Introduction: Study was conducted with an objective of investigating the inhibitory effect of Phaseolus lunatus seeds extract on three enzymes (α-amylase, maltase and glucoamylase) involved in diabetes. The disadvantages related to the use of synthetic drugs make it necessary to search for alternative medicines from medicinal plants. One therapeutic approach for treating postprandial hyperglycaemia is to decrease the plasma glucose level, which can be attained by lowering the starch hydrolysis by digestive enzymes such as α-amylase, maltase and glucoamylase. The use of synthetic antidiabetic agents caused gastrointestinal side effects. Methods: Hence, the research was aimed to evaluate the potential of Phaseolus lunatus seeds extract to inhibit α-amylase, maltase and glucoamylase as a possible mechanism of hypoglycemia caused by this plant with fewer side effects. Phaseolus lunatus, also known as Lima bean, is native to Tropical America and grown worldwide. Lima bean has been prescribed traditionally to treat different diseases, including diabetes. Result: The results of the present study showed that Phaseolus lunatus seeds extract has exerted both time and concentration-dependent Significant inhibitory effects on these digestive enzymes might be due to the cumulative impact of phytoconstituents in the plant extract. Conclusion: Therefore, it can be said that the part mechanisms by which Phaseolus lunatus exhibited its antidiabetic activity might be through inhibiting this digestive enzyme.

Dr. salman ahmed

Cardiovascular disease (CVD) remains the leading reason of death among patients with diabetes mellitus (DM). Individuals with DM have a two to five time's greater risk of developing CVD than non-DM. Unfortunately, little data exists on Libya's prevalence and characteristics of cardiovascular risk factors. This study aimed to evaluate the cardiovascular risk factors and to assess their control among patients with type 2 DM (T2DM). All the patients with T2DM who attended the outpatient clinic at National Diabetes Hospital from September 2013 to April 2022 were interviewed and examined and included in this study. Demographical data age, smoking habit, body mass index measure, drug intake, history of previous cardiovascular events, blood pressure and fasting lipid profile were all recorded. 1049 patients have completed the study with a mean age of 54.06 ± 14.5 years old (females represented 68.0% of the studied sample size), there were different duration of diabetes between the studied sample, varying from newly diagnosed patients (n = 265, 25.2%) and above ten years of diabetes duration patients (n = 488, 46.5%). Active smoking in 129 patients (12.3%), the bodyweight of studied patients ranged from 44.0 Kg to 186 Kg (85.65 ± 1.73), 820 of the patients had uncontrolled body weight (78.85%). Uncontrolled blood pressure, even with treatment, was found in 304 patients (29.0%), uncontrolled dyslipidaemia in 45 patients (04.3%), and uncontrolled hyperglycaemia in 816 patients (77.9%). Established CVD was positive in 295 patients (28.2%), maximum age group was in 54 - 74 years (n = 516, 49.3%). The most typical age group with multiple (more than three) CVD risk factors was 54 - 74 years of age, were female patients with more than ten years of history of diabetes, uncontrolled hyperglycemia (HBA1c > 10%), uncontrolled body weight, uncontrolled blood pressure and dyslipidemia. Thus, the present data indicated that Libyan patients with diabetes mellitus have high CVD risk factors. Even in patients with previous events, these uncontrolled risk factors elevate the likelihood of repeated cardiovascular events. Patients with diabetes mellitus necessitate a more aggressive approach to control the modified risk factors such as hypertension, dyslipidemia, obesity and smoking.

Mediterranean journal of pharmacy and pharmaceutical sciences

Araucaria columnaris is one of the ornamental plants of all over the world. It is commonly known as Christmas tree. In the present study tree exudates – resin from the bark of the Araucaria columnaris belonging to the family Araucariaceae were investigated for phytochemical and antibacterial activity. The resin was separately extracted with different solvents based on its polarity, water, methanol, ethyl acetate and benzene. The extracts were screened for phyto-chemical analysis, the result shows that methanolic extract involved in extraction of large number of phytochemicals when compared with other extracts and subjected to antibacterial assay against major human pathogens. Methanolic extract act as good inhibitory agent against major microorganisms. This finding revealed that methanolic resin extract of Araucaria columnaris had significant potential for the control of dreadful diseases causing human pathogens.

