It is with more sorrow and tremendous sadness we remember the death of our colleague the Libyan pharmacist, professor Mokhtar Ramadan Haman, at his home in Tripoli, Libya after long-suffering from brain cancer. He died on 02, February 2017 and his immaculate corpse was buried on the following day at the Souk-Al-Ahad cemetery, Bin Ghashir Palace. Professor Haman, was born in Tripoli, Libya, on January 1, 1957. He obtained his Bachelor of Pharmaceutical Sciences in 1981 at the University of Tripoli and his Ph.D. in Pharmacognosy in 1989 at Cardiff University, UK.

Mediterranean journal of pharmacy and pharmaceutical sciences

Cet article s’articule autour de la question de la satire chez Sony Labou Tansi dans La vie et demie. Conscient de la complexité de la notion de la satire dans le temps et chez les spécialistes, il nous a semblé judicieux de confiner notre étude dans le strict cadre de la satire entendue comme genre et non comme esprit ou mode. Nous avons démontré que la satire dans La vie et demie se justifie par la présence des topiques qui fonctionnent comme une signature du genre. L’argumentation a mis un accent sur la dimension rhétorique de la satire en parlant des formes de comique mises en place dans La vie et demie, lesquels participent à l’étayage de la satire politique du Guide providentiel et de ses nuisibles descendants. Aussi, avons-nous souligné que la dimension rhétorique de la satire se justifie par la présence de la ménagerie. L ’imagerie animale qui permet de caractériser les personnages de Sony Labou Tansi emprunte à la faune sauvage sa diversité des bêtes.

Assanvo

Hypertension is a high-risk factor for cardiovascular diseases and its prevalence rate is increasing due to risk factors such as unhealthy lifestyles and aging populations. Managing hypertension is crucial to avoid complications such as stroke, heart failure, and kidney failure. In Northern Cyprus, where hypertension is a growing public health concern, pharmacists are increasingly recognized as key players in managing this ongoing condition. This study investigates the impact of pharmacists in controlling hypertension in Northern Cyprus through a survey-based observational approach. Data were collected from 70 hypertension patients engaging with community pharmacists. The results highlight pharmacists’ contributions to patient education, blood pressure monitoring, and medication adherence. Relevant studies in other countries contextualize the findings about the importance of the pharmacist role. An analysis of the data confirms significant improvements in patient outcomes with pharmacist interventions. The survey results provide insights suggesting that overcoming systemic barriers and strengthening collaboration can optimize pharmacists' roles in managing hypertension in Northern Cyprus.

Mediterranean journal of pharmacy and pharmaceutical sciences

Vehicular adhoc structures (VANETs) handle the Public Key Infrastructure (PKI) and Certificate Revocation Lists (CRLs) for their security. In any PKI structure, the check of a got message is performed by checking if the check of the sender is joined into the current CRL, Verifying the reliability of the certification and standard for the sender. In this paper, it has been propose a Vehicular Digital Hash Gen show up (VDHG) for VANETs, which replaces the dull CRL checking process by a profitable revoking checking process. The renouncing check process in VDHG uses a Private Key Infrastructure (PKI), where the key used in finding the VDHG is shared particularly between On-Board Units (OBUs). In like manner, VDHG uses a novel probabilistic key stream, which extras with OBUs to trade and revive an issue key. VDHG can on a very basic level lessen the data torment in light of the message declaration deferral pulled back and the standard assistance structures using CRL

Dr h shaheen

Background: Acute and chronic heart or kidney failure affect each other in cardiorenal syndromes (CRS). In CRS, hemodynamic and non-hemodynamic changes occur, causing acute or progressive renal and cardiac failures. CRS is classified into five types based on the first organ failure and causes failure of the other organ. We believe that the current CRS classification is not the correct one that effectively describes the underlying cause of CRS. Hence, we consider it better to be classified into three categories (cardiorenal, renocardiac, and cardio-reno-cardiac syndrome) and then subdivided into acute and chronic types or types 1 and 2 (respectively, according to the onset of the underlying type of failure (i.e., acute or chronic). Other subtypes that occur inthe heart and dysfunction occur simultaneously are acute cardio-reno-cardiac syndrome (type 5) and Chronic cardio-reno-cardiac syndrome (type 6). Aim: In Part 1 of the review series, the pathophysiological mechanisms and clinical and therapeutic applications of all types of CRS will be narratively discussed and updated. Furthermore, we provide a comprehensive review of diagnostic biomarkers and their clinical significance in the identification, outcome prediction, and treatment of all CRS types. Method: An extensive search of PubMed, Google, EMBASE, Scopus, and Google Scholar was conducted for review articles, original articles, and commentaries published between Jan 2010 and Aug 2024 using different phrases, texts, and keywords, such as CRS, renocardiac syndrome, and CRS. The topics included secondary CRS, CRS pathogenesis, CRS therapy, SLGT inhibitor use in CRS, novel therapy in CRS types, and prevention of CRSs. Conclusion: Renal and cardiac failure in patients with CRS seem to have different pathophysiological mechanisms. Early detection and treatment can improve the outcomes of CRS. Clinical manifestations and therapy protocols vary according to pathophysiology. Hence, new guidelines and research on universal diagnostic and treatment techniques are urgently required. Moreover, the current nomenclature for CRS is confusing; therefore, we believe that a new nomenclature system should be introduced, reducing confusion and making differentiation between CRS types easier and less confusing.

Karishma

The purpose of the study was explored to find out the land and aquatic plyometric training on vital capacity among college men athletes. For the purpose of the study, forty five (n=45) men college athletes from Pudukkottai, Tamilnadu, India during the year 2019-2020 were selected as subjects. Their ages were from 18 to 21 years. The selected participants were divided at random into three groups of fifteen each (n=15). Group-I underwent land plyometric training, group-II aquatic plyometric training, and group-II acted as control group. The duration of the training period was restricted to eight weeks and the number of sessions per week was confined to five. The selected variable vital capacity was assessed by wet spirometer. The data were collected prior to and immediately after the training period of twelve weeks. The data obtained from the experimental groups before and after the experimental period were statistically analyzed with analysis of covariance (ANCOVA). Whenever the ‘f’ ratio for adjusted post test means was found to be significant, the scheffe’s post hoc test was applied to determine the paired mean differences. The level of confidence was fixed at 0.05 level for all the cases. The results of the study showed that aquatic plyometric training group is better than land plyometric training group and control group on improving vital capacity.

Dr.i. john parthiban

This paper centers around how innovations adds to enhancing interoperability between IoT gadgets, and making effectively utilization of IoT gadgets. The proposed stage innovation gives semantic-based IoT data administrations, and semantic interoperability of IoT gadgets. This administration stage can be material to a great deal of semantic IoT administrations: gathering imperceptible data in genuine condition by brilliant gadgets, giving keen life benefits by sharing, taking an interest, circulating open detecting data.

Dr h shaheen

Investigating school performance and competencies, especially on leadership, received a considerable attention in the past. In fact, there have been multitudes of evidence that leadership can impact school performance, student achievement, or outcome. Also, there was no single measurement of school performance. This study examined the influence of leadership and core behavioral competencies on the school performance of school heads. This was to build a new model of school performance. Using an explanatory research design, it administered a survey questionnaire to 192 randomly chosen school heads from the 37 districts of Department of Education Division of Surigao del Sur. Also, it used data mining for the performance ratings of school heads from the division office. Regression analysis tested three hypothesized models of school performance where leadership and core behavior competencies serve as independent variables. Results showed that leading people was a significant predictor of school performance. Thus, leading people can best explain the school improvement as a proposed model. The results have implications for future research, leadership practice, and theoretical development of school performance model among school heads.

Manuel caingcoy

Considering the site (habitat) specific variations in the metabolic activities in the freshwater bivalves, we reported here the changes in the rate of oxygen consumption, rate of ammonia excretion and O: N ratio in the freshwater bivalve mollusc, Lamellidens marginalis (Lamark) from lotic and lentic water habitats on April-May during summer season. The adult freshwater bivalves, Lamellidens marginalis (82-84 mm shell length) from lotic and lentic water near Jayakwadi dam on Godavari river was selected for determination of rate of oxygen consumption, rate of ammonia excretion and O: N ratio. The adult bivalves from lotic water habitat showed high rate of oxygen consumption and low rate of ammonia excretion. The O: N ratio showed higher values in bivalves collected from lotic water than lentic water during summer season. The results of study are discussed in the light of possible physiological processes in freshwater bivalve molluscs.

Dr. pritesh ramanlal gugale

During COVID-19 pandemic health professional need to develop good communication skills. Good communication skills will lead to professionalism. The information that are given to patients, their families and the community has to be transparent, true and scientifically relevant. The awareness one creates about the pandemic includes mode of infection, transmission, symptoms, vaccines, vaccination, viral heterogeneity and mutations. Such transmission of true information requires proper training of health personnel including the social media in developing good communication skills

Mediterranean journal of pharmacy and pharmaceutical sciences

Homoeopathy is one of the latest systems of medicine discovered at the latter part of 18th century, first rose to prominence in the 19th century due to its success in treating epidemics and is currently second largely utilized system of medicine globally. Prophylaxis through Homoeopathy has been strongly promulgated by stalwarts and popular among the general public in the recent times, but still controversy revolves around it. Aim of the study is to review the available literature for analyzing the usefulness of Homoeopathy in prophylaxis of human, animal as well as plant diseases. A comprehensive search has been made in electronic database aimed to target the available literature of various levels of evidence. Examples are summarized under different areas of applicability of homeopathic medicine as prophylactic. Currently there is convincing evidence to support effectiveness of Homoeopathy in prophylaxis, though sparse. More rigorous research studies are warranted to enlarge the horizon of its application.

Dr deepthi gilla

In 2016, the World Health Organization (WHO) estimated that approximately 4.2 million premature deaths world wide were attributable to exposure to particulate matter 2.5 μm (PM2.5). This study assessed the environmental burden of disease attributable to PM2.5 at the national level in Malaysia. We estimated the population-weighted exposure level (PWEL) of PM10 concentrations in Malaysia for 2000, 2008, and 2013 using aerosol optical density (AOD) data from publicly available remote sensing satellite data (MODIS Terra). The PWEL was then converted to PM2.5 using Malaysia's WHO ambient air conversion factor. We used AirQ+ 2.0 software to calculate all-cause (natural), ischemic heart disease (IHD), stroke, chronic obstructive pulmonary disease (COPD), lung cancer (LC), and acute lower respiratory infection (ALRI) excess deaths from the National Burden of Disease data for 2000, 2008 and 2013. The averagePWELs for annual PM2.5 for 2000, 2008, and 2013 were 22 μg m-3, 18 μg m-3 and 24 μg m-3, respectively. Using the WHO 2005 Air Quality Guideline cut-off point of PM2.5 of 10 μg m-3, the estimated excess deaths for 2000, 2008, and 2013 from all-cause (natural) mortality were between 5893 and 9781 (95 % CI: 3347–12,791), COPD was between 164 and 957 (95 % CI: 95–1411), lung cancer was between 109 and 307 (95 % CI: 63–437), IHD was between 3 and 163 deaths, according to age groups (95 % CI: 2–394) and stroke was between 6 and 155 deaths, ac-cording to age groups (95 % CI: 3–261). An increase in estimated health endpoints was associated with increased estimated PWEL PM2.5 for 2013 compared to 2000 and 2008. Adhering the ambient PM2.5 level to the Malaysian AirQuality Standard IT-2 would reduce the national health endpoints mortality

Mohamad iqbal mazeli

The study was undertaken to evaluate the nutrient composition, physical and sensory properties of bread samples produced from wheat, ground bean and sweet potato flour blends. The ground beans and sweet potatoes were prepared into flours and used at varying replacement levels (5-25% and 5-25%) for wheat flour in the production of bread loaves with 100% wheat flour bread as control. The nutrient composition, physical and sensory properties of the bread samples were determined using standard methods. The moisture, crude protein, fat, crude fibre and ash contents of the bread samples increased significantly (p<0.05) with increase in the addition of ground bean and sweet potato flours from 7.53-8.03%, 9.06-14.52%, 3.12-4.68%, 3.42-5.15% and 2.41-3.04, respectively, while the carbohydrate and energy contents decreased from 74.46-64.58% and 362.16-358.52 KJ/100 g, respectively. The mineral composition of the bread samples also increased significantly (p<0.05) with increase in substitution of ground bean and sweet potato flours from 76.32-102.33 mg/100 g (calcium), 86.33-106.76 mg/100 g (potassium), 43.17-70.79 mg / 100 g (phosphorus), 92.14-112.15 mg / 100 g (magnesium), 1.52-2.05 mg / 100 g (iron) and 2.13-2.98 mg/100 g (zinc), respectively. The thiamine, riboflavin, niacin, ascorbic acid, vitamin A and vitamin E contents of the bread samples increased significantly (p<0.05) with increase in the addition of ground bean and sweet potato flours from 42.17-59.19 mg/100 g, 62.31-80.69 mg/100 g, 24.15-47.57 mg/100 g, 12.15-12.15-12.73 mg/100 g, 18.32-47.33 mg/100 g and 15.31-43.67 mg/100 g, respectively. The physical properties (loaf volume, loaf height, loaf weight, oven spring and specific loaf volume) of the bread samples decreased significantly (p<0.05) with corresponding increase in the addition of ground bean and sweet potato flours from 310.21-115.41 cm3, 6.82-3.84 cm; 410.21-246.31g, 458.15-407.94 cm and 0.76-0.26 cm3/g, respectively. The sensory properties of the samples showed that the control sample (100% wheat flour bread) was the most acceptable to the panelists and also differed significantly (p<0.05) from the composite flour breads in colour, texture, taste and flavour. Although the 100% wheat flour bread (control) had better sensory and physical properties, it had the least values in nutrient contents compared to the composite flour bread loaves. However, the study showed that the nutrient contents of wheat flour breads could be improved by enriching wheat flour with ground bean and sweet potato flours at the levels of 5-25% and 5-25%, respectively in the production of bread loaves.

Okechukwu obed chukwuemeka

Livestock plays a significant role in the economy of a nation but its productivity can be hampered by numerous haemoparasites thereby leading to economic losses to the livestock industry. The prevalence of haemoparasite in cattle slaughtered at the Jalingo abattoir was investigated. A total of four hundred blood samples were collected at the point of slaughter, processed, and screened for haemoparasites by examining Giemsa-stained thin blood smears. An overall prevalence of 12.25% was recorded. Four haemoparasites of cattle with prevalence rates of 5.0%, 6.75%, 0.25%, and 0.25% for Anaplasma, Babesia, Microfilaria and Trypanosoma respectively were observed. The prevalence of haemoparasite in relation to sex, revealed higher infection in females (13.75%) than in males (10.0%) which were not found statistically different (P > 0.05). All breeds encountered during the study were infected with haemoparasites with the highest prevalence of 13.91 % recorded in White Fulani, Red Bororo (10.94%), and Sokoto Gudali (10.00 %), while Adamawa Gudali had the least prevalence of 0.5%. There was no statistically significant difference in the prevalence of haemoparasite in relation to breeds (P > 0.05). High prevalence was observed in the young (14.29%) more than the adult (11.59%) and older (12.14%). The current study has revealed the haemoparasites status in cattle slaughtered at Jalingo abattoir. Therefore, there is a need for effective preventive and control policy of these haemoparasites to enhance livestock productivity

Bitrus inuwa

Background: Lichen planus (LP) is a papulosquamous cutaneous disorder that manifests as intensely itchy violaceous flat-topped polygonal papules and plaques. To compare the efficacy of topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in the treatment of LP. Methods: This prospective Comparative Study was conducted at the Dermatology Department, Services Institute of Medical Sciences (SIMS)/Services Hospital, Lahore, from May 1, 2022, to April 30, 2023. Ethical approval was obtained from the institutional review board at the Department of Dermatology, SIMS/Services Hospital, Lahore. A total of 80 patients were selected after fulfilling the selection criteria. The study participants were placed into two groups, A and B. In group A, the patients were advised to use the topical application of clobetasol propionate (0.05%) ointment twice daily. In group B, tacrolimus ointment (0.1%) was used twice daily. Treatment response was assessed at 3 weeks, and then finally efficacy was evaluated at 6 weeks. Results: Treatment efficacy was observed in 34 patients (42.5%). Group A (Clobetasol) demonstrated a significantly higher efficacy of 55% compared to 30% in Group B (Tacrolimus; p = 0.024). Conclusions: The 0.05% clobetasol propionate topical formulation demonstrated superior efficacy in treating LP compared to 0.1% topical tacrolimus. Further validation of these findings through large-scale clinical trials is warranted.

Karishma

Plants produce a diverse range of bioactive compounds making them a rich source of different types of medicines. Ornamental plants are cultivated for adornment and to enhance the appearance of houses and also for commercial purposes. However, only very few of these ornamental plant species have found to be used in medicine and only little literature exit on their chemical and biological actions. In the present study, the evaluation of antimicrobial activities and identification of bioactive compounds using TLC and GC-MS of the A. columnaris bark extract were performed. In GC-MS bioactive compounds with medicinal value were identified, such as Benzoic acid, 1H-N-Hydroxynaphth (2,3) imidazole-6,7-dicarboximide, 2-Propenoic acid, 3-(4-methoxyphenyl), 1H-N-Hydroxynaphth (2,3-d) imidazole-6,7-dicarboximi. To prove the nontoxic nature of the plant, its crude bark extract was subjected to toxicity study using human embryonic kidney cell line. It reveal that the plant is minimal toxic to the human kidney cell line so usage of appropriate level will found to be safe and also carrying out some structural modification will help in the extraction of new drugs for pharmaceutical purpose.

Dr. saranya devi k

Therapeutic nucleic acids demand specificity and accuracy in design as well as delivery strategies used in replacement or silencing of the target gene. Gene therapy is believed to be the therapy in which the root cause of the diseases can be treated at the molecular level. Generally gene therapy helps in the identification of the origin of the disorder instead of using drugs to diminish or control the symptoms. The application of nucleic acids to treat and control diseases is known as “gene therapy.” Gene therapy consists on the substitution or addition of a functional gene into the nucleus of a living cell, in order to treat a disease or repair a dysfunction, caused by this gene failure. This therapy is used to correct defective genes, which are responsible for genetic diseases. Thus, gene therapy can be used to prevent, treat or regulate hereditary or acquired disorders, by the production of therapeutic proteins. The gene therapy is mediated by the use of viral and non-viral vectors to transport foreign genes into somatic cells to restorative defective genes. This review focuses on viral vectors in detail.

Dr.p.v.kamala kumari

The rate of aging is rapidly increasing and the term of geriatric refers to offer a medical care to elderly people. Drug consumption study on geriatric population is a vital issue since this group is totally neglected in Libya. The aim of this study was to assess drug utilization pattern among elderly patients in terms of world health organization core prescribing indicators and to evaluate the treatment cost. A total of 106 prescriptions were randomly collected from different community pharmacies located in Tripoli during the summer 2019, and were evaluated (total number of prescribed drugs is 359) for their clinical efficacy and safety. The findings revealed that 60 drugs acting on GIT (16.7%), 50 antimicrobial drugs (13.9%), 31 antihypertensive drugs (8.6%) and 30 drugs for respiratory diseases (8.4%) were prescribed to patients who are 65 years old or more. With regard to disease pattern in the elderly Libyan patients, 27 drugs were prescribed for diabetes mellitus (7.5%), 24 drugs for cardiovascular drugs (6.7%) and 14 drugs for anti-hyperlipidemia (3.9%). According to the WHO core drug use indicator pattern, the average number of drugs prescribed per encounter was 3.3. Prescription by generic name was low (41.5%). Antibiotics were 36.8% while injections were 26.6%. Thus, this study suggest that geriatric medicine and rational drug use should strongly be implanted in medical schools and teaching hospitals. Besides, a drug pattern use of the Libyan community is urgently required to avoid drug prescribing errors.

Mediterranean journal of pharmacy and pharmaceutical sciences

Cancer is one of the most severe medical conditions in the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer requires novel, efficacious treatment modalities. Natural remedies offer feasible alternative options against malignancy in contrast to available synthetic medication. Selective killing of cancer cells is privileged mainstream in cancer treatment, and targeted therapy represents the new tool with the potential to pursue this aim. The discovery of innovative therapies targeting essential components of DNA damage signalling and repair pathways, such as ataxia telangiectasia mutated and Rad3-related Checkpoint kinase 1 (ATR-CHK1), has offered a possibility of significant therapeutic improvement in oncology. The activation and inhibition of this pathway account for chemopreventive and chemotherapeutic activity, respectively. Targeting this pathway can also aid in overcoming the resistance of conventional chemo- or radiotherapy. This review enlightens the anticancer role of natural products by ATR-CHK1 activation and inhibition. Additionally, these compounds have been shown to have chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Ideally, this review will trigger interest in natural products targeting ATR-CHK1 and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel, efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medicines. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signalling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemopreventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed