The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated that the level of the cardiac bio-marker troponin I in the blood plasma of rats exposed to severe hypobaric hypoxia for 3 h increased signifi-cantly compared to the control group, indicating myocardial injury. At the same time, the administration ofthe HIF-1α transcription factor inhibitor did not affect the plasma level of troponin I. In contrast, the releaseof the non-specific biomarker myoglobin into the bloodstream did not increase in response to hypoxia com-pared to the control animals. In addition, 24 h after the exposure to severe hypobaric hypoxia the serum myo-globin level was significantly lower in animals administered with the HIF-1α inhibitor topotecan than in ratsthat did not receive topotecan. Therefore, it may be assumed that the inhibition of the HIF-1α transcriptionfactor 10 min before exposure to severe hypobaric hypoxia reduces skeletal muscle damage. The mechanismsthat affect the adaptation of heart and skeletal muscles to hypoxia are discussed.

Даниил Федоров

Hybanthus enneaspermus, traditionally used as an aphrodisiac was investigated for its potential to reverse antidepressant-induced sexual dysfunction in female rats. The aqueous extract was evaluated for secondary metabolite, amino acid and mineral constituents. Alkaloids, tannins, flavonoids, anthraquinones, steroids, terpenoids, phenolics, calcium, potassium, sodium, glutamine and leucine are some of its notable constituents. 60 healthy, sexually responsive female albino rats (144.7±5.9 gm) were divided into six groups (A-F) of 10 rats each; of which 50 were induced into sexual dysfunction. Rats in group A were administered distilled water throughout the experimental period and served as a control group, while rats induced into sexual dysfunction (Groups B-F) by fluoxetine were given water, the reference medication (Tadalafil) and oral doses of the extract (250, 500, and 1000 mg/kg body weight) once daily for seven days, respectively. When administered to sexually active rats, fluoxetine significantly decreased the frequency of darting, hopping, lordosis, genital grooming, and licking behavior by 57.4%, 42.5%, 43.9%, 64.0%, and 41.8%, respectively. However, the latency of darting, hopping and lordosis were significantly increased by 50.6%, 47.7%, and 54.9%, respectively. Hybanthus enneaspermus aqueous extract administered at doses of 250, 500, and 1000 mg/kg significantly reversed fluoxetine-mediated changes in all sexual behavior parameters. The extract's ability to reverse the characteristics of sexual behavior at 1000 mg/kg was comparable to those of tadalafil-treated rats. Additionally, all the extract dosages reversed the levels of blood luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin and estrogen after it has significantly been altered by fluoxetine. The results indicated that the aqueous extract of Hybanthus enneaspermus improved the proceptive, receptive and orientational behavior of rats. The extract also enhanced reproductive hormone concentration by restoring sexual competence in sexually-impaired female rats. The findings of this study provide further evidence in favor of Hybanthus enneaspermus widespread usage in the management of female sexual dysfunction.

Mediterranean journal of pharmacy and pharmaceutical sciences

The current study was conducted to determine the insoluble, soluble, and total dietary fiber content of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn. , and Phaseolus vulgaris Linn. , and legume flours by using AOAC enzymatic-gravimetric analysis. The results showed that M. uniflorum, P. lunatus, and P. vulgaris legume flours contained 155.91, 120.01, and 90.80 mg/g insoluble dietary fiber, respectively. At the same time, soluble dietary fiber was not found in any tested sample.

Dr. salman ahmed

Background Type 2 diabetes and obesity are serious public health concerns globally and a growing burden in Africa. Both conditions have serious repercussions on health when they co-occur, yet the extent of their co-occurrence in Africa remains unknown. Therefore, this review aimed to identify the prevalence and associated factors of overweight and obesity among persons with type 2 diabetes in Africa. Method A systematic search was conducted on PubMed, MEDLINE, Embase, African Index Medicus (AIM), and African Journals Online (AJOL) for observational studies that reported the prevalence of overweight and/or obesity among type 2 diabetes patients in Africa. The prevalence data from individual studies were aggregated through a random-effects meta-analysis. The I2 statistic was used to evaluate between-studies heterogeneity, while subgroup analysis and mixed-effects meta-regression were performed to identify sources of heterogeneity. We assessed publication bias using funnel plots and Egger’s test. This review adhered to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Results Of 1753 records retrieved, 80 articles were eligible for this review, with 74 cross-sectional studies included in the meta-analysis. The pooled prevalence of overweight and obesity was 35.6% and 25.6% respectively, while the overall prevalence of both overweight and obesity was 61.4%. Also, the pooled prevalence of both overweight and obesity across the five geographical areas in Africa ranged from 56.9% in East Africa to 88.5% in Southern Africa. Nineteen factors were significantly associated with overweight and obesity among patients with type 2 diabetes. Conclusion The high prevalence of overweight and obesity among patients with type 2 diabetes is a significant public health concern that transcends geographical boundaries within Africa. The findings from this review highlight the need for innovative weight management interventions that are tailored to the cultural context of the African setting

Emmanuel ekpor

Background: Pulses are well known richest source of vegetable protein and is known as poor man’s food because of its essential component in diet. The frontline demonstrations of pulses were carried out on 311.8 ha area with 694 demonstrations in different clusters of Nagaur district of Rajasthan. Methods: Front line demonstrations on chickpea, mung bean and moth bean crop were conducted by Krishi Vigyan Kendra, Nagaur-I, Agriculture University, Jodhpur during rabi and Kharif season of 2011-12 to 2019-20. Result: In demonstrations up to 29.43%, 30.29% and 35.22% yield increase of chickpea, mungbean and moth bean crop was observed over the farmer’s practices in the year 2011-12, 2017 and 2016. The yield gap between improved technology and conventional farmer’s practices was ranging from 1.98 to 4.54 q/ha, 0.61 to 2.55 q/ha and 0.6 to 1.68 q/ha, respectively. Whereas, the highest net returns of ` 71,881 ha-1 , ` 45,884 ha-1 and ` 14,315 ha-1 was observed in the year 2019-20, 2014 and 2016, respectively with the highest incremental cost benefit ratio of 1:3.71, 1:3.95 and 1:1.97 under demonstrations practices.

Dr. babu lal jat

Legumes are the richest source of protein, starch, minerals, and vitamins and are considered the earliest domestic plants. They belong to the leguminosae family, one of the largest and most important families of flowering plants. The present review describes the history, consumption, nutritional aspects, traditional medicinal uses, pharmacology, and commercial aspects of legumes.

Dr. salman ahmed

As one of the flow-based passive sorting, the hydrodynamic filtration using a microfluidic-chip has shown to effectively separate into different sizes of subpopulations from cell or particle suspensions. Its model framework involving two-phase Newtonian or generalized Newtonian fluid (GNF) was developed, by performing the complete analysis of laminar flow and complicated networks of main and multiple branch channels. To predict rigorously what occurs in flow fields, we estimated pressure drop, velocity profile, and the ratio of the flow fraction at each branch point, in which the analytical model was validated with numerical flow simulations. As a model fluid of the GNF, polysaccharide solution based on Carreau type was examined. The objective parameters aiming practical channel design include the number of the branches and the length of narrow section of each branch for arbitrary conditions. The flow fraction and the number of branches are distinctly affected by the viscosity ratio between feed and side flows. As the side flow becomes more viscous, the flow fraction increases but the number of branches decreases, which enables a compact chip designed with fewer branches being operated under the same throughput. Hence, our rational design analysis indicates the significance of constitutive properties of each stream.

Myung-suk chun

Viral hepatitis is one of the main public health concerns around the world. Even though infection management techniques have been implemented over the last few decades, eradication or significant reduction has remained a mystery. The purpose of this study is to look into the prevalence of acute infectious hepatitis in the East of Libya and how the type of virus, age, gender, clinical manifestations, and outcome are related. This is a hospital-based retrospective study. The data on the frequency and distribution of viral hepatitis based on age, gender, seasonal, clinical, and ultrasound findings, and the outcomes during a period of two years from January 2020 to December 2021 were collected and analyzed. Of the 0.39% (72 cases) of total hospital admissions (18340) under the age of 15 years old for acute infectious hepatitis patients, the most common age group was 5-12 years (79.6%). Winter accounted for 41.6% of all the cases. Females made up 65.3% of the cases. Jaundice was the most prevalent presentation (87.5%). Hepatomegaly was seen in 83.3% of the patients. Most of the cases have mild hyperbilirubinemia (5-9 mg/dL, 75.0%). Approximately 1/5th of the patients' serum glutamic-oxaloacetic transaminase (SGPT), and nearly 1/3rd of the patients' SGPT levels were in the range of 1000-2000. One patient's hepatitis C was positive, one patient's hepatitis B was positive, and 97.2% were positive for hepatitis A. 88.8% of the individuals recovered without complications, whereas 11.1% showed symptoms of hepatic failure but recovered. The present study indicates that acute hepatitis A is more prevalent, especially in the winter. Those who are females and 5-12 years of age were more affected by acute viral hepatitis in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

This journal article investigates the evolving landscape of healthcare monitoring systems empowered by Artificial Intelligence (AI). Through an in-depth analysis of recent developments, methodologies, and case studies, the article elucidates the pivotal role of AI in revolutionizing patient care, diagnostics, and overall clinical outcomes.

Dhruvitkumar talati

With the projected growth of the global electric vehicle market that is estimated to double in the next decade, the expansion of the battery manufacturing capacity will primarily depend on the auto market’s electrification. Moreover, the market growth puts new requirements on the end-of-life phase and the recycling components. Therefore, the report provides a feasibility research study aimed at investigating the international initiative. It identifies the production and exportation of Lithium-Ion Batteries to the Chinese electric vehicle manufacturers and consumers as a business opportunity and discusses the gaps in the current market. The research also includes a look at the cost estimates that are bound to affect the company. Additionally, the report also includes recommendations for the company to ensure that it understands the policy frameworks and market systems for electric cars adoption. By doing so, the report discusses several aspects of the entire Lithium-Ion Battery business, justifying the business idea.

Mohamed sorogy

Background: Dilation of pupil in Ophthalmic OPD is a routine procedure. Whether a sympathomimetic agent like phenylephrine should be used in hypertensive patients is still a question to be answered. This study tries to resolve the issue. Objective: To evaluate cardiovascular effects of combination of topical 5% phenylephrine and 0.8% Tropicamide. Method: Total 150 patients were subjected for this study (male and female) between 30-80 years of age. Combination of 5% phenylephrine and 0.8% tropicamide eye drops was instilled at an interval of 15 minutes thrice in the eyes of each patient. Any change in BP or HR was recorded Result: The data was collected and subjected to appropriate statistical method using R software version 4.2.1. This study has shown no significant increase in Blood Pressure and Heart Rate after instillation of 5% Phenylephrine and 0.8% Tropicamide eye drops except in one case. Conclusion: We conclude that combination of 5% Phenylephrine and 0.8% Tropicamide can be safely used in all patients who come for ocular examination but precautionary measures should be taken in hypertensive patients.

Dr. ashwani kumar ghai

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

Mamta gaur

This study aims to improve the ability to think critically in class IV SDN 1 Sukamulya in science subjects through the application of learning strategies jeopardy review. This type of research is a quantitative study using the method research Quasy Experimental Design and the design used is pretest-poststest design. The population in this study were students of class IV (A, B, dan C) SDN 1 Sukamulya Academic year 2019/2020. Totaling 85 students, while the samples in this study were group IVB as the experimental class and class IVC as the control class. The sample was taken using cluster random sampling technique. In this study, the data collection tools used were test, observation, and dokumentation. The instrumen test used was critical thinking essay questions. Hypothesis testing using statistical analysis Independent Sample t-Test. Based on the result of the study obtained the average value of the experimental class 83,00 while the average value of the control class was 76,28. Results hypothesis testing using the analysis of Independent Sample t-Test with a significance level 5% (0,05), i,e. 0,000 < 0,05 so that H0 is rijected and Ha is accepted, so it can be drawn conclusion that there is an influence of the jeopardy review learning strategy on critical thinking skills of grade IV students on material wealth of energy sources in Indonesia at SDN 1 Sukamulya Academic Year 2019/2020. Penelitian ini bertujuan untuk meningkatkan kemampuan berpikir kritis kelas IV SDN 1 Sukamulya pada materi IPA dalam tema kayanya negeriku dengan cara menggunakan strategi pembelajaran jeopardy review pada saat proses pembelajjaran berlangsung. Jenis penelitian yang digunakan oleh peneliti adalah penelitian kuantitatif dengan menggunakan metode penelitian Quasy Eksperimental Group Design dan menggunakan desain penelitian yakni Pretest-Posttest Group Design. Populasi pada penelitian ini adalah peserta didik kelas IV (A, B, dan C) SDN 1 Sukamulya Tahun Pelajaran 2019/2020 yang prserta didiknya secara keseluruhan berjumlah 85 peserta didik, sampel pada penelitian ini yakni kela IV B sebagai kelas penelitian dan kelas IV C berperan sebagai kelas kontrol. Sampel ini diambil dengan menggunakan cara cluster random sampling. Pada penelitian ini instrumen yang digunakan yaitu observasi, dan test, serta dokumentasi. Instrument test yang digunakan yakni soal dalam bentuk essay untuk mengukur kemampuan berpikir kritis. Uji hipotesis pada penelitian ini menggunakan analisis data statistik Independent Sample t-Test. Berdasarkan hasil penelitian diperoleh hasil nilai rata-rata kelas eksperimen sebesar 83,00 sedangkan nilai rata-rata kelas kontrol sebesar 76,28. Hasil uji hipotesis menggunakan analisis Independent Sample t-Test dengan menggunakan taraf signifikasi 0,05 (5%), yaitu 0,000 < 0,05 sehingga hasilnya H0 ditolak dan H1 diterima, sehingga dapat disimpulkan bahwa terdapat pengaruh strategi pembelajaran jeopardy review terhadap kemampuan berpikir kritis peserta didik kelas IVB pada materi IPA tema kayanya negeriku di SDN 1 Sukamulya Tahun Pelajaran 2019/2020.

Educare: journal of primary education

Background:Calcium, the very important mineralhelps in growth and development ofinfants.Calcium helps in building strong bones, teeth,proper functioning of nerves and muscle, blood clot and in activating the enzymes that convert food into energy. Infants and Children are growing new bone all the time, they need continuous supply of calcium to support the healthy growth.Milk is the only food for infants which is richest source of calcium. Some infants are sensitive to lactose in milk because they have Lactose Intolerance. The present study aimsto develop an alternate milk forlactose intolerance infants with finger millet and pearl millet.Method:Traditional methods were used to process the milletswhich help in retaining and increasing the nutritional content in millets.The millet milk was analyzed for calcium content using the ICPMS.The millet milk was supplemented for 6 weeks to albino rats in comparison with cow milk. The tibia weight and length were measured and calcium content in tibia was analyzed. Result:The calcium content of the millet milk was 80mg/100mlwhere as in cow milk it was 120mg/100ml.The mean calcium content of the tibia inalbino rats was15.35±3.50mg/dl fed with millet milkand20.40±3.74mg/dl in rats fed with cow milk.Conclusion: The developed millet milk contain good amount of calcium on par with cow’s milk, it can be used as substitute milk for lactose intolerant infants.

Kimeera ambati

This research paper examines the dynamic interplay between social movements and Indian politics to assess their importance in shaping the socio-political landscape of the nation. In recent decades, India has witnessed the rise of various social movements, from grassroots activism to large-scale protests, each with distinct goals and socio-political implications. This study uses a multidimensional approach that combines historical analysis, case studies, and theoretical frameworks to reveal the complex connections between social movements and political transformations. The research begins by delving into the historical context of social movements in India, highlighting their evolution from the pre-independence era to the present. By examining key movements such as India's independence struggle, the Chipko movement, anti-corruption protests and farmers' agitations, this paper seeks to identify recurring patterns, strategies and outcomes across periods. The study further examines the impact of social movements on policy-making, political discourse and institutional reforms. By analyzing specific cases where social movements have influenced legislative decisions or brought about political change, the research aims to assess the tangible results of grassroots activism on the functioning of Indian democracy. The role of social media and technology in amplifying the voices of social movements is also explored, emphasizing their transformative influence on public opinion, mobilization and information dissemination. This study uses a comparative analysis of movements with varying degrees of success to distinguish the factors that contribute to their effectiveness and endurance. the research presents a comprehensive assessment of the role played by social movements in shaping Indian politics. By synthesizing historical perspectives, contemporary case studies and theoretical insights, this article contributes to a nuanced understanding of the complex relationship between social activism and political change in the Indian context. The aim of the findings is to inform policy makers, scholars and activists about the potential of social movements as catalysts for positive social transformations and democratic development.

Dr gedam kamalakar

BACKGROUND AND OBJECTIVES: Fixed-bed column has been considered an industrially feasible technique for phosphate removal from water. Besides the adsorption capacity, the effectiveness of an adsorbent is also determined by its reusability efficiency. In this study, phosphate removal by a synthesized amorphous zirconium (hydr)oxide/MgFe layered double hydroxides composite in a fixed-bed column system was examined. METHODS: The effects of flow rate, bed height, phosphate concentration, solution pH, and adsorbent particle size on the phosphate adsorption ability were examined through a series of continuous adsorption experiments. The appropriate breakthrough curve models, phosphate adsorption from real anaerobic sludge and synthetic seawater, column regeneration and reusability, and adsorption mechanism were also investigated for practical application feasibility. FINDINGS: The results showed that the increased bed height and phosphate concentration, and reduced flow rate, pH, and adsorbent particle size were found to increase the column adsorption capacity. The optimum adsorption capacity of 25.15 mg-P/g was obtained at pH 4. The coexistence of seawater ions had a positive effect on the phosphate adsorption capacity of the composite. Nearly complete phosphate desorption, with a desorption efficiency of 91.7%, could be effectively achieved by 0.1 N NaOH for an hour. Moreover, the initial adsorption capacity was maintained at approximately 83% even after eight adsorption-desorption cycles, indicating that the composite is economically feasible. The high phosphate adsorption capacity of the composite involves three main adsorption mechanisms, which are electrostatic attraction, inner-sphere complexation, and anion exchange, where the amorphous zirconium hydr(oxide) on the surface of the layered double hydroxides likely increased the number of active binding sites and surface area for adsorption. CONCLUSION: The amorphous zirconium (hydr)oxide/MgFe layered double hydroxides composite, with its high adsorption capacity and superior reusability, has the potential to be utilized as an adsorbent for phosphorus removal in practical wastewater treatment. This study provides insights into the design of amorphous zirconium (hydr)oxide/MgFe layered double hydroxides composite for phosphorus removal and recovery in a practical system.

Professor j. nouri

The current study was designed to explore the analgesic effects of methanol extracts from the leaves of Samanea saman Merr. and Prosopis cineraria Druce., using tail immersion test. Thermal stimuli produced painful reactions in mice by dipping the tail tips of the mice into hot water. Methanol extracts of the leaves of Samanea saman Merr. and Prosopis cineraria Druce. were administered intraperitoneally at the dose of 100mg /kg body weight. Pethidine 50mg/Kg intraperitoneally was used as a standard analgesic drug. The tail-flick latency delay was measured at 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 hours after the intraperitoneal administration. Both extracts produce analgesic effects when compared with pethidine.

Dr. salman ahmed

The orientation he/she chooses has a bearing on his/her long-term success. This orientation is known as your "locus of control." Its study dates back to the 1960s, with Julian Rotter's investigation into how people's behaviours and attitudes affected the outcomes of their lives. Locus of control has been defined as the degree to which an individual perceives having control over the environment (Rotter, 1966). According to Rotter (1975), there are two types of control, internal and external, which anchor a continuum that approximates a normal distribution. People are said to have an internal locus of control when they believe reinforcements are contingent upon their own behaviour or stable personal characteristics. External locus of control results when people believe that reinforcements are due to luck, fate, or powerful others outside of their control. Current study focuses on investigating the influence of demographic variables (age, gender, education level), marital status and socio economic status (occupation, income) on the level of internal/ external locus of control with the help of data collected from residents (aged between 20 and 50) of a select suburbs in Mumbai city. On analysing the data so collected, it is found that age has a major influence on an individual’s level of internal locus of control.

Nandini

The global burden of metabolic disorders, including obesity and type 2 diabetes, necessitates innovative therapeutic strategies. SLU-PP-332, a synthetic agonist of estrogen-related receptor α (ERRα), has emerged as a promising exercise mimetic, demonstrating preclinical efficacy in enhancing mitochondrial biogenesis, insulin sensitivity, and energy expenditure. This brief review synthesizes current knowledge on SLU-PP-332 and related ERRα agonists, highlighting their molecular mechanisms, preclinical outcomes, translational challenges, and ethical considerations. ERRα activation by SLU-PP-332 upregulates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), driving fatty acid oxidation and mimicking exercise-induced metabolic adaptations. However, pan-ERR activity raises concerns about off-target effects such as cardiac hypertrophy and hepatotoxicity. Despite robust preclinical data, clinical translation remains hindered by the absence of human trials and undefined long-term safety. Future research must prioritize isoform-selective agonist design, rigorous clinical validation, and equitable access frameworks.

Mostafa eissa

Since 2006, multiple outbreaks of avian influenza (AI) have been reported in Nigeria involving different subtypes. Surveillance and molecular epidemiology have revealed the vital role of live bird markets (LBMs) in the dissemination of AI virus to commercial poultry farms. To better understand the ecology and epidemiology of AI in Nigeria, we performed whole-genome sequencing of nineteen H9N2 viruses recovered, from apparently healthy poultry species, during active surveillance conducted in nine LBMs across Nigeria in 2019. Analyses of the HA gene segment of these viruses showed that the H9N2 strains belong to the G1 lineage, which has zoonotic potential, and are clustered with contemporary H9N2 identified in Africa between 2016 and 2020. We observed two distinct clusters of H9N2 viruses in Nigeria, suggesting different introductions into the country. In view of the zoonotic potential of H9N2 and the co-circulation of multiple subtypes of AI virus in Nigeria, continuous monitoring of the LBMs across the country and molecular characterization of AIVs identified is advocated to mitigate economic losses and public health threats.

Bitrus inuwa