Dr. saranya devi k

This article presents the relevance of Mahatma Gandhi’s philosophy toward the Social Work Profession in India. It is a review article prepared with secondary data available in books and journal articles. Mahatma Gandhi was a prominent leader of the Indian independence movement in British-ruled India. His principles viz. Non-violence, Satyagraha, Swadesi, Sarvodaya and Democratic leadership led Indians to strive to bring independence to India. He had launched the freedom struggle movements viz. Dandi Salt March, Quit India and Non-Cooperation Movement for Independence. Gandhi found a few disparities in India and developed a concept called constructive programme with the points of conflicts between different religious groups, castes, untouchability, fear arising out of ignorance, economic disparities, decaying condition of our villages, the plight of Adivasis, Kisans and the labourers, and the position of women, etc. Gandhiji motivated his followers, and freedom fighters to work on the said disparities. These constructive programme points are very relevant to the social work profession and nowadays many social workers are working on these programmes. This article presents how Gandhian principles like Nonviolence, Satyagraha, Swadesi, and Sarvodaya are relevant to the social work profession. Gandhiji Principles such as seeking truth through service to the poor and needy, individual self-development and self-reliance, nonviolence social action and material simplicity are very related to the code of ethics of professional social workers. The study suggested that professional social workers should practice the principles of Mahatma Gandhi in their interventions. The associations of professional social workers should adopt the Gandhiji principles and include them in the social work curriculum

Vijaya abraham

Community pharmacy has undergone a rapid expansion with various services moving away from the traditional supply function to other patient-focused services. Thus, the aim of this study is to examine consumer views and expectations toward the services provided in Libyan private community pharmacies, as well as customers' skepticism and their general satisfactions toward these services. The study is descriptive, cross-sectional survey and self-designed administered questionnaire. Study population comprised 0f adult patients or costumers who visited the community pharmacies. Out of the 600 questionnaires were personally handed, 462 of the distributed questionnaires were returned (response rate 77%). The majority of the participants reported that community pharmacy staff dealing with customers in polite ways (75%) and providing privacy and sufficient consideration (60%). Respondents agreed that the staff listens attentively and satisfied with encounter time by 60% and 50%, respectively. For provision of drug information as “how the drug work in the first-time use”, “customer experience of the side effects” and “their ability to using the prescribed medicine properly” were reported by 45%, 30% and 30%, correspondingly, while 60% of the respondents denied that staff provided the medication storage information. Regarding the customer skepticism toward community pharmacy services, 55% respondents agreed that services of community pharmacies tend to just concern on commercial aspects and 60% of respondents believed that services concern toward the business matter more likely than patient health. Interestingly, 85% of the respondents acknowledged the role of community pharmacy as indispensable healthcare setting. The availability of the pharmaceutical product and the cost of pharmacy products satisfied by 40% and 20% of the respondents, respectively. In conclusion, this study demonstrated low customer satisfaction with regard to community pharmacy services in the southern region of Libya. Community pharmacy staff should have an understanding of the codes of conduct and the ethical requirements for their practice of pharmacy profession.

