World Health Organization (WHO) estimation disclosed over 116 million girls (3.4%) area unit stricken by PCOS worldwide. The predisposing risk factors embrace genetic science, system, lifestyle/environment, fatness that contributes to the event of PCOS. it's calculable that between 5 to ten % of U.S. girls of childbearing age have PCOS. that is regarding five million girls, which makes the condition one among the foremost common secretion endocrine disorders among girls of generative age. A study to assess the prevalence of PCOS among adolescent women at hand-picked setting, Chennai. Objective: to assess the prevalence of PCOS among adolescent women. Methodology: A non-experimental descriptive analysis style was adopted during this study. The non-probability convenient sampling technique was accustomed choose the sample size of two hundred adolescent Girls. The assessment of the prevalence of PCOS was administrated employing a self-reported check list through a Googletype. A survey link was sent to the respondents, via email and WhatsApp& teams. knowledge was analyzed by descriptive and inferential statistics. Result: our Majority (36.5%) of the samples had gentle & moderate PCOS symptoms and twenty-sevenths had severe symptoms. relating to physical activity, the bulk (38%) of the samples had gentle physical activity, thirty-fourth had moderate physical activity and twenty-eighth had severe activity. There was a direct correlation between PCOS symptoms and Physical activity. There was a statistically vital relationship between PCOS symptoms with age, religion, academic standing, dietary habits, previous information, supply of data, the cycle of emission and BMI and there was a statistically vital relationship between physical activity with age, Religion, academic standing, monthly family financial gain, age at the time of start, previous information, supply of data, variety of family, Cycleof emission & BMI. Conclusion: PCOS among adolescents is a rising problem that wants careful assessment, timely intervention, and appropriate treatment. Diagnosis of PCOS in adolescence remains a challenge attributable to overlapping symptoms of PCOS with traditional time of life changes in adolescents. life-style modifications for weight reduction and dietary modifications and psychological content plays vital role in these young ladies for preventing long run complications. Keywords: Poly cystic ovarian syndrome (PCOS), Prevalence, PCOS symptoms, Physical activity, Adolescent Girls.

Elsi queen

The Performance Management System is considered as most important system in organization. HR Analytics in Performance Management helps to understand better what is required among their Employees to increase Productivity and ultimately improves the employee Performance. HR Analytics is a method used to measure and organize information related to employee that give clean insights about the performance and productivity of an employee. It also helps the Organisations to maintain record and analyse information of specific employee with specific skill sets, this helps in cost reduction, optimizing recruitment and improving talent quality. For every organization, their employees are very precious asset. Thus, it is extremely essential to analyse, assess, and predict employee requirements. In this Modern Era measuring the performance of employees in IT Companies is a great task. This paper highlights the importance of Performance management in organisation and its influence on employee’s better performance, job achievement and work life balance.

Js

Legumes are the richest source of protein, starch, minerals, and vitamins and are considered the earliest domestic plants. They belong to the leguminosae family, one of the largest and most important families of flowering plants. The present review describes the history, consumption, nutritional aspects, traditional medicinal uses, pharmacology, and commercial aspects of legumes.

Dr. salman ahmed

The current study seeks to develop and validate a high-performance liquid chromatography method for atorvastatin diastereomer separation and analysis. In particular, we wish to identify the many diastereomers in atorvastatin, which can help us to better understand their pharmacological properties and provide significant information for pharmaceutical applications. Atorvastatin was chromatographed on a Chiralcel® OD-RH column and n-hexan-2-propanol (95:05 v/v) as the mobile phase, with an injection volume of 10 µL. The solution was pumped at a continuous flow rate of 1 mL/min, with a detection wavelength of 260 nm. The investigation found two peaks with retention times of 3.23 and 3.85 min, respectively. The resolution, capacity, and selectivity factors obtained were Rs = 1.2, k′1 = 3.50, k′2 = 4.37, and α = 1.24.

Mediterranean journal of pharmacy and pharmaceutical sciences

The choice of the study design is a major determinant of scientific quality and clinical value of a research study. To select an appropriate study design is a perplex task for novice as well as veterans in research. AYUSH systems of medicines have evidence database showing the effectiveness in a wide range of clinical conditions, yet improving the quality of trials by well- designed studies is indispensable to demonstrate widespread utility on more scientific grounds. This article describes the structured classification of research designs done on the basis of a selective literature search concerning medical research. The study design and type that can best answer the particular research question at hand must be determined not only on a scientific basis, but also in view of the available resources, ethical issues and practical feasibility of study.

Dr deepthi gilla

Self-medication, the practice of using medications without professional guidance, is a significant public health concern globally, particularly among medical students who, despite their pharmacological training, often engage in this practice at high rates. This cross-sectional study aimed to assess the prevalence and patterns of self-medication among medical students at the University of Tripoli, Libya. A sample of 121 undergraduate medical students was surveyed using a semi-structured questionnaire. The results revealed a high prevalence of self-medication (82.6%), with analgesics (51.2%) and vitamins (31.4%) being the most commonly used medications. Headache (80.4%), pain (79.9%), and respiratory issues (73.2%) were the primary health complaints prompting self-medication. Key determinants included pharmacist advice (43.8%), prior medical knowledge (32.2%), and recommendations from family or friends (12.4%). Factors such as residing in Tripoli and higher parental education levels were significantly associated with increased self-medication practices. Notably, 62.0% of the students reported using antibiotics without a prescription, raising concerns about antimicrobial resistance. The study highlights the need for educational interventions to promote responsible self-medication practices among medical students, emphasizing the risks associated with inappropriate drug use. Addressing these issues early in medical education could help mitigate the public health implications of widespread self-medication.

Mediterranean journal of pharmacy and pharmaceutical sciences

2-Pyrazolines are well known, and important nitrogen-containing five-membered heterocyclic compounds which belong to the family of azoles and have been found to possess considerable activities, like anticancer, antibacterial, antifungal, immunosuppressant and antiamoebic activity. In the present work, ten novel pyrazolines were prepared from chalcones, characterized and evaluated for their antibacterial activity against Staphylococcus aureus and Escherichia coli using Ciprofloxacin as standard and using DMSO as a solvent. Their activity was evaluated by measuring the zone of inhibition in mm. All the compounds exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli. Among ten derivatives of compounds synthesized, the derivative with 2-chloro and 4-chloro substituted phenyl rings attached to pyrazolines exhibited the highest activity against both types of organisms. The derivatives with an unsubstituted phenyl group attached to pyrazolines exhibited comparatively less activity. Thus it can be concluded that pyrazolines containing substituted phenyl groups are effective broad spectrum antibacterial agents, and they can be developed as effective antibacterial agents.

Vinod b

Social media use is inherently linked to everyday life in the digital world, from professional contexts to leisure time. Prior research focused on antecedents of social media use such as personality traits, age, gender, social skills, and also on broad range of its various effects. Positive effects include extension of friendship network, diminishing anxiety in social interaction, and improving exercise motivation. Problematic social media use and addiction are related to stress, depression, suicidal thoughts, loneliness, and scarce school engagement. Less attention has been paid to the relationship between social media use and well-being. Inconsistent results were obtained; being emphasized either small relationship between time spent using social media and psychological well-being, or absence of significant correlation. Aims: Therefore, we analyzed in this research what degree and how active social media use and self-esteem would lead to subjective well-being. Starting from the necessary distinction between the passive and active social media use, the aim of this study was to analyze the direct and indirect effects of active use and self-esteem on subjective well-being. Method: Based on a cross-sectional design, the survey data was collected from a sample consisted of 653 participants (male = 274; M age = 21.52; SD = 4.33). To verify the hypothesized direct and indirect effects included in the multiple mediation model, a path analysis was performed. Results: The findings showed positive association between active social media use, self-esteem, affective engagement in social media use, sense to belong to online community, number of friends/followers, and subjective well-being, The path analysis revealed excellent fit between proposed mediation model and sample data. Active social media use has directly effect on subjective well-being, and indirectly via sense to belong to online community. Interaction between active social media use and self-esteem significantly predicts subjective well-being. The relationship between affective engagement in social media use and sense to belong to online community is mediated by number of friends or followers on social media platforms. Conclusion: The findings of this study extend the previous research, providing support for the relationship between active social media use and subjective well-being. Keywords: active social media use; number of friends/followers; affective engagement in social media use; sense to belong to online community; subjective well-being; mediation analysis.

Elena stănculescu

Background: In addition to the recent civil war in Yemen, the COVID-19 pandemic resulted in a collapse of the health system, a decline in vaccination coverage, and the spread of numerous outbreaks. In 2022, a measles outbreak impacted Al Dali governorate. This study aimed to describe the demographics of measles patients, measles risk factors, and disease outcomes in Al Dali Governorate, Yemen. Methods: All measles-infected children who sought medical attention at Al Tadhamon Hospital in Al Dali, Yemen, between February and December 2022 were included in this prospective and observational study. Results: During the study period, 154 parents gave their consent to enroll their children in this study; 88 (57.1%) were males, and 66 (42.9%) were females. The mean age of the children was 3.56±2.90 (0.3–12 years). More than half of the mothers (n=88, [57.1%]) were illiterate or had a basic educational level, while most of the fathers (n=126, [81.8%]) were well-educated. Nutritional status was normal in most children (n=146, [94.8%]), and all children were unvaccinated. Most children (n=152, [98.7]) came from areas having measles and most of them (n=130, [84.4]) were in contact with measles cases. Health facilities were close (<3 km) to many children (n=151 [98.1]), and house ventilation was good in 66.2% (n=102) of cases while crowdedness was found in 135 (87.7) cases. Family members were 7 or more in 90 (58.4) cases. Two children under the age of 5 years died because of the disease. Conclusion: Our study showed that the main risk factor for the recent measles outbreak in Al Dali governorate was lack of vaccination, as all involved children were unvaccinated. Routine immunization needs to be reinforced through health centers in different districts and community education about the dangers of the disease and the benefits of the vaccines should be enhanced to prevent outbreaks from recurring.

Karishma

Organisations may either belong to the private sector or the public sector. When they are in the private sector, they can be large, small or medium-sized depending on the annual income and the number of workers they hire. Global organisations are developing rapidly because of the need to tap into new markets and production locations. Under the organisational structure, the organisation selected was Nike. It has several functional units whose activities are interrelated. For instance, human resource units ensure that the right personnel for finance or marketing are recruited and promoted. The emergence of new markets in BRIC and the digital revolution are highly relevant to external factors that affect the organisation. As a response, Nike has used social media and the digital revolution to reach customers directly. It, however, needs to take on new markets and products to remain in business.

Zamzam abdelazim

Epithelial cells, lining the skin and internal organs, play a crucial role as protective barriers and regulators of substance transport. Traditionally, these cells were not considered to employ electrical signaling for communication. However, recent investigations have unveiled that epithelial cells generate slow electrical signals, termed the "silent scream," in response to injury, thus challenging conventional views of intercellular communication. A recent experimental investigation provided compelling evidence for this phenomenon, demonstrating the ability of these cells to transmit electrical signals over considerable distances within the epithelium. The research utilized microelectrode array chips to precisely detect subtle electrical events in keratinocytes and Madin-Darby Canine Kidney (MDCK) cells, revealing spiking activity characterized by slow propagation speeds, distinct from the rapid action potentials of neurons. The mechanisms underlying this novel signaling are explored, focusing on the involvement of mechanosensitive ion channels, calcium signaling, and Adenosine triphosphate (ATP) release. Calcium ions, well-established intracellular messengers, appear to play a central role in this biological phenomenon. Integrating this newly discovered communication mode into the existing understanding of skin cell biology reveals a more intricate picture of how skin senses and responds to its environment. The implications of this finding extend to various facets of skin physiology and pathology, including wound healing, inflammation, and skin aging. In wound healing, where endogenous electric fields guide cell migration and promote repair, this unique type of electrical signaling potentially plays a crucial part. Furthermore, aberrant electrical signaling might contribute to chronic inflammatory conditions, and age-related changes in this signaling could underlie the functional decline observed in aged skin. The potential for other environmental stressors to trigger the epithelial-generated electric signals also warrants investigation. The exploration concludes by discussing potential technological applications, such as bioelectric sensors and enhanced wound healing therapies, and future research directions aimed at further elucidating the molecular mechanisms and functional roles of this non-excitable cell electrophysiology.

Karishma

Background: Breast cancer is a commonly found malignancy worldwide in women, and effective treatment is regarded as a substantial clinical challenge even in the presence of several options. Extensive literature is available that demonstrates polyphenols, the richly introduced phytopharmaceuticals, as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, and curcumin are reported to have tremendous potential against breast cancer. However, till now, no comprehensive survey has been found about the anticarcinogenic properties of luteolin against breast cancer. Scope and approach: This review targeted the available literature on luteolin in the treatment of breast cancer, its effects in combination with other anticancer drugs, and possible mechanisms. Key findings and conclusion: Lutein's outstanding therapeutic potential in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent but also complemented by its synergistic effects with other anti-cancer therapies such as cyclophosphamide, doxorubicin, and NSAIDs such as celecoxib and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.

Dr. salman ahmed

The international opioid crisis highlights the important role of pharmacists in prevention, using their availability and drug knowledge to prevent abuse. In this study, the knowledge, attitudes, and practices of Mangalore pharmacists towards preventing opioid abuse were assessed. From February to March 2025, a cross-sectional survey was done among 203 pharmacists aged 18-46 years in Mangalore using a pre-tested structured questionnaire. Data were analyzed using the Chi-square test, and thematic analysis of qualitative feedback. Pharmacists showed high knowledge, with 93.6% identifying opioids' mechanism as binding to CNS receptors correctly, 78.8% identifying naloxone's role in reversing overdose, and 70.0% knowing prescription drug monitoring programs' usefulness. Attitudes were optimistic, with 92.6% considering patient education a primary responsibility, 92.1% identifying multiple visits to the pharmacy as misuse, and 93.1% supporting medication-assisted treatment. The practice was active, with 93.1% checking prescription drug monitoring programs for suspected misuse and 69.0% advising take-back programs, but 43.8% associated early refills with misuse. Mangalore pharmacists show strong knowledge, attitudes, and practice against opioid abuse, being very strong in education and medication-assisted treatment support but having voids in misuse detection (for example, recognition of early refill) and naloxone confidence. Stronger training, better prescription drug monitoring program access, and policy adjustments can enhance their role in India's opioid strategy. Pharmacists are presented as front-line champions of opioid misuse prevention in this study, with implications for localized harm reduction.

Mediterranean journal of pharmacy and pharmaceutical sciences

Urolithiasis is a common worldwide problem with high recurrence. This review covers thirty-six (36) families starting from alphabet M to R. It includes Rubiaceae (17); Phyllanthaceae and Rutaceae (09); Polygonaceae (08); Pinaceae and Piperaceae (06); Menispermaceae, Myrtaceae, Oleaceae, Oxalidaceae, Plantaginaceae and Ranunculaceae (05); Moraceae and Musaceae (04); Meliaceae, Orchidaceae and Rhamnaceae (03); Moringaceae, Onagraceae, Papaveraceae, Pedaliaceae, and Polygalaceae (02); Magnoliaceae, Malpighiaceae, Molluginaceae, Myoporaceae, Nyctaginaceae, Paeoniaceae, Parmeliaceae, Parnassiaceae, Periplocaceae, Platanaceae, Polypodiaceae, Portulacaceae, Primulaceae and Punicaceae (01) plant used globally in different countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Accounting is a fundamental aspect of business operations because it records transactions through which businesses achieve and retain profitability. Recoding transactions is an important aspect of business because the primary goal of businesses is to maximise profitability (Tirole, 2010). Accounting lays the groundwork to manage the income, expenses, assets and cash flow of the firm, all of which are pivotal to the financial health of the business regardless of its size. This report discusses different accounting principles in practice. The first task utilises the double-entry method to record the transactions of the business in ledgers using the double-entry method. This task also includes the formulation of a trial balance using the balance off rule and illustrates to which final account each trial balance entry is attributable. The second task involves the creation of final accounts for different businesses. The legal implications of varying business structures differ, so their financial statements are different. This task also includes a discussion of the properties, purposes, and structures of different financial statements. The third task addresses bank reconciliation. Bank reconciliation resolves any discordance between the records of the business and its bank statement. The gist of the fourth task is the use of control accounts. Control accounts summarise ledger balances to ensure a match between those accounts and the accounts in the ledger of each account.

Zamzam abdelazim

The main focus of this paper is to examine the relationship between insecurity in Nigeria and how traditional institutions such as traditional monarchical system can be used as veritable tool to curtail increasing insecurity in a democratic system such as Nigeria. The pervasive nature of insecurity,though,not an entirely Nigerian problem, has been trending of late, andhence, become a huge source of worry for scholars,experts,public commentators and the international community at large.The menace of insecurity finds expression in wanton killings, kidnapping,farmers-herders conflicts, rape, communal clashes, militia activities, ethnic secessionist agitations and many other strands of violence. The multiplier effects of all these challenges have been very devastating in terms of the recent attacks witnessed all over the country in recent times. This study observes that most of the people engaged in some of these atrocities might be well known to traditional rulers in the communities where they come from. This is because traditional rulers are closest to the people. The work is an exploratory study and relies solely on literature and works of experts in the broader field of security studies for investigation. The paper sums up a conclusion and recommends that there is a need for the adoption of both vertical and horizontal approaches to tackle the menace of insecurity, particularly, using the instrumentality of traditional institutions as a point of departure.

Canice erunke

Rasa aushadhis are known for their uniqueness in curing the diseases with a very low dosage. These formulations are divided into two types based on their mode of preparation i.e., Single drug and Compound drug formulations. Based on their origin, the drugs are divided into three types, Herbal, Mineral and Animal. Any of these two or three together is combined to make a compound formulation. Apart from these, the other major factor which is needed for a formulation is the Rasa Panchaka of a Drug. Many of the formulations are being prepared based on their availability, keeping their Rasa Panchaka and Samprapti vighatana in mind. These formulations are designed in such a way that two or more drugs will be having one common quality, or Opposite Qualities or an Antidote of a particular Vishadravya, which can help in curing the disease. So an attempt is made to Review Tribhuvanakeerti Rasa with its Probable mode of action.

Suri abhiram

Increasing presence of women in economic pursuits like entrepreneurship activities is believed to be the result of development policies. This belief ignores the role of socioeconomic factors in the growth and development of women entrepreneurship. Many women entered the world of business and they have become successful entrepreneurs in various business activities. Women entrepreneurs in Dakshina Kannada district have set up business ventures in a range of industries. The study has been conducted to know the extent of problems faced in managing work and life by women entrepreneurs. Majority of the respondents started their business or service to become independent and to meet the financial needs of their family. From the study it has to be found that majority of the women find it difficult to manage their work and family and they are trying to overcome these difficulties by time management and with the help of their family members.

Thara s shetty

Melilotus officinalis (L.) Pallas. is used traditionally to treat hypertension and chronic venous insufficiency. The high prevalence of hypertension and the side effects of antihypertensive drugs potentiate us to evaluate Melilotus officinalis. The hypotensive effect of Melilotus officinalis butanol fraction (MOBF) was investigated in anaesthetised normotensive rats. The doses of 60, 80 and 100 mg/kg, i.v., produced a significant (P <0.05) decrease in blood pressure. The statistically non substantial reduction in blood pressure was shown by 20 and 40 mg/kg, i.v. These results suggest that Melilotus officinalis exhibited a hypotensive effect in normotensive rats. However, further evaluation of compound-related activity is required.

Dr. salman ahmed

Sheath blight and Sheath rot of rice caused by Rhizoctonia solani and Sarocladium oryzae is an economically important disease causing rigorous yield losses. Biological control of the disease using plant growth promoting rhizobacteria (PGPR) is a potential substitute to the presently available chemical control methods. The present investigation was aimed to study the plant growth promoting (PGP) activity and antagonistic activity of two rhizobacteria Pseudomonas fluorescence and Rhizobium sp., isolated from rhizosphere area of rice, against two major rice pathogens. In the present work IAA (Indole acetic acid production) was found maximum amount in Pseudomonas fluorescence (30 mg / ml) and trace amount in Rhizobium sp. Maximum amount of Siderophore production was noticed in both isolates. Pseudomonas fluorescence showed positive result for the HCN production but Rhizobium sp., was found to be negative and both bacterial isolates solubilized phosphate in very effective manner. Both rhizobacteria were found to produce ammonia and catalase. The cross streak studies revealed that the complete inhibition of mycelia growth of Rhizotonia solani (85%) and partial inhibition of Sarocladium oryzae (45%) against two rhizobacteria. Antifungal compound extracted from both rhizobacteria were found to exhibit maximum antagonism against rice pathogens. This result concluded that both PGPR’s can be used as best bio-control agent against rice pathogens instead of hazards chemicals.

Dr. saranya devi k