India is a country of immense diversity. It is home to people of many different racial, languages, ethnic, religious, and national backgrounds. Groups of people in India differ from each other not only in physical or demographic characteristics but also in distinctive patterns of behavior and these patterns are determined by social and cultural factors like language, region, religion, and caste. Apart from behaviour, economic development, level of education and political culture of the people in various social segments differ from region to region. More you can say that economy and cultures have been enriched by the contributions of migrants from round the globe. In an increasingly globalised world, migratory movements is continuously shaping the countries all over the world. Some countries like India and Ireland, which set the example of economic development and social integration, have the positive impact of the migration by globalisation and some countries like USA, which recently witness racism, xenophobia and discrimination have the negative impact on the migrants. It does not mean India do not face fragmentation and USA do not have cohesion. USA have many stories which show successful integration process, that facilitated the lives of immigrant communities, but being a developed country it still suffers from cultural alienation. In these countries, borders are built within borders to create cultural divides that do not allow people to integrate. Recently, this problem has become more prominent due to the rise of terrorism, clash of cultures in the world, leading to the glorification of stereotypes. People are becoming less accepting towards anyone who does not belong to their region. Migration does not stop after people move from one place to another place. The main question start after that ‘now what’ they will do. That is why this topic needs to be discussed thoroughly in order to find better solutions. This paper will begin with an analysis of different approaches to Migration, discuss the target groups for integration policies, provide indicators of the current situation of migrants and proceed to an analysis of integration tools: legislation, social policies and participatory processes. It will focus not only on the impact of migration but also on social integration, mix culture like indo-western culture in a comparative basis.

Ekta meena

Animals like plants are also medicinal agents for preventing and curing different health problems worldwide, practically in all human cultures. Zootherapy is ancient and has strong evidence of the medicinal use of animal resources. Different animal body parts and preparations are used in folk medicines. Zootherapy reveals that medical practitioners have always considered animals a source of surprising and numerous therapeutic effects. A high diversity of animals, their parts, and derivative products are used, and this is a heritage that could constitute a fundamental step in the discovery and isolation of natural extracts and new and low-cost alternative drugs from animals. About 12% of people worldwide are affected by different types of urolithiasis; the recurrence rate in females is 47-60%, and in males is 70-80%. According to WHO, 75% of the population relies on traditional medicines to prevent and cure diseases. Hence, there is a need to concentrate on all folk natural products effective in urolithiasis for their pharmacological evaluation and isolation of single drug molecules responsible for anti-urolithiasis activity to develop suitable formulations against urolithiasis.

Dr. salman ahmed

Background: Allied health science students often experience elevated academic stress due to the demanding nature of their curricula, which blend theoretical instruction with clinical practice. Examination periods, in particular, exacerbate psychological pressure, potentially compromising academic performance and overall well-being. Physical activity (PA) has been widely recognized for its protective role against stress, yet limited research has been conducted specifically among allied health science students. This study examined the correlation between physical activity and perceived stress levels among undergraduate allied health students during examination periods at Desh Bhagat University. Methods: A descriptive cross-sectional correlational study was conducted over eight weeks, from October to November 2024. 250 undergraduate students were proportionately and randomly selected from the Nursing, Physiotherapy, Radiography, and Medical Laboratory Science departments. Data collection instruments included the International Physical Activity Questionnaire–Short Form (IPAQ-SF) and the Perceived Stress Scale (PSS-10). Descriptive statistics, Pearson’s correlation, and one-way ANOVA were performed using SPSS version 25 to analyze the data. Results: Out of 250 questionnaires distributed, 237 were deemed valid for analysis. Among the respondents, 40.9% reported low physical activity, 38.4% moderate, and 20.7% high. In terms of stress levels, 65.4% experienced moderate stress, and 19.4% reported high stress. A statistically significant negative correlation was observed between physical activity and perceived stress (r = -0.42, p < 0.001). Furthermore, one-way ANOVA revealed that students with higher physical activity levels had significantly lower stress scores (F = 18.93, p < 0.001). Conclusion: Physical activity is an effective non-pharmacological strategy for mitigating academic stress among allied health science students. The results highlight the importance of promoting regular physical activity, particularly during high-stress academic periods, as a means of enhancing mental well-being and academic success.

Karishma

Ascorbic acid (vitamin C) is a water-soluble vitamin; it is present in the highest concentration in the brain. Ascorbic acid in high doses acts as a potential treatment for various neuropathological and psychiatric conditions. Flumazenil is a benzodiazepine antagonist; it competitively inhibits the activity of benzodiazepine and non-benzodiazepine substances that interact with benzodiazepine receptors site on the GABA/benzodiazepine receptor complex. This study aims to investigate the effect of flumazenil on the anxiolytic action of ascorbic acid using an elevated plus maze model of anxiety in rats. Male Albino Wistar rats weighing between 250 and 320 grams were used. Rats were divided into four equal groups of seven rats each and treated as follows: Group I, the control group received a single dose of 1.0% tween 80; Group II treated with a single dose of 125 mg/kg ascorbic acid; Group III was injected by a single dose of 1.0 mg/kg flumazenil; Group IV received a combination treatment of 125 mg/kg ascorbic acid and 1.0 mg/kg flumazenil. Behavioural measurements using a plus maze were scored 30 min after the administration. The parameters scored are the time spent on the open and closed arms, the lines and number of entries into open and closed arms, and the anxiety measure. Ascorbic acid decreased anxiety measure and increased the total lines and total number of entries; this effect was abolished by the administration of flumazenil with ascorbic acid. Thus, ascorbic acid produces an anxiolytic-like effect in rats; this effect was abolished by flumazenil administration with ascorbic acid. This may indicate that the GABA/benzodiazepine receptor complex has to be stimulated to produce the anxiolytic effect.

Mediterranean journal of pharmacy and pharmaceutical sciences

This book presents more than 600 eye-catching structural geological photographs and explanatory descriptions, from different Indian terrains. This book will enable easy identification of deformation features, one of the most important tasks in structural geology at the meso- and micro-scales.

Rajkumar ghosh

Salah satu mata pelajaran yang dianggap sulit oleh siswa adalah matematika. Sehingga pelajaran ini kurang diminati siswa. Permasalahan inilah yang menyebabkan banyak siswa mengalami kesulitan belajar matematika. Rumusan masalah dalam penelitian ini yaitu: Kesulitan Belajar Matematika Siswa MI Da’watul Falah Kecamatan Tegaldlimo Kabupaten Banyuwangi Tahun Pelajaran 2018/2019? Sedangkan tujuan penelitian ini adalah untuk mendeskripsikan kesulitan belajar matematika siswa MI Da’watul Falah Kecamatan Tegaldlimo Kabupaten Banyuwangi. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian fenomenologi. Subjek penelitian dalam penelitian ini menggunakan purposive sampling. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan dokumentasi. Sedangkan analisis data menggunakan model analisis Miles, Huberman dan Saldana yaitu data Condensation, data Display, serta Conclusion drawing/verivication. Adapun pengecekan keabsahan data yang digunakan adalah triangulasi sumber dan triangulasi teknik. Hasil penelitian ini menunjukkan bahwa kesulitan belajar matematika siswa disebabkan salahnya mindset yang dibangun dari awal oleh siswa, sehingga mereka kesulitan dalam memahami materi yang diajarkan di kelas. Adapun faktor-faktor yang menyebabkan kesulitan belajar terdiri dari faktor internal dan faktor eksternal.

Educare: journal of primary education

The gold standard anesthesiologic procedure for urgent femur fracture surgery is Spinal Anesthesia. It is not always feasible because of patients' severe comorbidities and difficulties in optimizing drug therapy in the appropriate time frame such as discontinuation of anticoagulant drugs. The use of four peripheral nerve blocks (tetra-block) can be a winning weapon when all seems lost. We present, in this case series, three Caucasian adult femur fractures (an 83-year-old woman, a 73-year-old man, and a 68-year-old woman) with different and major comorbidities (cardiac or circulatory disorders on anticoagulants therapy that were not discontinued on time; breast cancer and others) underwent the same anesthesiologic approach in the urgent setting. Ultrasound peripheral nerve blocks, that is femoral, lateral femoral cutaneous, obturator, and sciatic with parasacral approach were successfully performed in all patients who underwent intramedullary nailing for intertrochanteric fracture. We evaluated the adequacy of the anesthesia plane, postoperative pain control with the VAS scale, and the incidence of postoperative side effects. Four peripheral nerve blocks (Tetra-block) can be alternative anesthesiologic management in urgent settings, in patients where drug therapy cannot be optimized, as in antiplatelet and anticoagulant therapy.