Mediterranean journal of pharmacy and pharmaceutical sciences

Migratory behaviour in Littorina scabra (Linne 1758) was studied in a mangrove ecosystem and observations were made in their natural habitat or in situ observation in Tanjung Tiram, Ambon. Migratory speed and pattern of L. scabra of different sizes (small and large) particularly in mangrove Sonneratia alba were observed throughout of the February 19th to March 11th, 2019 during the day and night on incoming or outgoing tides and these are usually a 3 hours (270 minutes) observation. Marked snails were used to track the position to investigate their migratory direction and speed during advancing and receding tides. Those organisms migrate up and down the trees following the tidal cycles. This study indicates that small size organisms which live on leaves, branches or trunks move faster than the big organisms and they move faster during the incoming tide than outgoing tide. For a big size L. scabra, they move slower during the incoming tide than the outgoing tide. This behaviour indicates that they move faster to avoid immersion during incoming tide than during the outgoing tide when they move slower because they are searching for food. The migration trials showed different patterns for all sizes of L. scabra and this pattern seems to be influenced by the area of surface they occupy such as leaves, branches or trunks. They tend to move forward in one direction (almost straight line) when they are on a small surface such as trunks and on the larger surface such as leaves and braches most L. scabra of all sizes make different trial patterns such zig-zag.

Irma kesaulya

The soil samples were collected from Melia dubia plantations in two different locations in Tamil Nadu. A total of twenty five actinomycetes isolates were isolated and they were screened for melanin pigment production using different culture media. Only two isolates were able to produce melanin pigment under in vitro study and one isolate showed positive reaction to L-tyrosine substrate. Based on morphological and bio-chemical characters the isolate was identified as Streptomyces sp. The DNA of the isolate was isolated and its 16S rDNA gene was amplified and sequenced. The phylogenetic analysis of Streptomyces puniciscabiei was carried out.

Dr. saranya devi k

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

La lecture de toute production romanesque signée d’une Africaine, laisse souvent transparaître a priori l’idée qu’elle évoque la victimisation de la femme par la gent masculine. Mais, à certain niveau, l’univers de sa fiction n’affiche pas de façon catégorique ou formelle cette question. Tel est le cas de Fatou Diome avec son roman en cours de décryptage. Le but de cet article est de montrer que l’auteure construit son texte autour de plusieurs facettes pour assurer la transmission des valeurs identitaires et que le choix de certains genres oraux et l’évocation de la problématique de genre (homme-femme) offrent des concepts qui servent à exprimer des faits propres à l’identité culturelle africaine. À partir d’une analyse thématique et sociocritique, nous comprenons qu’elle adosse insidieusement à ce thème la problématique de l’identité. Ce, à partir de plusieurs artifices littéraires qui sont entre autres le potentiel oral traditionnel du terroir et le discours revalorisant la femme, par ricochet l’identité africaine.

Assanvo

Background: Cancer is burden for almost all societies in the world. It is estimated that approximately 20 million persons are suffering with cancer and every year 10 million die due to cancer. Methods: A descriptive and comparative survey from January 2024 to June 2024 with a quantitative research approach was used. The non-probability convenient sampling technique was used, and 60 nurses (30 each from Cancer Hospital; and General Hospital) had given consent for participation in the study. The tools used for data collection were personal profile, structured knowledge questionnaire, modified Likert-type attitude scale, and opinionnaire for utility of SIM. Results: The study found that 83.35% of General Hospital and Cancer Hospital nurses had strong knowledge, while 10% and 6.66% had low knowledge. All nurses from both institutions have mildly positive to extremely positive thoughts about how oral cancer affects oral hygiene and nutrition. Mean knowledge scores of nurses from General and Cancer hospitals were 14.73 and 16.33, and mean attitude scores were 149.80 and 150.20. Cancer hospital nurses' expertise and attitude correlated significantly. The results show that 86.67% of nurses believe SIM is a valuable source of information and content to assist them better manage oral cancer patients' oral hygiene and nutrition. Conclusions: The study found that cancer hospital nurses had a higher mean knowledge score than general hospital nurses. Thus, knowledge and attitude are linked, and nurses with higher knowledge have a more positive attitude.

Dr k c yadav

Purchasing is one of the key managerial activities in every organisation, its significance having been identified during the 19th century. According to Kasilingham (2012, p.57), the period shortly before the Second World War marked the discovery of the fact that a firm’s success was not so much dependent upon what it was capable of selling but rather on how able organisations were to acquire necessary services together with materials from vendors. This discovery was triggered by a global shortage of virtually all fundamental materials for supporting operations, coupled with an abnormal rise in prices following the First World War. Since that time, purchasing has gained significance for the critical role it plays towards ensuring continuity of production (Hacioglu, 2019 p.265). Worth noting is that purchasing acts as “an interface between suppliers and functional areas within the buying organisation” (Crandall, Crandall & Chen, 2009 p.265). Among some of the functional areas that are influenced by purchasing are finance, marketing, production, and quality assurance (Magad & Amos, 2013 p.225). A vital deduction that can be made from this latter statement is that for the purchasing function to proceed smoothly and make the other functions- and the entire organisation- active, organisations must cultivate and maintain good relationships with suppliers and all other players in the supply chain. In addition, organisations operate in environments that are highly unpredictable; the techniques needed to perform the purchasing function become more refined almost every day due to constant changes in the market (Kasilingam, 2012 p.57). Subsequently, there is a need for managers in organisations to understand and embrace the idea of sustainable procurement.

Mohamed sorogy

Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Dr. salman ahmed

Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)–activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells. Diabetic model rats were administered standard diets supplemented with 5% oyster mushroom powder (mushroom-treated (MT) group) and 5% fenugreek seed powder (fenugreektreated (FT) group) for 8 weeks. The results showed improvements in both glycemic and lipid profiles, with both oyster mushroom and fenugreek enhancing the phosphorylation of AMPK in muscle tissue. However, no effect on insulin secretion was observed. These findings suggest that both substances reduce hyperglycemia through an insulin-independent pathway. In silico analysis of both mushroom and fenugreek seed extracts revealed bioactive compounds having a strong binding affinity to α-glucosidase, which suggests mushroom and fenugreek supplements might control postprandial blood glucose levels.

Arafat hassan razon

Pneumocephalus is a rare condition characterized by the presence of intracranial air, most commonly seen after head trauma or surgery. Although it is often asymptomatic, it can lead to serious complications such as tension pneumocephalus and seizures. This study presents a case of iatrogenic pneumocephalus and seizures that developed after a flap rotation operation in a patient with a history of craniotomy. An 82-year-old male patient presented to the emergency department shortly after flap rotation surgery with loss of consciousness and generalized tonicclonic seizures. Brain computed tomography revealed a left temporal bone defect and epidural air collection. Diffusion magnetic resonance imaging showed no acute ischemic lesion. The patient was initially started on levetiracetam, but due to side effects, he was switched to a combination of valproate and lamotrigine. The patient developed pneumonia during follow-up and was treated in the intensive care unit and discharged in stable condition. In patients who have previously undergone craniotomy, the risk of pneumocephalus should be considered even in minor surgical procedures, and early imaging should be performed when new neurological symptoms develop.

Karishma

By January 2020, severe acute respiratory syndrome coronavirus-2 has spread internationally to a pandemic that mainly targets the respiratory system. The relevant infectious disease has been identified as coronavirus disease-2019 (COVID-19) by World Health Organization and declared as a global pandemic. In Libya, National Center for Disease Control reported the first case of coronavirus disease-2019 on 24th March, 2020. The authorities decided to close borders and activate designated treatment centers to deal with COVID-19 cases and contain the outbreak of SARS-COV-2. This study aimed to assess and evaluate the pharmaceutical situation of medications used in pharmacological management of hospitalized COVID-19 patients in Tripoli, Libya. Three WHO availability indicators were selected to be studied and reported. A comprehensive list of medicines used in the management of hospitalized COVID-19 patients was constructed after reviewing and comparing seven national and international pharmacological management protocols and guidelines for hospitalized COVID-19 patients. This comparison revealed that nearly 50 medications are intended for use in COVID-19 inpatient pharmacological management. They all agreed about the use of three medications, representing one from each main class. This list was used to cross check their availability at the chosen designated COVID-19 treatment center. This study proved that local treatment center’s protocol is more in line with international guidelines than the national treatment guideline. The later was issued on March 2020. The Libyan National Essential Medicines’ List contained 25 out of 50 medications of the comprehensive list based on the last update in April 2019. This study recommends that national treatment guidelines and National Essential Medicines’ list require updating. Not all medications used in COVID-19 inpatient management were available in local treatment centers, although, the Emergency Management Department of Ministry of Health in Libya is responsible for the supply of the required medical supplies and medications to the COVID-19 treatment centers.

