Trace elements are minerals present in living tissues in small amounts. Some of them are known to be nutritionally essential, others may be essential, and the remainder are considered to be nonessential. Trace elements such as zinc, copper, selenium, iron, chromium and, others are essential elements for growth and body health. They form an integral part of many enzymes and bioactive centers that are responsible for biochemical reactions such as metabolism, protein and, DNA synthesis. They are said to contribute to the development of cancer based on epidemiologic evidence. The blood level of trace elements in the human body is affected by cancer and drug treatment. The low trace elements level is a sign of leukemia patients, where cancer cells consume body nutrients and essential elements for growth. The Libyan patients were divided into four age groups and were either newly or old diagnosed with leukemia, including patients with acute leukocyte leukemia, acute myeloid leukemia, chronic myelogenous leukemia, and aplastic anemia. The samples were tested for direct aspiration onto inductively coupled plasma spectrometry at specific wave lengths. The findings showed the blood level of trace elements in leukemia patients is lower than in the healthy individuals. A negative correlation between copper and zinc levels in leukemia patients was found. The copper level increases in leukemia patients as they get older.

Mediterranean journal of pharmacy and pharmaceutical sciences

Cleome brachycarpa Vahl . and Cleome viscosa L. were evaluated for anti-emetic activity in the copper sulfate-induced chick emesis model. Emesis was induced by copper sulfate (50 mg/kg), and the methanolic extracts of leaves were tested orally at a dose of 150 mg/kg. Chlorpromazine (150mg/kg orally) was used as standard anti-emetic drug. The anti-emetic activity was determined by calculating the mean decrease in the number of retching as compared with the control. Cleome brachycarpa and Cleome viscosa showed comparable anti-emetic activity with chlorpromazine.Cleome brachycarpa Vahl ., and Cleome viscosa L., leaves extract in a dose of 150 mg/kg body weight., reduced the numbers of retches by 57.57% and 43.06%. Cleome brachycarpa significantly (**P<0.005) reduced the number of retches. The group of chicks treated with chlorpromazine had 45 retches compared to the 71 retches of the control group, thus chlorpromazine reduced the retches by 36.99%. From the results, it is clear that Cleome brachycarpa Vahl. and Cleome viscosa L. leaves extracts have antiemetic potential and are comparable with standard chlorpromazine. Although the result is significant the mode of action is not known. Antiemetic activity by using copper sulfate proposed 5-HT3, 5-HT4, or NK1 receptor antagonism. Therefore, the extracts effectively prevented its effect and had a peripheral anti-emetic action. As mentioned earlier, triterpenoids such as brachycarpone, deacetoxybrachycarpone, cabralealactone and ursolic acid are reported from Cleome brachycarpa6, whereas flavonoids are reported from Cleome viscosa. Flavonoids and triterpenoids possess anti-emetic properties18. So, if flavonoids and triterpenoids are present in the studied extracts, the observed anti-emetic effects may be due to flavonoids and triterpenoids. The present study is on the preliminary level, and further investigation is required to confirm the anti-emetic effect of Cleome brachycarpa Vahl ., and Cleome viscosa L. leaves and determine the compounds responsible for this activity with their possible mode of action.

Dr. salman ahmed

Objective: To determine the association between oral health literacy, oral hygiene and gingival health status. Methods: This cross-sectional study was conducted among patients attending University of Benin Teaching Hospital, Benin City. Data were collected through interviewer-administered questionnaires. Index used in this study for estimating oral health literacy levels was Rapid Estimate of Adult Literacy in Dentistry- 30 (REALD-30). The participant’s oral hygiene status was assessed using the Simplified Oral Hygiene Index while gingival health was assessed using the Gingival Index. Results: Two hundred and eight participants with 130 (62.5%) males and 78 (37.5%) females formed the population of the study and their mean age was 28.32 ± 10.5 years. The prevalence of low oral health literacy was 86 (41.3%). The oral hygiene status of most of the participants 100 (48.1) was fair. The prevalence of gingivitis was 58.2%. Oral health literacy had significant statistical negative correlation with age, oral hygiene and gingival health status. Oral health literacy consistently emerged as a predictor of oral hygiene and gingival health status. Conclusion: Majority of the participants with low oral health literacy had fair/poor oral hygiene status (p = 0.000, OR= 17.870, 95% CI = 7.320-43.627) and gingivitis (p = 0.000, OR= 7.054, 95% CI = 3.514-14.164).