Dario cirillo

Experiment was carried out to standardize the artificial diet for mass rearing of Helicoverpa armigera (Hübner) under laboratory conditions. The average length and breadth of egg was 0.51±0.06 mm, 0.46±0.37 mm and 0.52±0.03 mm, 0.48±0.62 on artificial and natural diet. The average length and breadth of first, second, third, fourth and fifth instar larvae was 1.40±0.09 mm, 0.46±0.02 mm and 1.42±0.01 mm, 0.47±0.16 mm and 4.03±0.22 mm, 0.66±0.07 mm and 4.31±0.01 mm, 0.89±0.25 mm and 8.19±0.36 mm, 1.57±0.63 mm, and 10.29±0.72 mm, 1.87±0.91 mm and 18.70±0.44 mm, 2.78±0.040 mm and 20.15±0.03 mm, 3.17±0.55 mm and 26.01±0.19 mm, 4.09±0.39 mm and 27.32±0.027 mm, 5.88±0.69 mm, respectively with the average duration of 2.69±0.32 and 2.54±0.29, 3.77±0.65 and 3.79±0.11, 3.88±0.49 and 3.72±1.23, 5.35±0.55 and 5.72±0.91 and 6.61±0.008, 6.46±1.07 days, respectively on artificial as well as on natural diet. The average length and breadth of adult male and female was 18.01±0.48 mm and 35.09±1.25 mm, 18.51±1.04 mm and 38.11±1.37 mm, 19.00±0.18 mm and 19.10±0.49 mm, 37.75±1.27 mm and 41.23±1.69 mm, respectively. The average pre-oviposition, oviposition and post-oviposition period was 2.52±0.86 and 2.76±0.84 days, 4.93±0.78 and 5.08±0.90 days and 0.65±0.49 and 0.79±0.93 days, respectively. The total life cycle of male and female was 40.50±2.29 and 41.81±1.89 days and 42.59±1.77 and 43.80±1.93 days.

Dr. babu lal jat

The present investigation is an attempt to evaluate the analgesic and antiemetic activities of Ficus exasperata and Cleome ciliata leaves methanolic extract by using the chick emesis model (oral treatment) and acetic acid-induced writhing test (intraperitoneal treatment) in mice, respectively. The antiemetic activity (150 mg/kg b.w., of extract) was carried out by using chlorpromazine (150mg/kg) as standard antiemetic drug. The analgesic activity (250 mg/kg b.w. of extract) was performed using aspirin (150mg/kg) as a standard analgesic drug. The results showed significant analgesic and antiemetic effects.

Dr. salman ahmed

Background: Infantile hemangioma (IH) is observed at varying frequencies among children, impacting 10% of infants. The majority of uncomplicated IH cases experience spontaneous involution, while a minority necessitate intervention. This study aimed to assess the safety and effectiveness of propranolol in treating IH in Libyan pediatric patients. Methods: From 2013 to 2016, a total of 100 patients diagnosed with infantile hemangioma (IH) were monitored at a pediatric tertiary hospital's hematology clinic. Their demographic and clinical information, along with digital images of the lesions, were collected prospectively to evaluate coloration, size, and improvement of the hemangioma lesions. Following parental consent to initiate treatment, a regimen of oral propranolol, atenolol, or a combination of propranolol and steroids was commenced. Results: The study included 100 children diagnosed with infantile hemangioma (IH), consisting of 62% females and 38% males. Out of these, 68 children were treated exclusively with propranolol, while 12 were started on atenolol. The remaining 20 children received a combination of steroids and propranolol. Hemangioma lesions were primarily located on the face (56%). After an average follow-up duration of 10.53 ±7.21 months, among the 68 children treated solely with propranolol, 12 under the age of 12 achieved complete resolution of their hemangiomas, 15 demonstrated near-complete resolution, and the remaining 41 showed a significant reduction in hemangioma size without considerable disfigurement. Following a six-month discontinuation of propranolol, 2 children from this group experienced a relapse of their lesions. In one instance, the lesion resolved after 12 months of resuming propranolol, while the other required 18 months of treatment. Among the children treated with atenolol, two attained complete resolution, two had near-complete resolution, and 8 exhibited a significant reduction in hemangioma size. No relapses or changes in lesion size were noted after the cessation of atenolol. Conclusion: Oral propranolol is considered both safe and effective for the treatment of IH at a daily dosage of 2 mg/kg, with no significant adverse effects reported. Atenolol serves as an alternative to propranolol, while steroids, despite their potential side effects, have been shown to improve lesions in certain pediatric patients. Nevertheless, further large multicenter studies are necessary.