Mediterranean journal of pharmacy and pharmaceutical sciences

Purpose of this study is examining the cause of stress among selected private banking employees. Stratified sampling method was used to carry out the data collection. For this employee of various private banks were chosen. A questionnaire with 12 items with dichotomous (Yes-1, NO-2) were developed and tested for reliability and prior to the distribution of questionnaire. 253 respondents were selected from various private banks in Mysore district, Karnataka state India. The survey questionnaire was sent via email, requesting to complete it. The questionnaire includes 11 demographic information’s and statements to measure. Chi-Square analysis was carried out to examine the cause of stress among employee using SPSS21. We found that designations have significant influence on employee and The other factors of do not have any significant influence on employee. Therefore we concluded that in private banks demographic variable such as designation creates stress in all aspects. Future research should consider a larger sample from leading sectors where job natures are similar. Analysis should be more rigorous, where Amos could be used for analysis.

Dr manjunatha m k

Learning is a process of interaction that occurs between teachers and students. The learning process requires a way or method so that interaction occurs reciprocally and can achieve the desired learning goals. This research uses a descriptive qualitative approach, and the type of research is a case study. Data collection techniques using observation, interviews, and documentation. While the data analysis with an interactive analysis model (interactive analysis)—the validity of this research data uses the triangulation technique. The results of this study indicate (1) Planning for STAD Type Cooperative Learning Methods in Fiqh Subjects at MIMA 42 Wuluhan, namely: The teacher makes a Learning Implementation Plan (RPP), makes observation sheets and score assessment sheets, choose learning media, makes materials and questions. group and individual assignments, and designing study groups. (2) Implementation of STAD Type Cooperative Learning Method in Fiqh Subjects at MIMA 42 Wuluhan: Initial activity: the teacher explains the material that will be given to students. The core activities are: The teacher explains the method to be used, divides students into several groups, plays videos as material, asks students to observe pictures/videos of people, and discusses the material in the video. And all groups present the results of their discussions. Closing activities, namely: providing reinforcement to the material presented by students, the teacher and students reciting prayers, and the teacher planning follow-up learning. (3) Evaluation of STAD Type Cooperative Learning Method in Class Fiqh Subjects at MIMA 42 Wuluhan Jember, namely: Evaluation of observation and performance (demonstration) on group performance. Meanwhile, individual evaluation is in the form of homework (PR).

Educare: journal of primary education

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Dr. wahul umesh b

Now a day’s contribution of Electronic banking towards economic development plays a crucial role in developing countries like India. Banks are no longer restricted to traditional banking rather it is shifted to the virtual banking system. Customers are experiences more feasible in banking operations because of Information technology. The banks are adopting IT-enabled tools and techniques for banking operations which improve in offering quality service to the customers. In traditional banking customers has to visit bank branches to avail banking services. Now with the ATMs, Internet banking, Mobile banking and Information Technology-enabled services are replacing the traditional method of service. In the recent days banks are concentrating on value-based service through E-banking. The present study throws a light on the growth of Electronic banking and its product which are used in the banking sector.

Kamal singh

This paper found that 35% of Adivasis have health problems, and 73% said that they are getting treatment with RMP. 87% have toilet facility and more than 12% still defecate openly. 18.3% said that they faced different problems at open defecation, and 50% of women not using sanitary napkins. Nearly 90% of respondents wash their hands after toilets and coming from outside of the home. Ten per cent of respondents said that they do not have an awareness of sanitation. Therefore, the study confirmed that the sanitation facilities considerably made the women's dignity and quality of life better in the study area. Moreover, four case studies also focused on open defecation problems in the study area.

B suresh lal