Overall, disability refers to a physical or mental state that impairs an individual's ability to function in daily life. It suffices to say that disability is a medical-social issue that affects both the family and the nation. In a country like India, where girl children are frequently stigmatized as a burden on society, the condition of girl children with special needs is frequently subject to carelessness, lack of compassion, and illiteracy. Though the situation has improved slightly since the introduction of inclusive education, the situation is critical for tribal girl students with special needs. In a fragile socioeconomic environment, tribal girls are already vulnerable to high dropout rates, early marriage, and an ignorant attitude from family members, but the situation is pitiful for tribal girls with special needs. The tribal girl students with special needs suffer quadruple discrimination of being female, being disabled, being ST, and being socio-economically backward. Here, intervention through artificial intelligence (AI) and AI-assisted devices can be critical in overcoming the barriers encountered by tribal girl students with special needs in the process of inclusion and development

Souren bhattacharya

Foreign Direct Investment as a strategic element of funding is required in every develop & developing country for achieving the financial growth & reforms and continue the pace of development and progress of the economy. FDI inflows are long term in nature which causes source of non debt finance, as well as bring modern & innovative technology in country by creating international network. In this paper, author attempted to discover how FDI is crucially important economic catalyst of Indian monetary progress by stimulating domestic investment. The essential purpose of this paper is to investigate the effect of FDI on fiscal growth by analyzing most important sector i.e. Banking Sector. And this sector is rapidly expanding with several challenges, raise due to competition by the new players in this ever growing sector. Whereas new initiatives of government like demonetization & Digital India, leads toward need of modern technologies & polices in banking sector which could be only possible by FDI in banking sector.

Anshuman vijay magar

Metformin, a widely prescribed biguanide for type 2 diabetes, has emerged as a promising candidate in skin cancer therapy due to its diverse anticancer mechanisms. Beyond its glucoselowering effects, metformin inhibits key oncogenic pathways, including the PI3K/AKT/mTOR and insulin/IGF-1 signaling pathways, activates AMP-activated protein kinase, and disrupts mitochondrial complex I function. These mechanisms are presumed to contribute to metformin's antiproliferative, pro-apoptotic, and anti-inflammatory effects, potentially reducing tumor growth and metastasis in melanoma and non-melanoma skin cancers. Predictive molecular docking studies reveal that metformin interacts with critical proteins in melanoma pathophysiology. Against PI3K/mTOR (PDB: 5OQ4), PTPN2 (PDB: 7UAD), and TRIP13 (PDB: 5VQA), metformin exhibited docking scores of -4.4, -4.6, and -5.6 kcal/mol, respectively, interacting via hydrogen bonding with residues such as ASP-836, ASP-964 (5OQ4), ASP-50 (7UAD), and SER-187, SER-138 (5VQA). Compared to standard inhibitors, PQR309 (-9.4 kcal/mol), ABBV-CLS-484 (-7.5 kcal/mol), and ATP (-10.8 kcal/mol), metformin displayed moderate binding affinity, suggesting potential but weaker inhibition of these targets. Preclinical and clinical studies support metformin's potential to reduce skin cancer risk, particularly in diabetic patients. However, challenges regarding bioavailability, optimal dosing, and patient selection persist, necessitating further investigation. Therefore, given its affordability, safety, and multitargeted action, metformin represents an attractive candidate for repurposing in skin cancer pharmacotherapy. Focusing future research on optimizing its therapeutic application, refining drug combinations, and identifying biomarkers would enhance clinical outcomes.

Karishma

Gender discrimination in the athletics industry has long been a controversial topic- even the founder of the modern Olympics, Baron Pierre de Coubertin, said in 1896, “No matter how toughened a sportswoman may be, her organism is not cut out to sustain certain shocks.” Since then, gender equality in sports has come a long way, including UNESCO recognizing sports and physical activity as a human right in 1978. Despite the obstacles women face in athletics, many women have led and are leading the way to gender equity. This paper profiles women athletes and administrators who have paved the way, and offers "Strategies for Change" that women and girl athletes, coaches, administrators, and parents can take to make school and college athletics more equitable. Participation in sports benefits women just as it does men, helping to develop leadership skills, boosting self-esteem and grades, and promoting physical fitness and health. Women and girls who participate in sports and fitness programs are healthier and more academically successful. Unsurprisingly, sports, which house the careers of the most passionate and the aspiring, are also a major concern when it comes to the issue of gender discrimination. Male dominance in sports has become a nightmare for female athletes, who in the hope of pursuing their careers in the field of sports, have been deprived of self-esteem among a plethora of gender discrimination instances. This in turn can lead to increased violence against women by these male athletes. We need to create a climate in which sports and fitness are for everyone, not just a few, and in which everyone's abilities are tested and respected.

