Object: The main purpose of the research is to develop modern tools for insurance management in the global economic crisis, to make an objective assessment based on a critical analysis of existing ones, to identify situations that could lead to international economic, social, and natural threats. It is made some recommendations for the development of insurance calculations for the republic of Uzbekistan. Methods: Methods for reforming modern calculation of insurance tariffication are recommended by means of theories of probabilities, statistical and mathematical analysis, and foreign advanced countries practical types of summarizing. Findings: While making an analysis, it has found that modern tools for the insurance management of Uzbekistan are needed. We proved this by the results of the modern calculation of insurance. For the development of the insurance market of Uzbekistan, it should be analyzed by means of penetration and density of insurance premiums, making the deepest calculation of risks of the economy of Uzbekistan, and using the main principles and formulas of the theory of probability. Conclusions: In the end, we can take some results, and give some recommendations such as using the tools of theories of probabilities can help us find the main risks of economy, it’s powers of influences of the market economy, statistical and mathematical analysis also add some practical, objective results for making under control of any types of insurance risks

Ikboljon odashev mashrabjonovich

Systemic onset juvenile idiopathic arthritis (SoJIA) is a rare inflammatory disorder. It is the severest form of juvenile idiopathic arthritis, and complications occur most commonly in this type. Non-responsiveness to standard therapy with corticosteroids and disease-modifying antirheumatic drugs is not uncommon. Interleukin-1 beta (Il-1β) has been shown to be a main contributor to the pathogenesis of SoJIA. Anakinra, a recombinant Il-1β receptor antagonist, was shown to be effective in small cohorts of therapy-resistant adult and pediatric still's patients. This study aimed to evaluate the real-world efficacy, steroid-sparing effect, and safety profile of anakinra in patients with SoJIA at a tertiary care center in Libya. A retrospective case series was conducted on patients with SoJIA treated with anakinra at the Tripoli Children's Hospital between 2010 and 2017. Data on demographic characteristics, disease activity, corticosteroid dosage, concomitant medications, and adverse events were collected at baseline and at 1-, 3-, 6-, and 12-month post-treatment. 13 patients were treated with anakinra with a mean age of 9.4±4.6 years at anakinra initiation and a female-to-male ratio of 2: 1. All patients were on corticosteroids and 92.3% on methotrexate at treatment initiation. The proportion of patients achieving inactive disease (Jadas 10=0) increased over time. A marked steroid-sparing effect was observed: the number of patients requiring high-dose steroids (>0.5 mg/kg/day) decreased from 100% at baseline to 7.6% at 12 months, and 53.8% successfully discontinued corticosteroids entirely. All patients experienced injection site reaction, and macrophage activation syndrome occurred in 15.4% as a side effect after treatment initiation. But no severe infections or fatalities occurred. Reasons for discontinuation included remission (46.1%), drug unavailability (23.0%), inefficacy (15.3%), and side effects (15.3%). Anakinra demonstrated significant efficacy in inducing rapid disease control and reducing corticosteroid dependence in patients with refractory SoJIA, with a manageable safety profile

Mediterranean journal of pharmacy and pharmaceutical sciences

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

The 2019 coronavirus (COVID-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. Molecular docking is a recognized computational tool to assist in early drug discovery and development. Molecular docking analysis was carried out using 2-(4-(aminomethyl)phenyl)isoindoline-1,3-dione Schiff base conjugates with SARS-CoV-2 protease enzyme and COVID-19 main protease in apo form 6M03). The compounds with the best normalized docking scores to protease enzyme (6LU7) were ARG3 (-8.1 kcal/mole), ARG7 (-8.1 kcal/mole) and ARG6 (-8.0 kcal/mole). The best docking ligands for main protease in apo form (6M03) were ARG7 (-8.7 kcal/mole), ARG6 (-8.6 kcal/mole) and ARG3 (-8.4 kcal/mole). The structural similarity between these conjugates inspired us to perform in silico studies to check their possible binding interactions with essential SARS-CoV-2 proteins. These studies provide insight into the potential binding between Schiff base derivatives and SARS-CoV-2 proteins to provide an insight for finding an effective therapy. Finally, ADMET calculations were performed for the Schiff base compounds to predict their pharmacokinetic profiles.