Hope inegbenosun

This research aims to evaluate the optimization of network security forensic tools on virtual router (VR) traffic. The methodology used includes the selection of several forensic tools on the Windows operating system such as Wireshark, Windump, and Network Miner, with testing in a virtual network environment. Testing, includes simulating various attack scenarios to assess the effectiveness of threat detection, performance of forensic tools, and impact on network performance. The main results show that the tools have varying detection capabilities with variations in resource usage and impact on network latency. Network traffic has been successfully recorded using the Win-dump tool in the static-forensics method, the Wireshark tool and Network Miner in the live-forensics method. The evaluation results of the meta-router network forensic recording tool recommend Win-dump as a recording tool that does not burden the Windows operating system with memory usage of 1696 kb while the Wireshark and Network Miner applications are recorded at more than 20MB. Based on this research, the static forensic method which have been built with meta-router objects can be used by investigators to detect cyber attacks. Proper selection and configuration of forensic tools is critical to achieving a balance between security and network performance, and specific adjustments to network requirements can increase the effectiveness of threat detection and mitigation.

Firmansyah yasin

"Chemical Pharmacognosy" explores natural drug discovery, traversing from traditional remedies to modern therapeutics. This interdisciplinary approach aids biodiversity exploration, supports conservation, and validates Traditional, Complementary and Alternative Medicine. The significance extends to drug formulation, quality control, and combating drug resistance. Symbolizing a holistic journey, it bridges traditional wisdom with scientific innovation, playing a pivotal role in harnessing nature's chemical diversity for human health and guiding drug development.

Dr. salman ahmed

To improve education quality and governance, the Higher Education Commission of India (HECI) has proposed four regulatory entities, including the National Accreditation Council (NAC). To build up India as a universal knowledge giant over the next ten years, the policy promotes equitable educational opportunities and transformative initiatives. To significantly improve the standards for higher education in India, quality control, accreditation, & ranking systems become crucial. With an emphasis on quality, employability, and lifelong learning, the National Education Policy-2020 (NEP-2020) seeks to create a flexible, value-based educational system that integrates 21st-century capabilities. India's higher education is currently at a critical juncture, requiring transformation to enhance its overall contribution to society and address social injustices. This involves examining how information is produced and how students are taught to promote sustainability and social responsibility. Higher education institutions must comprehend and address student expectations regarding quality because the service sector is expanding quickly due to liberalization, privatization, and globalization. As a result, evaluating service quality becomes crucial for future enhancements and feedback. The Higher Education Commission of India (HECI) legislation, 2018, was introduced by the Ministry of Human Resource Development toward the end of June with the goal of repealing the University Grants Commission (UGC) Act, 1956, which has been in place for seven decades. The HECI will interchange with the University Grants Commission (UGC), which has been the foundation of India's college and university structure. This transition analyzes the proposed bill and examines its shortcomings. This advocates that the current bill be unsuccessful in reporting the flaws of the previous official; instead, it merely reflects those issues and will not resolve the long-standing problems of low autonomy and subpar instruction in the higher education system. As the new regulator, HECI's strategy isn't very revolutionary. Regulators who encourage centralization of duties to reduce autonomy must be disregarded at moments when Indian institutions are striving to rank highly in the world.

