Over the past 20 years, universities have been faced with sustained change, driven by external factors. This has led to the evolution of the teaching and research mission and the creation and rise of the third mission. Such mission extension has led to the emergence of entrepreneurial universities which has seen a move from traditional research and teaching business models, to business models which incorporate a much wider range of activities, to meet stakeholder demands as well as sustaining and growing universities in the era of intense national and international competition. This special issue extends knowledge by providing novel insights into the multidimensional antecedent contextual influences, consequences and implications of university mission expansion. We also provide a foundational research agenda which will help guide future research exploring the changing and expanding university missions and business models. Higher education system plays an important role for the country’s overall development which includes industrial, social, economic etc. Indian higher education system is third largest in the world. The role of Indian higher educational institutes such as colleges and universities in the present time is to provide quality based education in the field of education, research etc to empower youth for self sustainability. This paper includes the key challenges that India is currently facing in higher education and also includes some initiatives taken by the government to meet those challenges.

Dr gedam kamalakar

Along with computer technology, the demand of digital image processing is too high and it is used massively in every sector like organization, business, medical etc. Image segmentation enables us to analyze any given image in order to extract information from the image. There are numerous algorithm and techniques have been industrialized in the field of image segmentation. Segmentation has become one of the prominent tasks in machine vision. Machine vision enables the machine to vision the real world problems like human does and also act accordingly to solve the problem so it is utmost important to come up with the techniques that can be applied for the image segmentations. Invention of modern segmentation methods like instance, semantic and panoptic segmentation have advances the concept of machine vision. This paper focuses on the various methods of image segmentation along with its advantages and disadvantages.

Manoj kumar pandey

This study sets out to explore the Critical Success Factors (CSFs) necessary for Total Quality Management (TQM) implementation in hotels. It also aims to classify participating hotels into groups based on their TQM adoption by using cluster analysis. A quantitative survey method was applied. Data were collected from a sample of managers from four- and five-star hotels in Jordan, 170 questionnaires were distributed to managers and 104 usable questionnaires were returned. The findings revealed that TQM is existed and implemented in the hotel industry. The researcher then confirmed that four- and five-star hotels can be classified into two groups, namely, “high TQM adopters” and “low TQM adopters”.

Mukhles m. al-ababneh

The purpose of this research was to examine the mediating effect of empowerment on the linkage between Total Quality Management (TQM) and service recovery performance in the hotel industry. Although much has been written about TQM, empowerment and service recovery performance, but the role of empowerment as a mediator in the relationship between TQM and service recovery performance has remained a relatively unexplored research area. A 93-item questionnaire is designed to measure TQM, empowerment and service recovery amongst employees in five-star hotels in Jordan, and 254 usable questionnaires were used in this study. Principal components analysis determined the factor structure and regression analysis determined the relationships between the study’s variables. The results revealed that the TQM implementations have positive effects on empowerment and service recovery performance. Moreover, the study found the full mediating effect of empowerment in the relationship between TQM and service recovery performance. Implications, limitations and future research are discussed at the end. This study proposes model of influence of TQM in service recovery performance, whereby empowerment fully mediates this relationship.

Mukhles m. al-ababneh

Vesical explosion during transurethral resection of the prostate (TURP) is an extremely rare, serious and dreadful complication, which should be considered as a blast injury requiring urgent exploratory laparotomy and repair. Until 2019, only 38 cases have been reportedin the International English literature. The underlying mechanism for this rare intravesical explosion is the generation and trapping of explosive gases under the dome of the bladder, which eventually detonates by sparks from the cutting electrode during TURP. Herein, we repor0low-up. Although uncommon, vesical explosion during TURP may occur and some preventive measures, discussed here, can be carried out to avoid this dreadful complication. In addition to the discussion of its mechanism, we will discuss the preventive measures of this dreadful event. To the best of our knowledge, this is the first case of a vesical explosion reported in our department.

