Current research investigates the nuanced impact of the COVID-19 pandemic on consumption patterns in rural Maharashtra, India. Our research has two main goals. First, we want to understand how factors like age, gender, job, education, and family size have affected how people in rural Maharashtra spent money during the pandemic. Second, we want to find out which of these factors had the biggest impact on spending in different parts of the state. Since rural areas have their own unique economic situations, we know it's important to look at how the pandemic affected these communities specifically. We're using math and tables to analyze the information and provide a detailed look at how the pandemic immediately changed spending habits and what it might mean for the future in rural households. This research is not only timely but also essential for informing policy decisions aimed at supporting rural communities in the aftermath of the pandemic. By unraveling the intricate dynamics of consumption in rural Maharashtra, we contribute to a deeper understanding of the economic challenges faced by these communities and provide insights that can guide targeted interventions to foster resilience and recovery.

Nandini jagannarayan

This study examines Javanese Krama's learning in improving students' ability to speak politely at MIMA 35 Nurul Ulum Ambulu. This research approach is a descriptive qualitative approach, and the type of research used is phenomenology. Data collection techniques using interviews, observation, and documentation. While the data analysis using the model of Miles, Huberman, and Johnny Saldana consists of data condensation, data presentation, and conclusion. The results of this study are 1) Planning for learning the Javanese Krama language to improve the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: the teacher prepares a Learning Implementation Plan, prepares to memorize material for the Javanese Krama language vocabulary for students. 2) Implementation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: opening, core, and closing activities. Then the habit of using Javanese manners during learning hours and outside the classroom. 3) Evaluation of Javanese Krama language learning in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu, namely: in the classroom using daily questions, PTS and PAS. Meanwhile, habituation outside of learning hours is by assessing students' speech and manners. 4) The implications of learning Javanese Krama in improving the ability of students to speak politely at MIMA 35 Nurul Ulum Ambulu have a positive impact on students becoming accustomed to using Javanese Krama when communicating with teachers both in attitude and speech.

Educare: journal of primary education

A leader is a person, who influences his followers. The role of leader is often associated with managerial concepts, where a leader leads a team of employees, guides them, motivates them and influences them, in such way that the organisational productivity is honed up. A lot emphasis is on the style of leadership, exhibited by the manager, in honing the productivity of the organisation. According to (Hanvey, 2002; Janus, Kopechanski, Cameron, & Hughes, 2007; Morinaka, 2012; Reio & Fornes, 2011), most parents have dreams and hopes about their children and their lives. But, parents of children with special needs, though have, such dreams and hopes, have a harder time meeting these goals. According to Hanvey (2002), these parents need to devote more time and responsibilities, when it comes to raising a child with special needs, like caring for the child’s physical requirements due to his/ her disability, helping them with their physical and social needs and also help them in developing relationships with the others, so that they get a feeling of belongingness. Families with children having special needs undergo a higher level of stress (Gottfried & McGene, 2013). Families that have children with special needs, go through enormous stress levels, at times even financially stressed are they … (Hanvey, 2002; Moriwaka, 2012). But, Current study focusses on the effective leadership role played by a mother during the Pandemic, which is helping the kids, especially the children with special needs in combating the stress, that they are undergoing. A case of a child, diagnosed with autism(a serious behavioural disorder among young children that now occurs at epidemic rates in developing countries like India), since she turned two and how her mother has been helping her adapt to the new normal of staying home for all her activities and coping up with the increased stress levels.