Dr. awadhesh singh gautam

Urolithiasis has been a common problem for centuries and has a high recurrence. This review covers the forty-two (42) antiurolithiatic plants of the family Apiaceae used in 18 different countries. Hopefully, this review will not only be helpful for the general public but also attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

cASUARINA EQUSITIFOLA IS A FAST GROWING EVERGREEN TREE GROWN BY FARMERS UNDER AGROFORESTRY SYSTEMS IN tAMILNADU state of Southern India

Dr. saranya devi k

Purpose: With an increase in updated technologies use of Fintech services have also been increased. Intention to use of Fintech services largely depend upon attitude of individuals towards adoption of these services. Drawing upon the Technology Innovation Model (TAM) theory this paper observes different factors associated with customer’s attitude towards acceptance of fintech facilities provided by banks that in turn affect intent about usage of these services. The features like Supposed Utility, Apparent Comfort for Usage, Supposed Peril, Trust Factor, Administration Sustenance, Consumer Innovativeness, Attitudes in the direction of Acceptance, Intent in the direction of Adoption are used in this study. Methodology: The data was collected from residents of Delhi using a survey method through online mode. A well-structured questionnaire was circulated among customers with the help of employees of each branch by using the online platform WeChat. Also, Questionnaire was circulated among customers with the help of employees of each branch who gave them proper instructions to fill the questionnaire. It was circulated through WeChat. To inspect the strength of the association amid factors, , Confirmatory Factory Analysis (CFA) and regression path analysis were applied using SEM in AMOS software. Findings: The findings revealed that Government Support is a key predictive variable for the adoption of Fintech services. Whereas Perceived Ease of Use and Perceived Risk are not significantly supported the attitude towards adoption of Fintech services. While other factors slightly supported attitude towards adoption. Practical Implications: The findings of this article are useful for banks to provide empirical framework for customers to adopt new, user-centered fintech services. Originality/Value: This article in useful for the banking institutions, Government agencies and insurance companies provide empirical framework for customers to adopt new, user-centered fintech services.

Nandini jagannarayan

This dissertation aimed to critically investigate how UK manufacturing companies can employ 3PL services to enhance business profitability. A simple, cross-sectional sequential mixed methods research methodology was implemented with the qualitative phase being used to explain the findings of the quantitative phase, which was performed first. Data for the quantitative period were collected using an online questionnaire that was designed and administered through a Google survey (N= 416). At the same time, semi-structured interviews were performed via Zoom calls with senior executives and managers of UK manufacturing firms (N= 5). Descriptive statistics, a one-sample t-test, and stepwise regression were used for quantitative data analysis using SPSS while manual analysis of interview data was performed in Microsoft Excel. The results showed that transportation and fleet management were the services that UK manufacturing companies outsourced to the most significant extent while clearing and forward and inventory management were the services that were outsourced to the lowest degree. The reasons behind this trend included the level of risk involved in outsourcing a particular service, availability of 3PL providers offering the outsourcing service, and the cost involved. In terms of feasibility, all items were scored highly, although increased operational flexibility and significant reduction of operational costs ranked highest. Finally, the stepwise regression test revealed four statistically significant models with an overall prediction power of 20.1% on business profitability. The statistically significant predictor variables were a reduction of operational costs, increased operational flexibility, reduced fixed asset costs, and the gaining of external resources from 3PL service providers.

Mohamed sorogy

Supply chain management, especially in manufacturing companies, is very important as the companies rely on the raw materials needed for production. Moreover, the success of a company is also determined by how it could gain competitive advantage to compete in the industry. It is proven that a company with effective supply chain management and competitive advantage would perform better. The purpose of this research is to see the effect of supply chain management and competitive advantage on company performance conducted at PT Ahlindo Perkasa Alam. This research uses quantitative method with Census sampling of 32 employees working in the company. The test results show that Supply Chain Management and Competitive Advantage have a positive significant effect on Company Performance at PT Ahlindo Perkasa Alam as much as 76.1%.