Karishma

Objective: This study fills an important research gap by focusing on the effectiveness of low-impact exercise in Parkinson's disease (PD), taking into account the different challenges faced by people with varying degrees of disease severity. Motivation: Unlike generic investigations into exercise and PD, our research prioritizes low-impact activities, considering safety concerns related to balance deficits and coordination challenges in the PD population. The study aligns with a patient-centred approach, aiming to provide a safer alternative to traditional exercise modalities. Approach: Conducting a comprehensive literature review, we conducted an online literature search on various databases, specifically investigating about low-impact exercises on both motor and non motor symptoms in PD individuals. Review process involved capturing diverse intervention types, durations, frequencies, and intensities. Findings: The amalgamation of diverse outcome measures, including UPDRS, Berg Balance Scale, TUG, 6MWT, and PDQ-39, showcased the multifaceted impact of low-impact exercises on both movement related and non-movement related symptoms. Notably, aerobic exercises being treadmill walking, cycling, and group sessions, emerged as pivotal interventions, demonstrating improvements in gait, balance, flexibility, and overall quality of life for PD individuals. Conclusion: While acknowledging limitations, such as potential publication bias and a focus on aerobic exercises, this study provides meaningful decision making information for clinicians and researchers. Future research should diversify interventions and methodologies to enhance the evidence base and address nuanced aspects of low-impact exercises in PD management. The results of this review contribute to the existing body of knowledge regarding the nuanced benefits of personalized low-impact exercise for Parkinson's disease.

Nagarjuna narayanasetti

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

Mamta gaur

In India, the campaign to legitimise community radio began in mid-1990s, soon after the Supreme Court of India ruled in its judgment of February 1995 that “airwaves are public property. Though the approval for setting up of Community radio stations in India was granted in 2002, it is yet to develop in the valley of Kashmir. Till now, the valley has not established any community radio station, but the first effort to use radio for the development of the community was made in 2009 when Panos South Asia, in collaboration with the Islamic University of Science and Technology (IUST), a rural University in Awantipora (Kashmir) started a community radio program in the Awantipora community. The program named “Pesh Kadam” meaning “Step Forward” started in 2009 and completed 350 episodes in 2018. This paper is aimed to study the reasons for absence of community radio stations in Kashmir. It also documents the efforts made to bring this medium to Kashmir and understand the evolution and challenges of first ever community radio program in Kashmir, study its content, analyse its popularity and efficacy. Both qualitative and quantitative research techniques are deployed in this study.

Ruheela hassan

Most of mosquito-repellent products and devices are made up of synthetic materials presenting market which causes various harmful effects on human beings. The resistance can be developed by the mosquito due to continuous exposure at high doses. Hence, the present research work represents the development and evaluation of mosquito repellent sticks with the help of various herbal products such as starch powder, wood powder, charcoal powder, eucalyptus oil, coconut oil, lavender oil, lemongrass and cinnamon oil, peppermint and citronella, neem oil making them ozone-friendly, financial effective, non-harmful.

Archana mehrotra

Paracetamol is one of the most found over the counter drugs worldwide. It is widely used as an analgesic and antipyretic drug. Many commercial types of paracetamol tablets are available under different brand names in the Libyan drug market. The present study was conducted to evaluate post-marketing quality parameters for three brands of paracetamol tablets marketed in Libya. All three brands were evaluated for weight variation, hardness, friability, disintegration time and uniformity of content following British pharmacopeia guidelines. The outcomes of this study showed all tested brands complied with the British pharmacopeia specifications for the weight variation test, friability test (0.05%-0.17%), and hardness test (171.3N-197.6 N). In addition, two brands passed the British pharmacopeia requirements for the disintegration time test, whereas one brand exceeded the allowed disintegration time by about five minutes. Furthermore, high performance liquid chromatography was used to determine paracetamol content. Although the average amount of paracetamol drug available in these brands is not very close to 100%, where one brand achieved the lowest value (438.1 mg), the loaded dose of paracetamol in selected tablets in the three brands was within the British pharmacopeia standard specifications for the uniformity content test. Therefore, it can be concluded that almost all the three tested brands of paracetamol tablets that are available in the Libyan drug market meet the British pharmacopeia specification for quality control analysis.

Mediterranean journal of pharmacy and pharmaceutical sciences

Sheath blight and Sheath rot of rice caused by Rhizoctonia solani and Sarocladium oryzae is an economically important disease causing rigorous yield losses. Biological control of the disease using plant growth promoting rhizobacteria (PGPR) is a potential substitute to the presently available chemical control methods. The present investigation was aimed to study the plant growth promoting (PGP) activity and antagonistic activity of two rhizobacteria Pseudomonas fluorescence and Rhizobium sp., isolated from rhizosphere area of rice, against two major rice pathogens. In the present work IAA (Indole acetic acid production) was found maximum amount in Pseudomonas fluorescence (30 mg / ml) and trace amount in Rhizobium sp. Maximum amount of Siderophore production was noticed in both isolates. Pseudomonas fluorescence showed positive result for the HCN production but Rhizobium sp., was found to be negative and both bacterial isolates solubilized phosphate in very effective manner. Both rhizobacteria were found to produce ammonia and catalase. The cross streak studies revealed that the complete inhibition of mycelia growth of Rhizotonia solani (85%) and partial inhibition of Sarocladium oryzae (45%) against two rhizobacteria. Antifungal compound extracted from both rhizobacteria were found to exhibit maximum antagonism against rice pathogens. This result concluded that both PGPR’s can be used as best bio-control agent against rice pathogens instead of hazards chemicals.

