Plants of family lamiaceae: a promising hand for new antiurolithiatic drug development

Urolithiasis has been a common problem for centuries and has a high recurrence. This review covers the forty-nine (49) antiurolithiatic plants of the family Lamiaceae used in 11 countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. Salman Ahmed Dr. salman ahmed

An analytical study on financial positions of selected telecom service sectors in india

Abstract Indian telecom industry has started growing rapidly since 1990 because of market liberalization. It has become one of the fastest growing telecom markets since then. Operating performance of a firm is depending upon certain key financial factors viz., turnover, profit, asset utilization etc. and the variables which are found in profit and loss account and balance sheet of a firm have a direct or indirect relation with each other. Financial performance of the firms can be analyzed by establishing a close relationship between the variables, in terms of liquidity, profitability, viability and sustainability. By establishing a close relationship between the variables, a firm can analyze its financial performance in terms of liquidity, profitability, viability and sustainability. Ratios and the statistical tool of ANOVA are normally used to identify the financial health of the firms and financial performances of the firms are measured accordingly. So the present study concentrates on empirical approach towards measuring deals with financial performance of the telecommunication companies.

Dr. Jeyalakshmi P Dr. jeyalakshmi p

Effective key management in dynamic wsn

Recently, wireless sensor networks (WSNs) have been deployed for a wide variety of applications, including military sensing and tracking, patient status monitoring, traffic flow monitoring, where sensory devices often move between different locations. Securing data and communications requires suitable encryption key protocols. In this paper, we propose a certificateless-effective key management (CL-EKM) protocol for secure communication in dynamic WSNs characterized by node mobility. The CL-EKM supports efficient key updates when a node leaves or joins a cluster and ensures forward and backward key secrecy. The protocol also supports efficient key revocation for compromised nodes and minimizes the impact of a node compromise on the security of other communication links. A security analysis of our scheme shows that our protocol is effective in defending against various attacks.We implement CL-EKM in Contiki OS and simulate it using Cooja simulator to assess its time, energy, communication, and memory performance.

Dr H Shaheen Dr h shaheen

New dimension in higher education in india

Higher Education has an important role in the task of rebuilding a nation and it pavCes the way for overall development of a nation. The twentieth century has witnessed several revolutions like Green revolution, White revolution, I.T revolution, so on and so forth, taking human civilization to new heights. At the start of 21st century, we gave a lot of importance given to higher education. Every country realized the value of higher education and the benefits that accrue from it. “The social demands for higher education continue to increase. The inabilities of the state to support this growing demand result in new financing arrangements for higher education. The recent reforms in this area could be broadly divided into two categories: the privatization of public institutions and the establishment of private institutions of higher education. Privatization implies the application of market principles in the operation of public institutions, while ownership rests within the public domain. Promotion of the private sector implies the growth and expansion of the non-state sector in higher education, and very often this sector does not rely on state funding for its growth and expansion. Both of these measures have paved the way for market operations in higher education

Dr Gedam Kamalakar Dr gedam kamalakar

Nanotechnology: future of sports medicine

The Nano-bio fusion is a booming area with high expectations that major steps in health treatment, body repair and body improvement can be made. It is regarded as the most innovative domain of this moment. Developments are in the field of: Nanomedicine: targeted drug delivery by medically functionalized nanoparticles, for rapid cure without side effects or human stimulation. Regenerative medicine: DNA programmed tissue engineering for quick and efficient wound healing, rebuilt of organs and other body parts. Smart implants: biocompatible implants that can sense and actuate in order to repair or enhance a body function. Nanotechnology idea has as of late gone into the exercises of day by day living. Nanotechnology in games solution cals be characterized as the adjustment of a wide range of improvements in nanoscale into therapeutic applications related with games wounds. The adjusted advancements can be either specifically related with the restorative mediations, for example, recovery of a tissue, implantation, and drug treatments or supporting components like imaging, strappings, and tapings. In this section, the impression of recently developed nanoscale advancements in regards to games wounds will be talked about with recent researches.

Yatendra Sharma Yatendra sharma

Analgesic, anti-inflammatory and diuretic activities of cicer arietinum l

: Analgesic, anti-inflammatory and diuretic activities of the methanol extract of two varieties of Cicer arietinum viz black or Desi and white or Kabuli were tested in 200 and 400 mg/kg doses. For the analgesic effect of the extracts, acetic acid-induced writhing, tail immersion and hot plate tests were employed in mice. The anti-inflammatory activity was carried out by carrageenan-induced inflammation in rats, whereas the diuretic action was determined using metabolic cages for rats. Animals were divided into six groups (n=7): (1) Control (2) Standard (3) MECAB 200 (4) MECAB 400 (5) MECAW 200 (6) MECAW 400. All extracts and standard drugs were administered orally. Acute oral toxicity of the extracts was also checked in mice up to 2000mg/kg dose, which showed a favorable safety. Significant analgesic and anti-inflammatory effects were observed. The results of diuretic activity were significant at the 12th and 24th hrs. Therefore, it is concluded that the methanol extracts of the seeds of Cicer arietinum have analgesic, anti-inflammatory and diuretic potential.

Dr. Salman Ahmed Dr. salman ahmed

Indian higher education system: challenges and suggestions

Over the past 20 years, universities have been faced with sustained change, driven by external factors. This has led to the evolution of the teaching and research mission and the creation and rise of the third mission. Such mission extension has led to the emergence of entrepreneurial universities which has seen a move from traditional research and teaching business models, to business models which incorporate a much wider range of activities, to meet stakeholder demands as well as sustaining and growing universities in the era of intense national and international competition. This special issue extends knowledge by providing novel insights into the multidimensional antecedent contextual influences, consequences and implications of university mission expansion. We also provide a foundational research agenda which will help guide future research exploring the changing and expanding university missions and business models. Higher education system plays an important role for the country’s overall development which includes industrial, social, economic etc. Indian higher education system is third largest in the world. The role of Indian higher educational institutes such as colleges and universities in the present time is to provide quality based education in the field of education, research etc to empower youth for self sustainability. This paper includes the key challenges that India is currently facing in higher education and also includes some initiatives taken by the government to meet those challenges.

Dr Gedam Kamalakar Dr gedam kamalakar

Prevalence of comorbidities, polypharmacy and drug related problems among hospitalized patients with chronic kidney disease

Chronic kidney disease is a public health problem affecting people worldwide. This study was aimed to examine the characteristics of patients with chronic kidney disease and to identify prevalence of drug-related problems among Libyan patients. This is a descriptive retrospective study carried out in Southern-west part of Libya, Sebha City. Information abstraction forms were used for collection of data. The investigators reviewed the medications, medical records and laboratory data to identify drug-related problems.1 000 patients' files during 2019-2020 were examined and only 120 files were selected for this study. The majority of the participants were male (73, 61.0%) and the mean age was 56.1 years. 576 comorbidities among the selected patients were identified (73.61%) and the average number per patients was 4.8 concurrent diseases. There were 1 350 medications prescribed and the average of prescribed drugs per patient was 11.25. The majority of patients use more than 10 drugs (64, 53.3%) and the average length of staying in the hospital was 5.58 days. 502 drug-related problems were identified with an average of 4.18 per patient. Untreated conditions such as Hyponatremia and anemia were the highest rate of drug-related problems identified (199, 39.6%) followed by improper drug selection (82, 16.3%) such as cefotaxime, vancomycin and aminoglycoside for chronic kidney disease and drug use without indications such as antibiotics (68, 13.5%) and over-therapeutic dose such as metoclopramide(63, 12.5%). In conclusion, all the patients have polypharmacy and the majority have comorbid conditions and chronic kidney disease with frequent drug-related problems, thus, to lower the incidence rate of drug-related problems, therapeutic interventions are needed. Subsequently, it is a crucial to involve clinical pharmacist in hospital to improve the care of patient with chronic kidney disease.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Hydrotropic solubility determinations and evaluation of dry powder for injection of poorly water soluble diuretic spironolactone

Dry powder injection of spironolactone was developed using lyophilization and hydrotropic solubilization method. It is fast acting medication in emergencies like refractory edema associated with heart failure and hepatic cirrhosis. The ultimate aqueous based powder prepared showed 892.85 and 378.57 times increased solubility of spironolactone with sodium salicylate and sodium benzoate as compared to its water solubility. Amongst six hydrotropic agents, the solubility was increased in the order sodium salicylate > sodium benzoate > nicotinamide > sodium ascorbate > urea > sodium acetate. IR graph showed shift of wavenumber of characteristic peaks. Lyophilization technique produced more stable product against different temperature cycles and stability parameters. Degradation was only about 0.45% at room temperature and it was more about 1.3% at higher temperatures. Haemolytic activities of lyophilized formulations observed were 8.54% to 96.85% for sodium salicylate based hydrotropic lyophilized system and 3.50 to 88.17% for sodium salicylate based hydrotropic lyophilized system.

Archana Mehrotra Archana mehrotra

Design of english corner extracurricular activities in the 4.0 industrial revolution era at madrasah ibtida'iyah

English Corner extracurricular activities are one of the choices for students to be able to learn English with more fun. Through the English Corner extracurricular program, the Madrasah provides provisions for its students to face the era of the industrial revolution 4.0. The purpose of this research is to add insight and to know the mechanism of the English corner extracurricular through the development, implementation, assessment, and evaluation of the English corner extracurricular in the 4.0 revolution era at MI Roudlotul Ulum Banyuwangi. This type of research is qualitative research with a descriptive design. Data collection techniques using interviews, observation, and documentation. Data analysis used the concept of Miles and Huberman. The validity of the data was measured by means of triangulation of sources and techniques. The results showed that 1). The development of the English corner extracurricular in facing the 4.0 industrial revolution pays attention to human resources, needs, infrastructure, talents, and interests. 2). The implementation of the English corner extracurricular is almost the same as learning in general and is made more relaxed so that it is more comfortable in its implementation. 3). This English corner extracurricular assessment uses a written manual assessment, after which it is recapitulated and entered into the Digital Report Card Application (ARD). 4). This English corner extracurricular evaluation is carried out every six months or at the end of the semester, taking into account the development and implementation that was carried out in the previous semester.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Tithonia diversifolia (hemsl.) a. gray: ethnopharmacology, biological and phytochemical investigation

The purpose of the presented monograph is to provide scientific information on the botanical features, traditional uses, active or major chemical constituents and pharmacology of Tithonia diversifolia. Studies on purified principles, mechanism of action and structure-activity relationship are relatively few and warrant further attention as traditional literature assures Tithonia diversifolia for the discovery of novel therapeutic agent(s). The safety, efficacy, quality control/quality assurance, clinical applications, contraindications, warnings, precautions, potential adverse reactions, and posology is not the part as very little data is available regarding the discussed plant. However, it helps in facilitating information exchange among practitioners Of orthodox and traditional medicine, pharmacists, and other health professionals, manufacturers of herbal products and research scientists and assist in developing their monographs or formularies.

Dr. Salman Ahmed Dr. salman ahmed

Awareness about special education in hyderabad

pecial Needs Education (SNE) highly plays a crucial for all those children and adults with disabilities. In this article, I aim to research the awareness levels of SNE in various schools and communities in the city of Hyderabad, India. A qualitative approach was taken for this purpose. My research also includes a case study of a special needs child along with his family and academic background, in order to know the degree of awareness among parents.

Husna habib Husna habib

Diversity of spiders as influenced by cultivation techniques in rice

Field studies were carried out in wet seasons of 2014 and 2015 in rice fields of College Farm, Rajendranagar, Hyderabad to understand the abundance and biodiversity of spiders in varied rice cultivation systems. Design of the experiment was split plot with three main modules, viz., transplanted, broadcasted and drum sown rice and subtreatments under each main module included three plant protection methods viz., organic protection, farmers’ practices and ‘no protection’ practices. Results showed that predator numbers in ‘no protection’ and organic protection plots of all main treatments were more than in farmers’ practices indicating the impact of the chemical pesticides. A total of 22 genera of spiders belonging to 12 families were recorded which comprised of seven guilds based on their hunting strategies and microhabitats. Shannon diversity index ranged between 1.83 and 2.26 and Pielou’s evenness index was 0.59-0.72 in two years of study indicating a stable ecosystem and even species distribution in rice crop at Rajendranagar. Study of the guild assemblage indicated that orb-weavers constituted 28.1% of the population, ground runners 23.51%, space web builders 18.38%, sheet-web builders 13.12%, stalkers 8.04% and ambushers made upto 0.38% of the spider population. Understanding the vertical stratification of various spider genera on the plant gave further insight into the prey preferences of these predators.

Gorthi anitha

Performance analysis of first order digital sigma delta adc

Ever-growing era of mobile and personal wireless networks, motivated research in several fields of engineering resulted in low power and low cost consumer products. The voice band processing required in mobile applications demand for architectures, which can easily be integrated in single chip SoC applications. The conventional approach is to have a dedicated IC outside the digital ICs to perform analog to digital conversion. The motivation of single chip radios demand for integration of such ADC modules on digital cellular related ICs. Mixed signal design is very challenging and hence usually it is preferred to have separate ADC chip before the ASIC/FPGA. In this paper we present a digital sigma delta ADC architecture, which can perfectly be integrated in any digital IC with a targeted sampling rate of 20 kS/s with more than 80 dB dynamic range.

P.a. harsha vardhini

The main problems at assessment of qualitative and quantitative indices of state activity

The article analyzes the main problems of making an assessment of public administration activities, gives important question and makes main ways of experiences of assessing criteria of public administration. This the article is also devoted to the analysis of the essence of efficiency and quality of public administration in the world and studies the main conceptual models of efficiency of public administration, the definition of types of efficiency and identification of the main problems when forming criteria for evaluation of efficiency and quality of the government

Ikboljon Odashev Mashrabjonovich Ikboljon odashev mashrabjonovich

Natural products targeting the atr-chk1 signaling pathway in cancer therapy

Cancer is one of the most severe medical conditions in the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer requires novel, efficacious treatment modalities. Natural remedies offer feasible alternative options against malignancy in contrast to available synthetic medication. Selective killing of cancer cells is privileged mainstream in cancer treatment, and targeted therapy represents the new tool with the potential to pursue this aim. The discovery of innovative therapies targeting essential components of DNA damage signalling and repair pathways, such as ataxia telangiectasia mutated and Rad3-related Checkpoint kinase 1 (ATR-CHK1), has offered a possibility of significant therapeutic improvement in oncology. The activation and inhibition of this pathway account for chemopreventive and chemotherapeutic activity, respectively. Targeting this pathway can also aid in overcoming the resistance of conventional chemo- or radiotherapy. This review enlightens the anticancer role of natural products by ATR-CHK1 activation and inhibition. Additionally, these compounds have been shown to have chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Ideally, this review will trigger interest in natural products targeting ATR-CHK1 and their potential efficacy and safety as cancer-lessening agents.

Dr. Salman Ahmed Dr. salman ahmed

In-vitro evaluation of chromium tolerant plant growth promoting bacteria from tannery sludge sample, dindugal, tamil nadu, india.

Industrial waste is one of the most essential sources of contamination in the environment. Chromium (Cr) is a toxic heavy metal, a major contaminant in tannery wastes and its accumulation in soil and water is a major environmental concern today. In the present study, an attempt was made and investigated the status of different beneficial microbes particularly plant growth promoting rhizobacteria (PGPR) from tannery sludge samples collected from tannery effluent treatment plant at Dindugal, Tamil Nadu, India. Experiments were conducted and evaluated their chromium heavy metal tolerance abilities and plant growth promoting activities under in-vitro. Based on molecular analysis, the PGPRs were identified as Achromobacter xylosoxidans (LK391696), Azotobacter vinelandii (LK391702) and. The production of IAA was found to be high by Achromobacter xylosoxidans (46μg/ml) followed by Azospirillum lipoferum (30μg/ml). Phosphate solublization activity was also found to be positive in all these PGPR isolates. Significance of these results revealed that there is a possibility of using these potential PGPRs for bioremediation of chromium contaminated sites and also as good plant growth promoter.

Dr. SARANYA DEVI K Dr. saranya devi k

The complex landscape of human trafficking: a comprehensive exploration with emphasis on legal safeguards for victims in egyptian and arab legislation

Human trafficking victims suffer a direct assault on their fundamental rights, enduring a modern form of slavery and exploitation. Perpetrated by criminal groups, human trafficking exploits victims, especially women and children, in forced labor, prostitution, or organ trafficking, treating them as commodities in a market driven by supply and demand, thereby profiting at the cost of fundamental rights and human dignity. This chapter underscores the critical significance of understanding the multifaceted challenges inherent in combating human trafficking, emphasizing the urgent need for effective measures. By delving into the complexities of the transnational organized structure of this crime, the chapter provides valuable insights into the hurdles faced by law enforcement and investigative agencies. Recognizing the gravity of human trafficking as a direct violation of fundamental rights and human dignity, this chapter aims to contribute to the development of comprehensive strategies and policies to address this pervasive issue.

Prof. Ramy El-Kady Prof. ramy el-kady

An integrated perspective crucial research issues in noc router design

A new reliable high throughput NOC router design is proposed with FSM based smart arbiter module for 4X4 Mesh architecture. This design is based the XY routing algorithm with prioritized round robin arbitration and synthesis of the proposed design is done on Spartan III FPGA. An enhanced work is also done in this paper to explore the drawbacks of the exceptional techniques of the existing generation and to research the scope for overall performance improvisation of the NoC designing

Trupti Patil Trupti patil

Whatsapp- messenger fever on students

WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on phones has turned to be goldmine for mobile and computer age. This paper focuses on understanding experimental viewpoint about the intensity, usage of whatsapp messenger and its impact on the academic performance of students in institutions. Instead of fast communication and enhancing effective flow of information and idea sharing among students, whatsapp has actually impacted in some pessimistic performance of students. For instance it takes up much of the students study time resulting in procrastination related issues , destroys students’ linguistic skills, leads to lack of concentration during lectures, results in difficulty in balancing online activities (whatsapp) and intellectual preparation and distracts learner from completing their assignments and adhering to their private studies time table. It is very userfriendly and easy to get initiated. Simply enter the telephone number of the device into the app. It then sorts through the contacts (with your permission) on the phone to figure out who else also has the app already installed. Users can then invite more contacts or go ahead and start sending messages to the ones that the app discovered. Brian Acton and Jan Koum (2009) invented Whatsapp messenger for easy and fast communication and distribution of multimedia messaging. Whatsapp is one of the trend and fashion in technology that is commonly used on specific mobile phones and computers. Since the Smartphones became popular, many messaging services were launched but Whatsapp has become widespread among them. The service is available free for one year and later user has to pay very less annual amount. Besides all, this Application is highly fanatic and can create a great impact on regular users, and apart from that it can leave a trace that becomes difficult to control and cure. With whatsapp messenger, communication through mobile phones has become easier, faster and cheaper. It is less expensive as compared to the normal phone messaging. An individual can chat with friends and family overseas through whatsapp without having to incur global SMS charges.

Sunita Singh Sunita singh

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