L

Macrotyloma uniflorum, commonly known as horse gram or kulthi bean, is grown as a pulse for livestock and human consumption. The beans contain about 1.3% fat, 18% protein, 15% carbohydrate, and vitamins and minerals. Traditional medicine uses it as an antihyperglycemic, antioxidant, antihypertensive and diuretic. Other important medicinal uses include the treatment of renal stones, obesity, piles, oedema and fever. The present study evaluated analgesic (by acetic acid-induced writhing, hot plate and tail flick tests in mice) and anti-inflammatory (carrageenan-induced paw oedema in rats) activities of Macrotyloma uniflorum fixed oil (MUFO). Four groups were included in the study: Group I: Normal Saline Control (2ml/kg), Group II: MUFO (2ml/kg), Group III: MUFO (4ml/kg), and Group IV: Standard Acetyl salicylic acid (ASA 300mg/kg). All results were significant; however, the tail flick and paw oedema tests observed a delayed onset of action. The oil's acute oral toxicity was also checked in mice and was found safe up to a 4ml/kg dose, as no signs of toxicity and mortality were observed. It is concluded that Macrotyloma uniflorum fixed oil may possess analgesic and anti-inflammatory activity, which can be related to a peripheral mechanism of action.

Dr. salman ahmed

Alzheimer Disease is a chronic neurological brain disease. Early diagnosis of Alzheimer illness may the prevent the occurrence of memory cellular injury. Neuropsychological tests are commonly used to diagnose Alzheimer’s disease. The above technique, has a limited specificity and sensitivity. This article suggests solutions to this issue an early diagnosis model of Alzheimer’s disease based on a hybrid meta-heuristic with a multi-feed-forward neural network. The proposed Alzheimer’s disease detection model includes four major phases: pre-processing, feature extraction, feature selection and classification (disease detection). Initially, the collected raw data is pre-processed using the SPMN12 package of MATLAB. Then, from the pre-processed data, the statistical features (mean, median and standard deviation) and DWT are extracted. Then, from the extracted features, the optimal features are selected using the new Hybrid Sine cosine firefly (HSCAFA). This HSCAFA is a conceptual improvement of standard since cosine optimization and firefly optimization algorithm, respectively. Finally, the disease detection is accomplished via the new regression- based multi-faith neighbors’ network (MFNN). The final detected outcome is acquired from regression-based MFNN. The proposed methodology is performed on the PYTHON platform and the performances are evaluated by the matrices such as precision, recall, and accuracy.

Dr. rajasekhar butta

Introduction: Loco-regional anesthesia role is increasingly important in surgery, especially in postoperative pain control. Using ultrasound-guided techniques has made the loco-regional approach increasingly safe and manageable, guaranteeing excellent analgesic results and patient compliance. This bibliometric research aimed to identify the most influential papers on the adductor canal blocks and outline their characteristics. Methods: All articles published from 1980 to 2022 were included in the Web of Science, PubMed, and Scopus databases and found using the keywords “Adductor canal block” or “Saphenous nerve block” or “Peripheral nerve block” or “Hunter canal block” or “Subsartorial canal block” or “ACB” or “Knee” or “TKR” or “TKA” or “Analgesia” or “Arthroplasty” or “Replacement” in the title section had bibliometric analysis performed. The first 25 papers were selected and analyzed by the number of citations. The correlation between numerical variables was evaluated using the Pearson Correlation coefficient. Results: Literature screening found 252 publications. One hundred ten were only about the adductor canal block. Of these, 25 articles were selected for our bibliometric study, published in 8 different journals and with a total number of citations equal to 1.457. “Regional Anesthesia and pain medicine” journal – with 9 articles – was the one that produced the most. There was a significant strong correlation between the n. of citations and the citation rate (R = 0.84, p < 0.001). Conclusion: The purpose of this study is to be a guide on regional anesthesia and, particularly, on adductor canal block, making the most effective as well as the most cited articles available to anesthesiologists or other researchers interested in this topic.

