Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

Aging seldom comes alone and it is considered to be the major factor for many diseases and comorbidities and disabilities. The objectives of the study are to examine demographic characteristics and prevalence of comorbidities and polypharmacy of elderly patients who were admitted at Sebha Medical Center according to the selected period. This study is descriptive and retrospective cross-sectional study conducted in Sebha during 2021. From 195 participants of the study, the highest rate of patients was from the age group of 65 - 74 years which accounted for 86 participants (44%) and followed by those age group of 75 - 84 years which was reported by 65 participants (33%). The majority of elderly patients have hypertension, (n = 116, 59%) and over one-third of the patients (n = 73, 37%) have diabetes mellitus while nearly one-quarter of patients have both diseases at the same time (n = 47, 24%). Nearly, three-quarters of patients have electrolytes imbalance (n = 142, 72%). Nearly, two-thirds of the patients had three to five comorbidity diseases (n = 122, 63%). Whereas, over one-third of the patients had just one or two comorbidities (n = 70, 36%). Almost all the participants have polypharmacy (n = 187, 96%). Just above half of the patients have five - ten medications (n = 100, 51%) compared with 45% of the patients from those who have more than ten medications (n = 87). This study showed that there is a strong relationship between the prevalence of polypharmacy and the number of comorbidities. A Spearman correlation test indicated that rate of comorbidities was related to polypharmacy with a significant correlation (P < 0.01). The present study found high prevalence of comorbidities and polypharmacy among elderly inpatients. Based on this high prevalence, practicing pharmaceutical care could play an effective role to reduce the risk of inappropriate polypharmacy among hospitalized elderly patients through encouraging clinical pharmacist to engage in clinical activities in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences

Flow control techniques are broadly classified into two types 1.passive control 2.active control. Present paper discuss about the experimental investigation of flow control using passive method on bluff body. Authors also explains about the various flow control techniques used in bluff body aerodynamics. Experimental setup consists of L m span and diameter d of cylinder model. The next model is having strip of cross section 0.01d dia is placed on the cylinder along the span wise distance with equal polar distance around 30o. both the models were kept between four walls in a Reynolds number ranging from 10000 to 15000. The results show that the Cp values changes according to the changes in cylinder roughness.

Boopathy govindarajan

Background: Evidence has suggested that school-based physical activity programs (SBPAPs) including structured physical education, extracurricular sports, and activity-based learningenhance memory and other cognitive functions. However, evidence on whether Indian adolescents can achieve improved cognition or increased academic performance also remains scarce. This study aimed to examine the relationship between SBPAPs and academic performance among Indian adolescents. Methods: A cross-sectional, mixed study was carried out from October 2024 to March 2025 in public and private secondary schools in Haryana and Punjab, north India. A total of 300 students aged 13 to 17 years were divided into an intervention group (n = 150) who participated in structured physical activity (PA) of at least 150 minutes per week and a comparison group (n = 150) who were involved in less than 30 minutes of PA per week. Academic performance was assessed in terms of composite scores of core subjects, while the level of PA was measured using the Physical Activity Questionnaire for Adolescents. Independent samples t-tests, one-way analysis of variance (ANOVA), and Pearson’s correlation analysis were all used for quantitative data handling. Qualitative data gathered from focus group discussions and key informant interviews with a subsample (n = 30) were thematically analyzed. Results: There were no significant differences in baseline demographics between the groups (p > 0.05). Compared with the comparison group, the intervention group showed significantly higher academic scores (mean = 76.4%, SD = 7.8; mean = 70.6%, SD = 8.4) with a moderate-to-large effect size (t = 6.30, p < 0.001, d = 0.72). A one-way ANOVA found that academic performance differed significantly among PA intensity levels (F(2,297) = 19.44, p < 0.001). There was a moderate positive correlation between PA levels and academic achievement (r = 0.44, p < 0.01). Qualitative findings corroborated quantitative data, showing that physically active students displayed improved concentration, emotional regulation, and academic motivation. Conclusions: Partaking in structured SBPAPs significantly increases Indian adolescents’ academic performance. These findings imply the necessity of including physical education in the academic curriculum as a low-cost, scalable method for supporting both cognitive growth and educational achievement.

Karishma

Therapies highly plays a crucial role for all those children and adults with disabilities. In this article, We aim to research the Special Educators’ Knowledge about Therapies in various special schools in the city of Hyderabad, Telangana, India. A qualitative approach was taken for this purpose. Questionnaires was used to collect the data. It was found that the teachers did not have proper conception on Therapies. The data indicated that the teachers are unaware about the unconventional therapies such as Drama Therapy, Pet Therapy and Laughter Therapy and there benefits when working with CSN. This lack of awareness needs to be addressed for the enhancement of the teacher as well students capabilities.

Husna habib

Right of entry to finance, especially by the poor and susceptible groups, is an essential indispensable for employment, economic development, poverty mitigation and social up-liftment. Here lies the importance of financial inclusion. Financial inclusion or inclusive financing is the deliverance of financial services at affordable costs to sections of disadvantaged and low income segments of the society. The Government of India has taken a number of initiatives so that the banks can serve the poor in a hassle-free manner. With a view to spreading the services to poor and weak groups Andhra Bank plays a vital role in financial inclusion. Keeping this view, the authors have attempted to discuss the role of Andhra Bank towards Financial Inclusion as the main purpose of this paper. It also analyses the performance of the Andhra Bank in terms of its deposits, advances, income, expenditure, profitability etc..

Dr tatayya bommali

Lytic lesions in adult spine are a common manifestation of aggressive disease such as primary bone tumor, metastasis, myeloma, or infectious pathology. Xanthoma arising in the spine with purely intraosseous component is an extremely rare occurrence with only six cases reported in the adult population, none in the cervical region. We report the first case of primary xanthoma of the cervical spine in a 50‑year‑old male solely confined to osseous compartment. The imaging mimics of lytic lesion with expansile mass in adult spine are reiterated.

Adnan

India is in the midst of a severe second wave of Covid-19. As per the Global Commission for Post-Pandemic Policy by mid-April of 2021, India had manufactured nearly 17 percent of all Covid-19 vaccine doses globally. It was the world’s fourth-largest producer, after China (about 36 percent), the United States (about 22 percent) and the European Union (more than 17 percent). Even so, following a shortage of vaccines and with insufficient local production, Government of India decided to import more foreign vaccines with quicker approval process for vaccines accepted in US/EU markets. India is currently using made-in-India vaccines, namely, Covishield manufactured by Serum Institute India and Covaxin of Bharat Biotech in its COVID-19 immunisation programme. The shortcoming in the production of vaccines and its dissemination within the country urges one to understand who the local producers are and how the market is playing out. This paper looks at the evolving market structure of vaccine production in India in the textbook framework of an oligopoly market. We use secondary data sources and daily newspaper briefs.

Nandini

Determinations of competency in adult criminal court have an extensive history, both procedurally and conceptually. Unlike criminal court, however, juvenile courts were designed for rehabilitation, rather than punishment, and, historically, the issue of competency was not often raised. Recently, however, as stakes for youth in juvenile court have begun to parallel those of defendants in criminal court, youths’ competence has become an important issue. The purpose of this study was to investigate whether defendants’ age and maturity affect judges’ ratings of juveniles’ adjudicative competence in juvenile and criminal court. Three hundred forty two criminal and juvenile court judges reviewed one forensic psychological report about a hypothetical defendant; only the age (12-17) and maturity level (less mature; more mature) of the defendant varied across reports. The judges then rated the juvenile’s adjudicative competence in both juvenile and criminal court, provided ratings of the individual competence components, rated their confidence in their decision, and rated the importance of various characteristics of the juvenile to their decisions. Judges also provided demographic information. Results revealed a main effect for age, with older juveniles generally deemed more competent, and a main effect for maturity, with more mature juveniles generally deemed more competent. There was no interaction between age and maturity. Results suggest that age and maturity play major roles in judicial determinations of juvenile competency

John dolores

This is a non-inclusive collection of my published articles.

Mostafa eissa

Mutual fund investment specifically in India and particularly in western Maharashtra is a very challenging aspect. This paper aims to study various factors influencing the investor’s choice of mutual fund, criteria for selecting particular scheme, previous performance of Mutual fund asset Management Company and services provided by them. Similarly Investor education and awareness. To have the competitive advantage proactive steps taken by the Asset management companies would be beneficial like proper financial planning guidelines, providing information pertaining to Net asset value, benchmark indices, analysing purchase decision involvement of the investors and very importantly understanding the risk averse behaviour of the investors and adequate and reliable information about the scheme.Understanding investor behaviour, specifically information search and Processing behaviour of mutual fund schemes is instrumental for effective marketing. Perhaps very few researchers have focused on investor behavioural finance. It is complex set of understanding pertaining to investor psychology; various parameters guiding principles and risk averse capability of the investor dynamically guide the behaviour. Mutual fund companies while promoting the products and marketing need to consider these several influencing parameters so as to effectively cater to the needs of the investor which would truly win the customers and enhance customer confidence and trust.Risk aversion behaviour is also the key to understand the investor risk appetite behaviour in terms of conservative or aggressive investor measuring various demographic and psychographic metrics that play a crucial role to predict and understand the likely behaviour.

Nitin mali

This study aims to investigate the relationship between green marketing elements and customer purchase intention. To conceptualize green marketing, the researcher has researched the literature and identified the green marketing elements which include Green products, Green price, Green place, Green promotion, and Green Distribution. By using the snowball sampling technique, questionnaires from the respondents were collected as part of the study's survey methodology. According to the study's findings, there is a clear, substantial correlation between customer purchase intention and Green marketing.

Santhosh sandy

Background: This study investigated the utilization of consumer health informatics in health promotion among the staff of tertiary institutions in Rivers state. Subjects & Methods: A cross-sectional descriptive research design was used. Two research questions guided this paper. The population of this paper comprised all the 13,046 staff of tertiary institutions in Rivers state. A sample of 1226 staff was drawn using multi-stage sampling techniques. An instrument titled, “Utilization of Consumer Health Informatics in Health Promotion Questionnaire” (UCHIHPQ) was adopted for data collection. The instrument was validated and reliability yielded an index of 0.80. Mean and Standard Deviation statistics were used to answer the research questions. The statistical analysis was performed with the use of SPSS v23. Results: The result revealed among others that to a very large extent, the respondents accepted that consumer health informatics was used to improve their nutritional and physical health status. Conclusion: It was therefore concluded and recommended among others that staff of tertiary institutions in Rivers state should regularly use intelligent informatics applications to attain a healthy balance between self-reliance and seeking professional help concerning nutritional and physical health matter

Fxintegrity publishing

The share of renewable energy share in India's energy mix of India has been increasing recently owing to the promotion and implementation of various government policies that promote the use of renewable sources of energy, depleting fossil fuel levels, increasing fuel prices, and stringent laws for emission reduction worldwide. The increase in the use of solar-evacuated-tube-collector-based domestic water heating is the result of this transition from conventional to nonconventional sources of energy. The recent urban agglomeration is challenging to install these solar water heaters in every household because the roof space is limited. Space reduction can be achieved by reducing the collector area by varying the diameter of the evacuated tubes. This study used a single tube and tank arrangement model with a fixed inclination to achieve a thermosyphon effect in a solar water heating system with three different diameter configurations of 48 mm, 54 mm, and 72 mm, with a tube measuring 1800 mm in length. Thermal assessment of the thermosyphon-based evacuated tube-solar water heater using the ANSYS CFD simulation software involves measuring the temperature at three different positions in the tank to study the thermosyphon initialization. This study signifies that the 72-mm-diameter evacuated tube is more capable of initializing the thermosyphon effect in the system. Nevertheless, the final temperature of the system is better achieved in the 48-mm-diameter evacuated tube

Swapnil ratnakar mane

This study was conducted to optimize the integration of solar-photovoltaic-distributed energy resources (SPVDERs) within the Nigerian power system networks using an AI-based Particle Swarm Optimization (PSO) Algorithm. By employing a mixed research method, primary and secondary data were gathered to calculate flow analysis, NR method's equations, PSO's position update model, particle swarm optimizer algorithm, and application modeling including Solar-PV DER modeling. The AI-based PSO algorithm design was developed for optimizing SPV-DER integration in Nigerian power system networks, and key parameters and variables that needed consideration were identified. The study also established how the performance of the AI-based PSO algorithm could be evaluated and compared with other optimization techniques for SPV-DER integration within Nigerian power system networks. The study's results showed that voltage limits were within acceptable ranges, and solar power contributions were estimated at 880.10MW with 46,718 panels needed. The study concluded and recommended that investing in AI-powered tools for efficient power distribution; monitoring and resource optimization for sustainable energy sources would optimize performance and unleash Nigeria's sustainable energy potential.

Fxintegrity publishing

Management accounting refers to the process of collecting, organising, and recording financial transactions with the aim of providing information for the management to make informed decisions about the operation of an organisation (Ameen, Ahmed, and Abd Hafez, 2018). Management accounting allows organisations to conform to the expectations of various financial agencies, such as tax agencies, by ensuring that all transactions that take place within an organisation are done correctly (Järvinen, 2016), thus enabling the organisation to meet its goals and objectives.

Zamzam abdelazim

This article explores how telemedicine, especially with the help of artificial intelligence (AI), is transforming healthcare. It covers its applications in monitoring patients, managing chronic diseases like diabetes, and improving cardiovascular care. The importance of wearable devices and non-invasive blood glucose monitoring is highlighted. The article emphasizes how AI-driven remote patient monitoring can enhance healthcare by providing early intervention, reducing hospitalizations, and offering personalized care.

Dhruvitkumar talati

The core of the current study is to find out a different source of diet that stimulates better growth rate and low-cost feed for commercial fish milkfish Chanos chanos. This study was to assess the impact of partial replacement of fish meal by soybean meal in the diet of juvenile milkfish, Chanos chanos (initial weight 25 ± 0.6 g). The juveniles were fed with two types of isonitrogenous diets (40% crude protein). Plant protein source diet (D1) comprised of soybean meal 45% and 10% fish meal, while animal protein source diet (D2) contained fish meal 25% and soybean meal 30%. The trial was conducted with two replications for 60 days. Fish juveniles (10 each) were stocked in outdoor fiberglass seawater tanks (5000 Liters). Results revealed that final weight gain (WG), and specific growth rate (SGR) were significantly lower in fish fed D2 diet. Fish fed D1 had better feed efficiency, weight gain (21.88 ± 1.9 g), and SGR (1.05 ± 0.3), while D2 had a lower growth rate, WG (18.71 ± 2.3 g) and SGR (0.93 ± 0.2). The maximum growth rate found on plant diet which is significantly higher weight gain than D2. In D2 feed conversion ratio (0.54 ± 0.21) was significantly higher (P≤0.05). Condition factor among both treatments did not differ significantly (P≥0.05). The survival rate remained constant (100%) in both treatments. Based on the obtained results, it is recommended that 45% soybean meal with addition of 10% fishmeal (40% protein) is more effective than 30% soybean meal with addition of 25% fish meal to the omnivorous milkfish for aquaculture.

Imtiaz kashani

Social media use is inherently linked to everyday life in the digital world, from professional contexts to leisure time. Prior research focused on antecedents of social media use such as personality traits, age, gender, social skills, and also on broad range of its various effects. Positive effects include extension of friendship network, diminishing anxiety in social interaction, and improving exercise motivation. Problematic social media use and addiction are related to stress, depression, suicidal thoughts, loneliness, and scarce school engagement. Less attention has been paid to the relationship between social media use and well-being. Inconsistent results were obtained; being emphasized either small relationship between time spent using social media and psychological well-being, or absence of significant correlation. Aims: Therefore, we analyzed in this research what degree and how active social media use and self-esteem would lead to subjective well-being. Starting from the necessary distinction between the passive and active social media use, the aim of this study was to analyze the direct and indirect effects of active use and self-esteem on subjective well-being. Method: Based on a cross-sectional design, the survey data was collected from a sample consisted of 653 participants (male = 274; M age = 21.52; SD = 4.33). To verify the hypothesized direct and indirect effects included in the multiple mediation model, a path analysis was performed. Results: The findings showed positive association between active social media use, self-esteem, affective engagement in social media use, sense to belong to online community, number of friends/followers, and subjective well-being, The path analysis revealed excellent fit between proposed mediation model and sample data. Active social media use has directly effect on subjective well-being, and indirectly via sense to belong to online community. Interaction between active social media use and self-esteem significantly predicts subjective well-being. The relationship between affective engagement in social media use and sense to belong to online community is mediated by number of friends or followers on social media platforms. Conclusion: The findings of this study extend the previous research, providing support for the relationship between active social media use and subjective well-being. Keywords: active social media use; number of friends/followers; affective engagement in social media use; sense to belong to online community; subjective well-being; mediation analysis.

Elena stănculescu

Worldwide, the threat created by antibiotic resistance to public health calls for immediate action. Antibiotic resistance is one of the main causes of the emergence and spread of dispensing of antibiotics without a prescription. This study aims to investigate the dispensing of antibiotics without a prescription and the reason behind that in the community pharmacy in Libya. The study was randomized analytical conducted between March and April 2023 among pharmacists and assistant pharmacists employed by community pharmacies in various Libyan areas Tripoli, Zawia, and Sabratha. The data were analyzed by Fisher's exact and Chi-square tests to predict the determinations of dispensing antibiotics without prescriptions. In this study, a total of 293 participants were included, 63 had been excluded because they did not meet the inclusion of the study. The remaining 230 were enrolled for final analysis, most of them were female subjects (70.7%). Findings showed that 78.7% of the participants consulted with patients about the reason for requesting a specific type of antibiotic, while 68.7% dispensed antibiotics with probiotics. Study participants with 2 - 4 years' work experience were 76.6% higher toward dispensing of antibiotics without a prescription (P=0.683). The major reason for dispensing antibiotics without prescriptions were pharmacists knowledgeable enough to give a patient antibiotics without a prescription (68.3%). In Libya, misuse of antibiotics by the public is widespread. People can purchase antibiotics without prescription. Thus, dispensing of antibiotics without a prescription in community pharmacies is an alarming issue in Libya which can increase antibiotics resistance. Pharmacists' knowledgeable is high in dispensing patients antibiotics without a prescription, but patient pressure and financial issues are the major reasons behind dispensing antibiotics without a prescription. It can be recommended that the importance of antimicrobial stewardship and the need for ongoing education support for community pharmacy professionals is of importance.

Mediterranean journal of pharmacy and pharmaceutical sciences