Mediterranean journal of pharmacy and pharmaceutical sciences

Covid 19, the pandemic originated in the Chinese city of Wuhan, had the entire world conquered. The structure and transmission of the causative organism, Coronavirus is well studied. Remdesivir, the product of Gilead pharmaceuticals, was effective against many viral infections, including Ebola and SARS. It comes under the category of nucleoside prodrug and has given promising results in the early trials against SARS COV 19. In depth, research is taking place at a rapid pace, so that Remdesivir will be available to the therapeutic community as an effective remedy for the pandemic caused by SARS COV2. If this meets success, the darkest era in the modern history of mankind may become a memory in the near future.

Vinod b

Abstract: Recent studies on hydrogels have shown them as promising biomaterials for numerous applications involving tissue engineering, drug-screening, drug-delivery, and 3-D bioprinting because they show unique physicochemical properties. The ability of these structures to hold large amounts of water is because of their hydrophilic nature that provides a soft and hydrated environment like natural tissues. This makes them ideal for mimicking the extracellular matrix and supporting cell growth and proliferation. In tissue engineering, hydrogels might be used to create scaffolds that promote cell growth and facilitate tissue regeneration. Hydrogels can also be engineered in such a way that they intimate the mechanical and biochemical in vivo characteristics making them a versatile tool for applications in tissue engineering. Hydrogels are being used in drug screening, as they can be functionalized with different biochemicals in order to match the microenvironment of specific tissues. This allows researchers to study how drugs interact with cells and tissues in-vitro conditions, which can lead to more efficient strategies for drug development. For applications in drug delivery hydrogels are designed to release drugs in a sustainable and controlled way, improving the drug efficacy and reducing the toxicity of drugs. Designing can also be done in a way that they can target specific tissues and cells making them a promising tool for personalized medicine. Hydrogels are being used in 3-D bioprinting, where they serve as bio-inks that can be fabricated into complex structures with high precision. In comparison to conventional technologies, this is a promising technique that allows the construction of complex three-dimensional structures in a sequential manner by a computeraided system. One major challenge in bioprinting is finding such material that is suitable for printing and also satisfies the mechanical strength requisite for tissue engineering applications. That is where hydrogels serve as the most appropriate model and have encouraging or favorable operation potential as cell-affable materials. This technique has revolutionized tissue engineering by allowing researchers to create functional tissues and organoids and spheroids. Overall, hydrogel-based tissue engineering, drug screening, drug delivery, and 3D bioprinting are exciting areas of research with great potential to significantly impact different areas of medicine and biology.

Deepika pal

In this article, we form the exact wave solutions of the Jimbo-Miwa equation and the Calogero-Bogoyavlenskii-Schiff equation by applying the new generalized (G'/G)-expansion method. We explained the new generalized (G'/G)-expansion method to look for more general traveling wave solutions of the above mentioned equations. The traveling wave solutions attained by this method are in terms of hyperbolic, trigonometric and rational functions. The graphical representation of the obtained solutions is kink soliton, singular kink soliton, singular soliton and singular periodic solution. This method is very significant for extracting exact solutions of NLEEs which habitually occur in mathematical physics, engineering sciences and applied mathematics.

Md khorshed alam

Natural products are a vital source of therapeutic agents due to their diverse chemical structures and wide range of biological activities. With the advancement of computational technologies, natural product databases have become essential tools in drug discovery, offering organized access to chemical structures, biological properties, and biosynthetic information. These databases support various stages of drug development, from target identification to lead optimization. This review outlines the essential features of Natural Products Databases and introduces the framework for the first Libyan Natural Products Database, a project designed to harness Libya’s unique biodiversity. This foundational work involves a detailed review of existing natural product databases to identify their core components, data architectures, and user interface designs. While acknowledging challenges such as data standardization, limited resources, and long-term sustainability, the creation of the Libyan Natural Products Database is expected to enhance local scientific capacity and contribute meaningfully to the global drug discovery landscape. This positions the Libyan Natural Products Database to play a foundational role in advancing pharmaceutical research and drug discovery.

Mediterranean journal of pharmacy and pharmaceutical sciences

PKN Subject is on one of lesson implemented on SD, SMP and SMA to apply student characters and to form the student to understand and love home land also understand global life. The research background of the low student achievement on study still using lecture method, giving assignments, answer and guestion on PKN subject. The purposes of this research: 1.how student achievement on PKN subject before using word sguare model. 2. How student achievement on PKN subject after using calassroom action rescarch with quantitative approach. The sample is the students of class III MIS NU 2 Pontianak.in order to get the data, researcher using observation shett, measurement technique and documentation study.The result concluded: 1.the student achievement before using word square model the average is 53 ( good category ) with KKM > 70 as 5 or 25% and students with KKM < 70 as 15 students or 75%. 2. The student achievement after using word square on cycle 1 is 68,5 ( Better category) with KKM 55%. On the other hands, cycle 11 is 82,5 (Great category ) with KKM 90%. Mata pelajaran PKn salah satu pelajaran yang diterapkan mulai dari SD, SMP dan SMA dengan membekali karakter dan membentuk peserta didik cinta tanah air dan paham dalam kehidupan yang serba global. Rumusan penelitian ini; 1) Bagaimanan hasil belajar siswa pada mata pelajaran pendidikan kewarganegaraan sebelum menggunakan model pembelajaran word square kelas 3 MIS NU 2 Pontianak. 2) Bagaimana hasil belajar siswa pada mata pelajaran pendidikan kewarganegaraan setelah menggunakan model pembelajaran word square kelas 3 MIS NU 2 Pontianak. Metode dan jenis penelitian ini menggunakan jenis penelitian tindakan kelas dengan pendekatan kuantitatif.Subjek penelitian ini adalah siswa kelas III MIS NU 2 Pontianak. Untuk mendapatkan data peneliti menggunakan lembar observasi, teknik pengukuran dan studi dokumentasi. Hasil dari penelitian ini yaitu: 1) Hasil belajar siswa pada Mata Pelajaran PKn sebelum menggunakan model pembelajaran Word Square diperoleh nilai rata-rata sebesar 53 (kategori cukup) dengan siswa yang tuntas mencapai nilai KKM ? 70 sebanyak 5 atau 25% dan siswa yang tidak tuntas dengan nilai KKM ? 70 sebanyak 15 siswa atau 75%. 2) Hasil belajar siswa pada Mata Pelajaran PKn setelah menggunakan model pembelajaran Word Square pada siklus I sebesar 68,5 (kategori baik) dan siswa yang mencapai KKM sebesar 55%. Sedangkan pada siklus II sebesar 82,5 (kategori sangat baik) dan siswa yang mencapai KKM sebesar 90.

Educare: journal of primary education

A survey was conducted to screen the presences of antibiotic-resistant Salmonella from broiler chicken meat brought from local retail shops situated at Kozhinjampara, Palakkad, Kerala. Based on the morphological and biochemical characterization, a total of 15 Salmonella sp were isolated. Among 15 isolates, five (S7, S8, S10, S12, S14) isolates exhibited 100% resistance to all tested antibiotics and only one isolate S9 shows sensitivity to maximum antibiotics tested. In the study, garlic extract was tested against antibiotic-resistant isolates and it exhibited maximum inhibition against S12 isolate (30mm) and minimum inhibition against S8 isolate (22mm). The analyses of the garlic extract by GC-MS confirmed that the major components of garlic having antimicrobial activity. The result specified that garlic extract was found to be effective in controlling antibiotic resistance Salmonella species from broiler chicken meat. Therefore, incorporating garlic products in poultry feeds will help reduce antibiotic-resistant pathogenic microbes which causes drastic infections in human beings.

Dr. saranya devi k

Pendidikan agama Islam sebagai upaya mengembangkan, mendorong serta membimbing peserta didik hidup lebih dinamis dengan berdasarkan nilai-nilai agama islam dan terbentuk pribadi peserta didik insane kamil. Rumusan dalam dalam peneltian ini: 1) Bagaimana peran PAI dalam pembinaan kesehatan mental siswa di SDN Sekarputih 1 Tegalampel Bondowoso? 2) Bagaimana peran PAI dalam pembinaan kesehatan pikiran/intelektual siswa di SDN Sekarputih 1 Tegalampel Bondowoso? Metode penelitian ini menggunakan pendekatan kualitatif deskriptif dan jenis penelitian studi kasus. Metode pengumpulan data dengan metode observasi, metode wawancara dan metode dokumentasi. Sedangkan analisis data menggunakan model analisis interaktif Milles, Huberman dan Saldana dengan tiga Langkah dalam proses analisis data yaitu: kondensasi data, penyajian data dan penarikan kesimpulan. Untuk memeriksa keabsahan data ini, menggunakan tehnik triangulasi yaitu triangulasi tehnik, triangulasi metode dan triangulasi data. Berdasarkan hasil penelitian ini dapat disimpulkan: (1) Peran PAI dalam pembinaan kesehatan mental siswa di SDN Sekarputih 1 Tegalampel Bondowoso yaitu: (a) Agama sebagai pembimbing dalam kehidupan peserta didik. (b) Agama sebagai penolong dalam menghadapi kesulitan untuk memecahakan masalah yang di alami siswa. (c) Agama sebagai penentram bathin. (2) Peran PAI dalam pembinaan kesehatan intelektual/kesehatan pikiran di SDN Sekarputih 1 Tegalampel Bondowoso yaitu: (a) Guru membimbing peserta didik secara akademis di dalam sekolah maupun di luar sekolah. (b) Kajian-kajian keagamaan oleh guru PAI sebelum atau sesudah mata pelajaran dimulai. (c) Membudayakan siswa untuh silaturrahim kerumah guru. (d) Bimbingan secara intelektual kepada dengan teori-teori keagamaan yang memadai, agar siswa tidak sekuler dalam berperilaku sehari-hari.

Educare: journal of primary education

Toxicity of different insecticides was evaluated against 2nd and 3rd instar larvae of Helicoverpa armigera under laboratory conditions by leaf dipping method. The insecticides viz., thiodicarb 75WP, novaluron 10EC, spinetroam 11.7EC, indoxacarb 15.8EC, quinalphos 25EC, rynaxypyr 18.5SC, emamectin benzoate 5SG and cypermethrin 25EC were tested. Spinetoram was found most effective in managing the 2nd instar larvae of H. armigera and it was followed by novaluron 10EC and indoxacarb 15.8EC as compared to cypermethrin 25EC. Emamectin benzoate 5SG @ 1 x 10-7 to 1 x 10-9 per cent concentrations recorded 100% mortality against 2nd instar larvae and LC50 values for 3rd instar larvae was 0.00000000045%. Insecticides novaluron 10EC, spinetoram 11.7EC and cypermethrin 25EC did not show promising and consistent results against 3rd instar larvae of H. armigera at 24 hrs. The LT50 of novaluron 10EC at 0.00005% concentration was 19.861 hrs and it was 28.144 hrs at 0.000001% against 2nd instar larvae of H. armigera

Dr. babu lal jat

There has been an increasing awareness about the importance of herbal plants in therapeutic uses which are safe, efficient and induce little side effects This study was based on the evaluation of antibacterial activity of ethanolic extracts of the leaves of Oleaeuropaea (Olive tree) and Ficuscarica (Fig tree), alone and in combination, against enterococcus faecalis (E. faecalis) strain using well diffusion method and minimum inhibitory concentration. The results revealed that the Oleaeuropaea leave extract is more potent than the Ficuscarica leave extract against E. faecalis, as the zone of inhibition was 23 mm and 3 mm, respectively. By mixing both extracts, the results showed a slight synergistic effect, as the zones of inhibition were 20 mm, 24 mm, 24 mm and 25 mm for 1:1, 1:3, 1:6 and 1:9 ratios of the Oleaeuropaea leave and the Ficuscarica leave extracts, respectively. The minimum inhibitory concentration for E. faecalis growth was 200 mg/ml for the Oleaeuropaea leave alone, Ficuscarica and mixed with Ficuscarica. The present findings conclude a potent antibacterial activity of the olive and fig leave, and, their potential as a source of drug in the treatment of E. faecalis infections is suggested.

Mediterranean journal of pharmacy and pharmaceutical sciences

Brilliant Grid is intended to incorporate progressed correspondence/organizing innovations into electrical power frameworks to make them ''more intelligent''. The current circumstance is that a large portion of the power outages and voltage lists could be forestalled in the event that we have better and quicker specialized gadgets and advancements for the electrical matrix. To make the flow electrical force lattice a Smart Grid, the plan and execution of another correspondence framework for the lattice are two significant fields of examination. Be that as it may, Brilliant Grid projects have just been proposed as of late and a couple of recommendations for forward-looking necessities and starting exploration work have been offered in this field. No efficient audits of correspondence/organizing in Smart Grids have been led at this point. In this manner, we direct an orderly survey of correspondence/organizing innovations in Smart Grid in this paper, including correspondence/organizing engineering, distinctive correspondence innovations that would be utilized into this design, nature of administration (QoS), upgrading the use of resources, control and the board, and so forth.

Dr.a.shaji george

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Dr. wahul umesh b

Accurate diagnosis of the cause of acute or chronic kidney dysfunction may require a percutaneous kidney biopsy (PKB). Unfortunately, the invasive nature of the procedure can lead to potential complications that may discourage the KBs. Lack of appropriate communication skills, experienced personnel and equipment, and high procedure costs can negatively impact complication rates and the frequency of conducted KBs. This nonsystematic review assesses KB procedures, indications, contraindications, complications, post-KB monitoring time, and cost. We looked for reviews and original articles published between January 2010 and Jan 2025 on Google, Google Scholar, and PubMed. Different keywords, phrases, and sentences include PKB, renal biopsy, native PKB, ultrasound guide, CT-guided, PKB, allograft PKB, and PKB procedures. KB makes histopathological and immunohistological diagnosis possible, which are necessary for diagnosis and treatment. It is often used despite the known complications. KB and other biochemical assays have tracked transplant rejection and antirejection drugs. Automatic gun spiral needles sizes 14 and 16 capture enough samples with fewer complications than gauge sizes 18 and 20. KB cost is another issue, especially in low-income areas, and deserves additional study.

Karishma

Melilotus officinalis (L.) Pallas. is used traditionally to treat hypertension and chronic venous insufficiency. The high prevalence of hypertension and the side effects of antihypertensive drugs potentiate us to evaluate Melilotus officinalis. The hypotensive effect of Melilotus officinalis butanol fraction (MOBF) was investigated in anaesthetised normotensive rats. The doses of 60, 80 and 100 mg/ kg, i.v., produced a significant (P<0.05) decrease in blood pressure. The statistically non-significant reduction in blood pressure was shown by 20 and 40 mg/ kg, i.v. These results suggest that Melilotus officinalis exhibited a hypotensive effect in normotensive rats. However, further evaluation of compound-related activity is required.

Dr. salman ahmed

The domestication of animals and cultivation of crops have been essential to human development throughout history, with the agricultural sector playing a pivotal role. Insufficient nutrition often leads to plant diseases, such as those affecting rice crops, resulting in yield losses of 20-40% of total production. These losses carry significant global economic consequences. Timely disease diagnosis is critical for implementing effective treatments and mitigating financial losses. However, despite technological advancements, rice disease diagnosis primarily depends on manual methods. In this study, we present a novel Self-Attention Network (SANET) based on the ResNet50 architecture, incorporating a kernel attention mechanism for accurate AI-assisted rice disease classification. We employ attention modules to extract contextual dependencies within images, focusing on essential features for disease identification. Using a publicly available rice disease dataset comprising four classes (three disease types and healthy leaves), we conducted cross-validated classification experiments to evaluate our proposed model. The results reveal that the attention-based mechanism effectively guides the Convolutional Neural Network (CNN) in learning valuable features, resulting in accurate image classification and reduced performance variation compared to state-of-the-art methods. Our SANET model achieved a test set accuracy of 98.71%, surpassing current leading models. These findings highlight the potential for widespread AI adoption in agricultural disease diagnosis and management, ultimately enhancing efficiency and effectiveness within the sector.

Mehdhar s. a. m. al-gaashani

A new feature generates customer delight by using modern computer vision techniques to drive new search paradigms through visual discovery.

Senthilkumar gopal

formulation and evaluation of herbal face pace pack

Sumaira taj