Dario cirillo

In these researched analyses of different forging product for controlling the forging waste in forging process. In forging process forging waste are carry with forging operation which identify by parting line of products. Parting which defines the product upper and lower die meshing area. Those extra material are used in forging operation which goes to out side of die that material is called as waste of forging. The foraging waste are not use for further any product manufacturing process for their hardness. There for such waste are to controlled for increasing the product utilization any minimising the production cost. In that paper we concentrate to minimizing waste of forging by amylases of different products.

Vijay jadhav

Uric acid has increasingly been associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Diabetic patients who are hyperuricemic have a risk of developing diabetic complications. Pathogenesis of uric acid may decrease nitric oxide bioavailability in vascular smooth muscle, endothelial cells and direct scavenging of nitric oxide by uric acid. A decrease in endothelial nitric oxide production by uric acid has also been associated with endothelial dysfunction and insulin resistance. This study aims is to determine the relationship between uric acid and glucose levels in patients with type 2 diabetes mellitus. The study included 161 Libyan patients (67 males and 94 females) diagnosed with type 2 diabetes mellitus. Both levels of serum uric acid and hemoglobin A1c (HbA1c) were determined. The patients were divided into two groups. The controllable diabetic group with HbA1c of less than 06.0% and the uncontrollable diabetic group with HbA1c of more than 06.0%. Patients who are suffering from type 2 diabetes mellitus without complications were included whereas patients with smoking, alcoholism, nephrotic disease, malignancy, hepatitis, and renal failure or kidney disease were excluded. The mean and standard deviation of uric acid, HbA1c and Pearson correlation coefficient test were considered. In the controllable diabetic group, serum uric acid mean was found to be 4.807 ± 1.39 and HbA1c was found to be 5.032 ± 1.39. In the uncontrollable diabetic group, serum uric acid was 4.897 ± 1.66 and HbA1c was 8.396 ± 1.65. Uric acid level has significantly been correlated with HBA1C in controlled and uncontrolled diabetic patients (p < 0.05). In addition, the uric acid level was found to be higher in uncontrolled diabetic group than that in the controlled group (p < 0.05). A possible relationship between serum uric acid and incidence of type 2 diabetes mellitus was noted. Thus, uric acid can be used as a potential biomarker to indicate impaired glucose metabolism.

Mediterranean journal of pharmacy and pharmaceutical sciences

A survey was conducted to screen the presences of antibiotic-resistant Salmonella from broiler chicken meat brought from local retail shops situated at Kozhinjampara, Palakkad, Kerala. Based on the morphological and biochemical characterization, a total of 15 Salmonella sp were isolated. Among 15 isolates, five (S7, S8, S10, S12, S14) isolates exhibited 100% resistance to all tested antibiotics and only one isolate S9 shows sensitivity to maximum antibiotics tested. In the study, garlic extract was tested against antibiotic-resistant isolates and it exhibited maximum inhibition against S12 isolate (30mm) and minimum inhibition against S8 isolate (22mm). The analyses of the garlic extract by GC-MS confirmed that the major components of garlic having antimicrobial activity. The result specified that garlic extract was found to be effective in controlling antibiotic resistance Salmonella species from broiler chicken meat. Therefore, incorporating garlic products in poultry feeds will help reduce antibiotic-resistant pathogenic microbes which causes drastic infections in human beings.

Dr. saranya devi k

Corporate social responsibility is a self-equipped business approach that helps an organization be socially responsible to its stakeholders and the overall public. Through the practice of CSR, companies are conscious and aware of the impacts they have on all aspects of society, including economic, social, and environmental (Goel and Ramanathan, 2014, p. 51). A case study scenario, in this case, is of StanBed Tours Ky, the impact of CSR on consumer loyalty, stating that the increase of CSR has resulted in the society's satisfaction with the business (Bediako, 2017, p. 1). CSR influences the people affected by it in various intensities and means. Such as, employees, who are part of the major stakeholders, are significantly affected by the organization's corporate social responsibility activities in marketing, which shape their logic, inspiration and lead to deeper commitments to achieving organizational goals and strategic plans (Makasi et al., 2014, p. 2600). Additionally, CSR investments in marketing significantly impact external shareholders such as consumers and the organization's image (Kaman, 2015, p. 7). CSR activities carried out by StanBed include tree planting exercises to mitigate carbon dioxide emissions resulting from flying airplanes, voluntary beach cleaning services to protect marine life, and providing educational services to children in the community of tours.

