Higher Education has an important role in the task of rebuilding a nation and it pavCes the way for overall development of a nation. The twentieth century has witnessed several revolutions like Green revolution, White revolution, I.T revolution, so on and so forth, taking human civilization to new heights. At the start of 21st century, we gave a lot of importance given to higher education. Every country realized the value of higher education and the benefits that accrue from it. “The social demands for higher education continue to increase. The inabilities of the state to support this growing demand result in new financing arrangements for higher education. The recent reforms in this area could be broadly divided into two categories: the privatization of public institutions and the establishment of private institutions of higher education. Privatization implies the application of market principles in the operation of public institutions, while ownership rests within the public domain. Promotion of the private sector implies the growth and expansion of the non-state sector in higher education, and very often this sector does not rely on state funding for its growth and expansion. Both of these measures have paved the way for market operations in higher education

Dr gedam kamalakar

The 2019 coronavirus (COVID-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. Molecular docking is a recognized computational tool to assist in early drug discovery and development. Molecular docking analysis was carried out using 2-(4-(aminomethyl)phenyl)isoindoline-1,3-dione Schiff base conjugates with SARS-CoV-2 protease enzyme and COVID-19 main protease in apo form 6M03). The compounds with the best normalized docking scores to protease enzyme (6LU7) were ARG3 (-8.1 kcal/mole), ARG7 (-8.1 kcal/mole) and ARG6 (-8.0 kcal/mole). The best docking ligands for main protease in apo form (6M03) were ARG7 (-8.7 kcal/mole), ARG6 (-8.6 kcal/mole) and ARG3 (-8.4 kcal/mole). The structural similarity between these conjugates inspired us to perform in silico studies to check their possible binding interactions with essential SARS-CoV-2 proteins. These studies provide insight into the potential binding between Schiff base derivatives and SARS-CoV-2 proteins to provide an insight for finding an effective therapy. Finally, ADMET calculations were performed for the Schiff base compounds to predict their pharmacokinetic profiles.

Mediterranean journal of pharmacy and pharmaceutical sciences

The space-time dynamics of chlorophyll a concentration and seawater excess viscosity has been investigated in the hydrographically contrasting inshore and offshore water masses of the eastern English Channel. This was done during the phytoplankton spring bloom dominated by Phaeocystis globosa before and after the very large-scale formation of foam induced by an increase in wind-driven turbulence and the related wave breakings. The results suggest that the dynamics of chlorophyll a concentration and seawater excess viscosity are differentially controlled by the formation of foam through the intensity of the spring bloom and wind-generated turbulence.

Irma kesaulya

The international opioid crisis highlights the important role of pharmacists in prevention, using their availability and drug knowledge to prevent abuse. In this study, the knowledge, attitudes, and practices of Mangalore pharmacists towards preventing opioid abuse were assessed. From February to March 2025, a cross-sectional survey was done among 203 pharmacists aged 18-46 years in Mangalore using a pre-tested structured questionnaire. Data were analyzed using the Chi-square test, and thematic analysis of qualitative feedback. Pharmacists showed high knowledge, with 93.6% identifying opioids' mechanism as binding to CNS receptors correctly, 78.8% identifying naloxone's role in reversing overdose, and 70.0% knowing prescription drug monitoring programs' usefulness. Attitudes were optimistic, with 92.6% considering patient education a primary responsibility, 92.1% identifying multiple visits to the pharmacy as misuse, and 93.1% supporting medication-assisted treatment. The practice was active, with 93.1% checking prescription drug monitoring programs for suspected misuse and 69.0% advising take-back programs, but 43.8% associated early refills with misuse. Mangalore pharmacists show strong knowledge, attitudes, and practice against opioid abuse, being very strong in education and medication-assisted treatment support but having voids in misuse detection (for example, recognition of early refill) and naloxone confidence. Stronger training, better prescription drug monitoring program access, and policy adjustments can enhance their role in India's opioid strategy. Pharmacists are presented as front-line champions of opioid misuse prevention in this study, with implications for localized harm reduction.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction: Augmented Reality (AR) technology is increasingly recognized for its potential to enhance various aspects of dental practice, including treatment planning, patient education, and training. Despite this potential, the understanding of dental professionals' knowledge, attitudes, and practices regarding AR technology remains underexplored. The objective of this research is to examine the experience, perceived advantages, and real application of augmented reality (AR) Technologies of dental faculty and students. Methodology: A sample of 132 dental students, some integrated into the workforce as part-time private dentists, and faculty members of a single dental school, completed a self-administered online survey. Knowledge and application of AR technology in dentistry, and Experience with AR practice, were the constructs of the study. An administered questionnaire, partially digital and partially paper and pencil, was divided into two parts: Knowledge Assessment and Practice Assessment. The survey results were analyzed using reference statistics. Results: Knowledge Assessment respondents confirmed understanding Augmented Reality (AR) technology (69.7), and AR technology in dental training/education was recognized (65.9). 57.6% of the participants in the Practice Assessment declared absence of AR in their educational and/or professional practice, but an AR technology practice was wanted (67.4). The self-rated proficiencies that 44.47% of the respondents professed were in the range of self-score 3 in the application of AR (moderate). A small fraction (16.7) declared their AR application self-score was above the higher order. Conclusion: It can be concluded from this work that AR technology in academic and practical dentistry is vastly underutilized, notwithstanding the high realization and appreciation for its application.

Oral sphere journal of dental and health sciences

We reported a case of cyclophosphamide (CYP)-induced posterior reversible encephalopathy syndrome (PRES) in a 26-year-old previously healthy male patient who was presented to the emergency department with a history of fever, shortness of breath, and hemoptysis. After extensive investigations, including bronchoscopy and autoimmune screening, he was diagnosed with renalpulmonary syndrome. The diagnosis of CYP-related PRES was based on the development of neurological clinical picture supported by magnetic resonance imaging findings. The dose of CYP was decreased to 75 mg/day, and the patient’s symptoms improved after 3 days.

Karishma

This research will discuss the new destination of Toraja coffee as a tourism development strategy. Questions that will be answered is what is the attraction of Toraja coffee tourism as a new tourist destination. Methods of research conducted are field observation and interviews with coffee stakeholders as an informant and foreign tourists as respondents. The results of this study concluded that the appeal of Toraja coffee as a tourism destination is Toraja coffee has characteristic (taste) differently based on the planting area Toraja coffee. There are 15 names of coffee products based on the region and the name of Toraja coffee products taken from the region. E.g. coffee Toraja Sapan, derived from the Sapan area, and coffee Sesean derived from the village of Sesean. Perception of foreign tourists to Toraja coffee is that the taste of Toraja coffee is different based on the height of the coffee planting area to be a tourism identity Toraja Agritourism.

Muhammad hasyim

This study investigated the management of teachers’ soft skills development and flexible learning environment as a correlate of teachers’ effectiveness in Unity schools in South- Eastern states of Nigeria. The correlational research design was adopted for the study. Two research questions were answered while two hypotheses were tested. The population of the study comprised all the 901 teachers of the 14 Unity schools in the 5 South-Eastern states of Nigeria. Stratified and disproportionate sampling techniques were used to select 399 sample size that was determined from the population using the Taro Yamane formula. Two sets of instruments titled; “Management of Seamless Technology Integration Questionnaire” and “Teachers’ Effectiveness Questionnaire” were used for data collection. Face and content validity was ensured by five experts including the researcher’s supervisors. The reliability coefficients of the two instruments were calculated to be 0.79 and 0.81 using Cronbach Alpha method. Multiple and simple regressions were used to answer the research questions. Analysis of variance associated with multiple regression and t-test associated with simple regression was used to test the null hypotheses at 0.05 alpha level. It was found that management of teachers’ soft skills development and flexible learning environment positively correlate (0.92 and 0.86 respectively) to teachers’ effectiveness in Unity schools in the South-Eastern states of Nigeria. Based on the findings, it was concluded that the management of seamless technology integration is positively and highly significant to teachers’ effectiveness in Unity schools in the South-Eastern states of Nigeria. It was therefore recommended among others that school administrators in the 14 Unity schools in the South-Eastern states should immediately embark on self-development in the management of seamless technology integration

Fxintegrity publishing

Background: Although geriatric depression is widespread in primary health care (PHC), local studies on the prevalence of depression in elderly PHC patients appear to be scarce. This study aimed to determine the prevalence of depressive symptoms and some of the associated risk factors among elderly PHC patients. Methods: A cross-sectional study recruiting elderly people (60 years or older) from five PHC centers in Port Said Governorate was conducted. All participants had a structured interview. The long version of the geriatric depression Scale (cut-off point ≥10) was used in elders with a Mini-Mental State Examination ≥24. Results: About two-thirds of the total sample (65.7%) was female. The total prevalence of depressive symptoms was 49.4% of all subjects, more commonly in women (58.1% vs. 32.8%). Multiple regression analysis shows that female gender, high education, unemployment, low income, lonely life, loss of a close person, chronic diseases, tumor, iatrogenic medications, and depression history were the significant associated risk factors of depression in the studied elders after adjusting all previous variables in addition to age and marital status. Conclusion: Depressive symptoms constitute a significant health problem among older PHC patients in the Port Said governorate. Routine screening for depression of every elderly PHC patient is recommended for early detection.

Karishma

The aim of this study was to examine university students’ fear of success from the perspective of positive psychology. Two objectives were addressed: first, analyzing the relation between fear of success, optimism, self-esteem, self-efficacy, and search for meaning in life; second, exploring the variance of the fear of success, taking into account the affective dimension of the self (self-esteem) and search for meaning in life. The results confirmed that fear of success was positively related to search for meaning, and negatively to optimism, self-esteem, and self-efficacy. The variance of the fear of success was explained by the self-esteem and search for meaning in life. Implications for school psychologists were discussed.

Elena stănculescu

Vitamin C is associated with history of the cause of the ancient hemorrhagic disease scurvy. Vitamin C is an essential nutrient with important antioxidant properties. It is required by the body for normal physiological function. The body cannot synthesize vitamin C, it is present in nature through foods and other natural sources and it exists as a nutritional food supplement. The antioxidant activity of vitamin C protects the body from free radical damage. Vitamin C is essential for the development and maintenance of connective tissues. It is used as therapeutic agent in many diseases and disorders. Vitamin C plays an important role in several metabolic functions, as the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin, and the conversion of cholesterol to bile acids. Vitamin C supplementation resulted in a significant increase in vitamin C levels in populations; its high intake is associated with positive effects on cardiovascular risk factors. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight infections. It has an important role in bone formation, wound healing and the maintenance of healthy gums. There is profound beneficial effect of vitamin C in respect to human diseases as cancer, atherosclerosis, diabetes, neurodegenerative disease and many metal toxicities. Several vitamin C analogs have been produced as anticancer and antioxidant activity. Vitamin C is useful if it is used as adjuvant therapy for several chronic diseases. Thus, this review summarizes the importance of vitamin C in the body’s physiology and biochemistry, in addition, the different mechanisms that vitamin C is implicated to treat different acute and chronic diseases. Future exploration should pay attention to chronic disease management by vitamin C.

Mediterranean journal of pharmacy and pharmaceutical sciences

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10 mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

Community acquired pneumonia is a prevalent disease in the Emergency Department (ED). The literature reveals that clinical practice could not be related with guidelines recommendations. The aim of this study is to determine the impact of the implementation of the recommendations of the Spanish society of Emergency Medicine in the Hospital Clínico Universitario Lozano Blesa (Zaragoza) ED in the management of community acquired pneumonia. Use of Pneumonia Severity Index (PSI) estimation was used to assess the adherence. This study was carried out from December, 2014 to February, 2015. Data was compared with the previous two months. The indicators management (discharge or admission decision, adequacy and anti-biotherapy) as well as the incidence of PSI estimation before and after the intervention in these parameters were evaluated. 209 patients were included, 97 before the intervention and 112 after the intervention. No significant differences were observed in the calculation of PSI. A significant decrease of admissions was observed after the intervention in the patients in whom the PSI was calculated (68.8% vs. 45.0%, p < 0.05). A greater use of the Observation Room was aimed at those patients in whom the PSI was calculated (06.3% vs. 17.5%, p < 0.05). PSI calculation significantly increased antibiotic prescription adherence (88.9% vs. 75.2%, p < 0.05). There were no modifications in the prescription after the intervention. In conclusion, PSI is a useful and effective measure to achieve a greater adherence to the recommendations. However, despite the positive trend in the use of the PSI and its interpretation, a low-intensity intervention is not sufficient to generalize its use.

Mediterranean journal of pharmacy and pharmaceutical sciences

We exist in a conscious experience of life that is transitive and moment-by-moment, yet significant enough non-zero-time latencies exist across the visual, auditory, and somatosensory systems that transduction and processing do not take place instantly. This paper attempts to examine these non-zero-time latencies to resolve the conflict, ultimately suggesting that instead of consciousness accessing an external world, it accesses a high-fidelity bioelectric representation of the external world generated during this pre-conscious time interval. This external representation is the byproduct of Default Space Theory (DST), which indicates that oscillatory movements of the brain and body form a continuous three-dimensional "default space" over time. The default space exists as we exist, separately. Our external inputs from the retina, cochlea, and dermis "clothing" the default internal configuration occur via phase-locked neural oscillations over time, which occur at significant non-zero latencies. For example, the earliest cortical stages for auditory and tactile processing occurs at ~10–20ms, while the olfactory and visual features of stimuli occur at ~50–70ms. This doesn't mean we're perceiving them in time; it's quite the opposite. We're not perceiving in time because the default space is so well-templated all at once that somehow, the brain must erase this time interval and use the integrated multisensory processing to update continuously. Thus, we need to redefine consciousness as this continuously updated internal projection of externalized realities instead of an experience of what's outside.

Genesis scientific publications

This study investigated the connection between translanguaging and reading comprehension of Filipino ESL intermediate learners. The respondents were intermediate pupils enrolled in the selected central schools in Bicol, Philippines. The respondents' ages range from 8 to 12 years old, and 124 students (27.55%) were males while 326 students (72.44%) were females. The descriptive-correlational method was used in the study. The descriptive method was used to describe the reading performance of the ESL intermediate learners and their translanguaging factors, while Pearson Product Moment Correlation was used to determine the relationship between the two variables. The primary instruments used were validated teacher-made reading comprehension test and translanguage factors survey questionnaire. Data disclosed that the general reading comprehension of the ESL intermediate learners along with vocabulary, drawing inferences, and getting the main idea, are very satisfactory. Meanwhile, the different translanguaging factors, along with personal, teacher, and social, were surveyed and identified in the study. The statistical test revealed that the reading comprehension of the respondents was significantly correlated with the identified translanguaging factors. Thus, it is recommended that teachers should promote group discussions and allow open interactions in the classroom. Teachers should allow the use of both the home language and English; employ translanguaging pedagogy in teaching reading; foster an understanding and acceptance of linguistic differences; promote multilingualism, and allow indigenous languages to be used in education to facilitate meaningful learning.

Darrel ocampo

A new feature generates customer delight by using modern computer vision techniques to drive new search paradigms through visual discovery.

Senthilkumar gopal

Currently, there are three popular theories of corporate governance widely applied in the field of jurisprudence worldwide. They are Agency Theory, Stewardship Theory, and Stakeholder Theory. Based on these theories, the article focuses on clarifying legal issues about corporate governance, thereby suggesting solutions to the improvement of corporate governance legislation in Vietnam at present time

Iaeme

In an era of rapid technological advancement, the digital divide between rural and urban communities has become increasingly apparent. This study aims to investigate consumer awareness towards cyber security in both rural and urban settings, recognizing its critical importance in safeguarding personal and sensitive information. The study underscores the urgent need for targeted interventions to bridge the digital divide in cyber security awareness. Policymakers, educators, and community leaders must collaborate to implement initiatives tailored to the unique needs of rural populations, including improving access to technology, enhancing digital literacy programs, and fostering a culture of cyber security consciousness. By addressing these disparities, we can strive towards a more inclusive and resilient digital society where all individuals, regardless of their geographic location, are empowered to navigate the digital landscape securely. This research paper delves into the awareness and attitudes of consumers regarding cyber security in both rural and urban settings. With the increasing prevalence of online activities, particularly e-commerce, understanding the level of awareness and concerns about cyber security is crucial. The study analyzes data collected from 100 respondents, examining demographics, online shopping behavior, encounters with security issues, familiarity with safety measures, and sources of information about cyber security. The findings provide insights into the digital divide between rural and urban communities and offer recommendations for enhancing cyber security awareness and education.

Dr. kishor bholane

The drug-drug interactions (DDIs) are actions or events that occur when two or more drugs administered together, may cause a clinical significance or not. There are certain factors that may affect the severity of DDIs such as age, gender, number of drugs prescribed, and physician specialists. This study aims to answer: Is there DDI in Libyan community pharmacies? In addition, to explore the factors that might be affecting DDI. Drug Interactions Checkers are used. 200 prescriptions were collected randomly from two different areas ( high and low income),100 from each one and were used to investigate the DDIs by using two different sources (Drugs.com and BNF platforms), bearing in mind, age, gender, prescribers’ specialty, and drug number (prescription size). A personal interview questionnaire with pharmacists for investigate a source of DDI knowledge was considered. The correlation test was used to analysis the findings. The randomly selected sample has 316 drug combinations. The study has revealed a minimum of three drugs (46.0%). In general, Drugs.com was the richer source of DDI than BNF (66.5% and 34.5%, respectively). It is found that 66.5% (67.0% of this is moderate DDI) of these combinations have DDI by Drugs.com. A significant correlation between DDI and gender (male > female, p = 0.035) was found. In a state of residential areas, the results are similar in both selected pharmacies. Most moderate DDIs (21.0% and 15.0%) are prescribed by orthopedics and psychiatrists, respectively. The observational interview questionnaire indicated that 100% of the participating pharmacists had no source of knowledge regarding DDI, 100% of 200 prescriptions had no chick it regarding DDI and 100% of found DDI is released to use by community pharmacies to patients. More than half of the prescribed drug combinations have DDIs (classified as moderate DDIs), and all of them are released for use by pharmacists.

Mediterranean journal of pharmacy and pharmaceutical sciences

Attempts have been made to formulate controlled release drug dosage forms using chitosan as a release controlling polymer. Granules of combination of chitosan, hydroxylpropyl cellulose, lactose, starch and Ibuprofen were prepared by wet granulation method using 1.0% lactic acid solution. The granules were physico-chemically characterized in terms of density, porosity, angle of repose, carr’s index and housner ratio and was found to be free flowing with good compressibility. FTIR spectroscopy was used and confirmed that there is no interaction between the drug and the added polymers. In vitro release of Ibuprofen, in phosphate buffer at pH 7.4, showed a steady and slow increase in the percentage of drug released over 24 hours as the percentage of chitosan was increased in the formulations compared to that from commercial tablets which released over 80.0% of their content in only two hours. The kinetic analysis using different mathematical models of the data revealed that the release kinetics of the drug form these formulations is somewhere between diffusion controlled, Fickian (anomalous) and non-Fickian which refers to a combination of diffusion and erosion controlled release. Thus, the high correlation coefficient of the data of drug release from most granules when zero order kinetics was applied revealed that there is a constant drug release with time for 24 hours.

Mediterranean journal of pharmacy and pharmaceutical sciences