Garcinia cambogia, commonly known as Asam Gelugur, has entrenched itself as a traditional herbal medicine, renowned for its applications in treating obesity and its integration into global nutraceutical formulations. The bioactive compounds within, particularly hydroxy citric acid, mediate various effects. This study aims to assess the in vitro cytotoxicity of Taxol, a cytotoxic drug used as a control, and the aqueous extract from Garcinia cambogia against the Vero cell line - a kidney-like cell. Cytotoxicity was evaluated using the 3-(4,5-dimetyl-2-2thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The assay relies on mitochondrial succinate dehydrogenase's potential to reduce MTT, providing a colorimetric indication of cell viability. The results revealed an IC50 value exceeding 500 µg/mL for the aqueous extract from Garcinia cambogia significantly higher than Taxol's 0.0581 µg/mL. This higher IC50 value implies lower toxicity, positioning the Garcinia cambogia extract as a safe component in nutraceuticals and herbal supplements. The aqueous extract of Garcinia cambogia demonstrates low cytotoxicity, reinforcing its safety profile for use in nutraceuticals, which contributes valuable insights into the safety considerations of incorporating Garcinia cambogia into herbal supplements.

Mediterranean journal of pharmacy and pharmaceutical sciences

The notable developments in renewable energy facilities and resources help reduce the cost of production and increase production capacity. Therefore, developers in renewable energy evaluate the overall performance of the various equipment, methods, and structure and then determine the optimal variables for the design of energy production systems. Variables include equipment characteristics and quality, geographical location, and climatic variables such as solar irradiance, temperature, humidity, dust, etc. This paper investigated and reviewed the current big data methods and tools in solar energy production. It discusses the comprehensive two-stage design and evaluation for examining the optimal structure for renewable energy systems. In the design stage, technical and economic aspects are discussed based on a robust analysis of all input/output variables for determining the highest performance. Next, assess and evaluate the effectiveness of each method under different circumstances conditions. Then convert each qualitative indicator into a quantitative measure using extensive data analysis methods to determine the overall performance of the various qualitative variables. The paper also provides an in-depth analysis of the mathematical techniques used in measuring the efficiency of the renewable energy production system and discussing future axes of work in the field of specific energy.

Acaa pub

Implementation of Statistical Process Control (SPC) techniques in food and beverage industry are crucial to deliver consumable product that meets customer expectations. This study investigated industrial pH forecasting and process stability in a syrup manufacturing facility. We analyzed 1,247 pH observations with three objectives: (1) Quantify instability via control charts, (2) Model pH dynamics using Seasonal Autoregressive Integrated Moving Average (SARIMA) and Classification And Regression Trees (CART), and (3) Develop diagnostic frameworks for unstable processes. Methodologically, Exponentially Weighted Moving Average (EWMA) charts assessed stability; Box-Cox transformed SARIMA (λ=2) with seasonal differencing was used for forecasting; CART identified variable importance. Control charts revealed profound instability: 83.3% of points violated 3σ limits; run tests significant (p<0.001). For SARIMA, (1,0,1)(0,1,1)₁₂ achieved significant parameters (p<0.0001) with improved residual diagnostics versus non-seasonal ARIMA, though minor autocorrelation remained at lag 12 (p=0.003). CART explained training R²=18.86% and test R²=17.93% of pH variation, identifying filling weight and sodium benzoate as key predictors. Crucially, this study demonstrates that forecasting retains diagnostic utility even in unstable environments: SARIMA residuals provide seasonal fingerprints of assignable causes, while CART thresholds guide intervention priorities. SARIMA(1,0,1)(0,1,1)₁₂ demonstrated superior residual properties: eliminated back forecast warnings (present in ARIMA), reduced autocorrelation at lag 24 (p=0.017 vs 0.040), and explicitly modeled 12-period seasonality. While process instability persists, SARIMA provides diagnostic fingerprints of assignable causes through seasonal parameters (SMA₁₂=0.9846, T=513.12) and residual patterns. We conclude that SARIMA offers enhanced short-term forecasting capability, but process intervention remains essential for reliability. The study advocates for integrated instability-informed forecasting combining SARIMA diagnostics, real-time control charts, and expanded sensor deployment.

Mostafa eissa

Background: Perforation is the most serious surgical complication of peptic ulcer disease due to its attendant high morbidity and mortality. Hypovolemia, a consequence of gastro-duodenal perforation, is considered to be a cause of renal hypo perfusion with accompanied decreased clearance of urea and creatinine. The aim of this study was to determine the preoperative baseline serum urea and creatinine profile among patients with perforated peptic ulcer disease and the relationship of serum urea and creatinine with the outcome of care. Methods: A retrospective study of patients who had operation for perforated peptic ulcer disease over a 5-year period at Dalhatu Araf Specialist Hospital, lafia, North-central Nigeria was conducted. Results: Sixty-four patients were studied with a mean age of 36.6 ± 12.3 years. Majority of the patients were males, 59 (92.2%). While 38 (59.3%) patients had elevated preoperative baseline urea levels, 37 (57.8%) patients had elevated creatinine levels. Out of 29 patients who had surgical site infection, 16 (55.2%) had elevated serum urea (p = 0.535) while 19 (65.2 %) had elevated serum creatinine (p = 0.579). An overall in-hospital mortality rate of 14.1% was recorded. There was statistically significant relationship between elevated serum urea and inhospital mortality (p = 0.007). Conclusion: This result showed that preoperative baseline serum urea and creatinine levels were elevated in majority of the patients. In addition, the result of this study suggests that elevated baseline serum urea level has considerable relationship with in-hospital mortality

Karishma

Women are multi taskers in their lives- mother, wife, daughter, sister and a lot more. And hence are exposed to a lot of emotions. A working woman is exposed to many other more roles- boss, subordinates. A working woman has to develop skills of self awareness, self management, be motivated, feelings of optimism, positivity and internality, empathy and social skills (collectively called as emotional intelligence) to perform her multiple roles, both at home and at, work place efficiently so as to meet the expectations of both the family members and their organization. Current study focuses on investigating the influence of demographic factors on the level of emotional intelligence among the respondents in Coimbatore city. These factors tested against being determined by their age, job profile, marital status.

Nandini

Abstract __ Considering the size and relevance of coffee industry to the Ethiopian economy this work presents the design, prototype development, analytical and numerical simulation as well as experimental investigation on an active solar coffee dryer. The solar collector and dryer system configuration has been optimized for minimal pressure drop by incorporating guide vanes and minimizing flow separation tendency using numerical simulation on ANSYS. The effect of air mass flow rate on optimal depth of collector, temperature rise and pressure drop were characterized including the effect of variation in solar insolation using CFD approach. By comparing different dryer configurations based on pressure drop and air flow uniformity, a new dryer configuration prototype was developed. In addition, thermal performance of the solar air heater was evaluated experimentally at three different airflow rates on a collector with corrugated absorber plate and another collector with flat absorber plate. High collector outlet temperature and efficiency were observed in a collector with corrugated absorber plate. The effect of depth of grain, moisture content on wet basis, airflow rate and humidity of air were explored for parametric sensitivity vis-à-vis drying time. Within 5 hours, coffee bean dried from 29% moisture content to 12.3% on a clear sunny day and within 7hours from 19% moisture content to 11.1% on a partially overcast day. Average thermal efficiency of the dryer was found to be 50.5% for clear sunshine day and 36.9% for partial overcast day. A good agreement has been observed between the experimental results and the CFD temperature rise predicted output with a deviation of 7.5%. Analytically predicted drying time compared with experimentally measured drying time within a 12.9% deviation. The cost -to-benefit analysis with a comparative assessment on traditional mode of coffee drying has been done and the payback period is found to be 1.03 years with significant benefits.

Tefera abera

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

In order to overcome the carcinogenic ‘polycyclic aromatic hydrocarbon’ emission from aromatic oils, which are restricted in European countries since 2010, various efforts have been made to replace the aromatic oil in rubber-based compounds either fully or partially. The authors in the present work have used liquid isoprene rubber (LIR50 or LIR) as a reactive plasticizer in natural rubber (NR) compound at different loadings (2, 4, 6 and 8 phr) and have studied its effect on viscosity, curing characteristics and physico-mechanical properties. These results were compared with the control compound containing conventional aromatic oil as plasticizer. From the experimental data, it was noticed that, the minimum torque for control compound was 0.33 dNm and that for LIR based compounds ranged between 0.16 to 0.56 dNm. The LIR based compounds exhibited slightly higher Mooney viscosity but offers the same scorch safety. The study supports the utility of LIR as a promising alternative, as revealed by the comparable rheological and physico-mechanical properties attained with the usage of appropriate quantity of LIR, unlike the other alternatives of the previous investigations that usually showed a property difference. Keywords: aromatic oil, liquid rubber, reactive plasticizer, safe processing oil.

Chandresh m. p.

eveloping automated systems with a reasonable cost for long-term care for elders is a promising research direction. Such smart systems are based on realizing activities of daily living (ADLs) to enable aging in place while preserving the quality of life of all inhabitants in smart homes. One of the research directions is based on localizing items used by elders to monitor their activities with fine-grained details of the progress. In this paper, we shed the light on this issue by presenting an approach for localizing items in smart homes. The presented method is based on applying machine learning algorithms to Radio Frequency IDentification (RFID) tags readings. Our approach achieves the required task through two stages. The first stage detects in which room the selected object is located. Then, the second one determines the exact position of the selected object inside the detected room. Additionally, we present an efficient approach based on gradient boosted decision trees for detecting the location of the selected object in a real-world smart home. Moreover, we employ some techniques of over- and under- sampling with data clustering for improving the performance of the presented techniques. Many experiments are conducted in this work to evaluate the performance of the presented approach for localizing objects in a real smart home. The results of the experiments have shown that our approach provides remarkable performance.

Shadi abudalfa

Self-concept and adjustments are important determinants of personality development of an individual and a conducive school environment can contribute building positive self-concept and making adjustment. This study attempted to investigate the level of self-concept and adjustment of visually impaired students attending special and inclusive school settings. Descriptive survey method was adopted to carry out this study and 165 visually impaired students studying in special and inclusive school settings located in Delhi and NCR participated as respondents for the study. The data gathering instruments used for this study include ‘Information Schedule’ designed by the researcher, Self-Concept Questionnaire (SCQ) by Sarswat and Adjustment Inventory for School Students (AISS) by Sinha and Singh. Data were analysed by applying statistical techniques namely– Percentage analysis, Mean, S.D. and t-test. Findings of the study indicated that visually impaired students in inclusive setting possess higher positive self-concept and demonstrate better adjustment than their counterpart in special school setting. Educational implications for different stakeholders are discussed.

Rubul kalita

This research paper examines the dynamic interplay between social movements and Indian politics to assess their importance in shaping the socio-political landscape of the nation. In recent decades, India has witnessed the rise of various social movements, from grassroots activism to large-scale protests, each with distinct goals and socio-political implications. This study uses a multidimensional approach that combines historical analysis, case studies, and theoretical frameworks to reveal the complex connections between social movements and political transformations. The research begins by delving into the historical context of social movements in India, highlighting their evolution from the pre-independence era to the present. By examining key movements such as India's independence struggle, the Chipko movement, anti-corruption protests and farmers' agitations, this paper seeks to identify recurring patterns, strategies and outcomes across periods. The study further examines the impact of social movements on policy-making, political discourse and institutional reforms. By analyzing specific cases where social movements have influenced legislative decisions or brought about political change, the research aims to assess the tangible results of grassroots activism on the functioning of Indian democracy. The role of social media and technology in amplifying the voices of social movements is also explored, emphasizing their transformative influence on public opinion, mobilization and information dissemination. This study uses a comparative analysis of movements with varying degrees of success to distinguish the factors that contribute to their effectiveness and endurance. the research presents a comprehensive assessment of the role played by social movements in shaping Indian politics. By synthesizing historical perspectives, contemporary case studies and theoretical insights, this article contributes to a nuanced understanding of the complex relationship between social activism and political change in the Indian context. The aim of the findings is to inform policy makers, scholars and activists about the potential of social movements as catalysts for positive social transformations and democratic development.

Dr gedam kamalakar

Cervical and ovarian cancers contribute significantly to female morbidity and mortality worldwide. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, offers poor outcomes. There are many side effects to traditional chemotherapeutic agents and treatment-resistant types, and often, the immune response is depressed. As a result, conventional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The potential anti-cancer peptides are less toxic to normal cells and can attenuate multiple drug resistance by providing a productive treatment approach. The physiological effects of marine peptides are described in this review, which focuses on various pathways, such as apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability. The review also highlights the potential role of marine peptides as safe and efficacious therapeutic agents for treating cervical and ovarian cancers.

Dr. salman ahmed

The prevalence rate of vitamin D deficiency over the last decades has grown up rapidly worldwide among young adults. Therefore, the aim of this study is to explore knowledge, attitude and practice of Libyan medical students of Sebha University regarding vitamin D deficiency. Out of a total of 200 questionnaires, 148 completed questionnaires were returned (74.0% response rate). The majority of respondents did not measure their vitamin D levels (62.1%). Participants who indicated they exposing to sunlight for less than 15 min were 47.2% while 74.9% exposing to less than 30 min with highly significant difference in gender (p < 0.001). All the males did not use sunscreen creams compared with females (43.5%). Nearly two-thirds of the participants (61.4%) denied drink milk almost daily with significant differences based on the gender (p < 0.005) while 56.0 % of the participants reported eat fish, 60.8% of the students denied eating fast food and 74.3% eating eggs daily or weekly. However, 49.3% of the students are usually drinking of tea and coffee after meals, and do not usually practice exercise (53.3%), however, disagreed that their food has a low amount of calcium (30.4%). Most of the students agreed with the benefits of vitamin D (72.0%). Based on the assessment of awareness of the participants about vitamin D information, the average of correct answers percentage of the respondents was 47.1%. The most frequent sources of vitamin D information were the internet which accounted for 49.3%, followed by relatives and friends (31.7%). Some of the respondents (58.7%) reported that unawareness is the main cause of vitamin D deficiency. This study highlights the lack of awareness about the importance of vitamin D among medical students. This finding provides the institutions of medical education in Libya with an evidence base for a deficit knowledge regarding young health which could be utilized it to draw a strategy to correct health behaviors of students and community through medical education programs.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Uterine leiomyoma is the most common benign smooth muscle tumor of unknown aetiology. Progesterone may contribute to leiomyoma growth through the induction of B-cell lymphoma-2 (BCL-2) protein in leiomyoma cells. This study aims to determine the patterns of Bcell lymphoma-2 (BCL-2) and progesterone receptor (PR) expression in uterine leiomyomas seen at LTH, Ogbomoso, over a five-year period using immunohistochemical techniques.Methods: This was a hospital-based retrospective study of histologically diagnosed leiomyomas in the histopathology department of a teaching hospital between January 2012 and December 2016. A total of 141 cases of uterine leiomyomas were semi-quantitatively analysed immunohistochemically for PR and BCL-2 antigens. Results: Immunohistochemical analysis showed that out of 141 cases studied, 74 (52.5%) and 118 (83.7%) were positive for BCL-2 and PR, respectively. Among the 141 cases, 23 (16.3%) were negative for both PR and BCL-2. There was a moderate positive correlation between the immunohistochemical expression of BCL-2 and PR antigens, with a p-value < 0.001 (Pearson correlation = 0.563). Conclusion: This study showed that the majority of women with leiomyomas expressed both progesterone receptor and B-cell lymphoma-2 antigens. Therefore, selective women with leiomyomas could benefit from progesterone receptor modulators instead of undergoing invasive procedures such as myomectomy or hysterectomy.

Karishma

Sigma-Delta (SD) analog to digital converters (ADCs) have several advantages over the nyquist rate type ADCs. The linearity over high dynamic range makes the SD ADCs an ideal choice for voice and precise instrumentation applications. The SD-ADC architecture is well established and analyzed [5, 6]. It is heavily based on digital processing and provides a high resolution, low noise output with very low analog implementation effort. The technique of sigma delta ADC is in practice from several decades. The feature of digital dominated design of SD-ADC makes it different from other types of ADCs. As the technologies are evolving, new realization methodologies are emerging for realizing SD-ADC. The conventional approach of realizing an ADC as a separate ASIC and providing the interface to digital IC (either Microprocessor or FPGA) for providing mixed signal processing platform has following limitations.

P.a. harsha vardhini

Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised by agranulocytosis as adverse effect. Subsequent to nonenzymatic hydrolysis, the primary metabolic step is N-demethylation of 4-methylaminoantipyrine (4-MAA) to 4-aminoantipyrine (4-AA). The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating this reaction. This study identified the relevant CYP using virus expressed isolated human CYP, human liver microsomes and rat liver microsomes with chemical inhibition studies. The substrate of 4-methylaminantipyrine was employed at six different concentrations (25, 50, 100, 400, 800 and 1200 µmol per l) with varying concentrations of selective inhibitors of CYP1A2 (furafylline, fluvoxamine), CYP3A4 (ketoconazole), CYP2A6 (coumarin), CYP2D6 (quinidine), CYP2C19 (omeprazole, fluvoxamine, tranylcypromine), CYP2C9 (sulphaphenazole) and CYP1A1 (alpha-naphthoflavone). 4-MAA and 4-AA were analyzed by HPLC and enzyme kinetic parameters (Km and Vmax) were determined by regression (Sigma plot 9.0). The N-demethylation of 4-MAA by microsomes prepared from baculovirus expressing human CYP was pronounced with CYP2C19. Intrinsic clearance of the most active enzymes were 0.092, 0.027 and 0.026 for the CYP enzymes 2C19, 2D6 and 1A2, respectively. Metabolism by human liver microsomes was strongly inhibited by fluvoxamin, omeprazole and tranylcypromine (IC50 of 0.07, 0.07 and 0.18, respectively) but with coumarin, sulphaphenazole, ketoconazole, moclobemid, quinidine alpha-naphthoflavone and furafylline were 0.79, 1.20, 1.36, 1.44, 3.46, 4.68 and 8.41, respectively. The enzyme CYP2C19 apparently has an important role in N-demethylation of 4-methylaminoantipyrine which should be further analyzed in clinical studies and which may also be interesting concerning the agranulocytosis.

Mediterranean journal of pharmacy and pharmaceutical sciences

Melilotus officinalis (L.) Pallas. is used traditionally to treat hypertension and chronic venous insufficiency. The high prevalence of hypertension and the side effects of antihypertensive drugs potentiate us to evaluate Melilotus officinalis. The hypotensive effect of Melilotus officinalis butanol fraction (MOBF) was investigated in anaesthetised normotensive rats. The doses of 60, 80 and 100 mg/ kg, i.v., produced a significant (P<0.05) decrease in blood pressure. The statistically non-significant reduction in blood pressure was shown by 20 and 40 mg/ kg, i.v. These results suggest that Melilotus officinalis exhibited a hypotensive effect in normotensive rats. However, further evaluation of compound-related activity is required.

Dr. salman ahmed

Learning is a process of interaction that occurs between teachers and students. The learning process requires a way or method so that interaction occurs reciprocally and can achieve the desired learning goals. This research uses a descriptive qualitative approach, and the type of research is a case study. Data collection techniques using observation, interviews, and documentation. While the data analysis with an interactive analysis model (interactive analysis)—the validity of this research data uses the triangulation technique. The results of this study indicate (1) Planning for STAD Type Cooperative Learning Methods in Fiqh Subjects at MIMA 42 Wuluhan, namely: The teacher makes a Learning Implementation Plan (RPP), makes observation sheets and score assessment sheets, choose learning media, makes materials and questions. group and individual assignments, and designing study groups. (2) Implementation of STAD Type Cooperative Learning Method in Fiqh Subjects at MIMA 42 Wuluhan: Initial activity: the teacher explains the material that will be given to students. The core activities are: The teacher explains the method to be used, divides students into several groups, plays videos as material, asks students to observe pictures/videos of people, and discusses the material in the video. And all groups present the results of their discussions. Closing activities, namely: providing reinforcement to the material presented by students, the teacher and students reciting prayers, and the teacher planning follow-up learning. (3) Evaluation of STAD Type Cooperative Learning Method in Class Fiqh Subjects at MIMA 42 Wuluhan Jember, namely: Evaluation of observation and performance (demonstration) on group performance. Meanwhile, individual evaluation is in the form of homework (PR).

Educare: journal of primary education

Gaucher Disease (GD) is the most common lysosomal storage disorder. The prevalence of GD is approximately 1/100,000, and type III GD accounts for 5% of cases. [1] It is an autosomal recessive disease due to a GBA gene mutation, leading to glucocerebrosidase enzyme deficiency. [1,2] Gaucher disease (GD) is categorized into three types according to clinical presentation: [3] Type I, which is non-neuronopathic and most common, particularly among Ashkenazi Jews; Type II, which is acute neuronopathic and marked by significant neurological involvement and high mortality rates; and Type III, which is subacute neuronopathic, exhibiting both systemic and neurological symptoms. In this report, we discuss a 24-year-old man from Libya diagnosed with GD type III. His diagnosis was established at the age of one due to symptoms including pallor, poor appetite, and hepatosplenomegaly. Laboratory tests indicated a hemoglobin level of 5.6 g/dL, chitotriosidase activity of 18,742 μmol/L, and an angiotensin-converting enzyme level of 251 UI/L. Genetic analysis confirmed a homozygous L444P mutation. He underwent splenectomy at the age of three, and enzyme replacement therapy (ERT) was administered intermittently with regular follow-ups until 2011. In December 2023, the patient experienced two weeks of abdominal pain, distension, and fatigue. A physical examination revealed ascites, dilated abdominal veins, and an enlarged liver and spleen.

Karishma

Research on treatment for diabetes and co-occurring eating disorders is sparse. We examined outcomes from multidisciplinary residential treatment for women with type 1 diabetes and eating disorders and the impact of treatment duration on outcomes. Participants were 29 women with type 1 diabetes and eating disorders receiving residential treatment. Repeated measures analyses of variance examined changes in blood glucose and psychological symptoms over treatment. Analyses were repeated to include treatment by duration interactions. Treatment produced significant reductions in blood glucose, eating disorder symptoms, and psychological concerns. Longer treatment duration was associated with greater improvements in psychological symptoms. Disordered eating is alarmingly common among individuals with type 1 diabetes mellitus, with rates of co-occurring diabetes and eating disorders estimated as high as 40% (Young etal., 2012; Young-Hyman & Davis, 2012). The most commonly noted link between type 1 diabetes and eating disorders is in the form of purging through insulin omission for weight loss purposes (Darbar & Mokha, 2008), which has been noted for individuals with diabetes co- occurring with anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS; Nielsen, 2002; Peveler & Fairburn, 1989). However, even among individuals with diabetes who do not omit insulin, eating disorder symptoms are elevated (Jones, Lawson, Daneman, Olmsted, & Rodin, 2000).

John dolores