Zamzam abdelazim

This research assessed the nutritional composition, microbiological and sensory attributes of maize-based fortified food with peanut and carrot blends. A total of six composite flour samples were formulated using varying ratios of maize, peanut, and carrot: (MPC1) 100% maize flour (control), (MPC2) 90% maize, 5% peanut, and 5% carrot, (MPC3) 80% maize, 15% peanut, and 5% carrot, (MPC4) 70% maize, 20% peanut, and 10% carrot, (MPC5) 60% maize, 25% peanut, and 15% carrot, and (MPC6) 50% maize, 30% peanut, and 20% carrot. The proximate, mineral, vitamin, antinutrient, and functional properties of these fortified food samples were assessed using established methodologies. The proximate analysis revealed a significant increase (p<0.05) in moisture, crude protein, fat, crude fibre, ash, and energy content of the fortified samples, with values ranging from 1.63% to 3.80%; 3.08% to 44.43%; 2.39% to 15.16%; 3.58% to 7.04%; 2.34% to 3.80%; and 381.75 to 432.52 KJ/100g, respectively, as the supplementation of peanut and carrot flours increased. Conversely, the carbohydrate content decreased from 86.98% to 27.64%. The mineral content of the fortified samples also showed a significant increase (p<0.05) with higher levels of peanut and carrot flour supplementation. The findings of this study indicated a statistically reduction (p<0.05) in the antinutrient profiles of the fortified food samples. Additionally, the vitamin content significantly increased (p<0.05) with the addition of peanut and carrot flours. The overall viable counts were significantly low, and there were no detectable coliform or fungal counts. Although, the result of sensory evaluation indicated that the control sample was more organoleptically acceptable than the substituted samples, incorporating these nutrient-rich and functional ingredients in the production of maize-based cereals may broaden the application of peanut and carrot flours in the creation of various cereal types and other cereal-based food items.

Okechukwu obed chukwuemeka

Aging seldom comes alone and it is considered to be the major factor for many diseases and comorbidities and disabilities. The objectives of the study are to examine demographic characteristics and prevalence of comorbidities and polypharmacy of elderly patients who were admitted at Sebha Medical Center according to the selected period. This study is descriptive and retrospective cross-sectional study conducted in Sebha during 2021. From 195 participants of the study, the highest rate of patients was from the age group of 65 - 74 years which accounted for 86 participants (44%) and followed by those age group of 75 - 84 years which was reported by 65 participants (33%). The majority of elderly patients have hypertension, (n = 116, 59%) and over one-third of the patients (n = 73, 37%) have diabetes mellitus while nearly one-quarter of patients have both diseases at the same time (n = 47, 24%). Nearly, three-quarters of patients have electrolytes imbalance (n = 142, 72%). Nearly, two-thirds of the patients had three to five comorbidity diseases (n = 122, 63%). Whereas, over one-third of the patients had just one or two comorbidities (n = 70, 36%). Almost all the participants have polypharmacy (n = 187, 96%). Just above half of the patients have five - ten medications (n = 100, 51%) compared with 45% of the patients from those who have more than ten medications (n = 87). This study showed that there is a strong relationship between the prevalence of polypharmacy and the number of comorbidities. A Spearman correlation test indicated that rate of comorbidities was related to polypharmacy with a significant correlation (P < 0.01). The present study found high prevalence of comorbidities and polypharmacy among elderly inpatients. Based on this high prevalence, practicing pharmaceutical care could play an effective role to reduce the risk of inappropriate polypharmacy among hospitalized elderly patients through encouraging clinical pharmacist to engage in clinical activities in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences