Ketorolac tromethamine, the non-steroidal anti-inflammatory drug, was formulated into mucoadhesive films to overcome the limitations in the currently available dosage and routes of administration which in sequence will increase patients’ compliance. Films were cast from organic and aqueous solvents using various bioadhesive polymers namely: HPMC E-15, Eudragit RLPO, Eudragit RSPO, Carbopol 934P. The prepared films were subjected to investigation for their physical and mechanical properties, swelling behaviors, in vitro bioadhesion, drug permeation via bovine buccal mucosa, and in vitro drug release. These properties were found to vary significantly depending on the preparation methods, the type of the polymers, and the ratio of addition of both plasticizers (i.e. polyethylene glycol and film forming agent. Formulation F4 is selected for best formulation because it shows the 98.85% drug release at time 6 hr. In addition, this film was subjected to in vitro and in vivo release. The obtained results indicate that the concentration of ketorolac in the oral cavity was maintained above 4.0 µg/ml for a period of at least 6 h. This film shows promising results for using the ketorolac mucoadhesive route of administration topically and systemically, and thus it will be subjected to clinical evaluation in future work.

Kuldeep vinchurkar

The chosen organisation for this research work is Tesco. Founded in 1919, Tesco is one of the most renowned retailing brands operating in the global market (Azad, 2018). It focuses on selling a wide variety of products to its customers at low prices. Since its inception, the organisation has focused on maintaining high efficiency in its internal management. This is done with the help of effective human resource practices and organisational behaviour. The organisation always seeks to maintain good relations with its employees to work hard to attain the organisational objectives. This research work will focus on understanding and analysing the concept of organizational behaviour. This will be done by applying the different concepts and theories of organisational behaviour in reference to Tesco. Concepts such as motivation, leadership, teamwork, change management, and many more will be discussed in this research work.

Zamzam abdelazim

The exponential growth of biomedical literature presents both an unprecedented opportunity and a significant challenge for medical professionals and students. Conducting a thorough yet efficient literature review is a fundamental skill, essential for evidence-based practice (EBP), research, education, and scholarly writing. However, navigating this vast information landscape effectively remains a common hurdle. This review aims to provide a comprehensive, step-by-step guide to conducting efficient and rigorous literature reviews tailored to the needs of medical professionals and students. It focuses on practical strategies, critical appraisal techniques, synthesis methods, and leveraging technology to optimize the process while maintaining scientific integrity. A narrative review methodology was employed, synthesizing established principles and methods from evidence-based medicine, information science, and academic writing. Key sources include guidelines from major medical libraries, EBP resources, and authoritative texts on research methodology and critical appraisal. The review outlines a structured approach encompassing: defining a focused question using frameworks like Participants; Intervention/Exposure; Comparison; and Outcome (PICO/PECO); developing and executing a systematic search strategy across multiple databases; efficient screening and selection of relevant literature; critical appraisal of study quality and relevance; effective synthesis of findings (narrative, thematic, or tabular); clear and concise writing; and strategies for maintaining currency. Emphasis is placed on leveraging technology (reference managers, databases, and AI tools) cautiously and avoiding common pitfalls, such as scope creep and uncritical acceptance of findings. A life-long experience that the academic writer learns through life, and yet may fall into them easily. An efficient literature review is not merely about speed, but about systematic rigor, critical thinking, and strategic use of resources. By adopting the structured, technology-enhanced, and critically appraised approach outlined, medical professionals and students can navigate the literature effectively, saving valuable time while producing high-quality, evidence-informed outputs for clinical practice, research, and education.

Karishma

This is a study on the growth of public relations in Malaysia based on the advertisements placed in the newspapers during the colonial period. Tracing the historical development serves to make a better understanding about the nature of public relations practice. This paper therefore aims at exploring the development of the public relations profession by studying the advertisements placed in the nationwide newspapers, the Straits Times and the Singapore Free Press & Mercantile Advertiser from 1939 which included the early advertisement that contained the phrase “public relations” to 1956 a year before the independence of the Federation of Malaysia. An analysis of the advertisements was made to fully understand the historical development of public relations in Malaya or then Malaysia. The very first advertisement that was identified was on 31 January 1948, which was placed by the Department of Public Relations of the federal government. The British colonial government had placed another four advertisements in 1949 and 1950. A British mining Co. was the first corporation to hire an information & public relations officer in 1956. The results showed some differences and similarities through the analyses of advertisements in the job specification, which included qualification, duties, and salaries. The results revealed that those who had higher education and experience obtained a higher salary. The results also showed that some advertisers companies/ organizations had substituted academic qualifications for working experience) when advertising for their public relations personnel.

Mohammed fadel arandas

This study demonstrates main reasons for choosing The National University of Malaysia (UKM) by international students and their needs and expectations toward the University. The study also shows the obstacles faced by those students and their satisfaction towards UKM. A total of 108 questionnaires were distributed in the main campus to the respondents who came from ten diffident countries. The main reasons for choosing UKM were its high ranking, reasonable tuition fees, faculty, programmes, and lecturers respectively. The results revealed that the main obstacles faced international students were tough visa procedures, improper hostels, social isolation and discrimination, and bureaucracy. Both the facilities and services of UKM and the studying approach have met the expectations satisfaction of international students. Yet, both social relationship and participation in activities and living conditions in UKM hostels have disappointed international students and did not meet their satisfaction. This study suggested that UKM should establish counselling unit and organise regular meetings to listen to the problems and suggestions of those students. Volunteer and pre-enrolment activities should be organised to introduce the Malaysian culture and gather international students with their local peer. Moreover, international students should be provided upon their arrival to UKM by hostels that combine proper conditions of living at a reasonable price.

Mohammed fadel arandas

Background: In a Benghazi medical center, this observational study assessed the role of laparoscopic cholecystectomy (LC) in the early stages of acute gallbladder illness. Materials and Methods: From January 2022 to December 2022, all emergency and urgent admissions for acute gallbladder disease were identified, and additionally, data from hospital medical records were then evaluated retrospectively. Results: Out of a total of 334 patients with gallstone diseases, we found 321 individuals (206 with acute biliary colic, 115 with acute calculous cholecystitis), and 13 with acalculous cholecystitis. Early laparoscopic surgery for acute calculous cholecystitis had a greater conversion rate than procedures for acute biliary discomfort (19% vs. 4%; p=0.002). When surgery was performed 72 h from the onset of the symptoms for patients with acute calculous cholecystitis, the conversion rate was considerably lower (one out of 25) than when surgery was postponed past 72 h (14 out of 53) or later performed electively (seven out of 23) (p=0.014). In comparison to elective surgery for acute biliary colic (three of 66), elective surgery for prior acute cholecystitis was linked to a higher conversion rate (seven of 22 patients) (p=0.002). Conclusion: LC for acute calculous cholecystitis needs to be done within 72 h of the onset of symptoms, and it is worthwhile.

Karishma

The 2019 coronavirus (COVID-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. Molecular docking is a recognized computational tool to assist in early drug discovery and development. Molecular docking analysis was carried out using 2-(4-(aminomethyl)phenyl)isoindoline-1,3-dione Schiff base conjugates with SARS-CoV-2 protease enzyme and COVID-19 main protease in apo form 6M03). The compounds with the best normalized docking scores to protease enzyme (6LU7) were ARG3 (-8.1 kcal/mole), ARG7 (-8.1 kcal/mole) and ARG6 (-8.0 kcal/mole). The best docking ligands for main protease in apo form (6M03) were ARG7 (-8.7 kcal/mole), ARG6 (-8.6 kcal/mole) and ARG3 (-8.4 kcal/mole). The structural similarity between these conjugates inspired us to perform in silico studies to check their possible binding interactions with essential SARS-CoV-2 proteins. These studies provide insight into the potential binding between Schiff base derivatives and SARS-CoV-2 proteins to provide an insight for finding an effective therapy. Finally, ADMET calculations were performed for the Schiff base compounds to predict their pharmacokinetic profiles.

Mediterranean journal of pharmacy and pharmaceutical sciences

Will discuss how the German giant Lidl plans to take expansionary steps in a Mexican or Norwegian market to add to its success records in the European and North American markets. Lidl began modestly in 1973 with a small shop that runs three members and offers 500 products to 10,500 stores in 29 countries. Lidl has many pros, plus the disadvantages to consider when evaluating the components available in each country, both the pros and cons of this analysis will be reviewed using PESTLE, five- force models, internal value-activities, international business being able to. Accordingly, the next targeted expansion decision will be made.

Mohamed sorogy

Kompetensi pedagogik merupakan kemampuan yang harus dimiliki guru dalam mengelola pembelajaran. Berkaitan dengan pengelolaan Pembelajaran Tematik fakta di sekolah menunjukkan banyak guru belum sepenuhnya mampu mengimplementasikan pembelajaran yang memiliki prinsip mengintegrasikan banyak materi. Untuk itu, penelitian ini bertujuan untuk mendeskripsikan kemampuan guru: 1) Memahami peserta didik dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 2) Merencanakan pembelajaran dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 3) Melaksanakan pembelajaran pada Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 4) Mengevaluasi hasil belajar dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. Hasil penelitian menunjukkan bahwa: 1) Kemampuan guru memahami peserta didik sudah sesuai indikator kompetensi pedagogik. 2) Kemampuan guru merencanakan pembelajaran sudah sesuai dengan indikator kompetensi pedagogik. 3) Kemampuan guru dalam melaksanakan pembelajaran ada satu indikator yang perlu diperbaiki. 4) Kemampuan dalam mengevaluasi hasil belajar sudah sesuai dengan indikator kompetensi pedagogik.

Educare: journal of primary education

Research Aim: This study investigates the influence of workload and work environment on employee performance, with work stress serving as the mediator Approach: The study employed a quantitative approach using SEM-PLS analysis. The sample included 75 factory workers selected through census sampling conducted from February to June 2023 at PT PSB, a manufacturing firm in Medan, North Sumatra Findings: Findings reveal that workload and work environment positively impact employee performance, mediated by work stress Theoretical Contribution/Originality: This research contributes to the literature by exploring work stress as a mediator in enhancing the understanding of employee performance within the manufacturing sector Policy Implication: Recommendations include PT PSB and similar companies prioritizing plant workers' stress levels, monitoring workload, and fostering a healthy workplace environment Research Limitation: The scope of the study was limited by the number of respondents and the factors considered in assessing employee productivity

L

The CuS@reduced graphene oxide (CuS/RGO) hybrid nanocomposite was synthesized by facile hydrothermal method and used as a photoelectrode material in photovoltaic applications. In the hydrothermal route, RGO is formed by the reduction of GO with simultaneous formation of CuS/RGO nanocomposites. The CuS/RGO nanocomposites was investigated using powder XRD, TEM, HR-TEM, Raman, XPS, DRS UV–Vis spectroscopy, Photoluminescence (PL) measurements. XRD and TEM results suggest that CuS crystalline with individual spherical like homogeneous nanoparticles sizes in the range of 45–35 nm, which is distributed throughout the RGO sheets. We further construct the flexible photoelectrodes by using CuS and RGO and studied the photovoltaic performance. Photovoltaic parameters, such as short-circuit photocurrent density, open circuit voltage, fill factor and conversion efficiency were found to be 16 mA/cm2 , 0.71 V, 70.1% and 7.81% respectively, for CuS/RGO photoelectrode. The improved photo conversion efficiency of CuS/RGO is due to enhancing the electronic injection ability and reducing the photogenerated charge recombination. These photovoltaic results indicate a simple methodology for the low cost and effortless synthesis of an alternative CuS/RGO photoelectrode in high performance photovoltaic devices.

Dr.k.k.saravanan

Multimedia data encryption attempts to prevent unauthorized disclosure of confidential multimedia information in transit or storage. Security of multimedia files attracts more and more attention and many encryption methods have been proposed in literature. If we call a multimedia data stream (message) plaintext , the process of transforming the plaintext into unintelligible data stream is referred to as multimedia encryption (MME) where the encrypted message (data stream) is often named ciphertext. The process of transforming the ciphertext back into plaintext is termed decryption. We propose a new block cipher based on randomized key of size n × n where n is the block size and the block undergoes n 2 iterations with the plaintext. Every iteration generates the pseudo cipher text. The encryption process generate the ciphertext C with the help of the randomized key. The decryption apply the key in reverse order on the cipher text, to get back the plain text. This work deals with the problem of efficient multimedia data encryption.

S arul jothi

Digital data is growing enormously as the year passes and therefore there is a need of mechanism to protect the digital contents. Image watermarking is one of the important tools for the human to provide copyright protection and authorship. For achieving the ideal balance between imperceptibility and robustness, a robust blind color image watermarking employing deep artificial neural networks (DANN), LWT and the YIQ color model has been presented. In the suggested watermarking method, an original 512-bit watermark is applied for testing and a randomly generated watermark of the same length is used for training. PCA is used to extract 10 statistical features with significant values out of 18 statistical features, and binary classification is used to extract watermarks here. For the four images Lena, Peppers, Mandril, and Jet, it displays an average imperceptibility of 52.48 dB. For the threshold value of 0.3, it does an excellent job of achieving good balance between robustness and imperceptibility. Except for the gaussian noise, rotation, and average filtering attacks, it also demonstrates good robustness against common image attacks. The results of the experiment demonstrate that the suggested watermarking method outperforms competing methods.

Manoj kumar pandey

The daily water distillation of the single basin conventional solar still is limited. In the present work, experimental analysis of a parabolic disc type solar still and conventional solar still are investigated. The solar radiation is focused to the single point to produce higher basin temperature. The water is flown continuously inside the copper receiver to utilize the incident solar radiation. The hourly readings were taken to analyze the thermal performance of the parabolic disc type solar still and conventional solar still. The water collection of parabolic disc type solar still is increased about 40% over conventional solar still.

Appadurai m

Introduction: The university experience often brings various personal and academic challenges that can negatively impact students’ mental health. This research aimed to evaluate the effect of a mindfulness program on stress, anxiety, depression, sleep quality, social support, and life satisfaction among university students. Methods: A quasi-experimental study was conducted with 128 participants, divided into experimental and waiting list control groups. The experimental group participated in a mindfulness meditation program consisting of 12 weekly sessions. Pre-test and post-test measurements were performed using the Perceived Stress Scale (PSS-10), the Zung Self-Rating Anxiety Scale (SAS), the Zung Self-Rating Depression Scale (SDS), the Pittsburgh Sleep Quality Index (PSQI), the Medical Outcomes Study Social Support Survey (MOS-SS), and the Satisfaction with Life Scale (SWLS) to assess the variables. Results: The experimental group showed statistically significant differences between the study phases and the groups after the intervention for all the variables examined (p < 0.05). The effect sizes calculated using the HC3 model were stress (η2 = 0.376), anxiety (η2 = 0.538), depression (η2 = 0.091), sleep quality (η2 = 0.306), social support (η2 = 0.704), and life satisfaction (η2 = 0.510). The mindfulness program was shown to be effective in reducing levels of stress, anxiety, and depression while also improving sleep quality, social support, and life satisfaction in college students. Conclusion: These findings indicate that mindfulness meditation may be valuable for enhancing psychological well-being in educational settings.

Paul alan arkin alvarado-garcia

The Fourth Industrial Revolution (4IR), internet definition is considered as growing out of the third industrial revolution, but is considered a new era rather than a continuation because of the explosiveness of its development and the disruptiveness of its technologies. It is not a new phenomenon that many South African manufacturers are facing important talent challenges when organising their business. Diverse IT skill sets, improved skills blend and a rearrangement of skills are necessary. It is undisputed that 4IR requires a highly skilled workforce, and one which South Africa, regrettably, has been struggling to produce. It was the purpose of the study to gain an understanding of what Essential Employee Knowledge Management and Re-Skilling is needed in the South African Automotive Industry towards 2030 with regards to the Fourth Industrial Revolution (4IR). Methodology: Firstly, an environmental scanning was performed, examining pertinent literature, thereafter a case study approach was used was used to describe the true experiences of assembly workers and their immediate supervisors in a South African automotive plant. Results: The automotive industry is extremely robust and skilled employees are essential. From the study, the major solution to remedy low competence was continuous skills transfer through highly structured cross-functional skill development programmes. Conclusion: The study results cannot be generalised but do give an insight into what the current situation is in an automotive industry in South Africa.

Luyolo mahlangabeza

To acquire algorithmic thinking is a long process that has a few steps. The most basic level of algorithmic thinking is when students recognize the algorithms and various problems that can be solved with algorithms. At the second level, students can execute the given algorithms. At the third level of algorithmic thinking, students can analyze the algorithms, they recognize which steps are executed in sequences, conditions or loops. At the fourth level, students can create their algorithms. The last three levels of algorithmic thinking are: the implementation of the algorithms in a programming language, modifying and improving the algorithms, and creating complex algorithms. In preliminary research related to algorithmic thinking, we investigated how first-year undergraduate computer science students of J. Selye University can solve problems associated with the second, third and fourth level of algorithmic thinking. We chose these levels because these levels do not require to know any programming language. The tasks that students had to solve were for example: what will be the route of a robot when it executes the given instructions, how many times we need to cross a river to carry everyone to another river-bank. To solve these types of tasks requires only good algorithmic thinking. The results showed that students reached 81.4% average score on tasks related to the execution of given algorithms, 72.3% average score on tasks where they needed to analyze algorithms, and 66.2% average score on tasks where students needed to create algorithms. The latter type of tasks were mostly various river-crossing problems. Even though, that students reached a 66.2% average score on these tasks, if we had accepted only solutions with the optimal algorithms (minimal number of river crossing), they would have reached only a 21.3% average score, which is very low. To help students find the optimal algorithms of river crossing puzzles, we developed several interactive web-based animations. In the last part of this paper, we describe these animations, we summarize how they were created and how they can be used in education. Finally, we conclude and briefly mention our plans related to our future research.

Ladislav végh

The article analyzes the main problems of making an assessment of public administration activities, gives important question and makes main ways of experiences of assessing criteria of public administration. This the article is also devoted to the analysis of the essence of efficiency and quality of public administration in the world and studies the main conceptual models of efficiency of public administration, the definition of types of efficiency and identification of the main problems when forming criteria for evaluation of efficiency and quality of the government

Ikboljon odashev mashrabjonovich

Pengembangan budaya keagamaan di sekolah merupakan suatu kewajiban yang harus dilaksanakan oleh sekolah dengan mendesain program pendidikan agama islam yang mengarah pada pengembangan budaya keagamaan. Fokus penelitian ini adalah Bagaimana perencanaan pengembangan program pembelajaran Pendidikan Agama Islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo? Bagaimana pelaksanaan pengembangan program pembelajaran Pendidikan Agama Islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo? dan Bagaimana pengawasan pengembangan program pembelajaran Pendidikan Agama Islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo? Penelitian ini menggunakan pendekatan deskriptif analisis, jenis studi kasus. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Analisis data menggunakan model interaktif dan keabsahan data menggunakan triangulasi sumber. Hasil dari penelitian ini menunjukkan: 1) Perencanaan pengembangan program pembelajaran pendidikan agama islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo, yaitu: penyusunan buku pintar, Penugasan anggota membuat rancangan kegiatan, nilai-nilai karakter prioritas utama, rencana strategis pendekatan botton up, perencanaan pengembangan budaya keagamaan oleh tim agama. 2) Pelaksanaan pengembangan program pembelajaran pendidikan agama islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo, yaitu: Roling tanggung jawab job deskription pengembangan budaya, Quality Insurence (Jaminan Mutu) pembiasaan keagamaan, Model uswah guru, pelaksanaan Budaya keagamaan. 3) Pengawasan pengembangan program pembelajaran pendidikan agama islam dalam meningkatkan budaya keagamaan di SDN Bletok Bungatan Situbondo, yaitu: pengawasan internal kinerja anggota dan eksternal melalui pengguna layanan siswa dan orang tua, evaluasi supervisor sekolah terhadap kinerja anggota, anak berkepribadian sesuai dengan nilai-nilai agama, monitoring oleh komponen sekolah dan tim agama, monitoring siswa, monitoring tingkah laku dan pembiasaan siswa, penetapan capaian dari Quality Insurence.

Educare: journal of primary education

Sexuality is a subject to be discussed without shying-away. This essay, discusses about how sexuality of a certain minority people in India and across borders, are being perceived by people in various countries and the consequences faced by the people whose sexuality seems deviant i.e. the sexual minorities from the majority . This essay provides illustrations in the form of research done by various sources that provides such evidences that paint a different picture of the sexual minorities viz. Lesbian, Gay, Bisexual, Transgender, Intersex and Queer (LGBTIQ) people in India and across the world aiming at eliminating the prejudice against them.

Hari hara sudhan r