Nandini

Background: Ending open defecation has been identified as a top priority for reducing global inequalities in water and sanitation (WASH). It is explicitly referenced in sustainable development goals (SDGs) target 6.2 and closely associated with more comprehensive efforts to end extreme poverty by 2030. Since 2000, the global rate of open defecation has decreased from 21% to 9% (0.7 percentage points per year). However, the 673 million people still practicing open defecation in 2017 were increasingly concentrated in a small number of countries, and these will need to be the primary focus of efforts to end open defecation by 2030. Objectives: To study the socio-economic background of Adivasis, to study the status of sanitation in rural areas, to examine whether economic conditions affect open defecation, to examine whether better sanitation facilities improve health conditions and to examine whether improved sanitation facilities impact the quality of life and thereby dignity of tribal women. Methods: Essentially it is an empirical study and a multi-stage random sample design was adopted. Data were collected from 120 sample households from two villages, i.e., Bandarigudem and Nadikudi of Khammam districts in Telangana State through a structured questionnaire. Statistical tools like frequency distribution, percentages, cross-tabulation with Chi-Square test, and a case study method were used. Results & Discussion: This paper found that 35% of Adivasis have health problems, and 73% said that they are getting treatment with RMP. 87% have toilet facility and more than 12% still defecate openly. 18.3% said that they faced different problems at open defecation, and 50% of women not using sanitary napkins. Nearly 90% of respondents wash their hands after toilets and coming from outside of the home. Ten per cent of respondents said that they do not have an awareness of sanitation. Therefore, the study confirmed that the sanitation facilities considerably made the women's dignity and quality of life better in the study area. Moreover, four case studies also focused on open defecation problems in the study area.

B suresh lal

The study was conducted on glass slides to observe the growth patterns of urinary calcium oxalate monohydrate crystals and their inhibition using 5, 10 and 15% Phaseolus vulgaris seed infusion. For this purpose, a drop of gel medium (sodium metasilicate of 1.06 specific gravity and 3M acetic acid solution) at pH 5.02-5.17 was placed in the middle of the glass slide and converted into gel. A single drop of 1 M oxalic acid was dropped to the left, and 1 M calcium chloride and magnesium acetate (1:1) solution fell to the right side of the adequately formed gel. The glass slide was observed under microscope till it was completely dried. In the case of the crystal inhibition study, a drop of Phaseolus vulgaris infusion was also added on the right side just after adding calcium chloride and magnesium acetate solution. The results without infusion showed detailed morphology and aggregation patterns of observed crystals as donut, dumbbells, needles, platy, prismatic, rosette, round edges, and loose and compact aggregates. All infusions of Phaseolus vulgaris showed defective crystals. 5 % infusion inhibited crystals of all morphologies with their loose and compact aggregates except rosettes. Whereas 10 and 15 % infusion converted the rosette crystals into ineffective calcium oxalate dihydrate crystals of tetragonal bipyramidal and elongated rod shape. The microscopic study of calcium oxalate crystal growth and its inhibition is simple and provides rapid qualitative analysis of antiurolithiatic activity.

Dr. salman ahmed

In this article, we study an Inventory Routing Problem with deterministic customer demand in a two-tier supply chain. The supply chain network consists of a supplier using a single vehicle with a given capacity to deliver a single product type to multiple customers. We are interested in population-based algorithms to solve our problem. A Memetic Algorithm (MA) is developed based on the Genetic Algorithm (GA) and Variable Neighborhood Search methods. The proposed meta-heuristics are tested on small and large reference benchmarks. The results of the MA are compared to those of the classical GA and to the optimal solutions in the literature. The comparison shows the efficiency of using MA and its ability to generate high quality solutions in a reasonable computation time.

Mohamed salim amri sakhri

This article investigates the integration of Artificial Intelligence (AI) with Electronic Health Records (EHR), exploring the transformative impact of this synergy on healthcare informatics. Through an in-depth analysis of recent advancements, practical implementations, and ethical considerations, the paper illuminates how AI is enhancing the efficiency, accuracy, and insights derived from EHR, ultimately contributing to improved patient care and clinical decision-making.

Dhruvitkumar talati

Introduction: The right lung has two fissures, an oblique and a horizontal, dividing it into three lobes namely the upper, middle, and lower. The nature of the fissure is of great importance in planning operative strategy for thoracoscopic pulmonary resection where an the incomplete fissure may contribute to post-operative air leakage Aim: To assess the gross morphological features of the right lung with special emphasis on the completeness of horizontal fissure. Material & Method: Material for the present study comprised of right lungs obtained from 50 well-embalmed adult human cadavers of both the sexes dissected as a part of 1 MBBS curriculum in the Department of Anatomy, Govt. Medical College, Amritsar. Results: Horizontal fissure was found to be complete in only 10% of the lungs while in rest 90% it was either incomplete or absent. Conclusion: Inferable from the huge variation in nonappearance or partial appearance of horizontal fissure in the right lung and to the absence of an acceptable classification of fissures, an endeavor has been made to give one such classification. In like manner, the horizontal fissure is evaluated from Grade zero to IV contingent on its absence and profundity from coastal surface to the hilum. Each evaluation is additionally divided into 3 subgrades relying on the culmination or incompleteness of these fissures with respect to their length.

Dr kulbir kaur

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

Background: Although geriatric depression is widespread in primary health care (PHC), local studies on the prevalence of depression in elderly PHC patients appear to be scarce. This study aimed to determine the prevalence of depressive symptoms and some of the associated risk factors among elderly PHC patients. Methods: A cross-sectional study recruiting elderly people (60 years or older) from five PHC centers in Port Said Governorate was conducted. All participants had a structured interview. The long version of the geriatric depression Scale (cut-off point ≥10) was used in elders with a Mini-Mental State Examination ≥24. Results: About two-thirds of the total sample (65.7%) was female. The total prevalence of depressive symptoms was 49.4% of all subjects, more commonly in women (58.1% vs. 32.8%). Multiple regression analysis shows that female gender, high education, unemployment, low income, lonely life, loss of a close person, chronic diseases, tumor, iatrogenic medications, and depression history were the significant associated risk factors of depression in the studied elders after adjusting all previous variables in addition to age and marital status. Conclusion: Depressive symptoms constitute a significant health problem among older PHC patients in the Port Said governorate. Routine screening for depression of every elderly PHC patient is recommended for early detection.

Karishma

Postpartum depression is a major maternal health problem after childbirth. It can start at any time within the first year after delivery and continue for several years. It is characterized by an inability to experience pleasure, anxiety symptoms, panic attacks, spontaneous crying and depressed mood. Some women with postpartum depression even have thoughts of harming their child and self-harm. The aim of this study is to find out the status of postpartum depression and the associated factors among postnatal mothers at first-, fourth- and sixth-month. This study is a prospective descriptive study, carried out in three major health facilities in Misurata. This study consists of three-part questionnaire. Part 1 covers demographic characteristics of the participants, while part 2 explores the associated risk factors according to the variables used. Part 3 constitutes for the psychological evaluation of the participants. Hundred mothers (age are between 15 and 43 years) were enrolled in this study. The findings revealed that prevalence of depression is 60% and 22% are suffering from borderline depression. Development of depression was strongly correlated with the sleeping disturbances, state of the neonate after birth, excess consumption of stimulants, less weight acceptance by mothers during pregnancy and infant illness. There was a weak relation between depression and delivery state, maternal admission to hospital during current pregnancy, and infant gender dissatisfaction. No correlation was found with development of depression regarding miscarriage, maternal medical problems after delivery, previous child sex, maternal age, education, parity or neonate weight. Thus, this study shows that a chance of having miscarriage and unhealthy neonate increases with advanced maternal age. It also shows that caesarean section is associated with bad neonatal outcomes, more weight gain and having gestational diabetes or preeclampsia during pregnancy. Maternal sleeping problems are more pronounced in the first month, attributing for the baby care, compared with fourth and sixth months. The study indicates that depression is a common state of psychiatric disorders among Libyan women and should have an appropriate attention by physicians and gynecologists.

Mediterranean journal of pharmacy and pharmaceutical sciences

Foreign bodies (FBs) in the scalp are a common incident following head trauma, especially in traffic accidents, and are detected in the early post-traumatic period. The persistence of these FBs may cause pain and paresthesia. We report a case of 41 years old man, whose victim it’s been 20 years of physical aggression, in which the victim was hit by a brick occasioning a frontal wound stitched at the time without sufficient exploration. Months later, the patient presented several episodes of a frontal scalp nodular lesion with pus leakage (Fig. 1). The lesions were only treated with local antibacterial agents. Four years before the patient consults at our level, he consulted a dermatologist who performed a removal of the skin lesion. Months later, the lesion reappeared. At our level the clinical examination suspected a bone lesion, so CT was performed. Brain imaging was strongly evoking bone tumors or osteitis (Fig. 2). The patient was operated on under general anesthesia. First, a carcinogenic removal of the scalp lesion was performed; then, when reaching the bone, hard red friable bodies well separated from proportionally healthy bone were found. Those findings raise suspicion of the presence of FBs nested in the bone from the first head trauma. Hence, a carcinologic removal of the affected bone was postponed, and simple curettage was performed (Fig. 3). The post-operative course was without complications. The histological study confirmed per-operative findings: Multiple stony FBs associated with inflammatory reaction especially lymphocytes around vessels and the FBs.

Karishma

The market for tertiary educational institutions, most especially for private universities, is highly competitive. The competitive nature of the market requires that Private Universities (PUs) step up their performance so as to remain competitive despite the major structural and market differences between them and public universities in the provision of tertiary education. The need for private universities to remain competitive in this turbulent market, calls for some careful examination of the factors that would enable private universities to enhance their performance. In this respect, this study sought to examine the effects of management competence, firm-level institutions, and human resource management (HRM) bundles on the performance of private universities in Ghana. Underpinned by the RBV and AMO theories, the study tested four hypotheses that sought to explain the relationships between the key variables of the study. The study was implemented using a quantitative research design. Out of the sixteen private universities sampled, thirteen private universities responded. The main research instrument was a structured questionnaire. Out of 230 questionnaires administered, 127 completed questionnaires were received and used for analysis. Collected data was analyzed using descriptive and inferential statistics (regression analysis) with the aid of SPSS software version 20 and AMOS version 23. Research findings from the tests of hypotheses established that management competence positively and significantly affected performance of private universities in Ghana. Though the study found that the composite variables of firm-level institutions and HRM bundles did not moderate the relationship between management competence and PU performance, the skills bundles (which is a component of the HRM bundles) significantly moderated the management competence – PU performance relationship in such a way that at high levels of skills bundle, management competence influences PU performance more than at low levels of skills bundle. Based on the findings of the study, it is recommended that PUs in Ghana institute competence acquisition and utilization policies, maintain appropriate firm-level institutions and HRM bundles and match these to their competence development strategies.

Cyril domeyelle dery

The share of renewable energy share in India's energy mix of India has been increasing recently owing to the promotion and implementation of various government policies that promote the use of renewable sources of energy, depleting fossil fuel levels, increasing fuel prices, and stringent laws for emission reduction worldwide. The increase in the use of solar-evacuated-tube-collector-based domestic water heating is the result of this transition from conventional to nonconventional sources of energy. The recent urban agglomeration is challenging to install these solar water heaters in every household because the roof space is limited. Space reduction can be achieved by reducing the collector area by varying the diameter of the evacuated tubes. This study used a single tube and tank arrangement model with a fixed inclination to achieve a thermosyphon effect in a solar water heating system with three different diameter configurations of 48 mm, 54 mm, and 72 mm, with a tube measuring 1800 mm in length. Thermal assessment of the thermosyphon-based evacuated tube-solar water heater using the ANSYS CFD simulation software involves measuring the temperature at three different positions in the tank to study the thermosyphon initialization. This study signifies that the 72-mm-diameter evacuated tube is more capable of initializing the thermosyphon effect in the system. Nevertheless, the final temperature of the system is better achieved in the 48-mm-diameter evacuated tube

Swapnil ratnakar mane

Schizophrenia is treated with antipsychotic drugs and is a chronic neuropsychiatric disorders. The influence of antipsychotics on the cytokine systems may be responsible for their clinical efficacy in schizophrenia. Granulocytopenia and agranulocytosis are severe side effects of antipsychotic therapy. The objective of this study was to estimate incidence of drug-associated agranulocytosis in newly diagnosed schizophrenic patients in and to evaluate the risk factors and outcomes. Seven participants groups were designed. Healthy persons as control. Schizophrenic patients before treatment. Schizophrenic patients after one-month of treatment. Schizophrenic patients after two - month of treatment. Schizophrenic patients after three - month of treatment. Schizophrenic patients after chronic treatments. Schizophrenic patients one month after chronic treatment. This study included screening for the expression and function of circulating leukocyte granulocyte-macrophage colony-stimulating factor receptor, screening of patient's biochemistry and haematology picture. Granulocyte-macrophage colony-stimulating factor expression was decreased after antipsychotic treatment for one month and continued to decrease after two months' treatment. Granulocyte-macrophage colony-stimulating factor expression starts to increase after the two-month treatment and continues increasing to controls or newly diagnosed schizophrenics or after chronic treatment. Complete blood counts were not changed compared. Liver function showed a transient increase in serum alkaline phosphatase after one and two month of treatment. All other parameters were not changed. Kidney function showed that urea and creatinine levels were within the normal range during the different treatments. Concerning lipid profile, low density lipoproteins levels were increased after one month, two months of treatment and after chronic administration of the antipsychotic drugs. It is concluded that antipsychotic treatment produces a decrease in granulocyte-macrophage colony-stimulating factor expression; the decrease reach the maximum effect after two months, then starts to increase back to normal levels. A transient increase in serum alkaline phosphatase in the first two months' treatment. Urea and creatinine levels and lipid profile were within normal range, except low density lipoproteins levels were increased during the two months treatment and after chronic administration of the antipsychotic drugs.

Mediterranean journal of pharmacy and pharmaceutical sciences

The maximum H. armigera and M. vitrata infestation was recorded in Pusa-992 (3.72% and 7.90%) and in D2 (1st week of July) sown crop with infestation of 4.54 and 13.08 per cent, respectively. Whereas, the infestation of pod fly, M. obtusa was maximum in Manak (2.72%) and 2.58 per cent pod infestation in D2 (1st week of July) sown crop. The infestation of pod borer complex was negatively associated with pod wall thickness (-0.909**, - 0.739*, -0.870*, -0.834*, -0.840*, -0.705* and -0.745*) and non-glandular type A (-0.730*, -0.945**, -0.768*, -0.766*, -0.923** and -0.728*) and (-0.751*, -0.759*, 0.766*, -0.852*, -0.802*, -0.895** and -0.832*) glandular type B (-0.864*, -0.734*, -0.871* and -0.858*) and (-0.729*, -0.705*, -0.730* and -0.845*) density of pod trichomes of top and middle canopy of the plant. Fat (-0.884**, -0.754*, -0.743*, -0.871* and -0.750*) phenol (-0.900** and -0.806*) and tannin (-0.792*, -0.812* and -0.763*) content showed negative correlation with the pod infestation, whereas, crude protein (0.740*, 0.881**, 0.734*, 0.810*, 0.823*, 0.856*, 0.844* and 0.711*) and total soluble sugar (0.738*, 0.792*, 0.793*, 0.898**, 0.714*, 0.816*, 0.888** and 0.819*) showed positive association. Based on the results, it can be concluded that the variety Pusa-992 and Manak was most susceptible to the pod borers.

Dr. babu lal jat

Our research is a contribution to the analysis of emergent practices in the mediatization of the Gospel. It mobilizes an intercultural approach of the appropriation of the TIC by social actors at ends of proselytism and propaganda. The mobilized problem is that of the seduction in the media revival of the neo-pentecostal leaders. By supporting us on an observation of the practices of the TVevangelism in Cameroon, we analyze the emergent social uses of the audio-usual mediums at ends of proselytism and propaganda. Our research reveals the interest to go beyond the deterministic analyses of the development of the TIC to propose an intercultural analysis which underlines the sociocultural contingency of the movement of emergence and development of the TIC. The aim is to propose an intercultural analysis which underlines the sociocultural contingency of the movement of emergence and development of the TIC in Africa.

Tedongmo teko

Background: Dyslipidemia is an established cardiovascular risk factor in persons with type 2 diabetes (T2D), yet the extent to which these conditions co-occur in Africa is unknown. This systematic review and meta-analysis aimed to determine the prevalence of dyslipidemia among persons with T2D in Africa. Methods: Medline, Embase, Global Health, Scopus, and Web of Science were searched on 5 December 2023. This review adhered to the PRISMA guidelines and was prospectively registered on PROSPERO. The prevalence data for dyslipidemia was pooled through a random-effects meta-analysis. The authors assessed heterogeneity and publication bias using I2 statistics and Egger’s test, respectively. Results: Our search identified 8035 records, of which 60 articles involving 20 034 individuals with T2D were included in this review. The pooled prevalence of dyslipidemia recorded 38.6% (95% CI: 34.1–43.4) for high TC (≥ 5.2 mmol/l), 52.7% (95% CI: 44.2–61.1) for high low-density lipoprotein cholesterol (LDL-C) (≥ 2.6 mmol/l), 43.5% (95% CI: 37.1–50.0) for low high-density lipoprotein cholesterol (HDL-C) (< 1.0 mmol/l in men and less than 1.3 mmol/l in women), and 37.4% (95% CI: 32.2–42.9) for high triglycerides (TG) (≥ 1.7 mmol/l). Subgroup analysis based on gender indicated a notably higher prevalence of dyslipidemia among females compared to males. Conclusion: Dyslipidemia is prevalent among persons with T2D in Africa. This highlights the need for early screening, diagnosis, and management of dyslipidemia to mitigate the risk of cardiovascular complications in this population.

Emmanuel ekpor

The use of spectroscopic analysis, particularly UV spectrophotometer, is a simple and essential technique for bulk drug estimation, formulation studies, and compatibility assessments of drugs with various excipients. In the pharmaceutical industry, various analytical instruments, including Fourier transform infrared spectroscopy (FTIR), are employed for investigating drug-excipient interactions that can impact the stability of active pharmaceutical ingredients. This study aimed to develop a UV spectrophotometric method for the analysis of Pioglitazone hydrochloride in phosphate buffer (pH 7.4) and methanolic solution, assessing its linearity and compliance with Beer's Law. Furthermore, we aimed to use FTIR to characterize potential interactions between Pioglitazone and common pharmaceutical excipients, such as Guar Gum, Chitosan, and Sodium Alginate. Standard solutions of Pioglitazone were prepared in phosphate buffer (pH 7.4) and methanol. UV spectrophotometer was conducted to determine the maximum absorption wavelength. Calibration curves were constructed to evaluate linearity and adherence to Beer's Law. FTIR analyses were performed to investigate drug-excipient interactions by examining the functional groups. In phosphate buffer (pH 7.4), the maximum absorption wavelength for Pioglitazone hydrochloride was 268 nm. The calibration curve for Pioglitazone in phosphate buffer (pH 7.4) demonstrated linearity in the concentration range of 1–20 μg/ml, with a correlation coefficient of 0.998. In methanol, the maximum absorption wavelength for Pioglitazone hydrochloride was found to be 272 nm. The calibration curve in methanol exhibited linearity in the range of 1–20 μg/ml, with a correlation coefficient of 0.999. FTIR analysis revealed potential drug-excipient interactions, particularly in the case of Guar Gum, Chitosan, and Sodium Alginate, suggesting the formation of stable hydrogen bonds. The developed UV spectrophotometric method for Pioglitazone analysis is a reliable, cost- effective, and reproducible approach, making it a valuable tool for drug development and quality control. Additionally, the FTIR characterization confirmed interactions between Pioglitazone and common pharmaceutical excipients, enhancing our understanding of formulation compatibility,

Archana mehrotra