Plants are an ancient source of medicine due to the presence of bioactive molecules of various compounds in their different parts. Convolvulus dorycnium plant belongs to the family of wind plants (convolvulaceae). The greatest variety of Convolvulus plants are broadly distributed over the world and was found in Western and Central Asia, Mediterranean, Macaronesia, East Africa, and Arabia. The plant C. dorycnium was collected from Tarhuna in Sidi Said area of Libya in May 2013. Plants belonging to Convolvulus genus contain various phytochemicals profiles. The focus of this study is on the phytochemical analysis of convolvulus dorycnium including phytochemical screening, extraction, isolation, and characterization. The phytochemical screening reveals the presence of flavonoids, tannins, saponins, steroids, carbohydrate, and coumarin in ethyl acetate and methanolic extract. Column chromatography and column chromatography and TLC were used to fractionate the ethyl acetate extract and H-NMR was used to elucidate the isolated compounds. Some compounds were isolated from the aerial parts of the plant; scopoletin, which is a phenolic coumarin (1) (7-hydroxy-6-methoxy coumarin), caffeic acid (2) (3,4-dihydroxycinnamic acid), and ferulic acid (3) (4-hydroxy-3-methoxy cinnamic acid) which are phenolic acids. The chemical constituents present in the extract have been reported to possess many biological activities

Mediterranean journal of pharmacy and pharmaceutical sciences

To the editor, Umbilical venous catheter (UVC) is a widely used venous access device in neonates of any gestational age due to the immediate accessibility of the umbilical vein and the simplicity of the procedure of its placement. Several complications of UVC have been reported, including the thrombotic and infective ones, its dislodgement, and embolization. [1] Retained UVC is an uncommon complication and needs prompt intervention to prevent its migration. We present a case of retained UVC and the algorithm for managing such cases.

Karishma

When mental health experts provide information to courts on the results of a risk assessment conducted on a defendant or patient, they engage in “risk communication.” We examined the effects of four different forms of risk communication (prediction, categorical, risk factors/risk management, or hybrid) on judges’ (n = 253) perceptions of risk assessment evidence introduced in a case where they must decide whether to release from the hospital an individual found not guilty by reason of insanity. Judges who received information in the risk factors/risk management form were more likely to release the patient than were those who received prediction-based or categorical risk information. Judges with greater experience hearing cases involving risk assessment evidence were also more likely to release. Moreover, judges who had positive attitudes towards risk assessment and social science evidence in general, were more likely to find the risk assessment evidence introduced in the particular case to be understandable, relevant, and dispositive. Implications of the results for how mental health experts communicate risk information to the courts are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

John dolores

Dengue is an acute infection disease caused by a flavi virus (species Dengue virus of the genus Flavi virus), transmitted by female mosquito aedes mosquito, infection has globally become a major public health concern since the incidence of the dengue fever has increased more than 30-fold over the last decades. The dengue fever has been a most important public health problems since many years and the various outbreak of the dengue cases has been seen time to time. One of the reasons for the increasing and time to time outbreak of the dengue may be the reason of climate change, global warming, lack of knowledge about signs, symptoms, transmission, preventive measure and lack of ignorance or lack of the preventive practice of the dengue fever. Method: Descriptive, cross-sectional study on 192 head of household's was study population residing in Kanchan RM, Rupandehi Respondent was selected using Non probability judgmental sampling techniques by face-to-face interview was used. Result shows 58.3% good knowledge and 62% good practice. Knowledge was found to be associated with Age, Types of family, Size of family, educational level and Family suffered from dengue. Preventive practice was found to be associated with the Ever heard from health professional. Study will contribute towards development of appropriate policy strategies at local level that will tackle the problem associated with the knowledge and preventive practice of DF and provide a basis for future research on this area. Inferential analysis shows that there is significant association between the level of knowledge with age, types of family, size of family, educational level and family suffered from dengue and the level of preventive practice was associated with the ever heard from health professional.

Raju khanal

The kidney contains mineral deposits in various phases of calcium salts, such as calcium oxalate and calcium phosphate. Calcium hydrogen phosphate dihydrate (CaHPO4.2H2O) / brushite is a stable form of calcium phosphate, which exists in the form of kidney and bladder stones. The study aimed to explore the possible morphological features of brushite crystals. The study was carried out on a glass slide under a microscope to observe the growth patterns of these crystals. For this purpose, a drop of gel medium (sodium meta silicate solution + 1M orthophosphoric acid solution) at pH 4.99-5.09 was placed in the middle of a glass slide and converted into a gel. A 1M calcium chloride drop was added to form the gel adequately. The glass slide was observed under a microscope till it was completely dried. Calcium hydrogen phosphate dihydrate was formed as elementary needles, needle clusters, an assemblage of needles with platy crystals, plates with spatial branches, radiating assemblage of platy crystals, star shape crystals and tetragonal bipyramidal. The Current study provides brushite crystallisation phases on glass slides for the first time. It may also be used as a model to evaluate prophylactic management against renal stones through in vitro assessment of crystal growth and aggregation inhibition and modulation of developing or developed crystals by using different natural products. However, it was a preliminary study with no quantitative or statistical analysis.

Dr. salman ahmed

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

Financial accounting can be viewed as the process through which businesses record, summarize, and report their business transactions over a specified time (Yu, Lin, and Tang, 2018). Financial accounting aims to keep track of all business transactions that the business has engaged in over a specified time. Financial accounting also provides a snapshot of the financial health of the business entity. Financial accounting is crucial due to various factors. First, financial accounting ensures that proper financial statements are preferred in line with accepted accounting standards (Mita et al., 2018). Secondly, financial accounting ensures that the managers make crucial financial decisions in line with the financial statements. Financial accounting is also carried out to ensure that a business complies with the set taxation laws. Financial accounting is also crucial when valuing the business for significant events like merging and sale of the business (Homburg, Theel, and Hohenberg, 2020). Financial accounting can also provide evidence in case of legal suit and also provides crucial information to external and internal users of financial information.

Zamzam abdelazim

Vitamin C is associated with history of the cause of the ancient hemorrhagic disease scurvy. Vitamin C is an essential nutrient with important antioxidant properties. It is required by the body for normal physiological function. The body cannot synthesize vitamin C, it is present in nature through foods and other natural sources and it exists as a nutritional food supplement. The antioxidant activity of vitamin C protects the body from free radical damage. Vitamin C is essential for the development and maintenance of connective tissues. It is used as therapeutic agent in many diseases and disorders. Vitamin C plays an important role in several metabolic functions, as the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin, and the conversion of cholesterol to bile acids. Vitamin C supplementation resulted in a significant increase in vitamin C levels in populations; its high intake is associated with positive effects on cardiovascular risk factors. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight infections. It has an important role in bone formation, wound healing and the maintenance of healthy gums. There is profound beneficial effect of vitamin C in respect to human diseases as cancer, atherosclerosis, diabetes, neurodegenerative disease and many metal toxicities. Several vitamin C analogs have been produced as anticancer and antioxidant activity. Vitamin C is useful if it is used as adjuvant therapy for several chronic diseases. Thus, this review summarizes the importance of vitamin C in the body’s physiology and biochemistry, in addition, the different mechanisms that vitamin C is implicated to treat different acute and chronic diseases. Future exploration should pay attention to chronic disease management by vitamin C.

