Micro Gas Turbines (MGTs) are compact power generation systems that offer several advantages such as highpower density, low emissions, and fuel flexibility. They are commonly used in remote areas where grid connectivity is limited or unreliable. However, MGTs suffer from inherent instability issues due to their small size and high rotational speeds. These instabilities can lead to irregular speed responses, affecting the overall performance and reliability of the system. To address these concerns, the researchers utilized a genetic algorithm (GA)-based approach and conducted sensitivity studies to analyze the iteration parameter of the GA and its impact on the speed response of the MGTs. To evaluate the performance of the developed solution, they employed the Mean Step of Absolute Speed Error (MSASE) evaluation metric and compared the outcomes of the proposed strategy with a baseline Proportional Integral (PI)-only solution. The results demonstrated that the proposed solution surpassed the baseline approach by delivering a superior error response. Similarly, the findings suggested that the optimal iteration parameter setting for the GA was a maximum of 30 compared to 20 and 10 consequently lessening the settling time from 140s to 60s. Accordingly, the researchers concluded that optimizing the GA's iteration parameter could lead to enhanced stability in the speed response of the MGT units. Subsequently, this can bolster the power generation capacities of the units, highlighting the potential for enhanced efficiency and stability in MGT operations. As a final recommendation, the study advised practitioners working with MGTs to adopt the proposed GA-based speed control strategy to optimize the overall performance and reliability of these units.
Hybanthus enneaspermus, traditionally used as an aphrodisiac was investigated for its potential to reverse antidepressant-induced sexual dysfunction in female rats. The aqueous extract was evaluated for secondary metabolite, amino acid and mineral constituents. Alkaloids, tannins, flavonoids, anthraquinones, steroids, terpenoids, phenolics, calcium, potassium, sodium, glutamine and leucine are some of its notable constituents. 60 healthy, sexually responsive female albino rats (144.7±5.9 gm) were divided into six groups (A-F) of 10 rats each; of which 50 were induced into sexual dysfunction. Rats in group A were administered distilled water throughout the experimental period and served as a control group, while rats induced into sexual dysfunction (Groups B-F) by fluoxetine were given water, the reference medication (Tadalafil) and oral doses of the extract (250, 500, and 1000 mg/kg body weight) once daily for seven days, respectively. When administered to sexually active rats, fluoxetine significantly decreased the frequency of darting, hopping, lordosis, genital grooming, and licking behavior by 57.4%, 42.5%, 43.9%, 64.0%, and 41.8%, respectively. However, the latency of darting, hopping and lordosis were significantly increased by 50.6%, 47.7%, and 54.9%, respectively. Hybanthus enneaspermus aqueous extract administered at doses of 250, 500, and 1000 mg/kg significantly reversed fluoxetine-mediated changes in all sexual behavior parameters. The extract's ability to reverse the characteristics of sexual behavior at 1000 mg/kg was comparable to those of tadalafil-treated rats. Additionally, all the extract dosages reversed the levels of blood luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin and estrogen after it has significantly been altered by fluoxetine. The results indicated that the aqueous extract of Hybanthus enneaspermus improved the proceptive, receptive and orientational behavior of rats. The extract also enhanced reproductive hormone concentration by restoring sexual competence in sexually-impaired female rats. The findings of this study provide further evidence in favor of Hybanthus enneaspermus widespread usage in the management of female sexual dysfunction.
Mediterranean journal of pharmacy and pharmaceutical sciences
The rate of aging is rapidly increasing and the term of geriatric refers to offer a medical care to elderly people. Drug consumption study on geriatric population is a vital issue since this group is totally neglected in Libya. The aim of this study was to assess drug utilization pattern among elderly patients in terms of world health organization core prescribing indicators and to evaluate the treatment cost. A total of 106 prescriptions were randomly collected from different community pharmacies located in Tripoli during the summer 2019, and were evaluated (total number of prescribed drugs is 359) for their clinical efficacy and safety. The findings revealed that 60 drugs acting on GIT (16.7%), 50 antimicrobial drugs (13.9%), 31 antihypertensive drugs (8.6%) and 30 drugs for respiratory diseases (8.4%) were prescribed to patients who are 65 years old or more. With regard to disease pattern in the elderly Libyan patients, 27 drugs were prescribed for diabetes mellitus (7.5%), 24 drugs for cardiovascular drugs (6.7%) and 14 drugs for anti-hyperlipidemia (3.9%). According to the WHO core drug use indicator pattern, the average number of drugs prescribed per encounter was 3.3. Prescription by generic name was low (41.5%). Antibiotics were 36.8% while injections were 26.6%. Thus, this study suggest that geriatric medicine and rational drug use should strongly be implanted in medical schools and teaching hospitals. Besides, a drug pattern use of the Libyan community is urgently required to avoid drug prescribing errors.
Mediterranean journal of pharmacy and pharmaceutical sciences
Colon is part of the digestive system in the human body responsible for absorbing water and nutrients from food residues. There are many problems affecting the colon including irritable bowel syndrome, constipation, hemorrhoids, anal fissures, abscess, colitis and colon cancer which considered one of the most common diseases among the Libyan community. The aim of this study was to search the presence of colonic disease and the tendency of those diseases to transform into colonic cancer at Benghazi medical center in Benghazi-Libya. A survey was comprised of 15 questions concerning colon diseases, proper diagnosis and treatment type. The survey was distributed to the physician specialized in medicine at Benghazi medical center and they fill it voluntary. The initial part of the questionnaire designed to obtain demographic data concerning the physicians who diagnose the colon illness. The rest part of the questionnaire was concerning special questions to define frequency of the diagnosed disease. There were 20 participants at this study. The response to all questionnaires were collected and analyzed for drug use, patients and disease distribution. In conclusion, this study demonstrates that the correct diagnosis, prescribing the appropriate treatment for the colon disease and using the medicine properly is one of the most important things that help in treating the disease and reducing its exacerbation. In some cases, eradication procedures may be required if the medicine is not sufficient to treat the disease without the need for operations
Mediterranean journal of pharmacy and pharmaceutical sciences
The seed flours of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn. were investigated for their total, soluble and insoluble oxalate contents by HPLC. The total oxalate content of Macrotyloma uniflorum, Phaseolus lunatus and Phaseolus vulgaris were 1.24, 1.77 and 1.71 mg/ g, respectively. The % age of soluble oxalate was Macrotyloma uniflorum (19.50), Phaseolus lunatus (15.08) and Phaseolus vulgaris (15.88). The calculated soluble oxalate: calcium ratio of all tested legume flours is lesser than one and hence will not create any resistance in calcium bioavailability.
Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.
The main focus of this paper is to examine the relationship between insecurity in Nigeria and how traditional institutions such as traditional monarchical system can be used as veritable tool to curtail increasing insecurity in a democratic system such as Nigeria. The pervasive nature of insecurity,though,not an entirely Nigerian problem, has been trending of late, andhence, become a huge source of worry for scholars,experts,public commentators and the international community at large.The menace of insecurity finds expression in wanton killings, kidnapping,farmers-herders conflicts, rape, communal clashes, militia activities, ethnic secessionist agitations and many other strands of violence. The multiplier effects of all these challenges have been very devastating in terms of the recent attacks witnessed all over the country in recent times. This study observes that most of the people engaged in some of these atrocities might be well known to traditional rulers in the communities where they come from. This is because traditional rulers are closest to the people. The work is an exploratory study and relies solely on literature and works of experts in the broader field of security studies for investigation. The paper sums up a conclusion and recommends that there is a need for the adoption of both vertical and horizontal approaches to tackle the menace of insecurity, particularly, using the instrumentality of traditional institutions as a point of departure.
The free senior high school policy is one of the best social and economic intervention policies that openly affect both parents and their wards in senior high school. This realisation is reached on the backdrop of the policy’s role in redeeming parents from their economic and financial burden. This study, therefore, looks at the effect of introducing the free senior high school policy on the economic and social lives of parents and students respectively. A correlational cross-sectional descriptive design was used. Questionnaires were administered to three hundred and thirty-six (336) parents of wards in three senior high schools in the North East and Upper East Regions of Ghana. The study confirms that the introduction of the free senior high school policy relieved the financial burden of parents, especially guardians from rural settlements. Besides, there was a lack of adequate stakeholder consultation, hence saddled with implementation challenges. Delay in disbursement of funds for feeding and learning materials presented yet another problem. It is important that governments find sustainable sources of funding for the educational system and also ensure the double-track system is regularised into a single-track system by expanding academic user facilities and increasing the numerical strength of both teaching and non-teaching staff in various senior high schools.
Treatment planning for oral squamous cell carcinoma (OSCC) is based on the clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the assumption that small tumours without clinical spread have a better prognosis than larger tumours with metastases. However, it is a well-known fact that some tumours with the same clinical staging show different growth patterns and clinical behaviour. This makes the prognosis for patients with OSCC difficult to predict on the basis of clinical staging alone. Although many histopathological characteristics of OSCC have been identified as prognostic factors, none is believed to be completely infallible. Therefore, a great need exists for more reliable prognostic markers, which will assist in treatment decisions. It is now well documented that several molecular events of significance for tumour spread, such as gain and loss of adhesion molecules, secretion of proteolytic enzymes, increased cell proliferation and initiation of angiogenesis occur at the tumour–host interface or invasive front, where the deepest and presumably most aggressive cells reside. This review describes the various molecular events and interactions, which take place in the invasive front of the OSCC, and elucidates their role as prognostic markers.
The Nano-bio fusion is a booming area with high expectations that major steps in health treatment, body repair and body improvement can be made. It is regarded as the most innovative domain of this moment. Developments are in the field of: Nanomedicine: targeted drug delivery by medically functionalized nanoparticles, for rapid cure without side effects or human stimulation. Regenerative medicine: DNA programmed tissue engineering for quick and efficient wound healing, rebuilt of organs and other body parts. Smart implants: biocompatible implants that can sense and actuate in order to repair or enhance a body function. Nanotechnology idea has as of late gone into the exercises of day by day living. Nanotechnology in games solution cals be characterized as the adjustment of a wide range of improvements in nanoscale into therapeutic applications related with games wounds. The adjusted advancements can be either specifically related with the restorative mediations, for example, recovery of a tissue, implantation, and drug treatments or supporting components like imaging, strappings, and tapings. In this section, the impression of recently developed nanoscale advancements in regards to games wounds will be talked about with recent researches.
Patent foramen ovale (PFO) is an embryonic interatrialdefect potentially associated withischemic cerebralstrokes. One option is the occlusion of the atrial shunt byendovascular means. This procedure is recommendedfor patients with a history of cryptogenic strokes.Patent foramen ovales (PFOs) are common in the general population (prevalence 20-30%) and do not constitute a pathology in their own terms. Nevertheless, a association has been established between the occurrence of certain cryptogenic ischemic strokes and the presence of a PFO. The risk appears higher when septal patency is associated with atrial septal aneurysm (ASA). The aim of this presentation is to study the association between the PFO and the occurrence of ischemic stroke, and the benefits of its closure.
Abstract Indian telecom industry has started growing rapidly since 1990 because of market liberalization. It has become one of the fastest growing telecom markets since then. Operating performance of a firm is depending upon certain key financial factors viz., turnover, profit, asset utilization etc. and the variables which are found in profit and loss account and balance sheet of a firm have a direct or indirect relation with each other. Financial performance of the firms can be analyzed by establishing a close relationship between the variables, in terms of liquidity, profitability, viability and sustainability. By establishing a close relationship between the variables, a firm can analyze its financial performance in terms of liquidity, profitability, viability and sustainability. Ratios and the statistical tool of ANOVA are normally used to identify the financial health of the firms and financial performances of the firms are measured accordingly. So the present study concentrates on empirical approach towards measuring deals with financial performance of the telecommunication companies.
Brushites are the most commonly found phosphate stones in the kidneys, ureters and urinary bladder. The study was conducted to observe the possible growth patterns of brushite crystals in the gel for 14 days. The crystal formation was observed as a bullet, needle, platy, columnar shaped and their aggregates. Magono and Lee's meteorological classification further explained these shapes. Besides the morphology, the average size, number and weight of crystals were also observed on the 7th and 14th days. Energy Dispersive X-ray, Fourier Transform Infra Red spectroscopy and Scanning Electron Microscopy were used to characterize the crystals. These results can help to determine the promotion, modulation and inhibition of the crystals, which will be helpful in evaluating the risk factors and prophylactic management of brushite-type urinary stones.
This paper throws light on the role played by culture and traditions specifically of Hindu religion in legitimising the subordinate position of women in Indian society. Along with presenting a brief account on the status of women from ancient times to contemporary situation, the sex-gender binary has also been explored. How a child after his birth socialised to behave in a certain way on the basis of his/her sex has been noted. This process of socialisation is based on the age old customs and traditions which are discriminatory in nature. The male child is taught to be strong, dominating and aggressive in nature and henceforth assigned laborious work to do for managing the finances of house. On the other hand, female child is taught to be sensitive, loving and caring and therefore assigned to manage household work, child nurturing and motherhood related responsibilities.
Presurgical Nasoalveolar molding have become an important procedure before proceeding with the surgical procedures for cleft lip and palate patient. PNAM reduces the size of the cleft which helps in better approximation and minimal scar formation.. To achieve this all proper tray selection is necessary and is a basic step in taking the impression of an infant. This article attempts to describe the various impression trays that can be used for the cleft patients routinely.
The use of Capsicum annum L. for culinary purposes dates back centuries. Its medicinal benefits have also been investigated in the past few days. Analgesic and anti-inflammatory activity in 4 different colored (green, yellow, orange, and red) sweet bell peppers (Capsicum annuum L.) were investigated in 200 and 400 mg/kg doses. Current research is directed at authenticating whether Capsicum can be used as an analgesic and anti-inflammatory, comparing the effects of the most used analgesic aspirin. The effects of ethanol extract of Capsicum annum L. were determined for analgesic activity by acetic acid-induced writhing, tail immersion and hot plate test. Animals were divided into ten groups (n=7): (1) Control (2) CAG 200 (3) CAG 400 (4) CAR 200 (5) CAR 400 (6) CAO 200 (7) CAO 400 (8) CAY 200 (9) CAY 400 (10) Standard. All the extracts given intraperitoneally in rat hind paws of seven animals in each treatment group received 200, 400 mg/kg. Acute toxicity was also determined by increasing the dose to 3000 mg/kg, which showed no evidence of mortality. A statistical calculation was performed using SPSS software to compare the effects of aspirin and Capsicum extract. Positive results were obtained as compared to the control group; the analgesic effect was statistically significant (P˂ 0.05). These observations revealed that the fresh fruit extract of four kinds of Bell pepper at 200 mg/kg and 400 mg/ kg possesses anti-inflammatory and pain-suppressing activities possibly mediated via PG synthesis inhibition.
n India, the education sector has been always attentive to adopt innovations and techniques in the teaching-learning process due to various challenges. But nowadays, academic institutions are becoming flexible in accepting the new teaching and learning techniques to satisfy the student sector which as cited as the most vital entity in the educational sector. New technologies, tools, and techniques are proving as a boom for innovative teaching and learning practices. One of the emerging teaching technique is Blended learning which is a process refers to “mixing of the different learning environment for educational transfer”. It combines the traditional face to face classroom method with online learning method supported by advanced technology and tools. Blended learning should be viewed not only as a temporal construct but also as a fundamental redesign model. Through this content, delivery becomes digital and online. Truly blended learning requires teachers should adopt the approach as guides and mentors and learning should go beyond the classroom walls. Blended learning is also known as Hybrid learning. Although, Indian Government is taking initiatives to implement a blending learning approach yet there is a need to access the behavioral aspect of the students to use this blending learning approach. Adopting a blended learning approach must start with a re-examination of the intended learning outcomes.The deployment of cloud in the blended learning process makes its existence more strong. This study is the review of literature selected to identify the need for blended learning deploy with cloud in the teaching-learning process in the Higher Education Sector.
The most important factor that affects the crop production in terms of nutritional content of foliar plants is the global climate change. Herbivore’s growth, development, survival and geographical distribution all are determined by elevated CO2 and temperature. The interactions between herbivores and plants have changed due to increasing level of CO2 and temperature. The effect of high CO2 and temperature on grain legume plant which change in to plant physiology (e.g., nutritional content, foliage biomass) and how it change in herbivory metabolism rate and food consumption rate. Plant injury is determined by two factors viz. resistance and tolerance and both are influenced by greater CO2 and temperature. Legumes are an important source of food and feed in the form of proteins and also improve the soil environment. The repercussions of the abiotic factors mentioned above needs discussion among the scientific community. We may able to limit the negative repercussions of stated factors in future breeding projects by harnessing the practical favourable impacts and by including such influences of elevated CO2 and temperature on pulses productivity. The extensive research is necessary to overcome the negative effects of high CO2 and temperature on insect-plant interaction
The study has examined the similarities and differences in the coverage of two Palestinian news agencies Ma’an and Palestinian Information Center (PIC) on the reactions of Palestinian President Mahmoud Abbas’s regarding relocating the US embassy from Tel Aviv to Jerusalem. The study has also aimed to explore the use of four function of framing by Entman 1993 in the news stories of both agencies. Qualitative content analysis has been adopted to achieve the aim of this study. The total sampling number was 9 news stories; 3 stories have been retrieved from Ma’an, and the other 6 have been retrieved from PIC. The time frame has started from December 5, 2017 which marked the day of informing Abbas by Trump’s decision to move the Embassy until December 22 2017 which was a day after gaining a sweeping victory in UN by President Abbas through a resolution that rejected the decision. Both of the news agencies were supportive to President Abbas in their coverage and none of them has any negative coverage about him. From the sampling number it can be seen that PIC has paid more attention for the coverage of this issue than Ma’an. However, PIC has ignored the success of President Abbas for achieving UN resolution against Trump’s decision. Morover, all the news stories has included “define the problem” while excluded “diagnose causes” functions. However both “make moral judgment” and “suggest remedies” have been included in all news stories of Ma’an, and only half of news stories of PIC.
Introduction: Study was conducted with an objective of investigating the inhibitory effect of Phaseolus lunatus seeds extract on three enzymes (α-amylase, maltase and glucoamylase) involved in diabetes. The disadvantages related to the use of synthetic drugs make it necessary to search for alternative medicines from medicinal plants. One therapeutic approach for treating postprandial hyperglycaemia is to decrease the plasma glucose level, which can be attained by lowering the starch hydrolysis by digestive enzymes such as α-amylase, maltase and glucoamylase. The use of synthetic antidiabetic agents caused gastrointestinal side effects. Methods: Hence, the research was aimed to evaluate the potential of Phaseolus lunatus seeds extract to inhibit α-amylase, maltase and glucoamylase as a possible mechanism of hypoglycemia caused by this plant with fewer side effects. Phaseolus lunatus, also known as Lima bean, is native to Tropical America and grown worldwide. Lima bean has been prescribed traditionally to treat different diseases, including diabetes. Result: The results of the present study showed that Phaseolus lunatus seeds extract has exerted both time and concentration-dependent Significant inhibitory effects on these digestive enzymes might be due to the cumulative impact of phytoconstituents in the plant extract. Conclusion: Therefore, it can be said that the part mechanisms by which Phaseolus lunatus exhibited its antidiabetic activity might be through inhibiting this digestive enzyme.