Background: Pre-eclampsia remains a significant contributor to maternal and perinatal morbidity and mortality. Research into changes associated with the disease offers some hope into identifying predictive and prognostic factors. In recent times, serum leptin has attracted interest as a possible marker for the disease. The aim of this study was to determine and compare the serum leptin levels in normotensive and pre-eclamptic pregnant women attending antenatal clinic at the Delta State University Teaching Hospital, Oghara, Delta State, Nigeria. Methods: This was a prospective case-control study design at the Delta State University Teaching Hospital, Oghara, Nigeria in which sixty three pregnant women who received antenatal care and developed pre-eclampsia were recruited into the study. For each selected pre-eclamptic, a matched normotensive was selected as control. Serum leptin level was measured by radioimmunoassay (RIA) ELISA. Results: There was a statistically significant difference in mean serum leptin levels between the normotensive and pre-eclamptic pregnant patients 15.11±4.81 ng/dl vs 38.98±8.66 ng/dl; p<0.001. Furthermore, there was a statistically significant difference in mean leptin levels between mild and severe pre-eclampsia; 16.49±8.22 ng/dl vs 39.03±8.58 ng/dl;p<0.001.Conclusion: This study revealed an association between serum leptin level and pre-eclampsia. Serum leptin may be a potential marker for pre-eclampsia and deserves further investigation.

Karishma

Dr. G. Kamalakar, Pursuing Post-Doctoral Fellow ICSSR, Research Assistant, ICSSR Major Research Project, Department of History, Dr. B.R. Ambedkar Open University. with a Ph.D in Political Science. He is awarded Doctorate by the Osmania University, Hyderabad, for the thesis on “WTO and GATS: Implication for the Indian Higher Education”. He is the recipient of RGNF Fellowship from the UGC and Pre-Doctoral Fellowship from OUCIP. He worked as a guest faculty at City College, Hyderabad and as a Counselor at Ambedkar Open University. He has written 3 books and edited 4 books and also published research articles in 17 UGC care list Journals. He also reviewed 11 Books and published them in UGC care list journals and sage publications. He received 7 awards including Amazing Grace Award, Pride India Award, Dr.B.R. Ambedkar Excellency Award, International Research Excellence Award, Dr. A.P.J. Abdul Kalam Life Time Achievement National Award, National best Teacher Award and Vidya Bharati Award. He presented research papers in more than 24 International, National Conferences and seminars. He has published thematic research papers in 13 National and 30 International Level Peer Reviewed / Refereed Research Journals He is also the Assistant Editor to an International journal and a Member of Editorial board & Reviewer for National and International journals published from 20 countries like USA, Turkey, Syria, UK, Pakistan, China etc. and has membership in 4 various associations.

Dr gedam kamalakar

Background: Salmonella typhi (S. typhi) antibodies may be considered as biomarkers of typhoid fever, a severe febrile systemic illness caused by an invasive Gram-negative Bacterium S. typhi. Worldwide, about 21-26.9 million cases of typhoid fever and 200 000-215 000 deaths, occur annually. Between 2003 and 2005, statistics have shown a rising trend in the incidence of typhoid fever in Abia and Enugu States. The aim of the study was to determine the sero-prevalence of S. typhi antibodies in some rural communities of Abia and Enugu States as proxy indicators of prevalence typhoid fever (TF) in the two states. Methods: This was a cross-sectional study of the sero-prevalence of S. typhi antibodies in ten rural communities of Umunneochi Local Government Area (LGA) of Abia State and Ezeagu LGA of Enugu State using 421 (200 in Abia and 221 in Enugu) blood samples for the Widal test to determine the titres of these antibodies. Results: In the Abia communities the mean sero-prevalence of S. typhi antibodies was 68.2%, while in Enugu it was 87.1%. Between the two states, difference in the sero-prevalence of S. typhi antibodies was significant (p=0.03). Conclusions: The sero-prevalence of S. typhi antibodies was higher (87.1%) in the Enugu communities, compared to the Abia communities (68.2%). To reduce the incidence and prevalence of TF in the communities, access to safe domestic water, improved sanitation and good food hygiene needs to be improved. Health-seeking behaviour also needs improvement.

Emmanuel umegbolu

Pyrazole is a nitrogen containing 5-membered heterocyclic compound containing 3 carbons& 2 nitrogen atoms in the adjacent position of ring structure and is chemically known as 1, 2- diazole. Pyrazole nucleus is present in many pharmaceutically important compounds and intermediates . Majority of anti-inflammatory agents currently employed have GI irritation and enhanced acidity as side effects. As part of our efforts to develop newer and effective anti-inflammatory agents , ten newer pyrazole carbaldehydes were synthesized and evaluated for their anti-inflammatory activity using Diclofenac was the standard. Out of ten compounds synthesized, all compounds exhibited comparable activity with that of the standard.Highest percentage of haemolysis was observed for Pyrazole carbaldehydes with methoxy phenyl groups as substituents. These compounds should be considered for developing as leads for newer & safer anti-inflammatory agents.

Vinod b

The aim of the paper is to evaluate the association of organic farming to strengthen the sustainability of organic agriculture. Organic agriculture shows abundant benefits, as it reduces many of the environmental impacts of conventional agriculture, it can increase efficiency in small farmers’ fields, and it reduces reliance on costly external inputs, and guarantees price premiums for organic products. Organic farmers also profit from farmer cooperative and the formation of social networks, which enhances good access to instruction, credit and welfare services. This paper brings out how the function of organic farming contributes for the sustainable practices and improving environment conservation, animal welfare, and product quality.

Svedbergopen

Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or its effects on peripheral tissues. Previous hospital based study have revealed high prevalence of hypothyroidism in pregnant women. Also, studies with small sample size indicated a rising trend of prevalence of hypothyroidism during pregnancy. Moreover, pregnancy is seen as a risk factor in the occurrence of thyroid dysfunctions. Thus, the aim of was to assess and analyze prevalence of hypothyroidism among Libyan pregnant women in Benghazi city in to study its relation and risk in pregnancy. The study was conducted on a sample size of 177 Libyan pregnant women in Benghazi city in Libya during 2018. A cross-sectional observational study was conducted in clinics located in Benghazi city. Responses to the question was coded and analyzed. The prevalence of hypothyroidism among the pregnant women was found to be 10.2% (n = 18) and no significant relation between age and hypothyroidism among women. Only nine percent of the pregnant women had medical conditions (as diabetes mellitus and high blood pressure). 28% of the hypothyroidism pregnant women are of the first gestation and 72% are of the second or more. 83% of the hypothyroidism pregnant women had no thyroidectomy. Thus, this study concludes that there is a high prevalence of hypothyroidism during pregnancy period in Benghazi and a national screening is necessary for hypothyroidism in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background and Objectives: Pulmonary tuberculosis (PTB) remains a public health issue in Nigeria. The rapid diagnosis of PTB is essential for the early initiation of treatment and management of patients. The utility of the BACTEC MGIT 960 TB system was evaluated and compared with the Lowenstein Jensen (LJ) culture method for the recovery of Mycobacteria from sputum samples. Methods: A total of 2400 sputum samples submitted to the South East TB Zonal Reference Laboratory, Amachara Umuahia, Nigeria were tested. Samples were decontaminated using the standard N-Acetyl-L-Cysteine Sodium Hydroxide method and concentrated before processing. The processed samples were inoculated into both MGIT 960 tubes and LJ medium and incubated accordingly. Results: From all sputum samples, Mycobacteria were recovered from 201 (8.4%) sputum samples by the MGIT 960 system and 175 (7.3%) by LJ culture (p=0.014). The sensitivity for MGIT and LJ culture for mycobacteria were 95.0% and 80.1%, respectively. Among the 201 MGIT-positive cultures, 127 (63.2%) were identified as Mycobacterium tuberculosis complex and 74 (36.8%) as Mycobacteria other than tuberculosis (MOTT). The recovery rate of MTBC from LJ-positive samples was 84.0% and MOTT 16.0%. MGIT 960 identified more MOTT than LJ culture (p=0.045). The contamination rate associated with MGIT and LJ culture was 4.1% and 2.5%, respectively (p=0.037). The time to detection of mycobacteria in MGIT 960 and LJ was 14.8 days and 33.2 days, respectively. Conclusion: MGIT 960 has good diagnostic accuracy. It provided a more rapid and higher recovery of all mycobacteria than the LJ culture.

Karishma

Dry powder injection of spironolactone was developed using lyophilization and hydrotropic solubilization method. It is fast acting medication in emergencies like refractory edema associated with heart failure and hepatic cirrhosis. The ultimate aqueous based powder prepared showed 892.85 and 378.57 times increased solubility of spironolactone with sodium salicylate and sodium benzoate as compared to its water solubility. Amongst six hydrotropic agents, the solubility was increased in the order sodium salicylate > sodium benzoate > nicotinamide > sodium ascorbate > urea > sodium acetate. IR graph showed shift of wavenumber of characteristic peaks. Lyophilization technique produced more stable product against different temperature cycles and stability parameters. Degradation was only about 0.45% at room temperature and it was more about 1.3% at higher temperatures. Haemolytic activities of lyophilized formulations observed were 8.54% to 96.85% for sodium salicylate based hydrotropic lyophilized system and 3.50 to 88.17% for sodium salicylate based hydrotropic lyophilized system.

Archana mehrotra

Background: Parkinson’s disease (PD) is one of the most common, disabling neuro-degenerative disorders. The disease has a significant clinical impact on patients, families, and caregivers through its progressive degenerative effects on mobility and muscle control. Available treatments for PD have varied results. Although there are anecdotal reports of improvement with Homoeopathy, there is a dearth of literature concerning usefulness in management of PD Objectives: To assess the usefulness of ultrahigh dilution of Zinc in the management of PD. Methods: A case of PD under standard care and refractory to treatment visited Out- Patient Department and was assessed with and Unified Parkinson’s Disease Rating Scale (UPDRS). As per the classical Homoeopathic guidelines Zincum metallicum 200 was prescribed after Repertorization. Results: UPDRS total score of 112 at baseline turned to 40 at the end of 1 year and 7 at the end of two years, in spite of reduction in the conventional medicines. Patient was on Stage 3 of Modified Hoehn and Yahr staging at the baseline and turned to Stage O in duration of 21 months. SEADL score has turned from 40% to 100%. Conclusion: Homoeopathic medicine Zincum met. is a valuable adjuvant in the management of Parkinson’s disease.

Dr deepthi gilla

Improving the agricultural productivity is an imminent need to meet the food requirement of constantly growing population rate. It can be gracefully satisfied if the farming process is integrated through technologies such as big data and IoT. The integration of agricultural processes with modern technologies has emerged as the smart agriculture technology. This research work is focused on proving the suitability of the big data analytics for smart agricultural processes in terms of increasing production and quality of yields with less resources and overhead. This research paper expounds the extensive review carried out on the related works in smart agricultural farming, challenges in implementing the smart farming technologies at large scale, followed by the conceptual framework model for the effective implementation of big data together with IoT devices in smart farming.

Dr h shaheen

Abstract Indian telecom industry has started growing rapidly since 1990 because of market liberalization. It has become one of the fastest growing telecom markets since then. Operating performance of a firm is depending upon certain key financial factors viz., turnover, profit, asset utilization etc. and the variables which are found in profit and loss account and balance sheet of a firm have a direct or indirect relation with each other. Financial performance of the firms can be analyzed by establishing a close relationship between the variables, in terms of liquidity, profitability, viability and sustainability. By establishing a close relationship between the variables, a firm can analyze its financial performance in terms of liquidity, profitability, viability and sustainability. Ratios and the statistical tool of ANOVA are normally used to identify the financial health of the firms and financial performances of the firms are measured accordingly. So the present study concentrates on empirical approach towards measuring deals with financial performance of the telecommunication companies.

Dr. jeyalakshmi p

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa

The Quantum Teaching learning model is a modification of the various interactions that exist in and around the moment in learning. This study aims to find out more about how to apply Quantum Teaching in measuring students' abilities including cognitive, affective and psychomotor aspects. This research method uses qualitative research methods with the type of research field research. Data collection techniques using observation techniques, interviews, and documentation. While the data analysis is a qualitative analysis model of Miles and Huberman and Saldana which consists of data collection, data condensation, data presentation and drawing conclusions. The results of this study are: (1) Implementation of Quantum Teaching in Class V Thematic Learning at MI Mambaul Ulum Kandangrejo cognitive aspects, namely students are able to think more critically and broadly, students are able to do assignments or exercises and can understand learning well, students able to provide questions and answers properly and appropriately. (2) Implementation of Quantum Teaching in Class V Thematic Learning at MI Mambaul Ulum Kandangrejo aspects in the affective aspect, namely: the curiosity of students increases, students become more focused, students' attitudes become more confident and courageous. (3) Implementation of Quantum Teaching in Class V Thematic Learning at MI Mambaul Ulum Kandangrejo psychomotor aspects, namely: students are able to practice well the learning media is provided, students are able to name the names and parts of the circulatory organs, students are able to show the circulatory organs blood using the medium.

Educare: journal of primary education

In the Indo-Pak subcontinent, the traditional systems of medicine, both Ayurvedic and Unani, are primarily based on herbs and herb-based preparation for therapy. Therefore, the importance of the herbal identification process remains critical in achieving the desired and successful therapeutic effect. To support the manufacturers and practitioners of both systems, many herbs are still collected from wild sources, as herbal farming is not very developed in this part of the world. During a survey program conducted in different areas of Pakistan, significant lacks and gaps were noted to be present in the identification & characterization of herbs, which needs to be addressed and fulfilled as many species look alike apparently or physically but have different biological or pharmacological activity. Based on this objective and approach, Centella asiatica was selected for the pharmacognostic and preliminary phytochemical investigation to establish a better correlation and to provide useful methods in its identification as the use of Centella asiatica is very common in Pakistan and other South Asian countries for CNS disorders therapy. Therefore, this study aimed to develop & report some and rapid identification methods for Centella asiatica. The present study includes physical, physicochemical, preliminary phytochemical and fluorescence analysis. For the first time, in the present study, NIR and FT-IR spectra of Centella asiatica have been reported for identification. The findings of the present study are quite promising and can be helpful for the manufacturers and researchers in the identification and development of Centella asiatica-based new drugs or formulations.

Dr. salman ahmed

Monitoring and controlling of clean area environment is of paramount importance to ensure product safety and quality. This comprehensive analysis evaluates environmental monitoring (EM) data from Class C and Class D controlled environments in pharmaceutical manufacturing, utilizing Active Air (AA), Passive Air (PA), and Contact Plate (CP) or Replicate Organism Detection And Counting (RODAC) surface samples. The study aims to identify contamination trends, anomalies, and compliance with ISO 14644-1 and EU GMP Annex 1 standards. Results reveal unexpected findings: Class C Active Air (43 CFU/m³) and RODAC (3 CFU/plate) overall averages are higher than Class D Active Air (34 CFU/m³) and RODAC (2 CFU/plate), respectively, deviating from expected cleanroom classification. Class D Passive Air (22 CFU/plate) is higher than Class C (17 CFU/plate), aligning with expectations. Persistent hotspots were identified in Class C (e.g., location labelled “AA C 12 NG0”AA averages± Standard Deviation (SD): 67.33±17 CFU/m³), indicating localized control failures, while Class D showed extreme individual spikes (e.g., AA D 99 Ac: Max 171 CFU/m³). Sporadic contamination events in Class C suggest transient breaches, necessitating root-cause investigations. The study also highlights limitations of Class D monitoring, which obscures temporal trends and risks missing critical excursions due to long intervals between samples. Recommendations include targeted engineering assessments for high-load zones, enhanced Standard Operating Procedures (SOPs) for cleaning and gowning, adoption of real-time biofluorescent particle counters to replace manual sampling, and increased monitoring frequency in Class D hotspots.

Mostafa eissa

A short review on the multi-use of this ancient herb, German Chamomille. Presented is a synthetic route to azulene, its most bioactive principle (antioxidant, disinfectant, wound-healing, antibacterial).

Stefan dahl

The contribution of financial perspective measures to improving organizational performance is empirically examined in this article. The study examines how financial metrics like ROI, cost control, profitability, and revenue growth relate to organizational effectiveness using the case of MTN Ghana. It is based on the balanced scorecard framework. The study uses a quantitative approach to investigate the relationship between financial performance metrics and important success indicators like market share, operational effectiveness, and shareholder value, using data from a dataset of different companies in multiple industries. The results of the study show how important financial perspective metrics are for reaching competitive advantage and sustainable growth. Businesses that put a high priority on strategic fiscal management typically perform better, especially when it comes to cost-effectiveness, liquidity, and profit margins. But the study also highlights the drawbacks of depending only on financial indicators. To create a more thorough performance evaluation system, it emphasizes the need to combine financial measurements with non-financial indicators like employee development, internal processes, and customer satisfaction. In summary, the study offers practitioners and scholars useful information by offering evidence-based recommendations for enhancing financial strategies. Organizations can develop a balanced approach to performance measurement that promotes long-term success by using both financial and non-financial metrics. The article ends with practical suggestions for businesses looking to increase output and streamline their budgets.

Suleman mohammed yakubu

Chronic kidney disease is a public health problem affecting people worldwide. This study was aimed to examine the characteristics of patients with chronic kidney disease and to identify prevalence of drug-related problems among Libyan patients. This is a descriptive retrospective study carried out in Southern-west part of Libya, Sebha City. Information abstraction forms were used for collection of data. The investigators reviewed the medications, medical records and laboratory data to identify drug-related problems.1 000 patients' files during 2019-2020 were examined and only 120 files were selected for this study. The majority of the participants were male (73, 61.0%) and the mean age was 56.1 years. 576 comorbidities among the selected patients were identified (73.61%) and the average number per patients was 4.8 concurrent diseases. There were 1 350 medications prescribed and the average of prescribed drugs per patient was 11.25. The majority of patients use more than 10 drugs (64, 53.3%) and the average length of staying in the hospital was 5.58 days. 502 drug-related problems were identified with an average of 4.18 per patient. Untreated conditions such as Hyponatremia and anemia were the highest rate of drug-related problems identified (199, 39.6%) followed by improper drug selection (82, 16.3%) such as cefotaxime, vancomycin and aminoglycoside for chronic kidney disease and drug use without indications such as antibiotics (68, 13.5%) and over-therapeutic dose such as metoclopramide(63, 12.5%). In conclusion, all the patients have polypharmacy and the majority have comorbid conditions and chronic kidney disease with frequent drug-related problems, thus, to lower the incidence rate of drug-related problems, therapeutic interventions are needed. Subsequently, it is a crucial to involve clinical pharmacist in hospital to improve the care of patient with chronic kidney disease.

Mediterranean journal of pharmacy and pharmaceutical sciences

Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA), with a mandate to provide at least hundred days of guaranteed wage employment in a financial year to every rural household whose members above the age of eighteen years volunteer to do unskilled manual work. The main focus of the act is to facilitate the social protection for the people living in rural India by providing employment opportunities and therefore contributing towards the overall development of the local people. The present study was attempted to figure out the impact of MGNREGA on overall economic and social development of beneficiaries in Gobichettipalayam, Erode district of Tamilnadu.. The results found the MGNREGA has significantly improved their social and economic well-being. The study also has highlighted on the fact that agricultural wages have gone up after the introduction on MGNREGA scheme in the current area.

Nandini jagannarayan

As it is increasingly being reported from India, we carried out a prospective study of patients with culture-proven melioidosis from south India, examining clinical, laboratory features, epidemiological data, risk factors, treatments, outcomes at three and six months, and factors associated with mortality.Between 2014 and 2018, 31 cases were identified. Diabetes (83.9%) and alcohol abuse (58.1%) were common risk factors. Musculoskeletal, skin and soft tissue manifestations together constituted 48.4% of presentations, while 29% had pneumonia. During the intensive phase, 74.2% received one of three recommended antibiotic regimes, but 51.6% did not receive continuation treatment. Pneumonia and lack of continuation treatment were independently associated with a high mortality of 25.8%. Hot spots for melioidosis exist in India, and there is considerable diversity of presentation, including skin, soft tissue, musculoskeletal and neurological involvement. High rates of bacteraemia are shown.

Aneesh basheer