Mediterranean journal of pharmacy and pharmaceutical sciences

There are several significant assays including bioavailability, Toxicity, high clearance, and further current therapies require higher and frequent dosing to gain desired therapeutic effects for Rheumatoid arthritis (RA). Nanoparticles have beenwidely investigated for rheumatoid arthritis (RA). Though, higher doses of Nanocarriers also increase the incidence of dreadful adverse effects. Wherever, nanocarrier properties are most populated by the use of different approaches like targeting ligands, to change the physicochemical properties including higher encapsulation, better penetrating ability in cells etc. The main advantage of the nanocarrier that they provide longer circulation which enhances drug localization at the inflamed site and selective targeting to enhance the therapeutic index of anti-arthritic drugs. However, the optimal properties of nanocarrier also depend on the route of administration and size of particles, thus larger size show more retention upon local injection and smaller sized ones are more optimal for passive targeting. The present article discusses the emergence of nano-carriers for antirheumatic drugs, which delivers drug molecule to the inflamed site by topical, intra-articular (i.a) and intra-venous (i.v) administration to take advantage of therapeutic efficacy by passive and active drug delivery. Advancements have been made extensively but still better investigations are needed to achieve the risk-benefit ratio for the development of safe, stable and effective targeting nanocarriers for the e treatment of rheumatoid arthritis (RA).

Dr. wahul umesh b

As it is increasingly being reported from India, we carried out a prospective study of patients with culture-proven melioidosis from south India, examining clinical, laboratory features, epidemiological data, risk factors, treatments, outcomes at three and six months, and factors associated with mortality.Between 2014 and 2018, 31 cases were identified. Diabetes (83.9%) and alcohol abuse (58.1%) were common risk factors. Musculoskeletal, skin and soft tissue manifestations together constituted 48.4% of presentations, while 29% had pneumonia. During the intensive phase, 74.2% received one of three recommended antibiotic regimes, but 51.6% did not receive continuation treatment. Pneumonia and lack of continuation treatment were independently associated with a high mortality of 25.8%. Hot spots for melioidosis exist in India, and there is considerable diversity of presentation, including skin, soft tissue, musculoskeletal and neurological involvement. High rates of bacteraemia are shown.

Aneesh basheer

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

Anemia is a common health problem among Libyan women. Age, heavy menstruation, and pregnancy are vital risk factors for this problem. In this study, we prospectively examined 60 Libyan women all of which were diagnosed with iron deficiency anemia, their hemoglobin levels were less than 10.0 g/dl. The level of hemoglobin is also analyzed for vegetarian and charcoal-eating women. We found that during pregnancy charcoal-eating women exhibit lower hemoglobin levels than non-eating women. Pregnant young women in the age of 17-27 years have the lowest hemoglobin levels than the other age groups. In addition, vegetarians, heavy coffee and tea drinking, and heavy menstruation in non-pregnant women, as well as breastfeeding, strongly lower hemoglobin levels as measured by their complete blood count.

Mediterranean journal of pharmacy and pharmaceutical sciences

Pharmacists are expected to play major roles as members of diverse perioperative care teams besides implementing medication safety standards, pharmacist’s roles include optimizing drug therapy and other clinical interventions. Yet, developing general perioperative management as another crucial role operation room, pharmacists play and incorporating it into pharmaceutical education would be important. Enriching perioperative care provided by pharmacists can contribute toward improving the clinical competence of these professionals. Presently, there are no pharmacists in Zawia who participate in perioperative care. The objective of this study was to assess the pharmacist's knowledge of general anesthesia and drugs used to anesthetize patients who suffer from hypertension. A cross-sectional study was conducted in Zawia City, Tripoli in 2023. A self-designed questionnaire was distributed to 100 pharmacists. The study found that more than half of the pharmacists have humble knowledge about the drugs used in anesthesia, the findings indicated weakness in their information about drugs used to manage hypertension in surgery, and 36.0% know that sodium nitroprusside is used to control blood pressure during the operation. In conclusion, this study reported that some of the study's pharmacist participants had weak points that contributed to a high percentage of incorrect knowledge. These weak points may be attributable to poor educational preparation or a lack of training before the pharmacists began working in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences

Pod sucking bugs are the key impediments for the low productivity in India. Nymphs and adults of tur pod bug, Clavigralla gibbose (Spinola) suck the cell sap from the pods and cause loss of the grain. Because of its high fecundity and wide host adaptability, it is necessary to check its damage potential. For this purpose, an experiment on bioefficacy of insecticides against this insect was conducted in the laboratory-cum-field conditions on cultivar “Paras” during kharif season 2010-11, 2011-12 and 2012-13. Eight insecticides viz., endosulfan 35EC, monocrotophos 36SL, chlorpyriphos 20EC, quinalphos 25EC, triazophos 40EC, decamethrin 2.8EC, fenvalerate 20EC and cypermethrin 25EC were selected based on their LC50 values against this insect. Among the tested insecticides, cypermethrin proved most toxic (63.94 times) against adults of C. gibbosa followed by decamethrin. Quick knock down effect of decamethrin and fenvalerate was recorded in the field conditions. Therefore, the combinations of decamethrin and quinalphos with DDVP (76 EC) were also tested under field conditions. Cypermethrin, decamethrin plus DDVP, decamethrin and monocrotophos were found effective in managing the C. gibbose population upto 10 days after application. None of the insecticides could manage the bug population below ETL after 14 days of their application. Application of cypermethrin @ 188 mL ha-1 recorded the highest grain yield, highest net monetary returns and highest incremental cost benefit ratio, followed by decamethrin, fenvalerate and monocrotophos. Either of dimethoate or oxydemeton methyl could also manage the bug population

Dr. babu lal jat

The general meaning of a word is the representation of the type from it, in linguistic contexts and certain grammatical forms and this meaning is opposed to the individualized meaning, the separation of a unique item of the type, distinguishable from others. The general meaning seems like a grammatical meaning that is not formally sufficiently marked, but the indefinite articles and the suffixes, in addition to other grammatical meanings, can also express a general meaning in certain contexts. A definite meaning of the noun is generally considered the meaning of the noun in the definite form and indefinite meaning the one of the indefinite noun. But how does the general meaning relate to them? Nouns with general meaning, whether in the indefinite form or in the definite form are meaningfully definite. Both the speaker and the listener know the class that the general noun marks. Despite the formal indefiniteness / definiteness, nouns with a general meaning are semantically definite.

Anglisticum

Kompetensi pedagogik merupakan kemampuan yang harus dimiliki guru dalam mengelola pembelajaran. Berkaitan dengan pengelolaan Pembelajaran Tematik fakta di sekolah menunjukkan banyak guru belum sepenuhnya mampu mengimplementasikan pembelajaran yang memiliki prinsip mengintegrasikan banyak materi. Untuk itu, penelitian ini bertujuan untuk mendeskripsikan kemampuan guru: 1) Memahami peserta didik dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 2) Merencanakan pembelajaran dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 3) Melaksanakan pembelajaran pada Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. 4) Mengevaluasi hasil belajar dalam melaksanakan Pembelajaran Tematik di MI Miftahul Hidayah Tegalsari Tahun Pelajaran 2018/2019. Hasil penelitian menunjukkan bahwa: 1) Kemampuan guru memahami peserta didik sudah sesuai indikator kompetensi pedagogik. 2) Kemampuan guru merencanakan pembelajaran sudah sesuai dengan indikator kompetensi pedagogik. 3) Kemampuan guru dalam melaksanakan pembelajaran ada satu indikator yang perlu diperbaiki. 4) Kemampuan dalam mengevaluasi hasil belajar sudah sesuai dengan indikator kompetensi pedagogik.

Educare: journal of primary education

Purpose: With an increase in updated technologies use of Fintech services have also been increased. Intention to use of Fintech services largely depend upon attitude of individuals towards adoption of these services. Drawing upon the Technology Innovation Model (TAM) theory this paper observes different factors associated with customer’s attitude towards acceptance of fintech facilities provided by banks that in turn affect intent about usage of these services. The features like Supposed Utility, Apparent Comfort for Usage, Supposed Peril, Trust Factor, Administration Sustenance, Consumer Innovativeness, Attitudes in the direction of Acceptance, Intent in the direction of Adoption are used in this study. Methodology: The data was collected from residents of Delhi using a survey method through online mode. A well-structured questionnaire was circulated among customers with the help of employees of each branch by using the online platform WeChat. Also, Questionnaire was circulated among customers with the help of employees of each branch who gave them proper instructions to fill the questionnaire. It was circulated through WeChat. To inspect the strength of the association amid factors, , Confirmatory Factory Analysis (CFA) and regression path analysis were applied using SEM in AMOS software. Findings: The findings revealed that Government Support is a key predictive variable for the adoption of Fintech services. Whereas Perceived Ease of Use and Perceived Risk are not significantly supported the attitude towards adoption of Fintech services. While other factors slightly supported attitude towards adoption. Practical Implications: The findings of this article are useful for banks to provide empirical framework for customers to adopt new, user-centered fintech services. Originality/Value: This article in useful for the banking institutions, Government agencies and insurance companies provide empirical framework for customers to adopt new, user-centered fintech services.

Nandini jagannarayan

Arisaema jacquemontii Blume (Araceae) is a medicinally important plant for treating different diseases, especially dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, and tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

The aim of the paper is to develop Indian economy growth and its impact of upcoming scenario. In the modern world education is becoming the most important resource for economic and social development of countries, improving well-being and individual development of citizens. Education in every sense is one of the fundamental factors of development. No country can achieve sustainable economic development without substantial investment in human capital. Education enriches people's understanding of themselves and world. It improves the quality of their lives and leads to broad social benefits to individuals and society. Education raises people's productivity and creativity and promotes entrepreneurship and technological advances. In addition it plays a very crucial role in securing economic and social progress and improving income distribution. Our higher education institutions serve and enrich society in many ways and their role in modern Ireland is multi-faceted

Dr gedam kamalakar

Background and Aim: Ultrasound popliteal sciatic nerve block (UPSNB) is commonly performed in foot and ankle surgery. This study aims to assess the use of dexmedetomidine and dexamethasone as adjuvants in UPSNB for hallux valgus (HV) surgery, comparing their efficacy in producing motor and sensory block and controlling postoperative pain. The adverse event rate was also evaluated. Methods: This mono-centric retrospective study included 62 adult patients undergoing HV surgery: 30 patients received lidocaine 2% 200 mg, ropivacaine 0.5% 50 mg and dexamethasone 4 mg (Group 1), whereas 32 patients received lidocaine 2% 200 mg, ropivacaine 0.5% 50 mg, and dexmedetomidine 1 mcg/Kg (Group 2). At first, the visual analogue scale (VAS) was evaluated after 48 hours. The other outcomes were time to motor block regression, evaluation of the first analgesic drug intake, analgesic effect, adverse effects (hemodynamic disorders, postoperative nausea and vomiting (PONV)) and patient satisfaction. The continuous data were analyzed with student’s t-test and the continuous one with χ2. Statistical significance was set at a p-value lower than 0.05. Results: No significant difference was found in VAS after 48 hours (4.5 ± 1.6 vs 4.7 ± 1.7, p = 0.621) to motor block regression (18.9 ± 6.0 vs 18.7 ± 6, p = 0.922). The number of patients that took their first analgesic drug in the first 48 h (p = 0.947 at 6 hours; p = 0.421 at 12 hours; p = 0.122 at 24 hours and p = 0.333 at 48 hours) were not significant. A low and similar incidence of intraoperative hemodynamic disorders was recorded in both groups (hypotension p = 0.593; bradycardia p = 0.881). Neither PONV nor other complication was found. Patients in Group 1 reported a lower degree of interference with sleep (p = 0.001), less interference with daily activities (P = 0.002) and with the affective sphere (P = 0.015) along with a more satisfactory postoperative pain management (p < 0.001) as compared to Group 2. Conclusion: No significant differences were observed in the duration of motor and sensory blockade between patients in both groups. Additionally, both groups showed good pain control with a low rate of adverse effects, even if there was no clinical difference between the groups. However, patients who received dexamethasone reported experiencing less interference with their sleep, daily activities and overall emotional well-being, and overall pain control.

Dario cirillo