Abstract Background: Hansen’s disease is a chronic infectious disease with a wide range of clinical manifestations. The clinical diagnosis must be confirmed by histopathological and bacteriological studies in order to adequately manage the condition and prevent drug resistance. Aim: To perform a clinico-histopathological correlation of skin lesions in all patients with a clinical suspicion of Hansen’s disease. Materials and methods: A retrospective, hospital based, cross-sectional study was conducted in the Department of Pathology, Father Muller Medical College, Mangalore. Skin biopsies of all suspected cases of Hansen’s disease received over a period of three and a half years were included in the study. Haematoxylin and eosin, Fite-Faraco stained sections of all cases were reviewed. The cases were classified according to Ridley–Jopling classification into TT, BT, BB, I, BL, and LL. Clinical details of the patient, including type and site of lesion were obtained from the patient’s medical records. Clinico-histopathological correlation was done for all the cases. In addition, wherever available, the corresponding slit-skin smears were also included. Results: A total of 76 cases were clinically diagnosed as Hansen’s disease. Clinico- histopathological correlation was seen in 33/76 cases (43.42%). The most common histological subtype of Hansen’s was Borderline Tuberculoid (BT) - 24/76 cases (31.58%). Maximum agreement was seen in Mid-borderline leprosy (92.11%). Fite Faraco stain was positive in 21 out of 76 cases. Slit skin smears were available for 55 cases and positive in 20 cases. Conclusion: Due to clinical and morphological overlap, it is imperative to correlate the clinical, histopathological and bacteriological index results in order to accurately subtype the categories in Hansen’s disease.

Archana

Monitoring and controlling of clean area environment is of paramount importance to ensure product safety and quality. This comprehensive analysis evaluates environmental monitoring (EM) data from Class C and Class D controlled environments in pharmaceutical manufacturing, utilizing Active Air (AA), Passive Air (PA), and Contact Plate (CP) or Replicate Organism Detection And Counting (RODAC) surface samples. The study aims to identify contamination trends, anomalies, and compliance with ISO 14644-1 and EU GMP Annex 1 standards. Results reveal unexpected findings: Class C Active Air (43 CFU/m³) and RODAC (3 CFU/plate) overall averages are higher than Class D Active Air (34 CFU/m³) and RODAC (2 CFU/plate), respectively, deviating from expected cleanroom classification. Class D Passive Air (22 CFU/plate) is higher than Class C (17 CFU/plate), aligning with expectations. Persistent hotspots were identified in Class C (e.g., location labelled “AA C 12 NG0”AA averages± Standard Deviation (SD): 67.33±17 CFU/m³), indicating localized control failures, while Class D showed extreme individual spikes (e.g., AA D 99 Ac: Max 171 CFU/m³). Sporadic contamination events in Class C suggest transient breaches, necessitating root-cause investigations. The study also highlights limitations of Class D monitoring, which obscures temporal trends and risks missing critical excursions due to long intervals between samples. Recommendations include targeted engineering assessments for high-load zones, enhanced Standard Operating Procedures (SOPs) for cleaning and gowning, adoption of real-time biofluorescent particle counters to replace manual sampling, and increased monitoring frequency in Class D hotspots.

Mostafa eissa

The core of the current study is to find out a different source of diet that stimulates better growth rate and low-cost feed for commercial fish milkfish Chanos chanos. This study was to assess the impact of partial replacement of fish meal by soybean meal in the diet of juvenile milkfish, Chanos chanos (initial weight 25 ± 0.6 g). The juveniles were fed with two types of isonitrogenous diets (40% crude protein). Plant protein source diet (D1) comprised of soybean meal 45% and 10% fish meal, while animal protein source diet (D2) contained fish meal 25% and soybean meal 30%. The trial was conducted with two replications for 60 days. Fish juveniles (10 each) were stocked in outdoor fiberglass seawater tanks (5000 Liters). Results revealed that final weight gain (WG), and specific growth rate (SGR) were significantly lower in fish fed D2 diet. Fish fed D1 had better feed efficiency, weight gain (21.88 ± 1.9 g), and SGR (1.05 ± 0.3), while D2 had a lower growth rate, WG (18.71 ± 2.3 g) and SGR (0.93 ± 0.2). The maximum growth rate found on plant diet which is significantly higher weight gain than D2. In D2 feed conversion ratio (0.54 ± 0.21) was significantly higher (P≤0.05). Condition factor among both treatments did not differ significantly (P≥0.05). The survival rate remained constant (100%) in both treatments. Based on the obtained results, it is recommended that 45% soybean meal with addition of 10% fishmeal (40% protein) is more effective than 30% soybean meal with addition of 25% fish meal to the omnivorous milkfish for aquaculture.

Imtiaz kashani

The presented mathematical model is used to form machine cells, optimize costs of exceptional elements and design the shop floor layout for various demands of components. The complete similarity measure algorithm forms machine cells and part families in a refined form. Later, exceptional elements are eliminated in linear programming optimization model by using machine duplication and part subcontract. Then the shop floor layout is designed to have optimized material movements between cells and within a cell. The performance evaluation of cell formation algorithm is done on case studies of various batch sizes to give the process capability compared with other similar methods. The result from a linear programming optimization model is cost savings, machines duplicated, parts subcontracted, inter intra cellular movements. Finally, the output of inbound facility design is the floor layout which has machine cell clusters with optimized floor area.

S ramesh

Livestock plays a significant role in the economy of a nation but its productivity can be hampered by numerous haemoparasites thereby leading to economic losses to the livestock industry. The prevalence of haemoparasite in cattle slaughtered at the Jalingo abattoir was investigated. A total of four hundred blood samples were collected at the point of slaughter, processed, and screened for haemoparasites by examining Giemsa-stained thin blood smears. An overall prevalence of 12.25% was recorded. Four haemoparasites of cattle with prevalence rates of 5.0%, 6.75%, 0.25%, and 0.25% for Anaplasma, Babesia, Microfilaria and Trypanosoma respectively were observed. The prevalence of haemoparasite in relation to sex, revealed higher infection in females (13.75%) than in males (10.0%) which were not found statistically different (P > 0.05). All breeds encountered during the study were infected with haemoparasites with the highest prevalence of 13.91 % recorded in White Fulani, Red Bororo (10.94%), and Sokoto Gudali (10.00 %), while Adamawa Gudali had the least prevalence of 0.5%. There was no statistically significant difference in the prevalence of haemoparasite in relation to breeds (P > 0.05). High prevalence was observed in the young (14.29%) more than the adult (11.59%) and older (12.14%). The current study has revealed the haemoparasites status in cattle slaughtered at Jalingo abattoir. Therefore, there is a need for effective preventive and control policy of these haemoparasites to enhance livestock productivity

Bitrus inuwa

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Experimental trials were conducted on the compatibility of urea 2% with insecticides of different groups viz., monocrotophos 36SL @ 500 ml/ha, cypermethrin 25EC @ 125 ml/ha, quinalphos 25EC @ 1000 ml/ha and novaluron 10EC @ 375 ml/ha against larval population of Helicoverpa armigera in the field conditions on chickpea cultivar “HC-1” during Rabi season 2011-12 and 2012-13 at CCS Haryana Agricultural University, Hisar (Haryana). These insecticides were found compatible with urea. Minimum larval population of H. armigera was recorded in novaluron 10EC @ 375 ml/ha at 3, 7 and 10 days after spraying. Monocrotophos 36SL @ 500 ml/ha, quinalphos 25EC @ 1000 ml/ha and cypermethrin 25EC @ 125 ml/ha could not provide consistent results against H. armigera. The larval population, pod damage and incidence were statistically at par with insecticides and their combination. No phytotoxicity effect was observed on the leaves with urea application in combination with insecticides. Minimum per cent pod damage (7.3%), maximum grain yield (14.6 q/ha) and monetary returns (` 6265/ha) was realized from novaluron 10EC @ 375 ml/ha plus 2% urea as compared to other treatments.

Dr. babu lal jat

This study sets out to explore the Critical Success Factors (CSFs) necessary for Total Quality Management (TQM) implementation in hotels. It also aims to classify participating hotels into groups based on their TQM adoption by using cluster analysis. A quantitative survey method was applied. Data were collected from a sample of managers from four- and five-star hotels in Jordan, 170 questionnaires were distributed to managers and 104 usable questionnaires were returned. The findings revealed that TQM is existed and implemented in the hotel industry. The researcher then confirmed that four- and five-star hotels can be classified into two groups, namely, “high TQM adopters” and “low TQM adopters”.

Mukhles m. al-ababneh

The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated that the level of the cardiac bio-marker troponin I in the blood plasma of rats exposed to severe hypobaric hypoxia for 3 h increased signifi-cantly compared to the control group, indicating myocardial injury. At the same time, the administration ofthe HIF-1α transcription factor inhibitor did not affect the plasma level of troponin I. In contrast, the releaseof the non-specific biomarker myoglobin into the bloodstream did not increase in response to hypoxia com-pared to the control animals. In addition, 24 h after the exposure to severe hypobaric hypoxia the serum myo-globin level was significantly lower in animals administered with the HIF-1α inhibitor topotecan than in ratsthat did not receive topotecan. Therefore, it may be assumed that the inhibition of the HIF-1α transcriptionfactor 10 min before exposure to severe hypobaric hypoxia reduces skeletal muscle damage. The mechanismsthat affect the adaptation of heart and skeletal muscles to hypoxia are discussed.

Даниил Федоров

Patients’ knowledge of hypertension and treatment has been found to affect health outcomes of hypertension. This study aimed to assess the impact of therapeutic patients’ education on knowledge of hypertension and lifestyle/dietary modification among hypertensive patients in Nigeria. The study was conducted among 317 hypertensive patients randomized into controlled and intervention groups (158 vs 159, respectively) between March 2021 and February 2022. Baseline knowledge of the patients was assessed and intervention was provided for the intervention group with a structured educational program at a baseline and six months. Descriptive data were presented with a frequency table in percentage while the chi-square test and univariate logistic regression were used to determine the association between categorical variables. Out of the total number of 318 patients, 275 completed the study (response rate: 86.8%) with 136 in the control group and 139 in the intervention group. The mean age of the patients was 59.5 (±12.5) and patients > 60 years (49.5%) were the most frequent age category. The baseline knowledge score of hypertension was 9.8 (±2.6) and 9.3 (±2.6) on a scale of 16 points in the control group and intervention group, respectively (P = 0.060) while at six months 11.9 (±2.3) vs 10.8 (±2.4) (P < 0.001) and 12 months 12.6 (±2.5) vs 9.5 (±2.0) (P < 0.001), respectively. Knowledge of lifestyle/dietary modification in the control group and intervention group at baseline was 7.0 (±2.1) and 6.6 (±2.0), respectively, while at six months 7.5 (±1.5) vs 9.9 (±1.3) (P < 0.001) and at 12 months 7.2 (±1.5) vs 10.4 (±1.2), respectively. Marital status, body mass index, and family history of hypertension were associated with knowledge of hypertension and lifestyle/dietary modification (P < 0.001). The educational intervention provided was found to be associated with a significant improvement in knowledge of hypertension and lifestyle/dietary modification. The marital status of the patients, body mass index and family history of hypertension influenced patients’ level of knowledge.

Mediterranean journal of pharmacy and pharmaceutical sciences

Creating a strong business and building a better world are not conflicting goals – they are both essential ingredients for long-term success. Canara Bank is one of the leading banks in the banking sector which is serving a lot of customers. The initiatives of the Bank under CSR have been the setting up of Trusts and Institutions which have created an impact in serving the people and society at large.Bank has been engaging employees and motivating them employees for participate in CSR activities. Bank has established a Community Development Section’ under FI Wing whose activities include organizing blood donation camps, health check up camps, career guidance and many more. The objective of this paper is to resolve the activities initiated by Canara Bank and the funds allotted in various areas.

Vidya bhat

Over the past 20 years, universities have been faced with sustained change, driven by external factors. This has led to the evolution of the teaching and research mission and the creation and rise of the third mission. Such mission extension has led to the emergence of entrepreneurial universities which has seen a move from traditional research and teaching business models, to business models which incorporate a much wider range of activities, to meet stakeholder demands as well as sustaining and growing universities in the era of intense national and international competition. This special issue extends knowledge by providing novel insights into the multidimensional antecedent contextual influences, consequences and implications of university mission expansion. We also provide a foundational research agenda which will help guide future research exploring the changing and expanding university missions and business models. Higher education system plays an important role for the country’s overall development which includes industrial, social, economic etc. Indian higher education system is third largest in the world. The role of Indian higher educational institutes such as colleges and universities in the present time is to provide quality based education in the field of education, research etc to empower youth for self sustainability. This paper includes the key challenges that India is currently facing in higher education and also includes some initiatives taken by the government to meet those challenges.

Dr gedam kamalakar

Hypnea pannosa J. Agardh (a methanol extract of the whole alga) was subjected to antifungal screening. The extract showed good activity against Trichophyton longifusus, low activity against Candida glabrata, and inactivity against Fusarium solani.

Dr. salman ahmed

This study aimed at the evaluation of the quality attributes and sensory properties of noodles produced from composite blends of acha, adu, mungbean and moringa oleifera seed. Composite flours of acha, adu, mungbean and moringa oleifera seed were formulated by total replacement of wheat with acha, adu, mungbean and moringa oleifera seed at different graded ratios (B= (55:35:5:5), C= (55:30:10:5, D= (50:30:15:5), E= (50:25:20:5), F= (45:25:25:5) while 100% wheat flour was used as the control (sample A)). The composite flours were used to produce noodles and the noodles subjected to proximate analysis and sensory properties evaluation. Proximate analysis revealed that the noodles contained moisture content of 10.22-13.90%, 2.32-4.48% ash, 10.13-17.90% protein, 1.50-5.71% lipid, 0.48-3.68% crude fibre, 54.33-75.35% carbohydrate and 340.31-355.42Kcal/100 g energy. There was an increase in the moisture, ash, protein, lipid and crude fibre contents with a decrease in carbohydrate and energy contents as the amount of mungbean flour increases. Sensory evaluation scores showed that noodles made with 0% wheat, 55% acha, 35% adu, 5% mungbean and 5% moringa oleifera seed can favourably compare with the control. It is recommended that the beany flavour of mung beans be removed before its addition in the composite blend in order to produce noodles that can be highly accepted.

Okechukwu obed chukwuemeka

Background: Preanalytical variability due to anticoagulant choice remains inadequately characterized in resource-limited tropical settings like Yemen, where environmental stressors exacerbate challenges. This study aimed to compare the stability and cost-effectiveness of K₂EDTA and K₃EDTA anticoagulants for complete blood count testing under simulated Yemeni conditions. Methods: Prospective study of 100 healthy adult male volunteers in Ad’Dla Governorate, Yemen (January–March 2025). Paired samples in K₂EDTA/K₃EDTA tubes were analyzed at baseline (T0) and after 6-hour storage at 22 ± 2°C (T6). Statistical analysis included Bonferroni-corrected repeated-measures ANOVA and paired t-tests. Results: Fresh samples showed high inter-anticoagulant concordance (ICC > 0.90). After 6-hour storage, K₂EDTA exhibited significant Mean Corpuscular Volume (MCV) reduction (Δ = −2.33 fL, p < 0 xss=removed xss=removed xss=removed> 2 hours), while K₃EDTA is preferable for immediate analysis. These findings provide preliminary guidance for hematology testing in Yemeni laboratories and similar tropical settings, pending validation in diverse populations and extreme conditions.

Karishma

Congenital constriction band syndrome (CBS) is a rare condition characterized by either partial or complete circular constrictions around limbs or digits. Possible consequences include acrosyndactyly of the digits, terminal amputations, and localized swelling with digital edema distal to the constrictions. Occasionally, a constriction band may lead to injury of a peripheral nerve. We report a case of CBS in a newborn presenting with radial nerve palsy caused by a constriction band at the level of the arm. Surgical release of the congenital constriction band was performed at 1 month of age, including neurolysis of the radial nerve. As a result, the nerve was decompressed, and hand function was restored. Given the rarity of radial nerve palsy as a complication of congenital constriction bands, this case enriches the limited literature by emphasizing the importance of early diagnosis and prompt surgical intervention to optimize functional outcomes. It also highlights the need for increased clinical vigilance and provides practical insights into managing isolated radial nerve palsies.

Karishma

The main purpose of this research is to know the relationship of liquidity and solvency in profitability of Ultra tech and Shree cements. Cement industry is one of the prime support services in giving work to the general population. In Ultra Tech Cement, return on equity is positively correlated with return on asset, current ratio and quick ratio and negatively correlated with debt equity ratio. In Shree Cements, return on equity is positively correlated with the independent variables. return on asset is negative weak relation with the independent variables. Current ratio is strong correlation with quick ratio and debt equity ratio

Dr. jeyalakshmi p

Background: Poverty and malnutrition are associated with the risk of developing tuberculosis (TB). Nutritional reintegration with anti-TB therapy may improve treatment success rate. Aim: To investigate the nutritional status of low-income pulmonary TB patients in relation to the different anti-TB treatment phases. Methods: Forty five pulmonary TB patients and 40 controls aged 19-54 years, receiving treatment at Infectious Disease Hospital, Calabar, Nigeria, between September 2018 and July 2019 were studied. Serum total protein, albumin, iron and vitamin A were determined by colorimetric and HPLC methods respectively. Height and weight were measured and BMI computed, and data analysed using Student’s t-test, ANOVA, and Pearson’s correlation at P<0 P=0.001).>0.05) respectively. Albumin and iron were significantly lower in CPAT-HIV compared with CPAT patients. Albumin correlated positively and significantly with iron (r=0.405, p=0.006) in TB patients. Conclusion: Tuberculosis is associated with decreased BMI, albumin, iron and vitamin A, and higher total protein, and globulin, suggesting that malnutrition may be associated with TB risk, poor treatment compliance and outcomes

Eworo raymond

This paper explores the topic of supply chain management using case studies of companies from the automotive industry. Focus is given to the manner in which supply chain strategies in the automotive industry are designed and implemented, and how automotive companies configure their supply chains through collaboration, lean principles and agility. The paper also explores how advanced technologies, notably Big Data analytics and the Internet of Things, are utilised in the automotive industry to maintain a competitive advantage. Key findings made in the discussion are that success in supply chain management is greatly enhanced if firms seek to integrate the different components making up the supply chain. Additionally, the collaboration between entities fosters trust, which is a vital ingredient in the application of lean principles. The automotive industry shows that companies should pursue flexibility and efficiency, which are captured in the notions of agility and leanness, respectively. The paper identifies collaboration and advanced technologies as two critical sources of sustainable competitive advantages to organisations primarily in reference to supply chain management.

Mohamed sorogy

The latest phase of capitalist expansion is called “globalisation”. That no state is an autarky but enjoys comparative advantage over others with certain resources and that free trade among these states would work for mutual benefit is the essence of it. Consequently, it advocates the minimization of the governmental intervention in economic affairs and encourages free play of market forces to foster economic development. The argument that this rationale is also applicable to higher education is increasingly gaining currency. But this paper attempts to problematise such a proposition and in contrary argues that this may prove inimical to national development. Education and especially higher education is considered to be one of the factors that help state to promoting national development. However, apologists of globalisation call for its commercialization and argue for the “withdrawal of the state” from this realm. This has only resulted in mystifying profound class inequalities within and without state. Higher education in India is not immune to this ideology in the guise of good economics. It is being structured in such a fashion since 1991 that it has been primarily coupled with the process of economic liberalization and privatization. International financial institutions like World Bank, IMF, GATT, GATS, etc are its votaries. Education was acknowledged as one of the key sectors to be traded. As a result, higher education as a “social good” is fast shifting to being a commodity in the market.

Dr gedam kamalakar