This study aims at classifing hotels in Jordan into groups based on their Total Quality Management (TQM) implementation. Using a survey methodology, the TQM questionnaire was designed to measure the level of TQM implementation throughout Critical Success Factors (CSFs) which are necessary for TQM implementation. A total of 345 TQM questionnaires were distributed to managers, working in 17 four- and five-star Jordanian hotels. The researcher obtained 227 usable TQM questionnaires. The results classified Jordanian hotels based on the CSFs for TQM implementation. More specifically, using cluster analysis on the CSFs of TQM resulted in two groups of hotels: ‘low TQM adopters’ and ‘high TQM adopters’. These two groups showed significant differences across the TQM CSFs

Mukhles m. al-ababneh

Background: Malnutrition is a deficiency of nutrients due to inadequate energy intake. Picky eating behavior in children could be a cause of malnutrition, but previous studies’ results were still inconsistent. This study aimed to determine the relationship between picky eating behavior and malnutrition among children aged 2-5 years. Methods: This case-control study involved 70 children aged 2-5 years in Kutukan Village, Randublatung District, Blora Regency. Malnutrition was defined as a weight-for-age Z score <-2.0 SD based on the WHO classification. Child eating behavior was evaluated using the Child’s Eating Behavior Questionnaire (CEBQ), identifying picky eaters if the food avoidance score surpassed the food approach score. Data analysis employed the Chi-Square test. Results: Boys experienced more malnutrition, with 20 (57.1%) affected, and the most affected age group was 24-35 months, with 19 (54.3%). Questionnaire processing revealed that the number of picky-eater children in the malnutrition group was 33 (94.3%), while in the non-malnutrition group, there were 31 (88.6%). Bivariate analysis showed no relationship between picky eating behavior and malnutrition in children aged 2-5 years (p=0.673; CI 95%=0.364-12.459).Conclusion: This study found no significant relationship between picky eating and malnutrition in children aged 2-5 years.

Karishma

The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated that the level of the cardiac bio-marker troponin I in the blood plasma of rats exposed to severe hypobaric hypoxia for 3 h increased signifi-cantly compared to the control group, indicating myocardial injury. At the same time, the administration ofthe HIF-1α transcription factor inhibitor did not affect the plasma level of troponin I. In contrast, the releaseof the non-specific biomarker myoglobin into the bloodstream did not increase in response to hypoxia com-pared to the control animals. In addition, 24 h after the exposure to severe hypobaric hypoxia the serum myo-globin level was significantly lower in animals administered with the HIF-1α inhibitor topotecan than in ratsthat did not receive topotecan. Therefore, it may be assumed that the inhibition of the HIF-1α transcriptionfactor 10 min before exposure to severe hypobaric hypoxia reduces skeletal muscle damage. The mechanismsthat affect the adaptation of heart and skeletal muscles to hypoxia are discussed.

Даниил Федоров

Dietary fatty acid composition in broiler influences carcass quality by altering fat deposition and fatty acid profile. Thus, the study was carried out to evaluate the effect of incorporation of rapeseed oil in broiler ration on omega-3 fatty acid concentration of carcass and its traits in broiler chicken. A total of 160 day-old straight run broilers (Vencobb 400) were randomly divided into four treatment groups (G1, G2, G3 and G4) having four replicates of ten chicks each. The basal diets (G1) were prepared to meet BIS (2007) nutrient requirements with palm oil at 1.5, 3, and 4.5 per cent in pre-starter, starter and finisher diets, respectively. The experimental diets were broiler rations prepared with rapeseed oil replacing 25, 50 and 100 per cent of palm oil in G2, G3 and G4 diets, respectively. The diets were fed ad libitum till 6 weeks of age. Six birds from each group were randomly selected and slaughtered on 42nd day to study omega-3 fatty acid concentration of carcass and its characteristics. The crude fat content of breast and thigh muscle was significantly (P<0.05) reduced in the group fed rapeseed oil included diets. However, carcass yield, processing yield and meat to bone ratio of cut up parts was not significantly affected. The colour and pH of breast and thigh muscles were similar among the treatment groups. Omega- 3 fatty acid concentration was significantly (P<0.01) increased in both breast and thigh muscle of G4 group broilers compared to G1 group. Thus, rapeseed oil inclusion in diet significantly increased omega-3 fatty acid concentration and significantly reduced crude fat concentration breast and thigh muscles with no effect on the carcass yield and its quality when included in the diet replacing palm oil at different proportion

Senthil murugan

Adolescents’ scholastic and social life has become increasingly reliant on the internet and mobile technology in recent years. Problematic Internet Use (PIU) is a growing problem in Indian adolescents. However, in many cases, this use has become obsessive, causing them to neglect other elements of their lives. Adolescents account for over 35% of internet users in India. The purpose of this study was to evaluate the psychosomatic problems related to internet overuse among school going adolescent students. This cross-sectional survey was conducted among 348 students in selected schools of Aspur block in Dungarpur-district, Rajasthan, India in the month of February 2016. Problematic internet use (PIU) was assessed by Young’s twenty question internet addiction test. The Depression, Anxiety, Stress Scale (DASS-42) and self structured questionnaire check list was used to measure psychosomatic problems among adolescents. Approximately 5.17% adolescents showed Problematic internet use (PIU). Adolescents with PIU were associated with age between 14-16 year, males,10th class of study, using internet since more than 3 years, being at home, mobile as a source of internet use, purpose of internet use with online gaming. Compared with normal internet users, there were significant correlation between Problematic Internet Use and Somatic Complaints r=0.3660, p<0.05, Depression r=0.3982, p<0.05. Anxiety r=0.2512, p<0.05 and Stress r=0.2886, p<0.05. Problematic internet use (PIU) is an increasing problem among teenagers and it has been linked to psychosomatic issues. Timely Effective measures are needed to prevent the spread of this problem

Dr k c yadav

Dietary supplements are extensively consumed, but irrational use is a health hazard. Pharmacy students, being future healthcare providers, can facilitate rational use. The present study evaluated the knowledge, attitudes, and practices of pharmacy students at Srinivas College of Pharmacy, Mangalore, about dietary supplements and their role as an advocate, in addition to mental health correlations. 250 students selected through stratified random sampling took part in a cross-sectional mixed-methods study. A 30-question instrument (Cronbach's alpha=0.85) measured demographics, dietary supplement usage, knowledge, attitude, practices, and mental health was evaluated with the depression, anxiety, and stress Scale-21 (DASS-21). The data were collected during January-March 2025 and were analyzed with the chi-square test, logistic regression, and Pearson correlation tests. 35.0% (n=88) used dietary supplements regularly, with a preference for multivitamins (50%) and protein supplements (30%). Knowledge was moderate (60% risk aware), attitudes favorable (70% in favor of counseling), but practice restricted (25% informed peers). Everyday use of dietary supplements escalated stress probability (OR=2.5, 95% CI: 1.8-3.4, p<0.001), with correlation (r=0.38, p<0.01). In conclusion, students have promise as dietary supplement champions but require additional training to close knowledge-practice gaps and mitigate mental health risks. Curriculum and policy interventions are needed to enhance students' abilities in encouraging rational dietary supplement use and identifying potential mental health effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Our society is reflected through the media, which represents what society is like and how it functions. The sole medium that serves to keep people informed is media, whether it is written, electronic, or on the web. It also serves to amuse, educate, and inform the audience about current events. Our society's voice is now dominated by the media. A number of media platforms have brilliantly stirred the views of the younger generation and other segments of our society. The study's goal is to examine the media's involvement and efficacy throughout the demonetization process. The study's major goals are to look into the role of the media in informing people about the demonetization process and its consequences. The study will contribute to a better understanding of the role of the media in conveying information on significant problems and how individuals learn about current events. In Lucknow's South City and Eldeco neighborhood, a poll of 300 persons was held. The researchers devised a data gathering interview plan that took into account the function and type of media in raising public awareness. The convenience sampling method was used in the research investigation. The study focuses on media consumption patterns and behaviour throughout the demonetization period.

Dr. amarjeet singh

Self-medication of antibiotics is an irrational use of drugs, contributing to microbial resistance, increasing health care cost and higher mortality and morbidity. This study was aimed to assess self-medication with antibiotics without a medical prescription in the community of Libya. This is a cross-sectional study conducted from June to December, 2022 and the total number of participants was 200. The design of the study and sample size were modified according to the proficiency of pharmacists and the medical and non-medical population of Libya. The questionnaire was developed in English and Arabic language and was distributed through social media platforms. The questions were used after a thorough literature search and assessing the validity and reliability. The significant signs regarding reasons for the treatment by self-medication drugs of antibiotics, because of its various drugs of antibiotic by pharmacist (n = 80, 40.0%) and family (n = 90, 45.0%) compare with experience and physicians by used prescription was 13 (06.50%) and significant sings regarding by nasal congestion self-medication of various antibiotics (n = 100, 50.0%). This sign must be practiced based on a previous physician’s prescription. The antibiotics are often self-administered as patient feel that they will save money and time but this can lead to substantial adverse drug reaction, antibiotic resistance, treatment failure and drug-related toxicity. This study respondent's medical and non-medical public of Libya who should be relatively informed and educated about the risk of treatment by self-medication of antibiotics with the development of resistance.

Mediterranean journal of pharmacy and pharmaceutical sciences

BACKGROUND AND OBJECTIVES: The requirements of stakeholders for the qualitative transformation of the approaches of industrial enterprises – environmental users to introduction of economic activities cause an increase in the role of environmental responsibility as their strategic priority for development. The purpose of the study is to improve the practical tools for calculating and developing strategies for the development of environmental responsibility of industrial enterprises. METHODS: In the study, tools for assessing the level of environmental initiative of an industrial enterprise as an integrated indicator of environmental initiative are suggested. It is expressed as the arithmetic mean of ten factors of environmentally proactive behavior of industrial enterprises. To achieve the objectives of the study, methods of criterion-qualitative assessment are suggested, such as expert assessment and survey. The assessment system includes ten factors rated on a 10-point scale and weighted by significance. The integrated indicator of the environmental initiative acquires values within, is a stimulant of environmental responsibility. FINDING: One justified a scientific and methodological approach to assessing the level of environmental responsibility or the industrial enterprise, including calculation of the corresponding taxonomic indicator with consideration of the quantitative factors of its environmental responsibility and the qualitative and quantitative factors of environmental initiative. This enables the possibility to assess the relevant state of environmental responsibility and determine the volumes for further correction of the ecological strategy for the development of the industrial enterprise. CONCLUSION: As a conclusion, practical recommendations are made for the implementation of organizational and economic support of environmental responsibility in the development strategy of an industrial enterprise taking into account the impact of its environmental initiative and environmental duty. The level of environmental responsibility of industrial enterprises taken into account when developing recommendations on adjustment of their environmental strategy of development is determined, which as a whole allowed to form organizational and economic support for environmental responsibility of the enterprises under study. Thus, an enterprise, which only ensures compliance with environmental emission standards (compensation strategy or sufficiency strategy) cannot be characterized by a high level of environmental responsibility. To ensure a high level of environmental responsibility, an industrial enterprise must rely on a proactive strategy or a strategy for sustainable use of nature.

Professor j. nouri

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

In this research study, the mechanical properties of several Polymer matrix composites are investigated. These composites are multi-phase materials in which reinforcing materials are properly mixed with a polymer matrix. More precisely, Nylon 6 reinforced with 5, 15 and 25 wt. % of silicon carbide (SiC) and Nylon 6 reinforced with 5, 15 and 25 wt. % of boron carbide (B4C), prepared by means of an injection moulding process at three different injection pressures are considered. Specific attention is paid to the tensile and impact strength of these composites. The Taguchi technique is used to optimize the process parameters such as reinforcement material, its percentage and the injection pressure. It is observed that the specimens 5% SiC with 80 MPa injection pressure display a better tensile strength and similarly the specimen 5% B4C with 90 MPa injection pressure have a superior impact strength.

Boopathy govindarajan

Drug discovery started when a man suffered from abdominal pain and accidentally healed by chewing the leaves of the plant. The story of Ethnopharmacology begins with the doctrine of signatures, the shape signatures of herbs to heal resembled parts of the body. Later, shape signatures were modified into colour and taste signatures for healing. The information exchange and understanding about people's use of natural resources to discover therapeutic and toxicological potential is now shaped into a branch of science, "Ethnopharmacology". Simply Ethnopharmacology, by using modern science, enables traditional knowledge to convert into medicine and acts as a powerful and creative drug discovery engine.

Dr. salman ahmed

In this article, a systematic flow of contents was provided with regard to the synthesis of Atovaquone 1a on critical examination of the prior-arts. Several patents and study articles were published, disclosing different synthetic methods for the preparation of Atovaquone 1a at various scales. Based on the starting materials used, there are a few one-step, two-step and multi-step synthetic routes were reported with varied yields. In this work, we have put in our sincere effort to collect all the synthetic routes of Atovaquone 1a in detail with distinct and elaborate reaction schemes for a better and collective process clarity. From this review, global researchers will get a platform to re-design or re-work on the synthetic approach of Atovaquone 1a with better atom economy and purity. In addition, the drug commercialization angle could also be looked in during the design stage itself alongside green chemistry concepts. We have done the chronic analysis of study articles to highlight the commercial feasibility of the disclosed synthetic methods. A special emphasis was given to the synthetic routes with process development initiatives towards, recovery/reuse of costly starting materials/reagents/solvents and their feasibility for large scale manufacturing of drug Atovaquone 1a.

Mediterranean journal of pharmacy and pharmaceutical sciences

This study aims to investigate the relationship between green marketing elements and customer purchase intention. To conceptualize green marketing, the researcher has researched the literature and identified the green marketing elements which include Green products, Green price, Green place, Green promotion, and Green Distribution. By using the snowball sampling technique, questionnaires from the respondents were collected as part of the study's survey methodology. According to the study's findings, there is a clear, substantial correlation between customer purchase intention and Green marketing.

Santhosh sandy

This paper aims to study the restructuring and change management of SARHS, which in turn will be accompanied by some complex, difficulties and discussions that may include personnel emotion, which must be taken into account. We will guide SARHS managers by conducting a comprehensive study of majority factors that will affect the success of the process, considering and covering all views. Which will result in the dismissal of some employees and the closure of their jobs permanently in the new job structure. The study will include many theories, models and justified recommendations to be followed to ensure a successful and safe restructuring and management change free from unresolved impediments and difficulties that could lead to a setback. Finally, restructuring is not a result but the beginning of a new process

Mohamed sorogy

Cardiovascular disease (CVD) remains the leading reason of death among patients with diabetes mellitus (DM). Individuals with DM have a two to five time's greater risk of developing CVD than non-DM. Unfortunately, little data exists on Libya's prevalence and characteristics of cardiovascular risk factors. This study aimed to evaluate the cardiovascular risk factors and to assess their control among patients with type 2 DM (T2DM). All the patients with T2DM who attended the outpatient clinic at National Diabetes Hospital from September 2013 to April 2022 were interviewed and examined and included in this study. Demographical data age, smoking habit, body mass index measure, drug intake, history of previous cardiovascular events, blood pressure and fasting lipid profile were all recorded. 1049 patients have completed the study with a mean age of 54.06 ± 14.5 years old (females represented 68.0% of the studied sample size), there were different duration of diabetes between the studied sample, varying from newly diagnosed patients (n = 265, 25.2%) and above ten years of diabetes duration patients (n = 488, 46.5%). Active smoking in 129 patients (12.3%), the bodyweight of studied patients ranged from 44.0 Kg to 186 Kg (85.65 ± 1.73), 820 of the patients had uncontrolled body weight (78.85%). Uncontrolled blood pressure, even with treatment, was found in 304 patients (29.0%), uncontrolled dyslipidaemia in 45 patients (04.3%), and uncontrolled hyperglycaemia in 816 patients (77.9%). Established CVD was positive in 295 patients (28.2%), maximum age group was in 54 - 74 years (n = 516, 49.3%). The most typical age group with multiple (more than three) CVD risk factors was 54 - 74 years of age, were female patients with more than ten years of history of diabetes, uncontrolled hyperglycemia (HBA1c > 10%), uncontrolled body weight, uncontrolled blood pressure and dyslipidemia. Thus, the present data indicated that Libyan patients with diabetes mellitus have high CVD risk factors. Even in patients with previous events, these uncontrolled risk factors elevate the likelihood of repeated cardiovascular events. Patients with diabetes mellitus necessitate a more aggressive approach to control the modified risk factors such as hypertension, dyslipidemia, obesity and smoking.

Mediterranean journal of pharmacy and pharmaceutical sciences

This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

Identity-based encryption (IBE) is a public key cryptosystem and eliminates the demands of public key infrastructure (PKI) and certificate administration in conventional public key settings. Because of the absence of PKI, the revocation drawback could be a crucial issue in IBE settings. Many rescindable IBE schemes are planned relating to this issue. Quite recently, by embedding associate outsourcing computation technique into IBE, Li et al. planned a rescindable IBE theme with a key-update cloud service supplier (KU-CSP). However, their theme has 2 shortcomings. One is that the computation and communication prices are above previous rescindable IBE schemes. The opposite disadvantage is lack of measurability within the sense that the KU-CSP should keep a secret worth for every user. Within the article, we have a tendency to propose a replacement rescindable IBE theme with a cloud revocation authority (CRA) to resolve the 2 shortcomings, namely, the performance is significantly improved and the CRA holds only a system secret for all the users. For security analysis, we demonstrate that the proposed scheme is semantically secure under the Decisional Bilinear Diffie-Hellman (DBDH) assumption. Finally, we have a tendency to extend the planned rescindable IBE theme to gift a CRA-aided authentication theme with period-limited privileges for managing an outsized range of varied cloud services.

Dr h shaheen

In the direction of computer globalization and digitization, India is rapidly developing education and information technology. People are taught how to invest in deposits, postal investments, government bonds, gold systems and bonds, and the private sector. The world in which we now live has been completely transformed by technology. The study indicates that there are more than 4 billion active Internet users worldwide, or nearly half of the world's population. Our lives are now faster, easier to manage, and more enjoyable thanks to modern technology. This paper focuses in experiencing and developing a stock application using PHP, React JS, NodeJS and CSS . All the stock data is stored in a MYSQL database. On the other side for developing machine language application python code is used to convert the data into csv format for machine learning algorithms. The investor is presented with a login screen in the python environment where they must enter their user name and password. The stock dashboard shows the investor's current stock holdings, as well as online stocks' their current price, percentage change in stocks, sensex, nifty, bonus, rights, IPO's, annual report etc. statistical methods are used as software modules for the investor, and with a single click of a button, they can compare and contrast their own stocks with online stocks, as well as the trend in the stock market position in order to decide whether to buy, hold, or sell the stocks. Data visualization component is used for comparison of various stocks, and by clicking of a button, stock prediction are displayed whether to hold, buy or sell in future according to the market trend. The trader must log in using their user name and password. The trader will browse the client current market price of all stocks, buying and selling stocks, contract note, client margin, e-off market transactions, ledgers, journals, commission of buying and selling stocks, and so on. In future strategy the stock application programming is converted by a portable mobile application by using python packages like Kivy, PyQt, or even Beeware's Toga library.

Dr.n.r.ananthanarayanan

The threshing quality of the machine was affected by moisture content. This parameter was one of the main causes of production losses. In Ethiopia, this problem was highly observed in the farm area during threshing. Therefore, the main aim of this research was, to minimize production losses during threshing by reducing the effect of moisture content on the crop, to improve threshing capacity, threshing and cleaning efficiency, to reduces fuel consumption, and to minimize grain damage by the machine during threshing. The experiment was done at four-time replication in the moisture level of 14%, 18%, and 22% for three selected cereal crops (barley, wheat, and tef) with a completely randomized design (RCBD) and 4 replicates as-block giving 12 total experimental units. Crop moisture content, size of the grain, sphericity, angle of repose, density, thousand-grain mass and coefficient of friction as well as threshing capacity, threshing efficiency, cleaning efficiency, germination rate, fuel consumption, and grain breakages were the parameters used to evaluate the performance of the thresher. Threshing capacity, threshing and cleaning efficiency, and density of grains showed decreased, as moisture content of crops increased. The other parameters mentioned above were increased with moisture content. A combined mean analysis of variances on the performance of thresher was significant at (p 0.05). The recommended amount of moisture content in this study was 14% because the result obtained by 14% moisture level was preferable to other moisture levels. At 14% of moisture content, the threshing capacity was (208.750, 285.45 and 68.181) kg/hr, threshing, and cleaning efficiency (%) were (98.603, 99.330 and 99.49 and 97.101, 98.22 and 93.731 respectively). Percentage of germination rate was (94.25, 94.50, and 91.25) and the amount of fuel consumption was also (1.14, 1.72, 1.70) l/hr., for barley, wheat, and tef crops respectively.

Dessye