Karishma

Background: From the public health point of view, the microbiological properties of domestic water supply are the most important parameters of domestic water supply because of the propensity for microbial water-related diseases. In Enugu State, statistics have shown that reported cases of waterborne diseases (including typhoid fever) have been on the increase since 2003. The aim of the study was to determine the bacteriological qualities of domestic water supply and prevalence of typhoid fever in five communities of Enugu State in connection with the rising incidence of typhoid fever in the state. Methods: This was a cross-sectional study of sources of domestic water supply and prevalence of typhoid fever in five rural communities of Ezeagu Local Government Area. 297 copies of structured questionnaire, 10 grab water samples analysed using the membrane filtration method and 227 blood samples collected for Widal test were used to generate the data for the study, analysed as frequency distributions, t-test of means difference and Pearson product moment correlations using MaxStat (version 3.60) statistical software. Results: 2 (40%) of the 5 communities complied with the WHO standard for faecal coliform counts. Prevalence of typhoid fever was high in all the communities (71.4%-100%). Only faecal coliform counts correlated positively and strongly (r=0.69) with prevalence of typhoid fever. Conclusions: Since faecal coliform counts correlated positively and strongly (r=0.69) with prevalence of typhoid fever, improving the bacteriological qualities of domestic water supply may help to reduce the prevalence of typhoid fever.

Emmanuel umegbolu

Metamizole or Novalgin® is a widely used well tolerated analgesic drug which is however compromised by agranulocytosis as adverse effect. Subsequent to nonenzymatic hydrolysis, the primary metabolic step is N-demethylation of 4-methylaminoantipyrine (4-MAA) to 4-aminoantipyrine (4-AA). The aim of the present study was to identify the human cytochrome P-450 enzyme (CYP) mediating this reaction. This study identified the relevant CYP using virus expressed isolated human CYP, human liver microsomes and rat liver microsomes with chemical inhibition studies. The substrate of 4-methylaminantipyrine was employed at six different concentrations (25, 50, 100, 400, 800 and 1200 µmol per l) with varying concentrations of selective inhibitors of CYP1A2 (furafylline, fluvoxamine), CYP3A4 (ketoconazole), CYP2A6 (coumarin), CYP2D6 (quinidine), CYP2C19 (omeprazole, fluvoxamine, tranylcypromine), CYP2C9 (sulphaphenazole) and CYP1A1 (alpha-naphthoflavone). 4-MAA and 4-AA were analyzed by HPLC and enzyme kinetic parameters (Km and Vmax) were determined by regression (Sigma plot 9.0). The N-demethylation of 4-MAA by microsomes prepared from baculovirus expressing human CYP was pronounced with CYP2C19. Intrinsic clearance of the most active enzymes were 0.092, 0.027 and 0.026 for the CYP enzymes 2C19, 2D6 and 1A2, respectively. Metabolism by human liver microsomes was strongly inhibited by fluvoxamin, omeprazole and tranylcypromine (IC50 of 0.07, 0.07 and 0.18, respectively) but with coumarin, sulphaphenazole, ketoconazole, moclobemid, quinidine alpha-naphthoflavone and furafylline were 0.79, 1.20, 1.36, 1.44, 3.46, 4.68 and 8.41, respectively. The enzyme CYP2C19 apparently has an important role in N-demethylation of 4-methylaminoantipyrine which should be further analyzed in clinical studies and which may also be interesting concerning the agranulocytosis.

Mediterranean journal of pharmacy and pharmaceutical sciences

In the direction of computer globalization and digitization, India is rapidly developing education and information technology. People are taught how to invest in deposits, postal investments, government bonds, gold systems and bonds, and the private sector. The world in which we now live has been completely transformed by technology. The study indicates that there are more than 4 billion active Internet users worldwide, or nearly half of the world's population. Our lives are now faster, easier to manage, and more enjoyable thanks to modern technology. This paper focuses in experiencing and developing a stock application using PHP, React JS, NodeJS and CSS . All the stock data is stored in a MYSQL database. On the other side for developing machine language application python code is used to convert the data into csv format for machine learning algorithms. The investor is presented with a login screen in the python environment where they must enter their user name and password. The stock dashboard shows the investor's current stock holdings, as well as online stocks' their current price, percentage change in stocks, sensex, nifty, bonus, rights, IPO's, annual report etc. statistical methods are used as software modules for the investor, and with a single click of a button, they can compare and contrast their own stocks with online stocks, as well as the trend in the stock market position in order to decide whether to buy, hold, or sell the stocks. Data visualization component is used for comparison of various stocks, and by clicking of a button, stock prediction are displayed whether to hold, buy or sell in future according to the market trend. The trader must log in using their user name and password. The trader will browse the client current market price of all stocks, buying and selling stocks, contract note, client margin, e-off market transactions, ledgers, journals, commission of buying and selling stocks, and so on. In future strategy the stock application programming is converted by a portable mobile application by using python packages like Kivy, PyQt, or even Beeware's Toga library.

Dr.n.r.ananthanarayanan

The study aims to explore the possible morphological features of calcium hydrogen phosphate dihydrate (brushite) crystals on a glass slide. The study was conducted on a glass slide under a microscope to observe the growth patterns. As a result, needle, platy, star shape, and tetragonal bipyramidal crystals were observed. Different patterns of platy crystals, like plates with spatial branches and radiating assemblages of platy crystals, were also found.

Dr. salman ahmed

The unprecedented global effort to develop and distribute COVID-19 vaccines has highlighted remarkable scientific achievements and persistent inequities in access across populations. Analyzing of regional vaccine deployment patterns reveals critical insights into pandemic response dynamics, shaped by manufacturing capacity, regulatory frameworks, procurement strategies, and regional health priorities. Data from WHO regions (Africa, the Americas, Eastern Mediterranean, Europe, and Western Pacific) demonstrate significant disparities in vaccine types and suppliers, underscoring the complexity of global vaccination efforts. (Figure 1) illustrates this regional vaccine distribution by WHO regions.

Karishma

The current study explores creative cultural tourism as a new model of the relationship between cultural heritage and tourism. Cultural heritage with its tangible and intangible components represents an essential part of culture tourism. Many changes have been happened in tourism due to new forms of consumption patterns, tourism activities, and tourism products. These changes require shifting from traditional culture tourism to creative cultural tourism as a new concept of cultural heritage. Tourists face many problems in the traditional culture tourism which is a form of mass tourism, thus, creative cultural tourism came to solve these problems. In addition, this study explains the transformation from traditional culture tourism to creative culture tourism.

Mukhles m. al-ababneh

Marine algae have been known and utilized since the ancient era. It is the source of chemical compounds mainly useful as a food for their richness in protein, fatty acids, minerals and vitamins. Physiologically active compounds also have a great potential to play an important role in cosmetics, medicine and pharmaceutical aid. In this review, the information provided will play an essential role in future medicinal and cosmeceutical production.

Dr. salman ahmed

Homoeopathy is one of the latest systems of medicine discovered at the latter part of 18th century, first rose to prominence in the 19th century due to its success in treating epidemics and is currently second largely utilized system of medicine globally. Prophylaxis through Homoeopathy has been strongly promulgated by stalwarts and popular among the general public in the recent times, but still controversy revolves around it. Aim of the study is to review the available literature for analyzing the usefulness of Homoeopathy in prophylaxis of human, animal as well as plant diseases. A comprehensive search has been made in electronic database aimed to target the available literature of various levels of evidence. Examples are summarized under different areas of applicability of homeopathic medicine as prophylactic. Currently there is convincing evidence to support effectiveness of Homoeopathy in prophylaxis, though sparse. More rigorous research studies are warranted to enlarge the horizon of its application.

Dr deepthi gilla

Introduction: Traumatic brain injury is caused by an external physical force which may result in altered level of consciousness with or without impairment of cognitive and physical functions in individuals. It is neither congenital nor degenerative in nature. The impairments can be permanent with partial or total functional disabilities or psychosocial maladjustment. The Intensive rehabilitation with multiple health disciplinary teams can improve a certain extent of physical and cognitive aspects of brain injury patients. Case Report: In this case report we are presenting a 19 year old boy diagnosed as diffuse axonal injury with Glasgow coma scale (GCS ) Score of 4/15 (E1M2V1) at the time of incident has come to our department after 8 months with no head control, no cognitive and no voluntary attempts to do functional activity. The main objective of management is to improve mobility, communication, perception and cognitive functions with minimum period of time by working as a health team. Conclusion: After 14 months post incident with intense rehabilitation of six months his GCS score is improved with scoring of 13/15 (E4M6V3). The improvement seen may be partly attributed to the coordinated work of the team members who meet in the case conference every two weeks to review & revise the treatment protocol. Such that common and individual goals are shared and total therapy time is managed, to incorporate all goals by team members

Nagarjuna narayanasetti

Impurity is something that is impure or makes something else impure. An impure substance may be defined as follows: a substance of interest mixed or impregnated with an extraneous or usually inferior substance, from the standpoint of its usage, the drug substance is compromised in terms of purity even if it contains another material with superior pharmacological or toxicological properties. The impurity may be developed either during formulation, or upon aging of both API’s and formulated API’s in medicines. The presence of these unwanted chemicals, even in small amount, may influence the efficacy and safety of the pharmaceutical products. The impurities are not necessarily always inferior. Highly sophisticated instrumentation, such as mass spectra meters attached to a Gas Chromatography or HPLC, are inevitable tools in the identification of minor components (drugs, impurities, degradation products, metabolites) in various matrices. Present article reveals different impurities found in the API’s, methods for identifying them and the possible measures to deal with the interferences caused by them in pharmaceutical analysis.

Prasanna pradhan