Yatendra sharma

The seeds of Phaseolus vulgaris are known as common beans or kidney beans. The dry seeds are eaten as pulse and are enriched with protein, fiber, starch, B vitamins (B1, B6, B9), iron, potassium and selenium. Beans also contain about 1-2 % of fixed oil. Phaseolus vulgaris is linked to anticancer, antihyperlipidemic, hypoglycemic, and antioxidant actions. The fixed oil of Phaseolus vulgaris (PVFO) seeds is extracted with hexane and used in this study to assess acute oral toxicity, analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and antiinflammatory (by carrageenan-induced paw edema in rats) actions. Four groups were made (n=6): Group-I: Normal Saline Control (2ml/kg), Group-II: PVFO (2ml/kg), Group-III: PVFO (4ml/kg) and Group-IV: Standard Acetylsalicylic acid (ASA 300 mg/kg). PVFO in 2ml/kg and 4ml/kg doses demonstrated analgesic and anti-inflammatory activities, but in hot plate, results were unreliable as significant activity started after 90 minutes. A 5ml/kg dose was administered orally in mice for a toxicity test, and no toxicity symptoms were observed. Therefore, PVFO is safe for oral use up to 5ml/kg and may possess analgesic and anti-inflammatory actions.

Dr. salman ahmed

Nanomaterials have been widely used in many fields in the last decades, including electronics, biomedicine, cosmetics, food processing, buildings, and aeronautics. The application of these nanomaterials in the medical field could improve diagnosis, treatment, and prevention techniques. Graphene oxide (GO), an oxidized derivative of graphene, is currently used in biotechnology and medicine for cancer treatment, drug delivery, and cellular imaging. Also, GO is characterized by various physicochemical properties, including nanoscale size, high surface area, and electrical charge. However, the toxic effect of GO on living cells and organs is a limiting factor that limits its use in the medical field. Recently, numerous studies have evaluated the biocompatibility and toxicity of GO in vivo and in vitro. In general, the severity of this nanomaterial’s toxic effects varies according to the administration route, the dose to be administered, the method of GO synthesis, and its physicochemical properties. This review brings together studies on the method of synthesis and structure of GO, characterization techniques, and physicochemical properties. Also, we rely on the toxicity of GO in cellular models and biological systems. Moreover, we mention the general mechanism of its toxicity.

Kamal singh

World Health Organization (WHO) estimation disclosed over 116 million girls (3.4%) area unit stricken by PCOS worldwide. The predisposing risk factors embrace genetic science, system, lifestyle/environment, fatness that contributes to the event of PCOS. it's calculable that between 5 to ten % of U.S. girls of childbearing age have PCOS. that is regarding five million girls, which makes the condition one among the foremost common secretion endocrine disorders among girls of generative age. A study to assess the prevalence of PCOS among adolescent women at hand-picked setting, Chennai. Objective: to assess the prevalence of PCOS among adolescent women. Methodology: A non-experimental descriptive analysis style was adopted during this study. The non-probability convenient sampling technique was accustomed choose the sample size of two hundred adolescent Girls. The assessment of the prevalence of PCOS was administrated employing a self-reported check list through a Googletype. A survey link was sent to the respondents, via email and WhatsApp& teams. knowledge was analyzed by descriptive and inferential statistics. Result: our Majority (36.5%) of the samples had gentle & moderate PCOS symptoms and twenty-sevenths had severe symptoms. relating to physical activity, the bulk (38%) of the samples had gentle physical activity, thirty-fourth had moderate physical activity and twenty-eighth had severe activity. There was a direct correlation between PCOS symptoms and Physical activity. There was a statistically vital relationship between PCOS symptoms with age, religion, academic standing, dietary habits, previous information, supply of data, the cycle of emission and BMI and there was a statistically vital relationship between physical activity with age, Religion, academic standing, monthly family financial gain, age at the time of start, previous information, supply of data, variety of family, Cycleof emission & BMI. Conclusion: PCOS among adolescents is a rising problem that wants careful assessment, timely intervention, and appropriate treatment. Diagnosis of PCOS in adolescence remains a challenge attributable to overlapping symptoms of PCOS with traditional time of life changes in adolescents. life-style modifications for weight reduction and dietary modifications and psychological content plays vital role in these young ladies for preventing long run complications. Keywords: Poly cystic ovarian syndrome (PCOS), Prevalence, PCOS symptoms, Physical activity, Adolescent Girls.

Elsi queen

Online interviews can be powerful tools in global health research. In this article, we review the literature on the use of and challenges associated with online interviews in health research in Africa and make recommendations for future online qualitative studies. The scoping review methodology was used. We searched on Medline and Embase in March 2022 for qualitative articles that used internet-based interviews as a data collection method. Following full-text reviews, we included nine articles. We found that online interviews were typically conducted via Microsoft Teams, Zoom, Skype, WhatsApp, Facebook Messaging and E-mail chats. Online interviews were used in Africa because of the restrictions imposed by the coronavirus disease 2019 pandemic and the need to sample participants across multiple countries or communities. Recruitment for online interviews occurred online, interviews were characterised by inaudible sounds, the inability to use video options and the challenges of including people with low income and education. We recommend that researchers critically evaluate the feasibility of online interviews within a particular African locality before fully implementing this data collection approach. Researchers may also collaborate with community-based organisations to help recruit a more socioeconomically diverse sample because of the potential of excluding participants with limited internet access.

Emmanuel ekpor

Several studies demonstrate a strong correlation between talent and organizational performance. This view has led to continued improvement of methodologies, human resource scorecards, benchmarking, and engaging in best practices aimed at attracting both talent and better business management. As all these underline advancements of organizational strategic goals, it also determines the development and alignment of individual performance (Savanevičienė and Vilčiauskaitė, 2017, pg. 247). Although most of the studies involve for-profit corporations incorporating them in various industries proves to be both logical and psychologically sound. Regarding this project, the major focus is on determining talent strategies that best companies use to attract and retain people. For the project, Deloitte has been chosen as the reference organization for the strategies it uses and how its human resource management has been able to sustain attracting and retaining good talent.

Zamzam abdelazim

Vigna aconitifolia (Jacq.) Marechal. (Papilionaceae) is a medicinally important plant used for treating different diseases, especially dermatological disorders. Alkaloids, phenols, flavonoids, and phytic acid have been reported in this plant. Vigna aconitifolia also exhibits antioxidant, antidiabetic, and hypocholesterolemic activities. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

Unmanned aerial vehicles (UAVs) are aerial systems controlled remotely or autonomously by astronauts. Massive advancements in electronics and information technology have prompted the popularity and growth of UAVs. As a result of the huge advances made in electronics and information technology, civilian tasks can now be accomplished with UAV in a more effective, efficient, and secure way. Known as a drone, UAVs are developed and operated using a variety of technologies such as machine learning, computer vision, artificial intelligence, and collision avoidance. Having become more affordable and accessible, drone technology has become more popular among civilians. Therefore, this technology is constantly evolving and can be used across a variety of fields. The application of drones makes a huge difference in the most demanding and complex industrial environments such as those in the mining industry, maritime, oil, gas, and seaports. The usage of drones is increasing among industrialists to improve and optimize processes, as well as to enhance operational efficiency in industrial process. This chapter discusses UAVs on a wide range of topics, including evolution and historical perspectives of UAV, taxonomy of UAV, significance of UAV to society and industry, and industrial and academic perspectives on UAV.

Dr h shaheen

Trace elements are minerals present in living tissues in small amounts. Some of them are known to be nutritionally essential, others may be essential, and the remainder are considered to be nonessential. Trace elements such as zinc, copper, selenium, iron, chromium and, others are essential elements for growth and body health. They form an integral part of many enzymes and bioactive centers that are responsible for biochemical reactions such as metabolism, protein and, DNA synthesis. They are said to contribute to the development of cancer based on epidemiologic evidence. The blood level of trace elements in the human body is affected by cancer and drug treatment. The low trace elements level is a sign of leukemia patients, where cancer cells consume body nutrients and essential elements for growth. The Libyan patients were divided into four age groups and were either newly or old diagnosed with leukemia, including patients with acute leukocyte leukemia, acute myeloid leukemia, chronic myelogenous leukemia, and aplastic anemia. The samples were tested for direct aspiration onto inductively coupled plasma spectrometry at specific wave lengths. The findings showed the blood level of trace elements in leukemia patients is lower than in the healthy individuals. A negative correlation between copper and zinc levels in leukemia patients was found. The copper level increases in leukemia patients as they get older.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: The goal of nursing profession is to prepare the nurses to meet diverse needs of the patients, delivering holistic care to the patients. It is the need of the hour for the Nursing students to utilize their knowledge, skills, and technologies to practice independently and collaboratively with all health professionals. Any type of negligence in their work may result in dire consequences. Method: Descriptive Survey Research design was adopted for a study to assess the Academic Procrastination factors for General Nursing students at selected Schools of Nursing, Bhopal, with Sample size of 50 General Nursing students. Result: Result revealed that majority, 35 nursing students were male whereas 15 were females, majority of students (18) were in age group of 22-23 years, 32 students were in GNM 3rd year, mostly (43) resided in Urban area, majority (44) belongs to nuclear family, and 28 mothers as compared to 41 fathers of students were educated. Out of 50 respondents who were the subjects of research on the causes of academic procrastination, namely: 12 respondents (24%) said that it was caused by habit, 15 respondents (30%) answered Poor time management, 23 respondents (46%) said it was due to Tiredness, 28 respondents (56%) said it was due to peer pressure, 22 respondents (44%) due to Low motivation, 14 respondents (28%) answered unclear tasks, and 36 (72 %) said it was due to Deadlines for submission. Majority of nursing students 38 (76%) were moderately affected by Personal factors, and by Environmental factors only 26 (52%) students were moderately affected as compared to academic factors at 12 (24%) students who were moderately affected. Conclusion: The study concluded that personal and environmental factors have more effects on academic procrastination as compared to academic factors

Dr k c yadav

Financial literacy education is a lifelong asset that every individual needs to function and fit well in modern-day society. It provides the financially savvy better decision making, best investment alternatives and family wellbeing. Unfortunately, most consumers especially in this part of our world appear relatively less active and less confident in participating meaningfully in the financial sector due to a lack of knowledge about the complex nature of financial products and services and indeed the risk that goes with them. As a contribution in addressing this problem, this study looked at financial literacy education and its implication on the economic and social life of the teacher in the Upper East Region of Ghana. With a descriptive survey design, 118 participants responded to questionnaires. Results showed low levels of financial literacy among participants which can negatively affect their daily financial management. It is therefore definite that the financially literate has the advantage to undertake prudent alternative investment decisions and is able to make informed retirement planning. Being financially illiterate adversely affects one’s life in relation to the culture of savings, expenditure pattern, investment decisions and budgeting skills, making the individual economically insecure. The study has policy frontier implications; policymakers in the financial sector, governments, non-governmental organisations and equity owners are encouraged to come to the aid of consumers, especially teachers, by way of introducing professional teacher development programmes specifically tailored at uplifting their financial literacy knowledge and skills.

Juabin matey

Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is used worldwide to test and trace the spread of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). “Extraction-less” or “direct” real time–reverse transcription polymerase chain reaction (RT-PCR) is a transparent and accessible qualitative method for SARS-CoV-2 detection from nasopharyngeal or oral pharyngeal samples with the potential to generate actionable data more quickly, at a lower cost, and with fewer experimental resources than full RT-qPCR. This study engaged 10 global testing sites, including laboratories currently experiencing testing limitations due to reagent or equipment shortages, in an international interlaboratory ring trial. Participating laboratories were provided a common protocol, common reagents, aliquots of identical pooled clinical samples, and purified nucleic acids and used their existing in-house equipment. We observed 100% concordance across laboratories in the correct identification of all positive and negative samples, with highly similar cycle threshold values. The test also performed well when applied to locally collected patient nasopharyngeal samples, provided the viral transport media did not contain charcoal or guanidine, both of which appeared to potently inhibit the RT-PCR reaction. Our results suggest that direct RT-PCR assay methods can be clearly translated across sites utilizing readily available equipment and expertise and are thus a feasible option for more efficient COVID-19 coronavirus disease testing as demanded by the continuing pandemic.

Bitrus inuwa

Increasing presence of women in economic pursuits like entrepreneurship activities is believed to be the result of development policies. This belief ignores the role of socioeconomic factors in the growth and development of women entrepreneurship. Many women entered the world of business and they have become successful entrepreneurs in various business activities. Women entrepreneurs in Dakshina Kannada district have set up business ventures in a range of industries. The study has been conducted to know the extent of problems faced in managing work and life by women entrepreneurs. Majority of the respondents started their business or service to become independent and to meet the financial needs of their family. From the study it has to be found that majority of the women find it difficult to manage their work and family and they are trying to overcome these difficulties by time management and with the help of their family members.

Thara s shetty

The main theme of this paper is to implement the mobility model in the Cooja simulator and to investigate the impact of mobility on the performance of Routing Protocol over Low power Lossy networks (RPL) in the IoT environment. In the real world, mobility occurs frequently. Therefore in this paper, a frequently used mobility model - Random Way Point (RWP) is used for analysis. RWP can be readily applied to many existing applications. By default, the Cooja simulator does not support mobility models. For this, the Bonn Motion is introduced into Cooja as a plugin. As IoT deals with the resource-constrained environment, a comparison is done between the static environment and the mobile environment in terms of power consumption. As expected, the results indicate that mobility affects the RPL in terms of Power Consumption

Chandra sekhar sanaboina

To the editor, Breast cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating innovative and multifaceted therapeutic strategies. [1] We propose a promising combination approach that synergizes Artificial Intelligence (AI), oncolytic virotherapy, probiotic therapy, stem cell therapy, and immunotherapy to target breast cancer more effectively.

Karishma

Datura arborea Linn is a sacred plant known for over 3000 years to have been used for magical and curative purposes. It was shown to have a central nervous system depressant effect. The active substances identified were tropane alkaloids: atropine, scopolamine, and hyosine. Therefore, we aimed to find out whether the ethanol extract of Datura arborea Linn has sedative and hypnotic activity. The extract was subjected to a thiopental sodium-induced sleep test and diazepam was used as a standard drug. The plant possesses sedative-hypnotic qualities, the findings indicate that doses of 35 mg/kg (2.70.24 min), 70 mg/kg (3.80.19 min), and 140 mg/kg (4.30.20 min) decreased the control's (9.2 min) latency to fall asleep. In comparison to the control, the length of sleep was increased by 23.46 minutes for 35 mg/kg (99.002.99 min), 70 mg/kg (132.605.53 min), and 140 mg/kg (118.606.04 min), respectively. The present study established the acute toxicity of Datura arborea Linn to be less than 600 mg/kg in mice. This study indicated that the ethanol extract of Datura arborea Linn has a sedative-hypnotic activity in the diazepam-induced sleep test. It is safe to suggest that the extract acts via either β-receptor by causing hyperpolarization or a decrease in spike activity in the cell, leading to relaxation, but these effects were not blocked by β-antagonist or α2-receptor to decrease acetylcholine release, leading to relaxation of the smooth muscle.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background and Objectives: The outpatient department (OPD) pharmacy is a section of the hospital pharmacy that helps patients obtain their prescribed medications. However, on-time delivery of medications and patients’ convenient access to the pharmacy are the hallmarks of a well-designed health-care system. Therefore, he aim of this study was to develop a pharmacy triage tool to improve patient flow and reduce waiting time in the fourth-floor pharmacy at Hamad General Hospital (HGH). Methods: This prospective and observational study was conducted on 14,740 patients who attended the OPD pharmacy (HGH, Qatar) between January 15, 2022 and March 15, 2022. This prospective and observational study consisted of three periods: A root cause analysis, a pre-intervention period of 1 month (January 15, 2021–February 14, 2021) and an intervention period of 1 month (15 February–15 March). We developed a pharmacy triage tool to improve patient flow and reduce waiting time by identifying patients who need their medications to be dispensed, as well as classifying patients to get the right patient to the right place and implementing a patient flow system to improve efficiency spends in pharmacy queues. Results: The results of this study showed that the use of the triage system in the pharmacy reduced the average waiting time of patients from 50 min to 15 min. The results were statistically significant at p<0.0001. Conclusion: We concluded that applying the pharmacy triage tool improved quality of services in health-care systems and decreased waiting time in the OPD pharmacy. The pharmacy triage tool is a new approach to enhancing the quality of healthcare and leads to an increase in the efficiency of OPD pharmacies.

Karishma