Dr. saranya devi k

The most important factor that affects the crop production in terms of nutritional content of foliar plants is the global climate change. Herbivore’s growth, development, survival and geographical distribution all are determined by elevated CO2 and temperature. The interactions between herbivores and plants have changed due to increasing level of CO2 and temperature. The effect of high CO2 and temperature on grain legume plant which change in to plant physiology (e.g., nutritional content, foliage biomass) and how it change in herbivory metabolism rate and food consumption rate. Plant injury is determined by two factors viz. resistance and tolerance and both are influenced by greater CO2 and temperature. Legumes are an important source of food and feed in the form of proteins and also improve the soil environment. The repercussions of the abiotic factors mentioned above needs discussion among the scientific community. We may able to limit the negative repercussions of stated factors in future breeding projects by harnessing the practical favourable impacts and by including such influences of elevated CO2 and temperature on pulses productivity. The extensive research is necessary to overcome the negative effects of high CO2 and temperature on insect-plant interaction

Dr. babu lal jat

Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised by agranulocytosis as adverse effect. Subsequent to nonenzymatic hydrolysis, the primary metabolic step is N-demethylation of 4-methylaminoantipyrine (4-MAA) to 4-aminoantipyrine (4-AA). The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating this reaction. This study identified the relevant CYP using virus expressed isolated human CYP, human liver microsomes and rat liver microsomes with chemical inhibition studies. The substrate of 4-methylaminantipyrine was employed at six different concentrations (25, 50, 100, 400, 800 and 1200 µmol per l) with varying concentrations of selective inhibitors of CYP1A2 (furafylline, fluvoxamine), CYP3A4 (ketoconazole), CYP2A6 (coumarin), CYP2D6 (quinidine), CYP2C19 (omeprazole, fluvoxamine, tranylcypromine), CYP2C9 (sulphaphenazole) and CYP1A1 (alpha-naphthoflavone). 4-MAA and 4-AA were analyzed by HPLC and enzyme kinetic parameters (Km and Vmax) were determined by regression (Sigma plot 9.0). The N-demethylation of 4-MAA by microsomes prepared from baculovirus expressing human CYP was pronounced with CYP2C19. Intrinsic clearance of the most active enzymes were 0.092, 0.027 and 0.026 for the CYP enzymes 2C19, 2D6 and 1A2, respectively. Metabolism by human liver microsomes was strongly inhibited by fluvoxamin, omeprazole and tranylcypromine (IC50 of 0.07, 0.07 and 0.18, respectively) but with coumarin, sulphaphenazole, ketoconazole, moclobemid, quinidine alpha-naphthoflavone and furafylline were 0.79, 1.20, 1.36, 1.44, 3.46, 4.68 and 8.41, respectively. The enzyme CYP2C19 apparently has an important role in N-demethylation of 4-methylaminoantipyrine which should be further analyzed in clinical studies and which may also be interesting concerning the agranulocytosis.

Mediterranean journal of pharmacy and pharmaceutical sciences

Human resource management (HRM) is the process of employing people, training them, compensating them, developing policies relating to them, and developing strategies to retain them. As a field, HRM has undergone many changes over the last twenty years, giving it an even more important role in today's organizations

Zamzam abdelazim

Worldwide, the threat created by antibiotic resistance to public health calls for immediate action. Antibiotic resistance is one of the main causes of the emergence and spread of dispensing of antibiotics without a prescription. This study aims to investigate the dispensing of antibiotics without a prescription and the reason behind that in the community pharmacy in Libya. The study was randomized analytical conducted between March and April 2023 among pharmacists and assistant pharmacists employed by community pharmacies in various Libyan areas Tripoli, Zawia, and Sabratha. The data were analyzed by Fisher's exact and Chi-square tests to predict the determinations of dispensing antibiotics without prescriptions. In this study, a total of 293 participants were included, 63 had been excluded because they did not meet the inclusion of the study. The remaining 230 were enrolled for final analysis, most of them were female subjects (70.7%). Findings showed that 78.7% of the participants consulted with patients about the reason for requesting a specific type of antibiotic, while 68.7% dispensed antibiotics with probiotics. Study participants with 2 - 4 years' work experience were 76.6% higher toward dispensing of antibiotics without a prescription (P=0.683). The major reason for dispensing antibiotics without prescriptions were pharmacists knowledgeable enough to give a patient antibiotics without a prescription (68.3%). In Libya, misuse of antibiotics by the public is widespread. People can purchase antibiotics without prescription. Thus, dispensing of antibiotics without a prescription in community pharmacies is an alarming issue in Libya which can increase antibiotics resistance. Pharmacists' knowledgeable is high in dispensing patients antibiotics without a prescription, but patient pressure and financial issues are the major reasons behind dispensing antibiotics without a prescription. It can be recommended that the importance of antimicrobial stewardship and the need for ongoing education support for community pharmacy professionals is of importance.

Mediterranean journal of pharmacy and pharmaceutical sciences

Education is power. It constitutes the foundation of all the multidimensional socio-economic development of a country. In the present context, we need manpower or human capital for generating the growth and development in a country. The Government of India has taken several many initiatives for promoting education at all the stages i.e. Primary, Secondary and Higher. But still, we find such issues as a high dropout rate at all the stages of education, rural-urban disparity, gender disparity, interstate variations pose as some of the problems that impedes the development of human resources in our country. Even the work participation rate in India indicates the necessity of proper planning of skill training and employment opportunity. Most interestingly, the existing general and conventional higher educational institutions have not effectively been able to cope with the contemporary challenges and changes with the result that the nature of curriculum which is by and large in place tends to create only degree inflation in our country. So, we need such institutes and institutional arrangement that can cater to the contemporary challenges so as to upgrade the quality of education as well as to provide need based educational programmes that can develop human power in the society. Effective or quality education especially at higher level can play a vital role in bringing around multifaceted human resource development, enabling the learner’s absorption in the job market and selfemployment. This paper will discuss how the accessibility of education can be promoted to all through a convenient mode of education system and how the disparities in education can be minimized, and also focus on the various strategies for strengthening higher education system in the country.

Dr gedam kamalakar

Stakeholder plays significant roles in project success. They ensure clear communication of project goals, contribute to decision-making, and demonstrate commitment, increasing the likelihood of successful outcomes. They also act as advocates within their organizations, generating buy-in and support. The main purpose of this paper is to identify and discuss the roles of shareholders in a project success. The paper is conceptual in nature and uses a number literatures ranging from 2007 to 2023 from a good number of journals. After scrutinized the literature review, the paper concludes a number of findings. The findings implies that stakeholders in a project is crucial for its success and sustainability. Stakeholders play a significant role in ensuring the performance of the project. Project managers need to acquire stakeholder management skills to address the communication requirements of stakeholders. This is important for the success of the project. The paper recommend that policymakers, practitioners and academia have to ensure the expectations and make a balance among the stakeholders.

Nazim ullah

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa

Several intricate interactions of environmental and genetic factors can lead to autoimmune conditions in susceptible hosts. Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease which can be triggered or exacerbated by infection or infectious reactions. The causal link between infections and autoimmunity has been established through clinical studies. Although several viral infections have been associated with SLE, yet the impact of COVID-19 on SLE onset and flares has not been well established. We report a young female who developed new-onset SLE shortly after having COVID-19 infection. Her clinical and lab parameters were highly suggestive of SLE and she responded to standard medical therapy. We also briefly discuss the pathogenetic mechanisms of autoimmunity in cases of viral infections.

Karishma

In this report, Tesco PLC's operation and project management have been fully elaborated on. Tesco PLC is a retail organization that deals with retailing and other related activities in insurance service and retail banking (REUTERS, 2020). Tesco is multinational general merchandise and groceries with headquarters at Welwyn Garden City in England. Based on gross revenue rating, Tesco is the third-largest retailer in the world. Tesco was created by Jack Cohen in 1919 in Hackney, London as a set of markets stalls. Tesco developed and expanded very fast in the whole world and above 100 Tesco shops in the entire Facebook. Tesco has segments in ROI and the UK that is; central Europe (Hungary, Slovakia, and the Czech Republic), the Republic of Ireland, and the United Kingdom which do similar activities to those done in Tesco bank in the United Kingdom (Bedford, 2022). Tesco avails different personal banking packages (services and products) that include personal loans, personal current accounts, and credit card receivables. Tesco's businesses are therefore Tesco Hungary, Tesco UK, Tesco Czech Republic, Tesco Slovakia, Tesco Ireland, Dunnhumby, and Tesco Bank.

Zamzam abdelazim