This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

Introduction: In recent years, the growing research towards new drugs has been targeted on plant-based drugs, and Neem (Azadirachta indica) is one of the plants that have been extensively researched for its diverse medicinal properties. The study aimed to determine the effects of neem on the hematological parameters (total white blood cells, neutrophil, monocyte and eosinophil counts) and histology of some organs of rats. Methods: Fifteen healthy male Wister rats divided into control (Nm0) and experimental groups (Nm11 and Nm22). Control group 1 (Nm0) was given 100mg/200g body weight of normal saline orally twice daily; experimental group 2 (Nm11), 100mg/200g body weight neem extract twice daily for 11 days and experimental group 3 (Nm22), 100mg/200g neem leaf extract twice daily for 22 days. Total number of white blood cells (WBC), lymphocytes, neutrophils, monocytes and eosinophils, packed cell volumes (PCV) and histological changes in the spleen, liver and kidneys were evaluated. Results: There were no significant differences in mean values of the hematological parameters (total WBC; PCV; neutrophils, lymphocytes, monocytes and eosinophils). We observed the central vacuolation and accumulation of lymphocytes in the spleen, hypertrophy of the central vein in the liver and shrinking of the glomeruli and accumulation of the lymphocytes in the kidney using hematoxylin and eosin staining following prolonged administration of neem extract (Nm22). Conclusion: Prolonged administration of neem affected the histology of some organs of the rats more than the hematological parameters

Emmanuel umegbolu

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in humans. It is characterized by excessive cell growth, accelerated intrusion of normal brain tissue, and a poor prognosis. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, is largely ineffective, with high mortality and recurrence rates. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The physiological effects of marine peptides in glioblastoma are mediated by a range of pathways, including apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability; autophagy and metabolic enzymes downregulation. Herein, we address the efficacy of marine peptides as putative safe therapeutic agents for glioblastoma coupled with detailed molecular mechanisms.

Dr. salman ahmed

Background: Acute and chronic heart or kidney failure affect each other in cardiorenal syndromes (CRS). In CRS, hemodynamic and non-hemodynamic changes occur, causing acute or progressive renal and cardiac failures. CRS is classified into five types based on the first organ failure and causes failure of the other organ. We believe that the current CRS classification is not the correct one that effectively describes the underlying cause of CRS. Hence, we consider it better to be classified into three categories (cardiorenal, renocardiac, and cardio-reno-cardiac syndrome) and then subdivided into acute and chronic types or types 1 and 2 (respectively, according to the onset of the underlying type of failure (i.e., acute or chronic). Other subtypes that occur inthe heart and dysfunction occur simultaneously are acute cardio-reno-cardiac syndrome (type 5) and Chronic cardio-reno-cardiac syndrome (type 6). Aim: In Part 1 of the review series, the pathophysiological mechanisms and clinical and therapeutic applications of all types of CRS will be narratively discussed and updated. Furthermore, we provide a comprehensive review of diagnostic biomarkers and their clinical significance in the identification, outcome prediction, and treatment of all CRS types. Method: An extensive search of PubMed, Google, EMBASE, Scopus, and Google Scholar was conducted for review articles, original articles, and commentaries published between Jan 2010 and Aug 2024 using different phrases, texts, and keywords, such as CRS, renocardiac syndrome, and CRS. The topics included secondary CRS, CRS pathogenesis, CRS therapy, SLGT inhibitor use in CRS, novel therapy in CRS types, and prevention of CRSs. Conclusion: Renal and cardiac failure in patients with CRS seem to have different pathophysiological mechanisms. Early detection and treatment can improve the outcomes of CRS. Clinical manifestations and therapy protocols vary according to pathophysiology. Hence, new guidelines and research on universal diagnostic and treatment techniques are urgently required. Moreover, the current nomenclature for CRS is confusing; therefore, we believe that a new nomenclature system should be introduced, reducing confusion and making differentiation between CRS types easier and less confusing.

Karishma

Plants have been used as medicine for the treatment of diseases for thousands of years. These herbal remedies, although natural, can cause some serious damaging effects on the vital organs of the body due to inadequacy in standardization and safety regulations. Mucuna pruriens Linn. belongs to the family Fabaceae and is used traditionally in various ailments. The present study reports the acute systematic toxicity and topical toxicity of methanolic extract of Mucuna pruriens (seeds) on albino mice and rabbits respectively. The test solution was injected intravenously into the tail as 1ml/20gm of the mice body weight. The observation was made immediately and after 1/2, 1, 4, 24, 48 and 72hours of drug administration. Mice showed normal activity till 72hours. The intracutaneous test is designed to evaluate local responses to the extracts of materials under test following intracutaneous injection into rabbits. The toxicological investigations of Mucuna pruriens with particular reference to intracutaneous toxicity in experimental animals displayed that it showed slight edema.

Dr. salman ahmed

Lack of development of adequate social skills of special need students results in many disruptive behavior and poor academic gains. School setting is also an indicator of rise in academics and learning of social skills. The purpose of the current study was to investigate the social skills development and educational outcomes of special need students attending special and inclusive settings. Only 110 visually impaired students (60 from special and 50 form inclusive school setting) represent as special need children who participated as sample of the study. Data were collected from 5 Special Schools for Visually Impaired and 5 Inclusive Schools located in Delhi and NCR. Hindi Version of the Matson Evaluation of Social Skills with Youngsters: Self-rating form (MESSY) by Sharma (2000) was used to assess social skills development and to measure the educational outcome, aggregate percentage marks obtained by the students in their previous year‟s annual examination were collected from the records of the schools. Hypotheses formulated for this study were verified by applying appropriate statistical techniques- Mean, Standard Deviation and t-test. Significant differences found in the development of social skills and educational gains of the special need children in special vs. inclusive settings. Inclusive setting, to a great extent provides conducive learning environment and platform to develop social skills. Results of the study recommend implications for special and normal children, teachers and administrators.

Rubul kalita

COVID-19 pandemic has spread all over the world and has caused psychological impacts. Medical students are known to be vulnerable population, experiencing higher levels of anxiety, depression and other psychological disorders compared to non-medical students. The nature of life changes like what happened and still happening during the pandemic have its impact on mental health of the students. The aim of this study was to identify the psychological impacts of COVID-19 on medical students among different universities to develop profiles to characterize students' anticipated levels of psychological impacts during the pandemic. Also, to search for potential risk factors that could make students more likely to experience these impacts. An online survey was filled by medical students (n = 100) at faculties of medicine, dentistry, pharmacy and medical sciences of different universities: University of Benghazi, Libyan International Medical University, Omar Almokhtar University, Cairo University and Alexandria University. The students were taken to the further analysis. Thus, 55% of the participants had psychological impacts due to the pandemic and 17% had severe effect. Some of these impacts were actually positive as a large number (58%) of the participants felt relaxed during the pandemic. Multiple stressors were identified that contributed to the increased levels of stress, anxiety and depression. These included concern about academic performance (80%), concern about self/dear-one’s health (90%), difficulty with concentration (46%), disruption to sleeping patterns (78%), increased social isolation (26%), disruption to eating patterns (48%), changing in the living environment (26%), financial difficulties (34%) increased class workload (20%) depressive thoughts (37%) and suicidal thoughts (07%). In conclusion, the study indicates that COVID-19 pandemic have positive and negative impacts on medical students. Thus, it is suggested that measures need to alleviate students’ stress, which might have harmful effects in different aspects.

Mediterranean journal of pharmacy and pharmaceutical sciences

This study aimed at the evaluation of the quality attributes and sensory properties of noodles produced from composite blends of acha, adu, mungbean and moringa oleifera seed. Composite flours of acha, adu, mungbean and moringa oleifera seed were formulated by total replacement of wheat with acha, adu, mungbean and moringa oleifera seed at different graded ratios (B= (55:35:5:5), C= (55:30:10:5, D= (50:30:15:5), E= (50:25:20:5), F= (45:25:25:5) while 100% wheat flour was used as the control (sample A)). The composite flours were used to produce noodles and the noodles subjected to proximate analysis and sensory properties evaluation. Proximate analysis revealed that the noodles contained moisture content of 10.22-13.90%, 2.32-4.48% ash, 10.13-17.90% protein, 1.50-5.71% lipid, 0.48-3.68% crude fibre, 54.33-75.35% carbohydrate and 340.31-355.42Kcal/100 g energy. There was an increase in the moisture, ash, protein, lipid and crude fibre contents with a decrease in carbohydrate and energy contents as the amount of mungbean flour increases. Sensory evaluation scores showed that noodles made with 0% wheat, 55% acha, 35% adu, 5% mungbean and 5% moringa oleifera seed can favourably compare with the control. It is recommended that the beany flavour of mung beans be removed before its addition in the composite blend in order to produce noodles that can be highly accepted.

Okechukwu obed chukwuemeka

Background: Cubital tunnel syndrome (CuTS) is the second most common nerve entrapment syndrome of the upper extremity after carpal tunnel syndrome. In situ decompression (ISD) and ulnar nerve transposition (UNT) are the major surgery methods in practice for the treatment of CuTS. However, controversies exist over the efficacy and safety of these methods. Aim: The objective of the study was to compare the short- and long-term clinical outcomes in patients treated with ISD and UNT surgery. Method: This was a retrospective study comprising 56 patients who underwent either ISD or UNT at Naresuan University Hospital between January 2013 and December 2022. Data on age, sex, hand involved, duration of the surgery, duration of the symptoms including the clinical outcomes such as elbow range of motion (ROM), quick disabilities of the arm, shoulder, and hand (QuickDASH), McGowan grade (MGG), Visual Analog Scale (VAS) for pain scores, motor and sensory conduction velocity (MCV1, MCV2, and SCV), and Tinel's sign were collected during the two-week, one-month, three-month, and six-month follow-ups post-surgery. Results: Of the 56 patients in the study, 62.5% were female. The number of patients aged <60 years was higher in both groups. The mean age of patients in the ISD group was 49.07±6.13 years, while in the UNT group, it was 51.5±7.04 years. After one month, 53.57% and 32.14% of the patients recovered to MGG 1 in the ISD and UNT groups, respectively. The majority of the patients had MGG 1 six months after the surgery. The QuickDASH score and pain scores of the patients improved during all follow-ups, but no statistical significance was revealed when the two techniques were compared. Conclusion: The study found that both the ISD and UNT were efficient and safe in treating CuTS. Further study with the inclusion of parameters such as revision surgery and complications would be vital.

Saran malisorn

Ever-growing era of mobile and personal wireless networks, motivated research in several fields of engineering resulted in low power and low cost consumer products. The voice band processing required in mobile applications demand for architectures, which can easily be integrated in single chip SoC applications. The conventional approach is to have a dedicated IC outside the digital ICs to perform analog to digital conversion. The motivation of single chip radios demand for integration of such ADC modules on digital cellular related ICs. Mixed signal design is very challenging and hence usually it is preferred to have separate ADC chip before the ASIC/FPGA. In this paper we present a digital sigma delta ADC architecture, which can perfectly be integrated in any digital IC with a targeted sampling rate of 20 kS/s with more than 80 dB dynamic range.

P.a. harsha vardhini

The conservation of traditional medicinal knowledge opens the door towards modern aspects of herbal drug discovery. It started with knowledge exchange through ethnic groups through oral tradition and then in the documented form. Herbaria conserving identified and authenticated plants for future correspondence play an important role. In presenting the review, the authors have declared different auxiliary aspects of herbaria for phytomedicinal research.

Dr. salman ahmed

This study conducted a simulation-based time-domain short-circuits fault evaluation and protection system reliability analysis in 300 MVA substations with 132 kV transmission lines in Asaba (Ibusa/Asaba), Delta State, Nigeria. The analysis focused on two primary parameters: protection system dependability and selectivity, to determine the conditions necessary for ensuring rapid fault clearance and stable substation operation under line-to-ground, double-line, and three-phase faults. Fault currents, voltages, and relay trip signals were generated and analyzed using MATLAB time-domain simulations. Results indicated that system dependability exceeded 97% and security surpassed 95% when total fault-clearing times remained below 120 ms. Relay coordination intervals of 0.2–0.4s, backup misoperation below 3%, and circuit breaker MTBF above 20,000 h ensured selective fault isolation. Extended fault durations beyond 120ms or improperly coordinated relay settings increased the likelihood of misoperation and voltage instability. It was concluded that uninterrupted substation operation depends on integrating time-domain fault evaluation, coordinated relay settings, and reliable breaker performance into protection management protocols. Accordingly, it was recommended that substation operators maintain precise relay coordination, implement continuous time-domain monitoring, and uphold breaker maintenance schedules. These actions will further enhance the protection reliability, reduce fault propagation risks and support safer, more stable operation of the 132 kV transmission network.

Fxintegrity publishing

Will discuss how the German giant Lidl plans to take expansionary steps in a Mexican or Norwegian market to add to its success records in the European and North American markets. Lidl began modestly in 1973 with a small shop that runs three members and offers 500 products to 10,500 stores in 29 countries. Lidl has many pros, plus the disadvantages to consider when evaluating the components available in each country, both the pros and cons of this analysis will be reviewed using PESTLE, five- force models, internal value-activities, international business being able to. Accordingly, the next targeted expansion decision will be made.

Mohamed sorogy

In this report, Tesco PLC's operation and project management have been fully elaborated on. Tesco PLC is a retail organization that deals with retailing and other related activities in insurance service and retail banking (REUTERS, 2020). Tesco is multinational general merchandise and groceries with headquarters at Welwyn Garden City in England. Based on gross revenue rating, Tesco is the third-largest retailer in the world. Tesco was created by Jack Cohen in 1919 in Hackney, London as a set of markets stalls. Tesco developed and expanded very fast in the whole world and above 100 Tesco shops in the entire Facebook. Tesco has segments in ROI and the UK that is; central Europe (Hungary, Slovakia, and the Czech Republic), the Republic of Ireland, and the United Kingdom which do similar activities to those done in Tesco bank in the United Kingdom (Bedford, 2022). Tesco avails different personal banking packages (services and products) that include personal loans, personal current accounts, and credit card receivables. Tesco's businesses are therefore Tesco Hungary, Tesco UK, Tesco Czech Republic, Tesco Slovakia, Tesco Ireland, Dunnhumby, and Tesco Bank.

Zamzam abdelazim

The study focuses on Library and Information Science (LIS) education in India. In India, traditional libraries and digital libraries currently coexist. India's LIS curriculum is still not adapting to the new positions. Students have not gained the crucial information technology-related knowledge and abilities from library institutions. Because of their expertise, Library and Information Science (LIS) professionals serve as a conduit between readers and information resources. The library follows the laws and regulations within the profession when acquiring and processing resources. Furthermore, there are drawbacks to these norms and restrictions. They are learned in the academic setting, where they are taught how to manage library information resources so that patrons can access them with ease. Cataloging, classification, indexing, inquiry work, user education training, facilitating, and assessment skills are among the fundamental abilities typically linked to library and information science. Depending on their library area, an information professional may have a range of these skills. Information technology skills, including word processing and spreadsheets, digitization, and internet search capabilities, as well as proficiency with loan systems, computer databases, managing content, and specially created programs and packages, are some crucial cross-sector competencies that are changing in the twenty-first century. Additionally, there are soft skills like time management, negotiation, and dispute resolution that are applicable to all encounters at work. Because of this, learners from LIS programs are not very competitive in the information industry. The paper talks about the difficulties of teaching LIS in India. It addresses the cooperation & resource sharing between institutions of librarianship as well as educating LIS professionals for managerial and leadership positions to promote India's economic and national development. Additionally, it covers job opportunities for LIS professionals, the abilities required, the influence of LIS education on graduates' work and careers, the recent emphasis on e-learning in LIS courses in India, and the ongoing professional growth of LIS professionals. It is essential for librarians to have the skills required to operate in a specialized job in the cutting-edge era of information technological advances, when client needs and equipment are changing quickly. Library and Information Science (LIS) education should therefore include contemporary information processing abilities to ensure the profession remains valid in the rapidly evolving 21st century.

Dr. awadhesh singh gautam

Unmanned aerial vehicles (UAVs) are aerial systems controlled remotely or autonomously by astronauts. Massive advancements in electronics and information technology have prompted the popularity and growth of UAVs. As a result of the huge advances made in electronics and information technology, civilian tasks can now be accomplished with UAV in a more effective, efficient, and secure way. Known as a drone, UAVs are developed and operated using a variety of technologies such as machine learning, computer vision, artificial intelligence, and collision avoidance. Having become more affordable and accessible, drone technology has become more popular among civilians. Therefore, this technology is constantly evolving and can be used across a variety of fields. The application of drones makes a huge difference in the most demanding and complex industrial environments such as those in the mining industry, maritime, oil, gas, and seaports. The usage of drones is increasing among industrialists to improve and optimize processes, as well as to enhance operational efficiency in industrial process. This chapter discusses UAVs on a wide range of topics, including evolution and historical perspectives of UAV, taxonomy of UAV, significance of UAV to society and industry, and industrial and academic perspectives on UAV.

Dr h shaheen

The paper reports the results collected from social work students (SW) and nonsocial work students (NSW) of Ho Chi Minh City Open University (OU) through attitudes toward poverty and poor people in Vietnam. The Attitude toward Poverty Short Form (ATP-SF) 21-item (ATP-SF) scale, developed by Yun & Weaver (2010), was used for the data collection. The sample of this study comprises 180 students enrolled in three disciplines: social work (n = 86), law (n = 34), foreign language (n = 30) and economics (n = 30). The questionnaire was used to collect the data for the study. Cronbach’s alpha and independent t-tests were run to compare means between two groups of students. All students voluntarily participated in the survey.

Le minh tien

While today, he was ready to serve 1.4 million meals for schoolchildren, Mr.CC Das, Program Director, Akshaya Patra Foundation from Bangalore also faced the challenges 15-years before its establishment like any other start-up. Similar was the case of Mr.Trilok Gautam, Executive Supervisor, who was working in a remote village called Baran in Rajasthan. On his visit during the mid-day meal preparation, he was inspecting the quality of meal, where women were busy in preparing food. They were preparing bread by rolling the dough, while few were chopping vegetables with utmost hygienic care. Cleaner, safer, quality meal was to be prepared and served for 1,500 poor students. These children earlier used to go hungry from the school. On November 28th 2001, Supreme Court of India gave a verdict and directed the State Government and Union Territories to provide mid-day meal to every child in Government and Government-assisted primary schools. The Right to Food Law emerged as a fundamental right, enforced due to constitutional amendment under Article 32 of the constitution. Hence, every State Government geared up to make the mid-day meal scheme successful in their respective States. The Karnataka government also participated and named this programme as ‘Akshara Dashoha’. Government of Karnataka took the pioneering step to involve NGOs like Akshaya Patra as an important partner of the government to run this innovative mid-day meal scheme under the Public Private Partnership (PPP) Model. Presently, Indian mid-day meal scheme considered as one of the largest mid-day meal programme in the world has a target to reach out nearly 120 million children in the country.

Nitin mali

This study aims to determine the functional literacy acquisition of Alternative Learning System learners and make a sound basis for strategic planning and pedagogical intervention that will help promote and develop the said program. The descriptive-evaluative method of research was used in the study. The descriptive method was used to identify the respondents' profile based on (a) age, (b) gender, (c) civil status, and (d) employment status. The evaluative method was used to determine the respondents' functional literacy acquisition in (a) communication skills, (b) scientific and critical thinking skills, (c) mathematical and problem solving skills, (d) life and career skills, (e) understanding the self and society, and (f) digital citizenship (formerly digital literacy). Frequency Count and Percentage Technique was used to describe the functional literacy acquisition of the respondents. Meanwhile, a modified survey questionnaire based on the functional literacy, education and mass media survey ("National Profile of Adult Literacy and Numeracy Skills," 2004, p. 91) was used as the primary tool to gather the data. The respondents in this study were the students enrolled in ALS-Sipocot (North and South District), the school year 2019-2020. Due to COVID restrictions, other ALS learners from other municipalities were not covered as part of the study. Findings revealed that ALS learners do not yet manifest the complete acquisition of functional literacy needed to face the globalized world's challenges because their attainment of the required functional literacy skills is generally low. Moreover, the study disclosed that sex, age, civil status, and employment status affect the acquisition of functional literacy skills among ALS learners in Sipocot, Camarines Sur. Based on the results, the researcher developed an extension activity to help the ALS learners improve their functional literacy, particularly in the digital citizenship area, where they got the lowest score.

Darrel ocampo

Arenaria serpyllifolia L. is a medicinally important plant found in subtropical and temperate regions of the Himalayas from Nepal to Kashmir. The plant is used traditionally to treat kidney and bladder-related problems. Flavonoids and xanthone-containing compounds, such as epicatechin, japonicumone, quercetin, etc, are reported in the plants. Plants have shown Inhibitory effects on Carboxyl esterase

Dr. salman ahmed