are implementing cutting-edge solutions to address a variety of community needs and encourage lifelong learning, despite obstacles such as limited financing, evolving librarian roles, privacy and security concerns, and adjusting to changing societal standards.

Dr. awadhesh singh gautam

Parkinson’s disease is a common movement disorder associated primarily with oxidative stress-mediated degeneration of dopaminergic neurons. Earlier studies showed that Sorghum bicolor-based supplement (SbS) exhibited antioxidant and neuroprotective activities and might likely rescue the death of dopaminergic neurons in Parkinson’s disease. This study examined the effect of SbS on rotenone-induced Parkinsonian-like motor deficits in rats and the involvement of oxidative stress and pro-inflammatory cytokines. Rats were divided into six groups and treated orally with sunflower oil (vehicle-control), rotenone (2.5 mg/kg) alone or in combination with each dose of SbS (50, 100, and 200 mg/kg) and levodopa-carbidopa (10 mg/kg) on an alternate day for 28 days. The changes in motor functions were evaluated on day 28 and the brain concentrations of oxidative stress biomarkers and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) were determined. Rotenone caused motor deficits by impaired locomotor activity in the open field test and induced catalepsy in the bar test, which were attenuated by SbS. Rats pretreated with SbS had reduced brain levels of malondialdehyde, nitrite, and pro-inflammatory cytokines compared to rotenone controls. SbS mitigated rotenone-induced depletion of reduced glutathione and antioxidant enzymes in the rat brain. The results suggest that SbS ameliorated rotenone-induced Parkinsonian-like motor dysfunctions by reducing neuronal oxidative stress and pro-inflammatory cytokines in rats.

Mediterranean journal of pharmacy and pharmaceutical sciences

The soil samples were collected from Melia dubia plantations in two different locations in Tamil Nadu. A total of twenty five actinomycetes isolates were isolated and they were screened for melanin pigment production using different culture media. Only two isolates were able to produce melanin pigment under in vitro study and one isolate showed positive reaction to L-tyrosine substrate. Based on morphological and bio-chemical characters the isolate was identified as Streptomyces sp. The DNA of the isolate was isolated and its 16S rDNA gene was amplified and sequenced. The phylogenetic analysis of Streptomyces puniciscabiei was carried out.

Dr. saranya devi k

This paper addresses global supply chain management (GSCM). The industry used to explore this topic is the automotive industry, as it is a core industry in the world economy, both in revenue generation and inefficiency. The paper explores both the positive and negative attributes of supply chain management, explores and analyses the gap between evaluation and implementation of improvements in supply chain management and then looks into the global issues affecting supply chain management and their solution.

Mohamed sorogy

Now-a-days there is a renewed interest in drugs of natural origin simply because they are considered as green medicine and are always safe. The advantage of natural drugs is their easy availability, economic and less or no side effects they have been used in traditional medicine practices. In the present investigation some medicinal weeds were analyzed, it includes Centella asiatica, Phyllanthus niruri, Argemone mexicana, Amaranthus viridis, Asclepias currasavica, Cyperus iria and Portulaca oleraceae. All the eight medicinal weeds collected during field visits were subjected to study organoleptic features, macroscopic studies, powder analysis, physicochemical limits and fluorescence analysis, single and double staining techniques.

Veerabhadraswamy al

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It is one of the most widely used chemotherapeutic agents for various solid tumors in the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin is mainly due to its ability to cross-link with DNA, thus blocking transcription and replication, Subsequently inducing apoptosis in cancer cells. However, because of drug resistance and numerous undesirable side effects such as severe kidney problems, allergic reactions, decreased immunity to infections, gastrointestinal disorders, hemorrhage, and hearing loss especially in younger patients. Other common side effects include ototoxicity, neurotoxicity, gastrointestinal toxicity, hematological toxicity, cardiotoxicity, and hepatotoxicity. These side effects together reduce the life quality of patients and require lowering the dosage of the drug, even stopping administration, thus weakening the treatment effect Therefore, substantial effort has been made to explore the complicated biochemical processes involved in the toxicology of cisplatin, aiming to identify effective ways to reduce or eradicate its toxicity. This review summarizes and reviews the updated advances in the toxicological research of cisplatin.

Nehal

The ability of antimicrobial peptides (AMPs) for effective binding to multiple target microbes has drawn lots of attention as an alternative to antibodies for detecting whole bacteria. We investigated pathogenic Escherichia coli (E. coli) detection by applying a microfluidic based biosensing device embedded with AMP-labeled beads. According to a new channel design, our device is reusable by the repeated operation of detection and regeneration modes, and the binding rate is more enhanced due to even distribution of the bacterial suspension inside the chamber by implementing influx side channels. We observed higher binding affinity of pathogenic E. coli O157:H7 for AMP-labeled beads than nonpathogenic E. coli DH5α, and the fluorescence intensity of pathogenic E. coli was about 3.4 times higher than the nonpathogenic one. The flow rate of bacterial suspension should be applied above a certain level for stronger binding and rapid detection by attaining a saturation level of detection within a short time of less than 20 min. A possible improvement in the limit of detection in the level of 10 cells per mL for E. coli O157:H7 implies that the AMP-labeled beads have high potential for the sensitive detection of pathogenic E. coli at an appropriate flow rate.

Myung-suk chun

Objective: To explore unusual association between Turner Syndrome (TS) and Hypopituitarism in a Tunisian cohort. Methods: We reported 6 patients with TS associated to Hypopituitarism, including three familial cases except the fourth sister who showed only a TS phenotype. Biochemical analysis, resonance magnetic imaging and cytogenetic analyses were performed. Results: The average age of our patients was 17.2 years (11-31 years). They were all referred for short stature and pubertal delay, except for the fourth sister who presented spontaneous puberty with the integrity of the pituitary axis and the presence of an X ring chromosome. Karyotype analysis showed monosomy in 3 cases and a mosaic TS in the 3 remaining cases, including one patient with abnormal X chromosome structure. Somatotropic and corticotropic deficiencies were confirmed in 2 sporadic cases while the gonadotropic and thyrotropic axes were spared. In contrast; familial cases were consistently affected by the integrity of the corticotropic axis. MRI showed pituitary hypoplasia in all familial cases and pituitary stalk interruption syndrome in only one sporadic case. No correlation was found between the chromosome formula and the anterior pituitary involvement. Conclusion: Co-segregation of congenital Hypopituitarism with pituitary hypoplasia and X chromosome aberrations could imply a molecular anomaly of transcription factors responsible for the differentiation and development of pituitary cells such as PROP1, POUF1, Hesx1, Lhx3, Lhx4. The etiopathogenic link between X chromosome abnormalities and the occurrence of Hypopituitarism remains unclear; however, the progress of molecular biology may clarify the interrelation between transcription factors and sex chromosome segregation abnormalities.

Mariam moalla

Malignant melanoma is the most dangerous type of skin cancer. It is becoming more common globally and is increasingly resistant to treatment options. Despite extensive research into its pathophysiology, there are still no proven cures for metastatic melanoma. Unfortunately, current treatments are frequently ineffective, costly, and have several adverse effects. Natural substances have been extensively researched for their anti-MM capabilities. Chemoprevention and adjuvant therapy with natural products is an emerging strategy to prevent, cure or treat melanoma. Numerous prospective drugs are found in aquatic species, providing a plentiful supply of lead cytotoxic chemicals for cancer treatment. Anticancer peptides are less harmful to healthy cells and cure cancer through several methods, such as altered cell viability, apoptosis, angiogenesis/metastasis suppression, microtubule balance disturbances and targeting lipid composition of the cancer cell membrane. This review addresses marine peptides as effective and safe treatments for MM and details their molecular mechanisms of action.

Dr. salman ahmed

The need for natural medicine and nutrients from natural product sources cannot be overstressed. Plant parts like leaves, stem, root, seed, nut and flowers supply enormous minerals, phytochemicals and other bioactive constituents apart from the primary metabolites. Terminalia Catappa (T. catappa) is a combretaceous plant often found in tropical and subtropical regions. The plant has many uses as an ingredient of various drugs such as anti-oxidants, anti-inflammatory, anti-cancer, and anti-diarrheal. Thus, the main objective of this study was to determine the proximate, mineral and physicochemical analysis of T. catappa seed nuts. The proximate composition was determined according to the previous standard methods and elemental analysis by Atomic Absorption Spectrophotometry and Flame Photometer. Proximate composition revealed a moisture content of 02.34%, ash 03.89%, fibre content 08.50%, crude protein 29.66%, fat 21.98% and carbohydrate 33.63%. Elemental analysis of the plant have indicated the presence of iron, zinc, calcium, magnesium, potassium, sodium, copper and chromium in the aqueous extract. Physicochemical parameters of the plant revealed a specific gravity of 0.9182, viscosity 33.62 mm2/s, refractive index 1.4642, acid value of 0.102 mg KOH/g, saponification value of 151.28 mg KOH/g, iodine value 47.19 g I2/100 g and peroxide value 8.93 meq/kg. In conclusion, the findings from this study confirmed that almond nut oil has a long shelf life which may explain its applications in pharmaceutical, non-pharmaceutical and personal care industries.

Mediterranean journal of pharmacy and pharmaceutical sciences